DE1064259B - Procedure for mixing liquids - Google Patents
Procedure for mixing liquidsInfo
- Publication number
- DE1064259B DE1064259B DET14119A DET0014119A DE1064259B DE 1064259 B DE1064259 B DE 1064259B DE T14119 A DET14119 A DE T14119A DE T0014119 A DET0014119 A DE T0014119A DE 1064259 B DE1064259 B DE 1064259B
- Authority
- DE
- Germany
- Prior art keywords
- liquids
- liquid
- flow
- helix
- mixing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims description 30
- 238000000034 method Methods 0.000 title claims description 7
- 238000004804 winding Methods 0.000 claims description 5
- 230000005484 gravity Effects 0.000 claims description 3
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 239000012530 fluid Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- External Artificial Organs (AREA)
- Sampling And Sample Adjustment (AREA)
Description
Die Erfindung betrifft ein Verfahren zur Mischung von Flüssigkeiten mit unterschiedlichem spezifischem Gewicht, die durch eine Leitung fließen.The invention relates to a method for mixing liquids with different specificities Weight flowing through a pipe.
Gemäß der Erfindung werden die miteinander zu mischenden Flüssigkeiten durch eine aus einem Rohr bestehende, mit mehreren in senkrechten Windungsebenen verlaufenden Windungen versehene Schraubenwendel gleichzeitig hindurchgeleitet. Hierbei findet eine gründliche Durchmischung der Flüssigkeiten statt. ίο According to the invention, the liquids to be mixed with one another are passed simultaneously through a helical helix consisting of a pipe and provided with a plurality of windings running in vertical winding planes. A thorough mixing of the liquids takes place here. ίο
Das Verfahren kann auch derart durchgeführt werden, daß mittels einer Pumpe Luft oder ein anderes gasförmiges Medium an einer in Strömungsrichtung vor der Schraubenwendel liegenden Stelle in den Flüssigkeitsstrom derart eingepreßt wird, daß innerhalb der Schrauben wendel sich die durch Gas oder Flüssigkeit gebildeten Fördermengen laufend abwechseln. The method can also be carried out in such a way that air or another by means of a pump gaseous medium at a point in the direction of flow in front of the helix in the Liquid flow is injected in such a way that the helix through gas or within the screw Alternate the flow rates formed by the liquid.
Das Verfahren eignet sich besonders zur Mischung von Flüssigkeiten in einem Gerät, das z. B. in der USA.-Patentschrift 2 797 149 beschrieben ist und zur Analyse von Blut oder anderen Körperflüssigkeiten dient und bei dem in die Leitung Luft eingeführt wird, um den Flüssigkeitsstrom in eine Anzahl von Flüssigkeitsabschnitten zu unterteilen, die durch Luftzwischenräume voneinander getrennt sind. Diese dienen dazu, Teilchen der Flüssigkeit von der Innenfläche der Leitung zu entfernen und die Leitung auf diese Weise sauberzuhalten, so daß mehrere Flüssigkeitsproben nacheinander durch die Leitung hindurchgeführt werden können, ohne daß eine der Proben durch eine vorhergehende Probe verunreinigt wird.The method is particularly suitable for mixing liquids in a device that z. B. in the U.S. Patent 2,797,149 and for the analysis of blood or other body fluids serves and in which air is introduced into the conduit to divert the flow of liquid into a number of To divide liquid sections, which are separated from each other by air gaps. These serve to remove particles of liquid from the inner surface of the conduit and open the conduit keep this clean so that several fluid samples are passed through the conduit one after the other without contamination of any of the samples by a previous sample.
In der Zeichnung zeigtIn the drawing shows
Fig. 1 einen Schnitt durch einen Teil der Mischvorrichtung in vergrößertem Maßstab,1 shows a section through part of the mixing device on an enlarged scale,
Fig. 2 einen Schnitt durch einen Teil der Windung der Mischvorrichtung und zeigt eine teilweise Mischung der Flüssigkeiten,Fig. 2 is a section through part of the winding of the mixing device and shows a partial Mixture of liquids,
Fig. 3 einen Schnitt, der die vollständige Mischung der Flüssigkeiten durch die Mischvorrichtung zeigt, bevor diese die Vorrichtung verlassen.3 is a section showing the complete mixing of the liquids by the mixing device, before they leave the device.
