DE102004014294A1 - Composition containing mixed oxide that includes aluminum or magnesium and branched alkanoic acid, useful for control of microbes, e.g. treating acne or in cleaning compositions - Google Patents

Abstract

Composition (A) comprises at least one mixed oxide (I) containing aluminum and/or magnesium and at least one 4-38C 2-alkyl-branched acid (II) and/or its derivatives. ACTIVITY : Dermatological; Antiseborrheic; Antibacterial; Virucide; Fungicide; Antiparasitic. The sodium salt of 2-butyloctanoic acid, at a concentration of 0.2%, produced an inhibition halo of 7-10 mm on Propionibacterium acnes and 4-6 mm on Staphylococcus aureus. MECHANISM OF ACTION : (II) (a) causes release of Al and/or Mg ions from (I), and these inhibit formation of sweat and (b) in cases of heavy sweating, prevents microbial decomposition of sweat.

Description

object The invention relates to compositions comprising mixed oxides and 2-alkyl branched acids or their derivatives and their use as against bacteria, Mykota and viruses effective substances.

The Healthy human skin is non-pathogenic with a variety of Microorganisms colonized and provides important protection Defense of opportunistic or pathogenic germs. Occasionally is it necessary or at least helpful this property of To support skin by adding antimicrobial substances.

bacteria belong to the prokaryotic unicellulars. They can be roughly shaped, as well as the structure of their cell wall (gram-positive, gram-negative) be differentiated. So exist aerobic, anaerobic as well as facultative anaerobic bacteria. Some are pathogenic in their properties Germs of medical importance, others are perfect harmless.

Versus Bacteria-active substances have been known for some time, e.g. about antibiotics. Antibiotics are chemical by definition Substances that hinder the multiplication of microorganisms. antibiotics From today's perspective, with increased caution and only in medical Indication used and are for cosmetic applications are not suitable, as often the organism in use is impaired in its metabolic functions.

A Object of the present invention is to provide substances available which are against Gram-positive and / or Gram-negative bacteria are effective without the use of the substance an unreasonable impairment the health of the user.

The fight Gram-positive bacteria play an important role in cosmetics. In bad skin, for example, among other influences are bacterial secondary infections significant. One of the most important microorganisms in the context with impure skin is Propionibacterium acnes. A special Object of the present invention was it against impure skin or Propionibacterium acnes effective substance or combination of substances to find. Another important group besides the bacteria that dangerous to humans could become, are the fungi, mycota or mycobionts, which in contrast to the Bacteria belong to the eucaryotes.

eukaryotes are living beings whose cells (Eucyten) in contrast to those of the so-called Procaryonten (Procyten) over one by Kernhülle and Nuclear membrane from the rest of the cytoplasm delimited nucleus have. Of the Nucleus contains the genetic information is stored in chromosomes. To representatives of Counting mycobionts for example, yeasts, molds, mildew, the wrong mildew and the mushrooms.

Dermatomycoses are diseases in which certain types of fungi, especially dermatophytes, invade the skin and hair follicles. The symptoms of dermatomycoses include blisters, exfoliation, rhagades and erosion, usually associated with itching or allergic eczema. Dermatomycoses can be divided into the following four groups:
Dermatophytoses (eg, epidermophytia, favus), yeast mycoses (eg, pityriasis), mold mycoses (eg, aspergillosis), and systemic mycoses (eg, chromomycosis).

task In the present invention, it is a substance or a combination of substances to find that work against fungi and fungi, mycota or mycobionts.

Furthermore there are the pathogenic and facultative pathogenic germs leading to the Group of yeast Candida species (e.g., Candida albicans) and such the family Pityrosporum, Pityrosporum species, especially Pityrosporum Oval, are for Skin disorders such as pityriasis versicolor, seborrhea in the forms Seborrhoea oleosa and Seborrhoea sicca, which are mainly as Seborrhoea capitis (dandruff) manifest seborrheic dermatitis or to blame for pityrosporum folliculitis.

