DE10075004I1 - N-substituierte p-Aminoethylsulfonanilide als antiarrhythmische Mittel und Zwischenprodukte dafuer - Google Patents

N-substituierte p-Aminoethylsulfonanilide als antiarrhythmische Mittel und Zwischenprodukte dafuer

Info

Publication number: DE10075004I1
Authority: DE; Germany
Prior art keywords: alkyl; group; formula; antiarrhythmic agents; substituted
Prior art date: 1986-05-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

DE2000175004

Other languages

English (en)

Other versions

DE10075004I2 (de

Inventor

John Edmund Arrowsmith

Peter Edward Cross

Geoffrey Noel Thomas

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Ltd Great Britain

Original Assignee

Pfizer Ltd Great Britain

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-01

Filing date

1987-04-29

Publication date

2000-04-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26290703&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE10075004(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1986-05-01 Priority claimed from GB868610668A external-priority patent/GB8610668D0/en

1986-12-17 Priority claimed from GB868630059A external-priority patent/GB8630059D0/en

1987-04-29 Application filed by Pfizer Ltd Great Britain filed Critical Pfizer Ltd Great Britain

2000-04-13 Application granted granted Critical

2000-04-13 Publication of DE10075004I1 publication Critical patent/DE10075004I1/de

2006-02-02 Publication of DE10075004I2 publication Critical patent/DE10075004I2/de

Status Active legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Steroid Compounds (AREA)
Saccharide Compounds (AREA)
Pyrrole Compounds (AREA)
Polyamides (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Fats And Perfumes (AREA)
Manufacturing Of Micro-Capsules (AREA)
Cephalosporin Compounds (AREA)
Lubricants (AREA)
Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
Medicines Containing Plant Substances (AREA)

DE2000175004 1986-05-01 1987-04-29 N-substituierte p-Aminoethylsulfonanilide als antiarrhythmische Mittel und Zwischenprodukte daf}r. Active DE10075004I2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB868610668A GB8610668D0 (en)	1986-05-01	1986-05-01	Anti-arrhythmia agents
GB868630059A GB8630059D0 (en)	1986-12-17	1986-12-17	Antiarrhythmic agents

Publications (2)

Publication Number	Publication Date
DE10075004I1 true DE10075004I1 (de)	2000-04-13
DE10075004I2 DE10075004I2 (de)	2006-02-02

Family

ID=26290703

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE8787303782T Expired - Lifetime DE3778201D1 (de)	1986-05-01	1987-04-29	N-substituierte p-aminoethylsulfonanilide als antiarrhythmische mittel und zwischenprodukte dafuer.
DE2000175004 Active DE10075004I2 (de)	1986-05-01	1987-04-29	N-substituierte p-Aminoethylsulfonanilide als antiarrhythmische Mittel und Zwischenprodukte daf}r.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE8787303782T Expired - Lifetime DE3778201D1 (de)	1986-05-01	1987-04-29	N-substituierte p-aminoethylsulfonanilide als antiarrhythmische mittel und zwischenprodukte dafuer.

Country Status (27)