Die Mischvorrichtung 10 der Fig. 1 enthält gemäß der Erfindung eine Schraubenwendel aus Glasrohr
oder aus einem Rohr eines anderen geeigneten, gegenüber den durchlaufenden Flüssigkeiten und Gasen
unempfindlichen Materials, das vorzugsweise mindestens teilweise durchscheinend oder durchsichtig ist,
so daß die Strömung des Mediums durch das Rohr beobachtet werden kann. Eine Dosierpumpe führt die
Flüssigkeiten, z. B. Blut oder andere Proben einer Körperflüssigkeit bzw. einer oder mehrerer Behandlungsflüssigkeiten,
und Luft der Wendel zu. Die Flüssigkeiten bzw. Gase werden dem Einlaß 14 der Wendel
10 zugeführt. Gleichzeitig mit den obenerwähnten Verfahren
zur Mischung von FlüssigkeitenThe mixing device 10 of Fig. 1 contains according to the invention a helical coil made of glass tube or a tube of another suitable, insensitive to the liquids and gases passing through material, which is preferably at least partially translucent or transparent, so that the flow of the medium through the tube can be observed. A dosing pump guides the liquids, e.g. B. blood or other samples of a body fluid or one or more treatment fluids, and air to the coil. The liquids or gases are fed to the inlet 14 of the helix 10 . Simultaneously with the above-mentioned procedures
for mixing liquids
Anmelder:Applicant:
Technicon International Ltd.,
Chauncey, N.Y. (V.St.A.)Technicon International Ltd.,
Chauncey, NY (V.St.A.)
Vertreter: Dr.-Ing. W. Reichel, Patentanwalt,
Frankfurt/M. 1, Parkstr. 13Representative: Dr.-Ing. W. Reichel, patent attorney,
Frankfurt / M. 1, Parkstrasse 13th
Beansprudite Priorität: V. St. v. Amerika vom 12. September 1956Claimed priority: V. St. v. America September 12, 1956
Andres Ferrari jun., Scarsdale, N. Y. (V. St. A.),
ist als Erfinder genannt wordenAndres Ferrari Jr., Scarsdale, NY (V. St. A.),
has been named as the inventor
Flüssigkeiten können weitere Behandlungsmedien in proportionalen Mengen zugeführt werden. Die Art und Weise, in der die Flüssigkeiten selbsttätig gründlich in der Wendel gemischt werden, während sie die Wendel durchfließen, geht aus den Figuren hervor.Liquids can be supplied with further treatment media in proportional amounts. The kind and manner in which the fluids are automatically and thoroughly mixed in the coil while they are the Flow through helix, emerges from the figures.
Aus Fig. 1 ist ersichtlich, daß das Blut B der Probe mit der Behandlungsflüssigkeit P vereinigt wird. Da das Blut ein höheres spezifisches Gewicht als die Behandlungsflüssigkeit hat, schichten sich die beiden Flüssigkeiten in der Verbindungsröhre 14 übereinander. Die Luft, die in das Rohr eingeführt wird, teilt den Strom des Blutes und der Behandlungsflüssigkeit in eine Anzahl von einzelnen, durch Luft getrennten Abschnitten SI, S 2, S3 usw., während die Medien weiterströmen und sich durch die Windungen der Mischwendel hindurchbewegen. Wenn die Flüssigkeitsabschnitte die Windungen der Schraubenwendel durchlaufen, werden das Blut und die Behandlungsflüssigkeit gemischt, wobei die teilweise Mischung in Fig. 2 und die vollständige und gründliche Mischung des Blutes und der Behandlungsflüssigkeit in Fig. 3 angedeutet ist. Es sei bemerkt, daß die Flüssigkeiten sich beim Durchlaufen der Wendel auf einer Bahn bewegen, die so ausgebildet ist, daß die sich miteinander mischen. Wenn z. B. das Blut schwerer als die Behandlungsflüssigkeit ist, dann fließt es anfangs am äußeren Rand der betreffenden Windung, wobei jedoch die schwerere Flüssigkeit infolge der Schwerkraft in die leichtere Flüssigkeit eindringt, die sichFrom Fig. 1 it can be seen that the blood B of the sample is combined with the treatment liquid P. Since the blood has a higher specific gravity than the treatment liquid, the