The object of the invention is to find substances which are resistant to the groups described, such as the eucaryotes, procaryotes, mycobionts, Candida species, pathogenic or facultatively pathogenic germs, without affecting the organism when used in its metabolic functions. By using the composition according to the invention, the bacterial flora on the skin can be reduced whoever, without affecting the entire microflora of the skin. The state of the art lacks substances which act against viruses and which, moreover, do not or only to a reasonable extent damage the host organism of the viruses.

in the Contrary to the prokaryotic and eukaryotic cellular organisms Viruses are biological structures that are biosynthesized as a host cell need. Extracellular Viruses consist of single- or double-stranded nucleic acid sequences and a protein coat, optionally an additional one lipid-containing shell surround. Medically important viral rats are, for example, influenza viruses, Lyssaviruses (e.g., rabies), enteroviruses (e.g., hepatitis A) or hepadnaviruses (e.g., hepatitis B).

virus killing Substances in the true sense do not exist, because viruses do not have one own metabolism. Possible Mechanisms of action in the fight against the viruses are primarily the disorder their replication, e.g. by blocking those important for replication Enzymes present in the host cell. Furthermore, the release the viral nucleic acids be prevented in the host cell. In the context of the present Invention is effective under the term "antiviral", or against viruses "virucidal" the property a substance understood a single or multicellular organism from harmful Consequences of a virus infection / replication, be it prophylactically or therapeutically, to protect, regardless of what the actual Mechanism of action of the substance or drug mixture is.

It gives a variety of intellectual property rights or other publications, the composition of antiperspirants and deodorants to the subject. Deodorants generally contain active ingredients, the as odor maskers, Odor absorbers, germ inhibitors, enzyme inhibitors and / or Antioxidants work very differently. Their effectiveness depends i.a. from the recipe base into which they are incorporated, and the excipients used in the production of deodorants. The use of perfume to cover or lamination of body odor is practically common since the existence of the perfumery itself and can therefore be considered the "classic" process become. Even with modern deodorant preparations does the perfuming a significant contribution to the effectiveness of these products.

odor absorbers are special substances that absorb odoriferous compounds and can largely hold on. They lower the partial pressure of the individual components and reduce it as well as their propagation speed. An example is the zinc salt of ricinoleic acid. It would be desirable, that an odor absorber in addition antibacterial effect, but without irritating the skin.

A another important method of control of body odor is the use of antimicrobial agents, which is a largely selective effectiveness against own the responsible bacteria. In this way, an excessive emergence can occur odor-causing substances are prevented from the outset. It should be noted that the population of affected bacteria only controlled and too strong growth should be prevented (bacteriostatic effect), but the bacteria by no means be completely killed allowed to (no bactericidal effect). This would be the biological balance the skin flora is severely impaired, so that pathogens can spread.

To the germ-inhibiting agents belong generally all suitable preservatives with specific activity against Gram-positive bacteria, e.g. Triclosan (2,4,4-trichloro-2-hydroxydiphenyl ether), chlorhexidine (1,1-hexamethylene-bis [5- (4-chlorophenyl) -biguanide) and TTC (2,4,4-trichlorocarbanilide). All these substances in common is their high antimicrobial effectiveness. They will therefore only used in low concentrations of 0.1 to 0.3% by weight. In The practice is also glycerol monolaurate (GML) as a bacteriostat used.

The Today's antiperspirants contain, for the most part, aluminum salts whose activity contract the welding channels lets and whose acidic reaction reduces the flow of sweat. These However, strong acid reaction can easily lead to redness and irritation of the skin to lead and heavily pollutes the textile fabric by staining. Furthermore these active ingredients are relatively ineffective in extreme perspiration.

In summary, it is the object of the present invention to provide antimicrobial, antimycotic, antiparasitic, antifungal and / or antiviral active ingredient combination-prophylactically or therapeutically-in particular for cosmetic and / or pharmaceutical formulations, in particular dere for use in deodorants or antiperspirants.

• (a) ein Mischoxid enthaltend Aluminium und/oder Magnesium und
• (b) eine 2-alkylverzweigte Säure und/oder deren Derivate, wobei die Säure 4 bis 38 Kohlenstoffatome aufweist, neben über die Säuregruppe hinaus ggf. weiteren Heteroatomen, vorzugsweise bis zu 4 weiteren,

obige Aufgaben lösen.It has surprisingly been found that compositions containing

• (a) a mixed oxide containing aluminum and / or magnesium and
• (b) a 2-alkyl branched acid and / or derivatives thereof, the acid having 4 to 38 carbon atoms, in addition to any other heteroatoms beyond the acid group, preferably up to 4 others,

solve the above tasks.

The average particle size (D ₅₀ ) of the mixed oxide, based on the starting material, is advantageously less than 10 μm, preferably less than 5 μm. A large surface is advantageous and as it is advantageous if the particles are not noticeable on the skin.

worin
R¹ und R² unabhängig Kohlenwasserstoffreste mit 1 bis 18 Kohlenstoffatomen sind, insbesondere lineare oder verzweigte, gesättigte Alkylreste, insbesondere steht R¹ für einen Alkylrest mit 1 bis 6 und R² für einen Alkylrest mit 1 bis 8 Kohlenstoffatomen.The 2-alkyl branched acid has, in particular, the following structure:

wherein
R ¹ and R ^{2 are} independently hydrocarbon radicals having 1 to 18 carbon atoms, in particular linear or branched, saturated alkyl radicals, in particular R ^{1 is} an alkyl radical having 1 to 6 and R ^{2 is} an alkyl radical having 1 to 8 carbon atoms.