Country	Link
US (2)	US4959366A (de)
EP (1)	EP0245997B1 (de)
KR (2)	KR870011084A (de)
CN (1)	CN1019801B (de)
AT (1)	ATE74906T1 (de)
AU (1)	AU578557B2 (de)
BA (2)	BA98301A (de)
CA (1)	CA1289140C (de)
DE (2)	DE3778201D1 (de)
DK (1)	DK175096B1 (de)
EG (1)	EG18188A (de)
ES (1)	ES2033840T3 (de)
FI (1)	FI88291C (de)
GR (1)	GR3004457T3 (de)
HU (1)	HU196743B (de)
IE (1)	IE59366B1 (de)
IL (1)	IL82373A (de)
LU (1)	LU90519I2 (de)
LV (1)	LV5715B4 (de)
MY (1)	MY111142A (de)
NL (1)	NL300002I2 (de)
NO (2)	NO168527C (de)
NZ (1)	NZ220151A (de)
PH (1)	PH23425A (de)
PL (1)	PL149924B1 (de)
PT (1)	PT84782B (de)
YU (2)	YU46195B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5602174A (en) *	1986-02-15	1997-02-11	Beecham Wuefling Gmbh & Co.	Treatment
NL8700842A (de) *	1987-04-10	1988-11-01	Duphar Int Res
SE8705150D0 (sv) *	1987-12-23	1987-12-23	Haessle Ab	Novel antiarrhythmic agents
US4906634A (en) *	1988-03-08	1990-03-06	Schering A.G.	Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents
GB8809314D0 (en) *	1988-04-20	1988-05-25	Wellcome Found	Anti-hypertensive sulfonanilides
GB8819307D0 (en) *	1988-08-13	1988-09-14	Pfizer Ltd	Antiarrhythmic agents
US5166209A (en) *	1989-04-21	1992-11-24	Burroughs Wellcome Co.	Pharmacologically active compounds
AU641394B2 (en) *	1989-06-02	1993-09-23	John Wyeth & Brother Limited	Amines
US5084463A (en) *	1989-12-11	1992-01-28	American Home Products Corporation	N-quinolinyl alkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class III antiarrhythmic activity
IL106549A0 (en) *	1992-07-31	1993-12-08	Syntex Inc	Heterocyclic derivatives,their preparation and pharmaceutical compositions containing them
US5451677A (en) *	1993-02-09	1995-09-19	Merck & Co., Inc.	Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
GB9404485D0 (en)	1994-03-09	1994-04-20	Cancer Res Campaign Tech	Benzamide analogues
DE4422517A1 (de) *	1994-06-28	1996-01-04	Dresden Arzneimittel	Neue (2-(3,4-Dimethoxy-phenyl)-ethyl)-(2-phenoxy-ethyl)-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AU2630095A (en) *	1994-08-04	1996-03-04	C & C Research Laboratories	Novel amine derivative, process for producing the same, and use thereof as antiarrhythmic
DE69500377T2 (de)	1994-08-19	1997-10-09	Mitsui Toatsu Chemicals	Pyrimidin-Dion-Derivate und diese enthaltende antiarrhythmische Zusammensetzungen
US5679706A (en) *	1994-09-30	1997-10-21	Bristol-Myers Squibb Company	Combination of a potassium channel activator and an antiarrhythmic agent
FR2726267B1 (fr) *	1994-10-26	1998-01-02	Smithkline Beecham Lab	Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer
CN1055682C (zh) *	1995-12-06	2000-08-23	中国药科大学	甲磺酰胺基苯乙胺衍生物的新制备方法
CN1055679C (zh) *	1995-12-06	2000-08-23	中国药科大学	具有心血管活性的苯乙胺衍生物
GB9722662D0 (en) *	1997-10-27	1997-12-24	Pfizer Ltd	Polymorphs
HUP9702411A2 (hu) *	1997-12-11	2000-03-28	Gyógyszerkutató Intézet Kft.	Fenoxi-alkil-amin-származékok és a vegyületeket tartalmazó antiaritmiás hatású gyógyszerkészítmények
EP1436258A4 (de) *	2001-03-08	2005-03-23	Univ Emory	Ph-wert-abhängige nmda-rezeptorantagonisten
CN100358865C (zh) *	2001-07-30	2008-01-02	中国科学院上海药物研究所	一类磺酰胺苯烷胺类化合物及其制备方法和用途
DE10201550A1 (de) *	2002-01-17	2003-07-31	Merck Patent Gmbh	Phenoxy-Piperidine
WO2003091205A1 (fr) *	2002-04-26	2003-11-06	Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences	Sulfamidophenylalkylamines, production et utilisation de ces dernieres
EP2332921B1 (de) *	2003-06-17	2016-03-02	Arena Pharmaceuticals, Inc.	8-Chloro-1 -methyl-2,3,4,5-tetrahydro-1 H-3benzazapine Hydrochlorid
JP4782003B2 (ja) *	2003-06-17	2011-09-28	アリーナファーマシューティカルズ，インコーポレイテッド	５ｈｔ２ｃレセプター関連疾患の処置に有用なベンズアゼピン誘導体
DE102004025726B4 (de) *	2004-05-26	2006-07-06	Roder, Hanno, Dr.	Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit
AU2007334381B2 (en) *	2006-12-14	2014-02-13	Tautatis, Inc.	Compositions and methods for the treatment of cancer
JP2010532382A (ja) *	2007-06-29	2010-10-07	エモリー・ユニバーシテイ	神経保護のためのｎｍｄａ受容体拮抗薬
CN101372467B (zh) *	2007-08-23	2011-09-14	明德国际仓储贸易(上海)有限公司	具有n,n-二烷氨基的桥基化合物及所应用的染料化合物
CN102015591B (zh)	2008-03-04	2014-01-29	艾尼纳制药公司	制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法
CN102648170A (zh)	2009-06-18	2012-08-22	艾尼纳制药公司	制备5-ht2c受体激动剂的方法
KR20130112848A (ko)	2010-06-02	2013-10-14	아레나 파마슈티칼스, 인크.	5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
CA2808909A1 (en)	2010-09-01	2012-03-08	Arena Pharmaceuticals, Inc.	Salts of lorcaserin with optically active acids
JP2013536859A (ja)	2010-09-01	2013-09-26	アリーナファーマシューティカルズ，インコーポレイテッド	５−ｈｔ２ｃアゴニストの非吸湿性塩
SG10201506896RA (en)	2010-09-01	2015-10-29	Arena Pharm Inc	Administration of lorcaserin to individuals with renal impairment
CN102531946A (zh) *	2012-01-05	2012-07-04	山东大学	3-甲氧基苯甲酰胺衍生物及其制备方法与应用
MY181736A (en)	2012-10-09	2021-01-05	Arena Pharm Inc	Method of weight management
FR3029113A1 (fr)	2014-12-02	2016-06-03	Univ Paris-Sud	Composes pour le traitement des maladies mitochondriales
CZ2017772A3 (cs) *	2017-12-01	2019-05-29	Farmak, A.S.	Způsob přípravy N-[4-(2-{[2-(4-methansulfonamidofenoxy)ethyl](methyl)amino}ethyl)fenyl]methansulfonamidu (Dofetilidu)
US10888524B2 (en)	2018-02-05	2021-01-12	Enaltec Pharma Research Pvt. Ltd.	Immediate release tablet of dofetilide

