DE102004016605A1 - Thiocarbamoylproline - Google Patents
Thiocarbamoylproline Download PDFInfo
- Publication number
- DE102004016605A1 DE102004016605A1 DE102004016605A DE102004016605A DE102004016605A1 DE 102004016605 A1 DE102004016605 A1 DE 102004016605A1 DE 102004016605 A DE102004016605 A DE 102004016605A DE 102004016605 A DE102004016605 A DE 102004016605A DE 102004016605 A1 DE102004016605 A1 DE 102004016605A1
- Authority
- DE
- Germany
- Prior art keywords
- dollar
- thiocarbamoylproline
- prophylaxis
- tumors
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- ANUAUSIRFPDWSC-BYPYZUCNSA-N (2s)-1-carbamothioylpyrrolidine-2-carboxylic acid Chemical compound NC(=S)N1CCC[C@H]1C(O)=O ANUAUSIRFPDWSC-BYPYZUCNSA-N 0.000 title 1
- 108010074860 Factor Xa Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000009424 thromboembolic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Neue Verbindungen der Formel I, DOLLAR F1 worin DOLLAR A R, R·1·, R·2·, R·3· und R·4· die in Patentanspruch 1 angegebene Bedeutung haben, DOLLAR A sind Inhibitoren des Koagulationsfaktors Xa und können zur Prophylaxe und/oder Therapie von thromboembolischen Erkrankungen und zur Behandlung von Tumoren eingesetzt werden.New compounds of the formula I, DOLLAR F1 in which DOLLAR AR, R · 1 ·, R · 2 ·, R · 3 · and R · 4 · have the meaning given in claim 1, DOLLAR A are inhibitors of the coagulation factor Xa and can be used for prophylaxis and / or therapy of thromboembolic disorders and for the treatment of tumors.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004016605A DE102004016605A1 (en) | 2004-04-03 | 2004-04-03 | Thiocarbamoylproline |
| PCT/EP2005/002745 WO2005097783A1 (en) | 2004-04-03 | 2005-03-15 | Thiocarbamoylprolines |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004016605A DE102004016605A1 (en) | 2004-04-03 | 2004-04-03 | Thiocarbamoylproline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE102004016605A1 true DE102004016605A1 (en) | 2005-10-20 |
Family
ID=34963324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE102004016605A Withdrawn DE102004016605A1 (en) | 2004-04-03 | 2004-04-03 | Thiocarbamoylproline |
Country Status (2)
| Country | Link |
|---|---|
| DE (1) | DE102004016605A1 (en) |
| WO (1) | WO2005097783A1 (en) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ508101A (en) * | 1998-04-10 | 2002-12-20 | Japan Tobacco Inc | Amidine compounds useful as factor Xa inhibitors and as anticoagulants |
| US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
| DE502004003688D1 (en) * | 2003-04-03 | 2007-06-14 | Merck Patent Gmbh | PYRAZOLIDINE-1,2-DICARBOXYLIC ACID-1 - ((PHENYL) -AMID) -2 - ((PHENYL) -AMID) DERIVATIVES AS COAGULATION FACTOR XA INHIBITORS FOR THE TREATMENT OF THROMBOSES |
| JP5015593B2 (en) * | 2003-06-18 | 2012-08-29 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 1-[(4-Ethynylphenyl)]-2-[(phenyl)]-pyrrolidine-1,2-dicarboxamide derivatives as inhibitors of coagulation factors Xa and VIIa for the treatment of thrombosis |
-
2004
- 2004-04-03 DE DE102004016605A patent/DE102004016605A1/en not_active Withdrawn
-
2005
- 2005-03-15 WO PCT/EP2005/002745 patent/WO2005097783A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005097783A8 (en) | 2007-04-19 |
| WO2005097783A1 (en) | 2005-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8139 | Disposal/non-payment of the annual fee |