According to the invention the used 2-alkyl branched acids or their derivatives 0.001 to 80 wt .-%, preferably 0.01 to 20 wt .-% and in particular from 0.02 to 10% by weight, used in the compositions.

The Mixed oxides are used in amounts of 0.001 to 80 wt .-%, preferably 0.1 to 40 wt .-% and particularly preferably 1 to 20 wt .-% based used on the composition, in particular in relation to the Deodorant or antiperspirants.

It it is advantageous to buffer the composition. Is advantageous a pH of 3 to 8, particularly favorable is a pH of 4.0 to 6.5.

preferred embodiments The invention are described below or subject matter of claims 2 and The following.

The mixed oxide is preferably a hydrotalcite, zeolite and / or a layered silicate. Phyllosilicates are water- and / or hydroxide-containing aluminosilicates with small amounts of magnesium, iron, sodium, potassium and / or calcium. Preference is given to a hydrotalcite having the general formula M ²⁺ _2x M ³⁺ ₂ (OH) _{4x + 4} A _{2 / n} ^n- · z H ₂ O where x is 0.5 to 10 in 0.5 steps,
A stands for an interstitial anion,
n is the charge of the interstitial anion, which is up to 8, usually up to 4, and
z is in integers from 1 to 6, in particular from 2 to 4,
M generally represents metal ions which are divalent as M ²⁺ and trivalent as M ³⁺ . Suitable divalent metals are, for example, Mg, Zn, Fe and trivalent metals Al or Fe,
where at least Mg or at least Al stands for M ²⁺ or M ³⁺ .

The following compounds may be mentioned as examples: Mg ₄ Al ₂ (OH) ₁₄ .4H ₂ O, Mg ₆ Al ₂ (OH) ₁₆ CO ₃ .4H ₂ O or Mg ₃ Al ₂ (OH) ₈ (C ₆ H ₆ O ₇ ) ₂ · 4H ₂ O to name. In 1 is the hydrotalcite PURAL of SASOL Germany GmbH shown. "Basal spacing" stands for "basal spacing".

Also preferred are aluminosilicates, for example phyllosilicates or zeolites of the formula: M _{2 / n} O Al ₂ O ₃ x SiO ₂ y H ₂ O, where x is values of 2 to 500, y is values of 0 to 500 and n is the charge of the cation. M is generally a metal ion, such as Na ⁺ , K ⁺ or Mg ²⁺ .

The following zeolites may be mentioned by way of example: zeolite A Na ₁₂ [(AlO ₂ ) ₁₂ (SiO ₂ ) ₁₂ ] .27H ₂ O, zeolite X Na ₈₆ [(AlO ₂ ) ₈₆ (SiO ₂ ) ₁₀₆ ] .264H ₂ O, Zeolite Y Na ₅₆ [(AlO ₂ ) ₅₆ (SiO ₂ ) ₁₃₆ ] 250H ₂ O, ZSM 5 Na _0.3 H _3.8 [(AlO ₂ ) _4.1 (SiO ₂ ) _91.9 ] or ZSM 11 Na _0.1 H _1.7 [(AlO ₂ ) _1.8 (SiO ₂ ) _94.2 ].

In addition, the following further suitable phyllosilicates may be mentioned: serpentine (Mg ₃ (OH) ₄ [Si ₂ O ₅ ]), or antigorite or chrysotile; Kaolinite (Al ₂ (OH) ₄ [Si ₂ O ₅ ]) / kaolin; Halloysite (Al ₂ (OH) ₄ [Si ₂ O ₅ ] .2H ₂ O); Talc (Mg ₃ (OH) ₂ [Si ₄ O ₁₀ ]); Pyrophyllite (Al ₂ (OH) ₂ [Si ₄ O ₁₀ ]); Saponite (Mg ₃ (OH) ₂ [Si ₄ O ₁₀ ] .nH ₂ O); Montmorillonite (Al ₂ (OH) ₂ [Si ₄ O ₁₀ ] n H ₂ O); Phlogopite (Mg ₃ (F, OH) ₂ [Si ₃ AlO ₁₀ ] K, Mg possibly replaced by Fe in small amounts); Biotite ((Mg, Fe ²⁺ , Mn, Ti, Al) ₃ (OH, F) ₂ [(Si, Al) ₄ O ₁₀ ] K); Muscovite (KAl ₂ [AlSi ₃ O ₁₀ ] (OH) ₂ ); Chlorite (Mg, Fe ++, Al) ₃ (OH) ₂ [(Si, Al) ₄ O ₁₀ ]. Mg ₃ (OH) ₆ ) or attapulgite ((H ₂ O) ₄ (OH) ₂ Mg ₅ Si ₈ O ₂₀ · 4H ₂ O).

