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DE1064259B - Procedure for mixing liquids - Google Patents

Procedure for mixing liquids

Info

Publication number
DE1064259B
DE1064259B DET14119A DET0014119A DE1064259B DE 1064259 B DE1064259 B DE 1064259B DE T14119 A DET14119 A DE T14119A DE T0014119 A DET0014119 A DE T0014119A DE 1064259 B DE1064259 B DE 1064259B
Authority
DE
Germany
Prior art keywords
liquids
liquid
flow
helix
mixing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DET14119A
Other languages
German (de)
Inventor
Andres Ferrari Jun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technicon International Ltd
Original Assignee
Technicon International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technicon International Ltd filed Critical Technicon International Ltd
Publication of DE1064259B publication Critical patent/DE1064259B/en
Pending legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40Mixing liquids with liquids; Emulsifying
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • External Artificial Organs (AREA)
  • Sampling And Sample Adjustment (AREA)

Description

Die Erfindung betrifft ein Verfahren zur Mischung von Flüssigkeiten mit unterschiedlichem spezifischem Gewicht, die durch eine Leitung fließen.The invention relates to a method for mixing liquids with different specificities Weight flowing through a pipe.

Gemäß der Erfindung werden die miteinander zu mischenden Flüssigkeiten durch eine aus einem Rohr bestehende, mit mehreren in senkrechten Windungsebenen verlaufenden Windungen versehene Schraubenwendel gleichzeitig hindurchgeleitet. Hierbei findet eine gründliche Durchmischung der Flüssigkeiten statt. ίο According to the invention, the liquids to be mixed with one another are passed simultaneously through a helical helix consisting of a pipe and provided with a plurality of windings running in vertical winding planes. A thorough mixing of the liquids takes place here. ίο

Das Verfahren kann auch derart durchgeführt werden, daß mittels einer Pumpe Luft oder ein anderes gasförmiges Medium an einer in Strömungsrichtung vor der Schraubenwendel liegenden Stelle in den Flüssigkeitsstrom derart eingepreßt wird, daß innerhalb der Schrauben wendel sich die durch Gas oder Flüssigkeit gebildeten Fördermengen laufend abwechseln. The method can also be carried out in such a way that air or another by means of a pump gaseous medium at a point in the direction of flow in front of the helix in the Liquid flow is injected in such a way that the helix through gas or within the screw Alternate the flow rates formed by the liquid.

Das Verfahren eignet sich besonders zur Mischung von Flüssigkeiten in einem Gerät, das z. B. in der USA.-Patentschrift 2 797 149 beschrieben ist und zur Analyse von Blut oder anderen Körperflüssigkeiten dient und bei dem in die Leitung Luft eingeführt wird, um den Flüssigkeitsstrom in eine Anzahl von Flüssigkeitsabschnitten zu unterteilen, die durch Luftzwischenräume voneinander getrennt sind. Diese dienen dazu, Teilchen der Flüssigkeit von der Innenfläche der Leitung zu entfernen und die Leitung auf diese Weise sauberzuhalten, so daß mehrere Flüssigkeitsproben nacheinander durch die Leitung hindurchgeführt werden können, ohne daß eine der Proben durch eine vorhergehende Probe verunreinigt wird.The method is particularly suitable for mixing liquids in a device that z. B. in the U.S. Patent 2,797,149 and for the analysis of blood or other body fluids serves and in which air is introduced into the conduit to divert the flow of liquid into a number of To divide liquid sections, which are separated from each other by air gaps. These serve to remove particles of liquid from the inner surface of the conduit and open the conduit keep this clean so that several fluid samples are passed through the conduit one after the other without contamination of any of the samples by a previous sample.

In der Zeichnung zeigtIn the drawing shows

Fig. 1 einen Schnitt durch einen Teil der Mischvorrichtung in vergrößertem Maßstab,1 shows a section through part of the mixing device on an enlarged scale,

Fig. 2 einen Schnitt durch einen Teil der Windung der Mischvorrichtung und zeigt eine teilweise Mischung der Flüssigkeiten,Fig. 2 is a section through part of the winding of the mixing device and shows a partial Mixture of liquids,

Fig. 3 einen Schnitt, der die vollständige Mischung der Flüssigkeiten durch die Mischvorrichtung zeigt, bevor diese die Vorrichtung verlassen.3 is a section showing the complete mixing of the liquids by the mixing device, before they leave the device.