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR977261A (fr) *	1948-11-04	1951-03-29		équilibrage des masses dans les moteurs à combustion interne
US3478149A (en) *	1962-01-24	1969-11-11	Mead Johnson & Co	Therapeutic compositions and methods employing sulfonamidophenethanolamines
GB993584A (de) *	1962-01-24
US3852468A (en) *	1967-02-27	1974-12-03	Ici Ltd	Alkanolamine derivatives as {62 -adrenergic blocking agents
US3574741A (en) *	1969-04-14	1971-04-13	Mead Johnson & Co	Sulfonamidophenalkylamines
US3758692A (en) *	1969-04-14	1973-09-11	Mead Johnson & Co	Ylamines sympathomimetic process and compositions employing sulfonamidophenalk
GB1263987A (en) *	1969-05-30	1972-02-16	Allen & Hanburys Ltd	Phenethylamine derivatives
BE757005A (fr) *	1969-10-02	1971-04-02	Bristol Myers Co	Phenethanolamines substituees et procede pour leur preparation
GB1301134A (en) *	1970-07-18	1972-12-29	Pfizer Ltd	SUBSTITUTED 1-PHENYL-2-ALLYLAMINO-ALKANOLS, 1-PHENYL-2-ALLYLAMINO-ALKANES AND alpha-AMINOALKYLPHENYL KETONES
DE2965655D1 (en) *	1978-06-28	1983-07-21	Beecham Group Plc	Secondary amines, their preparation, pharmaceutical compositions containing them and their use
CA1120058A (en) *	1978-07-03	1982-03-16	Jack Mills	Phenethanolamines, formulations and potentiation of oncolytic drugs
EP0021636B1 (de) *	1979-06-16	1982-12-01	Beecham Group Plc	Sekundäre Amine, ihre Herstellung und Verwendung in pharmazeutischen Zusammensetzungen
DD157796A5 (de) *	1979-12-04	1982-12-08	Ciba Geigy Ag	Verfahren zur herstellung neuer derivate des 2-amino-aethanols
FR2541999B1 (fr) *	1983-03-04	1986-09-19	Bristol Myers Co	Phenethanolamines et leurs utilisations
EP0164865B1 (de) *	1984-05-04	1988-12-21	The Upjohn Company	N-(Aminoalkylphenyl)sulfonamide, ihre Herstellung und ihre therapeutische Verwendung
US4569801A (en) *	1984-10-15	1986-02-11	Eli Lilly And Company	Alkylsulfonamidophenylalkylamines