two liquids in the connecting tube 14 are layered on top of one another. The air introduced into the tube divides the flow of blood and treatment fluid into a number of individual air-separated sections SI, S 2, S3 , etc., while the media continues to flow and move through the turns of the mixing helix. When the liquid sections pass through the turns of the helical coil, the blood and the treatment liquid are mixed, the partial mixing being indicated in FIG. 2 and the complete and thorough mixing of the blood and the treatment liquid being indicated in FIG. It should be noted that as the liquids pass through the helix, they move on a path which is designed to mix with one another. If z. B. the blood is heavier than the treatment liquid, then it initially flows at the outer edge of the winding concerned, but the heavier liquid penetrates due to gravity in the lighter liquid that is
909 609/226909 609/226
Claims (2)
Britische Patentschrift Nr. 641 978.Considered publications:
British Patent No. 641,978.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US609366A US2933293A (en) | 1956-09-12 | 1956-09-12 | Method of intermixing a plurality of liquids of different specific gravities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1064259B true DE1064259B (en) | 1959-08-27 |
Family
ID=24440490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DET14119A Pending DE1064259B (en) | 1956-09-12 | 1957-09-09 | Procedure for mixing liquids |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US2933293A (en) |
| DE (1) | DE1064259B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3328530A1 (en) * | 1983-08-06 | 1985-02-21 | Mathias 4815 Schloss Holte Mitter | Foam generator |
| EP0805233A4 (en) * | 1995-01-16 | 1998-04-29 | Grudinin Alexandr Vladimirovic | PROCESS FOR TREATING FIBROUS MATERIAL USING CHEMICAL REAGENT AND TREATMENT DEVICE |
| DE19731891A1 (en) * | 1997-07-24 | 1999-01-28 | Hoechst Ag | Apparatus for mixing in heat exchanger or carrying out reactions |
| DE102006017360A1 (en) * | 2006-04-11 | 2007-10-18 | Diasys Diagnostic Systems Gmbh | Method for dosing and mixing |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3128993A (en) * | 1964-04-14 | Device for commingling slowly flowing liquids | ||
| NL257371A (en) * | 1959-10-30 | |||
| US3047367A (en) * | 1959-12-01 | 1962-07-31 | Technicon Instr | Automatic analysis with fluid segmentation |
| US3231090A (en) * | 1961-05-17 | 1966-01-25 | Technicon Instr | Continuous solvent extraction apparatus |
| US3119704A (en) * | 1961-12-04 | 1964-01-28 | Dow Chemical Co | Preparation of aerated cementitious products |
| US3432268A (en) * | 1964-08-28 | 1969-03-11 | Peter Unger | Method and apparatus for testing cell suspensions |
| US3306229A (en) * | 1965-04-05 | 1967-02-28 | Technicon Instr | Pump apparatus and method of operation thereof |
| US3488154A (en) * | 1965-07-02 | 1970-01-06 | Calgon C0Rp | Pressurized flow system |
| BE756423A (en) * | 1969-09-22 | 1971-03-22 | Technicon Instr | METHOD AND APPARATUS FOR THE AUTOMATIC DETERMINATION OF SAMPLES, IN PARTICULAR BLOOD SAMPLES |
| US3634039A (en) * | 1969-12-22 | 1972-01-11 | Thomas L Brondy | Blood testing machine |
| US3726297A (en) * | 1971-04-14 | 1973-04-10 | Technicon Instr | Method and device for introducing for mixing a first liquid into a second liquid |
| JPS5027463U (en) * | 1973-07-04 | 1975-03-29 | ||
| US4379637A (en) * | 1979-02-28 | 1983-04-12 | Peerless Electronics Research Corp. | Radiation measuring apparatus |
| US4273449A (en) * | 1979-02-28 | 1981-06-16 | Peerless Electronics Research Corp. | Radiation measuring apparatus |
| US4312635A (en) * | 1980-06-20 | 1982-01-26 | Geochem Research, Inc. | Method and apparatus for fluid analysis |