Some suitable derivatives of 2-alkyl-branched acids - as they are also mentioned in the subclaims - are described in more detail below, wherein each R ¹ and R ^{2 is} independently an unbranched, saturated alkyl radical having 1 to 18 carbon atoms.

Ester 2-alkyl branched acids

according to the general formula: [(R ¹ -) (R ² -) CH-COO-] _w R wherein each independently
R ¹ and R ^{2 have} the meaning defined above,
R is an aliphatic, linear or branched, saturated or unsaturated mono- to polyalcohol having an alkyl radical having 1 to 36 carbon atoms, and
w 1 to the number of hydroxyl groups of the alcohol, eg up to 8 indicates.

Generally Thus, R can be e.g. For Methanol, ethanol, propanol, isopropanol, butanol, isobutanol, pentanol, Hexanol, heptanol, octanol, nonanol, decanol, dodecanol, tetradecanol, Hexadecanol, octadecanol, eicosanol, tallow fatty alcohol, coconut fatty alcohol, Palm fat alcohol, castor alcohol, oleyl alcohol, linolyl alcohol, linolenyl alcohol, Behenyl alcohol, stearyl alcohol, benzyl alcohol, cyclohexanol, vinyl alcohol, Isostearyl alcohol, isooctanol, isononanol, isodecanol, 2-ethylhexanol, 2-propylheptanol, 2-butyloctanol, 2-butyldecanol, 2-hexyloctanol, 2-hexyldecanol, 2-hexyldodecanol, 2-octyldecanol, 2-octyldodecanol, 2-decyltetradecanol, 2-dodecylhexadecanol, 2-tetradecloctadecanol, Benzyl alcohol, cyclohexanol, vinyl alcohol, lactic acid and their oligomers, hydroxybutyric acid and their oligomers, mandelic acid and their oligomers, glycerolic acid and their oligomers or citric acid and their oligomers, phenols; Diols, e.g. Ethylene glycol, diethylene glycol, Triethylene glycol, propylene glycol, butylene glycol, pentylene glycol, Polyglycerol, hexylene glycol, neopentyl glycol, malic acid and its oligomers, tartaric acid and their oligomers or cyclohexanediols; Triols, e.g. Glycerine or Trimethylolpropane and polyols, e.g. Sugar alcohols, diglycerides, triglycerides, Polyglycerides, pentaerythritol or dipentaerythite are.

Carboxylates of 2-alkyl branched acids:

according to the general formula: [(R ¹ -) (R ² -) CH-COO-] _w - M where R ¹ and R ^{2 have} the meaning defined above,
M is a counter cation, such as H, Na, K, Al, Zn, Mg, K, Ca, monoethanolamine (MEA), monopropanolamine (MPA), monoisopropanolamine (MiPA), triethanolamine (TEA), and
w represents the value of the counter cation.

Ethoxylated 2-alkyl branched acids

The application further relates to polyglycol esters of the general formula: (R ¹ -) (R ² -) CH-COO- (C _x1 H _y1 O) _n (C _x2 H _y2 ) _o (C _x3 H _y3 ) _m R _y wherein each independently
R ¹ and R ^{2 have} the meaning defined above,
x1 for a value of 2 to 10,
y1 for 4 to 20,
x2 for 2 to 10,
y2 for 4 to 20,
x3 for 2 to 10,
y3 for 4 to 20,
R _{y is} an alkyl radical having 1 to 36 carbon atoms; or a counter cation such as H, Na, K, Al, Zn, Mg, K, Ca, MEA, MPA, MiPA or TEA, and
n, o and m independently represent a value of 0 to 200, wherein the sum of n, o and m is at least one.

Ester ether sulfates of 2-alkyl branched fatty acids

The application furthermore relates to ester ether sulfates and sulfates of the general formula: (R ¹ -) (R ² -) CH-COO- (C _x H _y O) _n SO ₃ M wherein each independently
R ¹ and R ^{2 have} the meaning defined above,
M for a counter cation such as H, Na, K, Al, Zn, Mg, K, Ca, MEA, MPA, MiPA or TEA,
X for a value of 2 to 10 and
Y stands for a value of 4 to 20 and
n can take a value from 0 to 200.