1987
- 1987-04-19 EG EG230/87A patent/EG18188A/xx active
- 1987-04-24 PH PH35179A patent/PH23425A/en unknown
- 1987-04-27 MY MYPI87000548A patent/MY111142A/en unknown
- 1987-04-29 PT PT84782A patent/PT84782B/pt unknown
- 1987-04-29 ES ES198787303782T patent/ES2033840T3/es not_active Expired - Lifetime
- 1987-04-29 IL IL82373A patent/IL82373A/xx not_active IP Right Cessation
- 1987-04-29 CA CA000535897A patent/CA1289140C/en not_active Expired - Lifetime
- 1987-04-29 PL PL1987265418A patent/PL149924B1/pl unknown
- 1987-04-29 FI FI871898A patent/FI88291C/fi not_active IP Right Cessation
- 1987-04-29 DE DE8787303782T patent/DE3778201D1/de not_active Expired - Lifetime
- 1987-04-29 DE DE2000175004 patent/DE10075004I2/de active Active
- 1987-04-29 AT AT87303782T patent/ATE74906T1/de active
- 1987-04-29 US US07/044,086 patent/US4959366A/en not_active Expired - Lifetime
- 1987-04-29 EP EP87303782A patent/EP0245997B1/de not_active Expired - Lifetime
- 1987-04-30 NO NO871820A patent/NO168527C/no not_active IP Right Cessation
- 1987-04-30 NZ NZ220151A patent/NZ220151A/xx unknown
- 1987-04-30 DK DK198702202A patent/DK175096B1/da active Protection Beyond IP Right Term
- 1987-04-30 HU HU871971A patent/HU196743B/hu unknown
- 1987-04-30 KR KR870004213A patent/KR870011084A/ko not_active Ceased
- 1987-04-30 YU YU78387A patent/YU46195B/sh unknown
- 1987-04-30 AU AU72260/87A patent/AU578557B2/en not_active Expired
- 1987-05-01 CN CN87103300A patent/CN1019801B/zh not_active Expired
- 1987-05-11 IE IE116587A patent/IE59366B1/en not_active IP Right Cessation
1988
- 1988-04-12 YU YU73588A patent/YU46541B/sh unknown
1990
- 1990-06-20 US US07/541,232 patent/US5079248A/en not_active Expired - Lifetime
- 1990-12-07 KR KR1019900020068A patent/KR930001339B1/ko not_active Expired - Lifetime
1992
- 1992-04-29 GR GR920400823T patent/GR3004457T3/el unknown
1995
- 1995-03-15 LV LV950058A patent/LV5715B4/xx unknown
1998
- 1998-03-30 BA BA980301A patent/BA98301A/bs unknown
- 1998-03-30 BA BA980211A patent/BA98211B1/bs active
2000
- 2000-02-01 NL NL300002C patent/NL300002I2/nl unknown
- 2000-02-09 LU LU90519C patent/LU90519I2/fr unknown
2001
- 2001-06-26 NO NO2001011C patent/NO2001011I1/no unknown

Also Published As

Publication number	Publication date
DK220287D0 (da)	1987-04-30
AU578557B2 (en)	1988-10-27
BA98301A (bs)	2001-09-14
PT84782A (en)	1987-05-01
YU46541B (sh)	1993-11-16
IE59366B1 (en)	1994-02-09
EP0245997A3 (en)	1989-12-20
DK175096B1 (da)	2004-06-01
EP0245997B1 (de)	1992-04-15
HUT43558A (en)	1987-11-30
DK220287A (da)	1987-11-02
YU46195B (sh)	1993-05-28
DE10075004I2 (de)	2006-02-02
HU196743B (en)	1989-01-30
US4959366A (en)	1990-09-25
IE871165L (en)	1987-11-01
KR870011084A (ko)	1987-12-19
EP0245997A2 (de)	1987-11-19
NO168527C (no)	1992-03-04
CA1289140C (en)	1991-09-17
NL300002I2 (nl)	2000-05-01
NO871820L (no)	1987-11-02
LV5715B4 (lv)	1996-02-20
NZ220151A (en)	1989-02-24
KR920014397A (ko)	1992-07-30
FI871898A0 (fi)	1987-04-29
CN1019801B (zh)	1992-12-30
KR930001339B1 (ko)	1993-02-26
MY111142A (en)	1999-09-30
FI88291C (fi)	1993-04-26
NO168527B (no)	1991-11-25
NO871820D0 (no)	1987-04-30
PL265418A1 (en)	1988-07-21
US5079248A (en)	1992-01-07
BA98211B1 (bs)	1999-08-02
IL82373A (en)	1992-01-15
IL82373A0 (en)	1987-10-30
PT84782B (pt)	1989-12-29
PH23425A (en)	1989-08-07
LV5715A4 (lv)	1995-10-20
CN87103300A (zh)	1987-11-11
YU78387A (en)	1988-08-31
FI871898A7 (fi)	1987-11-02
AU7226087A (en)	1987-11-19
DE3778201D1 (de)	1992-05-21
LU90519I2 (fr)	2000-04-10
NO2001011I1 (no)	2001-07-16
EG18188A (en)	1992-09-30
YU73588A (en)	1990-04-30
NL300002I1 (nl)	2000-04-03
FI88291B (fi)	1993-01-15
ES2033840T3 (es)	1993-04-01
PL149924B1 (en)	1990-04-30
GR3004457T3 (de)	1993-03-31
ATE74906T1 (de)	1992-05-15

Publication	Publication Date	Title
DE10075004I1 (de)	2000-04-13	N-substituierte p-Aminoethylsulfonanilide als antiarrhythmische Mittel und Zwischenprodukte dafuer
PT82674B (pt)	1988-08-17	Processo para a preparacao de amidas
DK0409435T3 (da)	1994-11-21	Heteroarylpiperaziner som antipsykotiske midler
ATE59842T1 (de)	1991-01-15	Indanamin-derivate als antiarrhythmische mittel.
ES518186A0 (es)	1984-06-01	Procedimiento para preparar alquenamidas y fenilalquenamidas n,n-disubstituidas.
DE69112095D1 (de)	1995-09-21	1-Phenoxycarbonyl-2-Pyrrolidon-Derivate und nootrope Wirkstoffe.