| CA1238900A (en) | 1982-11-15 | 1988-07-05 | Stephen Saros | Single channel continuous slug flow mixing of discrete fluid components |
| EP0183950B1 (en) * | 1984-10-18 | 1990-05-16 | Hewlett-Packard GmbH | Method of processing liquid within a tube |
| US4834877A (en) * | 1985-08-09 | 1989-05-30 | The Dow Chemical Company | Apparatus for membrane-permeation separations using segmented flow |
| US4684470A (en) * | 1985-08-09 | 1987-08-04 | The Dow Chemical Company | Apparatus and method for membrane-permeation separations using segmented flow |
| US20030040105A1 (en) * | 1999-09-30 | 2003-02-27 | Sklar Larry A. | Microfluidic micromixer |
| US6632014B2 (en) * | 2000-12-04 | 2003-10-14 | Yeda Research And Development Co., Ltd. | Device and method for mixing substances |
| US7041218B1 (en) | 2002-06-10 | 2006-05-09 | Inflowsion, L.L.C. | Static device and method of making |
| US7264394B1 (en) * | 2002-06-10 | 2007-09-04 | Inflowsion L.L.C. | Static device and method of making |
| US7045060B1 (en) | 2002-12-05 | 2006-05-16 | Inflowsion, L.L.C. | Apparatus and method for treating a liquid |
| US20060280027A1 (en) * | 2005-06-10 | 2006-12-14 | Battelle Memorial Institute | Method and apparatus for mixing fluids |
| EP2660482B1 (en) * | 2005-08-22 | 2019-08-07 | Life Technologies Corporation | Vorrichtung, System und Verfahren unter Verwendung von nichtmischbaren Flüssigkeiten mit unterschiedlichen Volumen |
| US8834016B1 (en) | 2011-04-27 | 2014-09-16 | Tetra Technologies, Inc. | Multi chamber mixing manifold |
| US9522367B1 (en) | 2011-04-27 | 2016-12-20 | Tetra Technologies, Inc. | Multi chamber mixing manifold |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB641978A (en) * | 1947-06-17 | 1950-08-23 | Ets Kuhlmann | Improvements in apparatus for determining the constituent proportions of a gaseous mixture |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2000953A (en) * | 1933-10-30 | 1935-05-14 | Hooker Electrochemical Co | Means for reacting semifluid materials |
| US2230255A (en) * | 1937-08-02 | 1941-02-04 | Lavigne Jean Loumiet Et | Method and apparatus for producing intimate contact between fluids |
| US2263118A (en) * | 1939-05-16 | 1941-11-18 | Phillips Petroleum Co | Apparatus for pelleting carbon black |
| US2516884A (en) * | 1948-12-08 | 1950-08-01 | George J Kyame | Method of and apparatus for preparation and distribution of sizing materials |
| US2784948A (en) * | 1951-05-18 | 1957-03-12 | Crown Cork & Seal Co | Liquid mixing device |
| US2797149A (en) * | 1953-01-08 | 1957-06-25 | Technicon International Ltd | Methods of and apparatus for analyzing liquids containing crystalloid and non-crystalloid constituents |
-
1956
- 1956-09-12 US US609366A patent/US2933293A/en not_active Expired - Lifetime
-
1957
- 1957-09-09 DE DET14119A patent/DE1064259B/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB641978A (en) * | 1947-06-17 | 1950-08-23 | Ets Kuhlmann | Improvements in apparatus for determining the constituent proportions of a gaseous mixture |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3328530A1 (en) * | 1983-08-06 | 1985-02-21 | Mathias 4815 Schloss Holte Mitter | Foam generator |
| EP0805233A4 (en) * | 1995-01-16 | 1998-04-29 | Grudinin Alexandr Vladimirovic | PROCESS FOR TREATING FIBROUS MATERIAL USING CHEMICAL REAGENT AND TREATMENT DEVICE |
| DE19731891A1 (en) * | 1997-07-24 | 1999-01-28 | Hoechst Ag | Apparatus for mixing in heat exchanger or carrying out reactions |
| DE102006017360A1 (en) * | 2006-04-11 | 2007-10-18 | Diasys Diagnostic Systems Gmbh | Method for dosing and mixing |
Also Published As
| Publication number | Publication date |
|---|---|
| US2933293A (en) | 1960-04-19 |
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