Ester phosphates of 2-alkyl branched acids

The application further relates to ester phosphates of the general formula (R ¹ -) (R ² -) CH-COO- (C _x1 H _y1 O) _n -P- [(OC _x2 H _y2 ) _m -O-C (O) -CH (-R ¹ ) (-R ² ) ] - [(OC _x3 H _y3 ) _o -OC (O) -CH (-R ¹ ) (- R ² )] wherein each independently
R ¹ and R ^{2 have} the meaning defined above,
n for a value from 0 to 200,
m for 0 to 200,
o for 0 to 200,
x1 for 2 to 10 and
y1 for 4 to 20,
x2 for 2 to 10 and
y2 for 4 to 20 and
x3 for 2 to 10 and
y3 stands for a value of 4 to 20.

Ester carboxylates of 2-alkyl branched acids

The application further relates to ester carboxylates of the general formula: (R ¹ -) (R ² -) CH-COO- (C _x1 H _y1 ) _n (C _x2 H _{y 2} O) _m CH ₂ C (O) OM wherein each independently
R ¹ and R ^{2 have} the meaning defined above,
x1 for 2 to 10,
y1 for 4 to 20,
x2 for 2 to 10,
y2 for 4 to 20 and
n and m have different or equal values from 0 to 200 and M stands for cations, such as Na, Al, Zn, K, Mg, K, Ca, MEA, MPA, MiPA, TEA or H.

Hetero-substituted compounds of 2-alkyl branched fatty acids

The application further relates to substituted compounds or salts of 2-alkyl branched fatty acids having the general formula: (R ¹ -) (R ² -) CH-C (= Y) (- X) wherein each independently
R ¹ and R ^{2 have} the meaning defined above,
X is F, Cl is Br, J, SR ³ , SH, NH ₂ or NR ⁴ R ⁵ , NR ⁶ H,
R ³ , R ⁴ , R ⁵ , R ^{6 are} branched, unbranched, saturated alkyl radicals having the formula CxHy and x is 1 to 40 and y is 3 to 81,
Y is O, S, NR ⁷ , PR ⁸ or an H atom and
R ⁷ , R ^{8 are} branched, unbranched, saturated alkyl radicals having the formula C _x H _y where X is 1 to 40 and Y is 3 to 81.

Sugar esters of 2-alkyl branched fatty acids

The application furthermore relates to sugar esters of 2-alkyl branched fatty acids having the formula: ((R ¹ -) (R ² -) CH-COO) _z- sugar R ¹ and R ^{2 have} the meaning defined above,
z for 1 to 10 and
Sugar for a sugar residue, in particular a monosaccharide having four, five or six C atoms, such as erythrose, threose, ribose, deoxyribose, glucose, fructose, arabinose, xylose, lyxose, allose, altrose, gulose, mannose, idose, galactose, Talose, disaccharides and polysaccharides.

• – 2-Butyloctansäure,
• – 2-Alkyl verzweigte Fettsäuresalze wie die Natrium, Kalium oder Aluminium-Salze der 2-Butyloctansäure oder der 2-Hexyldecansäure,
• – Mono-, Di- und Tri- Glycerinester von 2-Butyloctansäure und 2-Hexyldecansäure,
• – Polyglycerolester mit einem Mol 2-alkyl verzweigter Fettsäure, im Besonderen Polyglycerolester von 2-Butyloctansäure,
• – Polyglycerolester mit 2 Molen 2-alkyl verzweigter Fettsäure, im Besonderen Polyglycerolester von 2-Butyloctansäure,
• – Polyglycerolester mit 3 Molen 2-alkyl verzweigter Fettsäure, im Besonderen Polyglycerolester von 2-Butyloctansäure,
• – Polyglycerolester mit 3 Molen 2-alkyl verzweigter Fettsäure,
• – 2-Butyloctansäurelactat,
• – 2-Butyloctansäureoligolactat,

soweit obige Ester bei der Herstellung einen Säureüberschuss aufweisen, kann dieser partiell oder vollständig mit Alkali- oder Erdalkalisalzen neutralisiert sein.Particularly interesting as 2-alkyl branched acid or its derivatives are the following compounds and mixtures thereof, wherein the fatty acids have 4 to 36 carbon atoms:

• 2-butyloctanoic acid,
• 2-alkyl branched fatty acid salts such as the sodium, potassium or aluminum salts of 2-butyloctanoic acid or 2-hexyldecanoic acid,
• Mono-, di- and tri-glycerol esters of 2-butyloctanoic acid and 2-hexyldecanoic acid,
• Polyglycerol ester with one mole of 2-alkyl branched fatty acid, in particular polyglycerol ester of 2-butyloctanoic acid,
• Polyglycerol ester with 2 moles of 2-alkyl branched fatty acid, in particular polyglycerol ester of 2-butyloctanoic acid,
• Polyglycerol ester with 3 moles of 2-alkyl branched fatty acid, in particular polyglycerol ester of 2-butyloctanoic acid,
• Polyglycerol ester with 3 moles of 2-alkyl branched fatty acid,
• 2-butyloctanoic acid lactate,
• 2-butyloctanoic acid oligolactate,

if the above esters have an excess of acid in the preparation, this may be partially or completely neutralized with alkali metal or alkaline earth metal salts.

