DE10011032A1 - Acetylsalicylsäure-Lösungen - Google Patents
Acetylsalicylsäure-LösungenInfo
- Publication number
- DE10011032A1 DE10011032A1 DE10011032A DE10011032A DE10011032A1 DE 10011032 A1 DE10011032 A1 DE 10011032A1 DE 10011032 A DE10011032 A DE 10011032A DE 10011032 A DE10011032 A DE 10011032A DE 10011032 A1 DE10011032 A1 DE 10011032A1
- Authority
- DE
- Germany
- Prior art keywords
- water
- vol
- pain
- organic solvent
- acetylsalicylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 11
- 239000003960 organic solvent Substances 0.000 title claims abstract description 8
- 208000002193 Pain Diseases 0.000 title claims description 9
- 239000000203 mixture Substances 0.000 title claims description 4
- 230000000699 topical effect Effects 0.000 title claims description 4
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 title abstract description 10
- 229960001138 acetylsalicylic acid Drugs 0.000 title abstract description 3
- 208000007514 Herpes zoster Diseases 0.000 title description 3
- 239000002904 solvent Substances 0.000 claims abstract description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 14
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims description 4
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims description 4
- 150000002576 ketones Chemical class 0.000 claims description 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 2
- 229940126601 medicinal product Drugs 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 12
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 239000007857 degradation product Substances 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- -1 ASA anhydride Chemical class 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 201000009053 Neurodermatitis Diseases 0.000 description 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001430 anti-depressive effect Effects 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10011032A DE10011032A1 (de) | 2000-03-07 | 2000-03-07 | Acetylsalicylsäure-Lösungen |
| PCT/EP2001/002282 WO2001066115A2 (de) | 2000-03-07 | 2001-03-01 | Acetylsalicylsäure-lösungen |
| AU2001272099A AU2001272099A1 (en) | 2000-03-07 | 2001-03-01 | Acetylsalicylic acid solutions |
| EP01956187A EP1263441A2 (de) | 2000-03-07 | 2001-03-01 | Acetylsalicylsäure-lösungen |
| GT200100035A GT200100035A (es) | 2000-03-07 | 2001-03-02 | Soluciones de acido acetilsalicilico |
| HN2001000039A HN2001000039A (es) | 2000-03-07 | 2001-03-05 | Soluciones de acido acetisalicilico |
| PE2001000218A PE20030207A1 (es) | 2000-03-07 | 2001-03-06 | Soluciones de acido acetilsalicilico |
| ARP010101068A AR028237A1 (es) | 2000-03-07 | 2001-03-07 | Soluciones de acido acetilsalicilico |
| SV2001000339A SV2002000339A (es) | 2000-03-07 | 2001-03-07 | Soluciones de acido acetilsalicilico ref. lea 33813-sv |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10011032A DE10011032A1 (de) | 2000-03-07 | 2000-03-07 | Acetylsalicylsäure-Lösungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10011032A1 true DE10011032A1 (de) | 2001-09-13 |
Family
ID=7633806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10011032A Withdrawn DE10011032A1 (de) | 2000-03-07 | 2000-03-07 | Acetylsalicylsäure-Lösungen |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1263441A2 (es) |
| AR (1) | AR028237A1 (es) |
| AU (1) | AU2001272099A1 (es) |
| DE (1) | DE10011032A1 (es) |
| GT (1) | GT200100035A (es) |
| HN (1) | HN2001000039A (es) |
| PE (1) | PE20030207A1 (es) |
| SV (1) | SV2002000339A (es) |
| WO (1) | WO2001066115A2 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007125492A3 (en) * | 2006-05-02 | 2008-01-10 | Pfeinsmith S A Pty Ltd | Acidic composition |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070196460A1 (en) * | 2004-02-16 | 2007-08-23 | Yukiko Inamoto | External preparation for treating skin or mucosal injury caused by viral infection |
| US11096949B2 (en) * | 2017-05-30 | 2021-08-24 | Rhoshan Pharmaceuticals, Inc. | In-vial deposition of a stable, sterile and crystalline O-acetyl salicylic acid |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4219548A (en) * | 1978-09-01 | 1980-08-26 | The Procter & Gamble Company | Topical anti-inflammatory composition |
| IL68965A (en) * | 1983-06-13 | 1987-02-27 | Rafa Labor Ltd | Topical pharmaceutical preparation comprising acetylsalicylic acid for the treatment of dermatological disorders |
| US5484606A (en) * | 1994-01-24 | 1996-01-16 | The Procter & Gamble Company | Process for reducing the precipitation of difficulty soluble pharmaceutical actives |
| MX9602955A (es) * | 1994-01-24 | 1997-06-28 | Procter & Gamble | Procedimiento para solubizar activos farmaceuticos dificilmente solubles. |
-
2000
- 2000-03-07 DE DE10011032A patent/DE10011032A1/de not_active Withdrawn
-
2001
- 2001-03-01 EP EP01956187A patent/EP1263441A2/de not_active Withdrawn
- 2001-03-01 WO PCT/EP2001/002282 patent/WO2001066115A2/de not_active Ceased
- 2001-03-01 AU AU2001272099A patent/AU2001272099A1/en not_active Abandoned
- 2001-03-02 GT GT200100035A patent/GT200100035A/es unknown
- 2001-03-05 HN HN2001000039A patent/HN2001000039A/es unknown
- 2001-03-06 PE PE2001000218A patent/PE20030207A1/es not_active Application Discontinuation
- 2001-03-07 AR ARP010101068A patent/AR028237A1/es unknown
- 2001-03-07 SV SV2001000339A patent/SV2002000339A/es not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007125492A3 (en) * | 2006-05-02 | 2008-01-10 | Pfeinsmith S A Pty Ltd | Acidic composition |
| US8114910B2 (en) | 2006-05-02 | 2012-02-14 | Pfeinsmith S.A. (Pty) Ltd. | Acidic composition |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1263441A2 (de) | 2002-12-11 |
| WO2001066115A3 (de) | 2002-02-14 |
| SV2002000339A (es) | 2002-06-07 |
| PE20030207A1 (es) | 2003-04-16 |
| AU2001272099A1 (en) | 2001-09-17 |
| HN2001000039A (es) | 2001-07-09 |
| AR028237A1 (es) | 2003-04-30 |
| GT200100035A (es) | 2001-12-18 |
| WO2001066115A2 (de) | 2001-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8139 | Disposal/non-payment of the annual fee |