Die Mischvorrichtung 10 der Fig. 1 enthält gemäß der Erfindung eine Schraubenwendel aus Glasrohr oder aus einem Rohr eines anderen geeigneten, gegenüber den durchlaufenden Flüssigkeiten und Gasen unempfindlichen Materials, das vorzugsweise mindestens teilweise durchscheinend oder durchsichtig ist, so daß die Strömung des Mediums durch das Rohr beobachtet werden kann. Eine Dosierpumpe führt die Flüssigkeiten, z. B. Blut oder andere Proben einer Körperflüssigkeit bzw. einer oder mehrerer Behandlungsflüssigkeiten, und Luft der Wendel zu. Die Flüssigkeiten bzw. Gase werden dem Einlaß 14 der Wendel 10 zugeführt. Gleichzeitig mit den obenerwähnten Verfahren
zur Mischung von Flüssigkeiten
The mixing device 10 of Fig. 1 contains according to the invention a helical coil made of glass tube or a tube of another suitable, insensitive to the liquids and gases passing through material, which is preferably at least partially translucent or transparent, so that the flow of the medium through the tube can be observed. A dosing pump guides the liquids, e.g. B. blood or other samples of a body fluid or one or more treatment fluids, and air to the coil. The liquids or gases are fed to the inlet 14 of the helix 10 . Simultaneously with the above-mentioned procedures
for mixing liquids

Anmelder:Applicant:

Technicon International Ltd.,
Chauncey, N.Y. (V.St.A.)
Technicon International Ltd.,
Chauncey, NY (V.St.A.)

Vertreter: Dr.-Ing. W. Reichel, Patentanwalt,
Frankfurt/M. 1, Parkstr. 13
Representative: Dr.-Ing. W. Reichel, patent attorney,
Frankfurt / M. 1, Parkstrasse 13th

Beansprudite Priorität: V. St. v. Amerika vom 12. September 1956Claimed priority: V. St. v. America September 12, 1956

Andres Ferrari jun., Scarsdale, N. Y. (V. St. A.),
ist als Erfinder genannt worden
Andres Ferrari Jr., Scarsdale, NY (V. St. A.),
has been named as the inventor

Flüssigkeiten können weitere Behandlungsmedien in proportionalen Mengen zugeführt werden. Die Art und Weise, in der die Flüssigkeiten selbsttätig gründlich in der Wendel gemischt werden, während sie die Wendel durchfließen, geht aus den Figuren hervor.Liquids can be supplied with further treatment media in proportional amounts. The kind and manner in which the fluids are automatically and thoroughly mixed in the coil while they are the Flow through helix, emerges from the figures.

Aus Fig. 1 ist ersichtlich, daß das Blut B der Probe mit der Behandlungsflüssigkeit P vereinigt wird. Da das Blut ein höheres spezifisches Gewicht als die Behandlungsflüssigkeit hat, schichten sich die beiden Flüssigkeiten in der Verbindungsröhre 14 übereinander. Die Luft, die in das Rohr eingeführt wird, teilt den Strom des Blutes und der Behandlungsflüssigkeit in eine Anzahl von einzelnen, durch Luft getrennten Abschnitten SI, S 2, S3 usw., während die Medien weiterströmen und sich durch die Windungen der Mischwendel hindurchbewegen. Wenn die Flüssigkeitsabschnitte die Windungen der Schraubenwendel durchlaufen, werden das Blut und die Behandlungsflüssigkeit gemischt, wobei die teilweise Mischung in Fig. 2 und die vollständige und gründliche Mischung des Blutes und der Behandlungsflüssigkeit in Fig. 3 angedeutet ist. Es sei bemerkt, daß die Flüssigkeiten sich beim Durchlaufen der Wendel auf einer Bahn bewegen, die so ausgebildet ist, daß die sich miteinander mischen. Wenn z. B. das Blut schwerer als die Behandlungsflüssigkeit ist, dann fließt es anfangs am äußeren Rand der betreffenden Windung, wobei jedoch die schwerere Flüssigkeit infolge der Schwerkraft in die leichtere Flüssigkeit eindringt, die sichFrom Fig. 1 it can be seen that the blood B of the sample is combined with the treatment liquid P. Since the blood has a higher specific gravity than the treatment liquid, the two liquids in the connecting tube 14 are layered on top of one another. The air introduced into the tube divides the flow of blood and treatment fluid into a number of individual air-separated sections SI, S 2, S3 , etc., while the media continues to flow and move through the turns of the mixing helix. When the liquid sections pass through the turns of the helical coil, the blood and the treatment liquid are mixed, the partial mixing being indicated in FIG. 2 and the complete and thorough mixing of the blood and the treatment liquid being indicated in FIG. It should be noted that as the liquids pass through the helix, they move on a path which is designed to mix with one another. If z. B. the blood is heavier than the treatment liquid, then it initially flows at the outer edge of the winding concerned, but the heavier liquid penetrates due to gravity in the lighter liquid that is