The Composition has proven to be resistant to bacteria, mycota, and mold Viruses proved effective. Suitable applications for introduction are in particular cosmetic, dermatological or pharmaceutical Formulations.

The Composition according to the invention let yourself without difficulty in common cosmetic, dermatological or pharmaceutical formulations incorporate or use the ingredients in this advantageous Such cosmetic, dermatological or pharmaceutical Formulations as pump sprays, aerosol sprays, creams, ointments, lotions, Deodorants, antiperspirant sticks, tinctures, nail care products but also in hair preparations, like shampoos, gels, mousses or body cleansers, like soaps, Washing lotions, dentifrices, cleaning agents or emulsions used.

Particularly preferred are anti-dandruff shampoos or anti-general-skin preparations such as in anti-acne preparations, as well as deodorants or toothpastes, which may be effective against halitosis. As far as in the present application, the term skin or skin-associated terms are mentioned, these include each of the mucous membranes.

It is possible, too and, where appropriate, advantageous, the compositions according to the invention to combine with other agents, such as with others antimicrobial, antimycotic, antiparasitic or antiviral effective Substances.

The cosmetic, dermatological or pharmaceutical formulations according to the invention may be composed as usual be and for the treatment of skin and hair in terms of dermatological Treatment or treatment in terms of nourishing cosmetics serve. You can but also used as a make-up product in decorative cosmetics become. The cosmetic, dermatological or pharmaceutical formulations according to the invention in the cosmetic, dermatological or pharmaceutical formulations usual Applied to the skin and or hair in sufficient quantity. Advantageous are cosmetic, dermatological or pharmaceutical formulations, the at least one UVA filter and or at least one UVB filter and / or at least one organic pigment.

The cosmetic preparations according to the invention can contain cosmetic aids, such as those commonly used in such preparations can be used, e.g. Preservatives, bacteriocides, antioxidants, perfumes, Antifoaming agents, dyes, pigments, thickeners, surface-active Substances, emulsifiers, emollients, humectants Substances, fats, oils, Waxes or other usual Ingredients of a cosmetic formulation such as alcohols, polyols, Polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.

In first line can the erfindungemäßen connections used in cosmetics. However, its advantageous Effect can also be used profitably in other areas. Furthermore, these are suitable, as partially described above, in care products or pharmaceutical products, in cosmetics, Detergents, cleaners, household cleaners, i.a. in cosmetic Emulsions, cosmetic formulations, shampoos, or in technical Cleaners, in dishwashing detergents, Hand washing pastes, basic bodies for toothpastes, in syndet and half-syntense soaps, in creams and tube shampoos, in Stick preparations, Ointment bases, in wax compositions for care products, antifoam agents, as a cleaning amplifier also in dry cleaning, in metalworking, in technical Cleaning and cleaning Degreasing agents and as corrosion inhibitors. Further applications are e.g. in disinfectants or as leather and textile auxiliaries, in wetting agents and detergents, anti-migration agents, scouring agents, Mercerizierenden means, as a brightener, foaming agent, in spin finishing Range, as antistatics or in decolorants.

• – sie sollen eine zuverlässige Desodorierung bewirken,
• – die natürlichen biologischen Vorgänge der Haut dürfen nicht durch die Desodoranten beeinträchtigt werden und deren Mikroflora soll geschont werden,
• – Hautverträglichkeit,
• – die Desodorantien müssen bei Überdosierung oder sonstiger nicht bestimmungsgemäßer Anwendung unschädlich sein,
• – sie sollen sich nach wiederholter Anwendung nicht auf der Haut anreichern,
• – sie sollen sich in übliche kosmetische Formulierungen gut einarbeiten lassen und mit einer möglichst großen Vielzahl an üblichen Hilfs- und Zusatzstoffen harmonisieren,
• – über einen längeren Zeitraum von mindestens einem halben Tag wirksam sein, ohne dass ihre Wirkung spürbar nachlässt.

A particular field of application of the composition according to the invention is antiperspirants. The deodorants / antiperspirants according to the invention should, if possible, fulfill the following conditions:

• - they should cause a reliable deodorization,
• - the natural biological processes of the skin must not be impaired by the deodorants and their microflora should be spared,
• - skin compatibility,
• - the deodorants must be harmless in case of overdose or other improper use,
• - they should not accumulate on the skin after repeated use,
• They should be easy to incorporate into conventional cosmetic formulations and to harmonize with the widest possible variety of customary auxiliaries and additives,
• - be effective over a longer period of at least half a day without noticeably reducing their effect.

The Skin shows no sweating usually at a pH of 5.5, which in welding, e.g. to a pH of 4 drops. The sweat resistance of conventional Aluminum salts thus begins i.d.R. only when sweat has already formed Has. This is especially true for people with heavy perspiration unfavorable. The antiperspirant If necessary, active ingredients are no longer sufficient and the user would already have an unpleasant, wet feeling before the actual effect ever one sets. For this purpose, it was found that the antiperspirant mixed oxides in combination with a weak acid use.

The combination of the mixed oxide with a 2-alkyl branched proved to be particularly advantageous Acid, which also has a certain antimicrobial, antimycotic, antiparasitic, antifungal and antiviral effect on its own.

Without being bound by theory, it is believed that the weak acid causes Al ³⁺ and / or Mg ²⁺ ions to be released from, for example, hydrotalcite, zeolites or phyllosilicates and inhibit perspiration. In particularly heavy sweats, such as in morbid cases, during exercise, or over a whole day, the weak 2-alkyl branched acid ensures that the freshly formed apocrine sweat, which is still completely odorless, is not decomposed by bacteria of the group gram-positive bacteria and the familiar unpleasant smell triggers or the unpleasant and unclean feeling for the user. There are basically two different types of body odor. Thus, the weaker "acid" type is associated with micrococci, which are found in the skin flora of all healthy people in large proportions.This type is found especially in female persons.As characteristic odor component of this type isovaleric acid was detected.

Of the other type of smell is called "pungent" produced by the lipophilic diphtheroids (mainly corynebacteria). These germs, which do not necessarily belong to the skin flora, are in much stronger Extent at male People found.

The 2-alkyl branched acids act against these bacteria and thus provide a suitable Active ingredient there. Depending on the amount of acid used and mixed oxide, a "storage" of the 2-alkyl branched acid in the Mischoxid is observable, so that these as needed by a low, acidic pH caused by perspiration and / or through increased Body heat released or increasingly released.

Furthermore, by the release of the A ³⁺ and / or the Mg ²⁺ ions which inhibit the formation of perspiration, the mixed oxide in the case of the zeolite to polysilicic acid o decomposed in the case of a hydrotalcid to alumina, which additionally binds the odor.

It So this system is a drug combination, which lasts long lasting against perspiration and prevents the formation of odors. Another advantage is the textile-sparing properties of the composition, staining Avoid and do not over iron to textile damage to lead. Furthermore have the compositions of the invention Advantages with regard to the release or release by the active ingredients because of the big one surface of the mixed oxide and in the metering.

Example Formulations (in each case in% by weight)

production:

The individual components from phase A were combined and heated to 75 ° C. Then The phase B was added in portions as a mixture.

(1) antiperspirant cream O / W

Phase A Hexadecanol / octadecanol (NAFOL ^® 1618 - SASOL Germany) 8.0% Hexadecanol / octadecanol - 11 EO (MARIPAL ^® 1618 / 11- SASOL Germany) 1.4% Hexadecanol / Octadecanol - 20 EO (GALENOL 2100 - SASOL Germany) 1.5% 2-octyldodecanol (ISOFOL 20 ^® - SASOL Germany) 8.0% 2-butyloctanoic acid (ISOCARB ^® 12 - SASOL Germany) 0.30%

Phase B Mg ₆ Al ₂ (OH) ₁₆ CO ₃ · 4 H ₂ O (PURAL MG ^® HT 61 - SASOL Germany) 19.8% water 61.0%

(2) antiperspirant cream O / W

Phase A Glycerol tri (octanoate, decanoate, dodecanoate) (Migliol ^® 812 - SASOL Germany) 46.0% Octadecanol (NACOL ^® 18 - SASOL Germany) 26.0%

2-Octyldodecanol - 30 EO (ISOFOL ^® 20 + 20 EO) 7.5 % 2-Butyloctadecansäure polyglycerol ester 600 (ISOCARB ^® 12 - PEG 600 ester) 0.30 %

Phase B Mg ₄ Al ₂ (OH) ₁₄ · 4 H2O (PURAL MG ^® HT 61 - SASOL Germany) 19.8% Perfume 0.40%