909 609/226909 609/226

Claims (2)

mit ihr zusammen in dem betreffenden, Abschnitt befindet. Patentansprüche:together with her in the relevant section. Patent claims: 1. Verfahren zur Mischung von Flüssigkeiten mit unterschiedlichem spezifischem Gewicht, dadurch gekennzeichnet, daß die miteinander zu mischenden Flüssigkeiten durch eine aus einem * Rohr bestehende, mit mehreren in senkrechten Windungsebenen verlaufenden Windungen versehene Schraubenwendel gleichzeitig hindurchgeleitet werden.1. Method for mixing liquids with different specific gravity, thereby characterized in that the liquids to be mixed with one another by one of a * Existing pipe with several turns running in vertical winding planes Helix are passed through at the same time. 2. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß mittels einer Pumpe Luft oder ein anderes gasförmiges Medium an einer in Strömungsrichtung vor der Schraubenwendel liegenden Stelle in den Flüssigkeitsstrom derart eingepreßt wird, daß innerhalb der Schraubenwendel sich die durch Gas oder Flüssigkeit gebildeten Fördermengen laufend abwechseln.2. The method according to claim 1, characterized in that by means of a pump air or a Another gaseous medium on one lying in front of the helical coil in the direction of flow Place is pressed into the flow of liquid in such a way that inside the helix the flow rates formed by gas or liquid alternate continuously. In Betracht gezogene Druckschriften:
Britische Patentschrift Nr. 641 978.
Considered publications:
British Patent No. 641,978.
Hierzu 1 Blatt Zeichnungen1 sheet of drawings © 909 609/226 8.59© 909 609/226 8.59
DET14119A 1956-09-12 1957-09-09 Procedure for mixing liquids Pending DE1064259B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US609366A US2933293A (en) 1956-09-12 1956-09-12 Method of intermixing a plurality of liquids of different specific gravities

Publications (1)

Publication Number Publication Date
DE1064259B true DE1064259B (en) 1959-08-27

Family

ID=24440490

Family Applications (1)

Application Number Title Priority Date Filing Date
DET14119A Pending DE1064259B (en) 1956-09-12 1957-09-09 Procedure for mixing liquids

Country Status (2)

Country Link
US (1) US2933293A (en)
DE (1) DE1064259B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3328530A1 (en) * 1983-08-06 1985-02-21 Mathias 4815 Schloss Holte Mitter Foam generator
EP0805233A4 (en) * 1995-01-16 1998-04-29 Grudinin Alexandr Vladimirovic PROCESS FOR TREATING FIBROUS MATERIAL USING CHEMICAL REAGENT AND TREATMENT DEVICE
DE19731891A1 (en) * 1997-07-24 1999-01-28 Hoechst Ag Apparatus for mixing in heat exchanger or carrying out reactions
DE102006017360A1 (en) * 2006-04-11 2007-10-18 Diasys Diagnostic Systems Gmbh Method for dosing and mixing