(3) antiperspirant stick

Phase A Glycerol tri (octanoate, decanoate, dodecanoate) (Migliol ^® 812 - SASOL Germany) 46.0% Hexadecanol / octadecanol (NAFOL ^® 1618 H - SASOL Germany) 26.0% 2-butyloctanoic acid, sodium salt (ISOCARB ^® 12 Na salt) 0.30% 2-Octyldodecanol - 30 EO (ISOFOL ^® 20 + 20 EO) 7.4%

Phase B Mg ₄ Al ₂ (OH) ₁₄ · 4 H ₂ O (PURAL MG ^® HT 61 - SASOL Germany) 20.0% Perfume 0.3%

Test method - Hemmhoftest:

1 ml of the respective test germ (germ density of 10 ⁴ to 10 ⁵ ) was mixed with about 20 ml of standard nutrient agar or malt extract agar in a sterile Petri dish. The life of the cast Petri dish was 1.5 to 2 hours at room temperature. In the nutrient medium 3 holes are punched with 1 cm diameter. In the punched holes 50 ul of the test substance are filled. After filling the test substance, the Petri dish is incubated for 24 or 48 hours in a humid chamber at 30 ° C. The diameter of the inhibition yard is measured after 24 and 48 hours (mm)

Table 1: Inhibition test

Table 2: Inhibition test

Claims (12)

Composition comprising: (a) at least one mixed oxide containing aluminum and / or magnesium and (b) at least one 2-alkyl branched acid and / or its derivative, wherein the 2-alkyl branched acid 4 to 38 Having carbon atoms. A composition according to claim 1, characterized in that the mixed oxide, based on the starting material, an average particle size (D ₅₀ ) of less than 10 microns, preferably less than 5 microns having. Composition according to at least one of the preceding claims, characterized in that the 2-alkyl branched acid has the following general formula

wherein R ¹ and R ^{2 are} independently hydrocarbon radicals having 1 to 18 carbon atoms, in particular linear or branched, saturated alkyl radicals and more preferably R ^{1 is} an alkyl radical having 1 to 6 and R ^{2 is} an alkyl radical having 1 to 8 carbon atoms. Composition according to at least one of the preceding Claims, characterized in that the composition comprises the 2-alkyl branched acids or their derivatives to 0.001 to 80 wt .-%, preferably 0.01 to Contains 20 wt .-% and in particular to 0.02 to 10 wt .-%. Composition according to at least one of the preceding Claims, characterized in that the composition is the mixed oxides to 0.001 to 80 wt .-%, preferably 0.01 to 20 wt .-% and in particular to 0.02 to 10 wt .-% contains. wherein Composition according to at least one of the preceding Claims, characterized in that the composition has a pH of 3 to 8, in particular from 4.0 to 6.5. Composition according to at least one of the preceding Claims, characterized in that the derivatives are carboxylates 2-alkyl branched acids, Alkoxylates of 2-alkyl branched acids, 2-alkyl branched acid ester ether sulfates, 2-alkyl ether phosphates branched acids, Ethercarboxylates of 2-alkyl branched acids, heterosubstituted compounds 2-alkyl branched fatty acids and / or sugar esters of 2-alkyl branched fatty acids. Composition according to at least one of the preceding claims, characterized in that the mixed oxides are hydrotalcites, zeolites and / or phyllosilicates, in particular hydrotalcites of the general formula: M ²⁺ _2x M ³⁺ ₂ (OH) _{4x + 4} A _{2 / n} ^n- · z H ₂ O where x is 0.5 to 10 in 0.5 steps, A is an interstitial anion, n is the charge of the interstitial anion which is up to 8, usually up to 4, z in integers from 1 to 6, in particular from 2 to 4, and M generally represents metal ions which are divalent as M ²⁺ and trivalent as M ³⁺ , at least Mg and / or Al being M ²⁺ and M ^3+, respectively, and in particular zeolites thereof Formula: M _{2 / n} O Al ₂ O ₃ x SiO ₂ y H ₂ O, where x is values of 2 to 500, y is values of 0 to 500, n is the charge of the cation and M is a metal ion. Use of the composition according to at least one of the preceding claims in cosmetic, dermatological or pharmaceutical formulations. Use of the composition according to at least one of the claims 1 to 8 in antiperspirants or as antiperspirant active ingredient. Use of the composition according to at least one of the claims 1 to 8 for the preparation of a medicament for the treatment of infestation with Propionibacterium acnes. Use of the composition according to at least one of the claims 1 to 8, in wetting and cleaning agents, in metalworking, as corrosion inhibitors, in disinfectants and / or as Leather and textile auxiliaries, in abrasives, in antistatic agents and / or in decolorants.