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US3128993A (en) * 1964-04-14 Device for commingling slowly flowing liquids
NL257371A (en) * 1959-10-30
US3047367A (en) * 1959-12-01 1962-07-31 Technicon Instr Automatic analysis with fluid segmentation
US3231090A (en) * 1961-05-17 1966-01-25 Technicon Instr Continuous solvent extraction apparatus
US3119704A (en) * 1961-12-04 1964-01-28 Dow Chemical Co Preparation of aerated cementitious products
US3432268A (en) * 1964-08-28 1969-03-11 Peter Unger Method and apparatus for testing cell suspensions
US3306229A (en) * 1965-04-05 1967-02-28 Technicon Instr Pump apparatus and method of operation thereof
US3488154A (en) * 1965-07-02 1970-01-06 Calgon C0Rp Pressurized flow system
BE756423A (en) * 1969-09-22 1971-03-22 Technicon Instr METHOD AND APPARATUS FOR THE AUTOMATIC DETERMINATION OF SAMPLES, IN PARTICULAR BLOOD SAMPLES
US3634039A (en) * 1969-12-22 1972-01-11 Thomas L Brondy Blood testing machine
US3726297A (en) * 1971-04-14 1973-04-10 Technicon Instr Method and device for introducing for mixing a first liquid into a second liquid
JPS5027463U (en) * 1973-07-04 1975-03-29
US4379637A (en) * 1979-02-28 1983-04-12 Peerless Electronics Research Corp. Radiation measuring apparatus
US4273449A (en) * 1979-02-28 1981-06-16 Peerless Electronics Research Corp. Radiation measuring apparatus
US4312635A (en) * 1980-06-20 1982-01-26 Geochem Research, Inc. Method and apparatus for fluid analysis
CA1238900A (en) 1982-11-15 1988-07-05 Stephen Saros Single channel continuous slug flow mixing of discrete fluid components
EP0183950B1 (en) * 1984-10-18 1990-05-16 Hewlett-Packard GmbH Method of processing liquid within a tube
US4834877A (en) * 1985-08-09 1989-05-30 The Dow Chemical Company Apparatus for membrane-permeation separations using segmented flow
US4684470A (en) * 1985-08-09 1987-08-04 The Dow Chemical Company Apparatus and method for membrane-permeation separations using segmented flow
US20030040105A1 (en) * 1999-09-30 2003-02-27 Sklar Larry A. Microfluidic micromixer
US6632014B2 (en) * 2000-12-04 2003-10-14 Yeda Research And Development Co., Ltd. Device and method for mixing substances
US7041218B1 (en) 2002-06-10 2006-05-09 Inflowsion, L.L.C. Static device and method of making
US7264394B1 (en) * 2002-06-10 2007-09-04 Inflowsion L.L.C. Static device and method of making
US7045060B1 (en) 2002-12-05 2006-05-16 Inflowsion, L.L.C. Apparatus and method for treating a liquid
US20060280027A1 (en) * 2005-06-10 2006-12-14 Battelle Memorial Institute Method and apparatus for mixing fluids
EP2660482B1 (en) * 2005-08-22 2019-08-07 Life Technologies Corporation Vorrichtung, System und Verfahren unter Verwendung von nichtmischbaren Flüssigkeiten mit unterschiedlichen Volumen
US8834016B1 (en) 2011-04-27 2014-09-16 Tetra Technologies, Inc. Multi chamber mixing manifold
US9522367B1 (en) 2011-04-27 2016-12-20 Tetra Technologies, Inc. Multi chamber mixing manifold

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GB641978A (en) * 1947-06-17 1950-08-23 Ets Kuhlmann Improvements in apparatus for determining the constituent proportions of a gaseous mixture

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US2000953A (en) * 1933-10-30 1935-05-14 Hooker Electrochemical Co Means for reacting semifluid materials
US2230255A (en) * 1937-08-02 1941-02-04 Lavigne Jean Loumiet Et Method and apparatus for producing intimate contact between fluids
US2263118A (en) * 1939-05-16 1941-11-18 Phillips Petroleum Co Apparatus for pelleting carbon black
US2516884A (en) * 1948-12-08 1950-08-01 George J Kyame Method of and apparatus for preparation and distribution of sizing materials
US2784948A (en) * 1951-05-18 1957-03-12 Crown Cork & Seal Co Liquid mixing device
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GB641978A (en) * 1947-06-17 1950-08-23 Ets Kuhlmann Improvements in apparatus for determining the constituent proportions of a gaseous mixture

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3328530A1 (en) * 1983-08-06 1985-02-21 Mathias 4815 Schloss Holte Mitter Foam generator
EP0805233A4 (en) * 1995-01-16 1998-04-29 Grudinin Alexandr Vladimirovic PROCESS FOR TREATING FIBROUS MATERIAL USING CHEMICAL REAGENT AND TREATMENT DEVICE
DE19731891A1 (en) * 1997-07-24 1999-01-28 Hoechst Ag Apparatus for mixing in heat exchanger or carrying out reactions
DE102006017360A1 (en) * 2006-04-11 2007-10-18 Diasys Diagnostic Systems Gmbh Method for dosing and mixing

Also Published As

Publication number Publication date
US2933293A (en) 1960-04-19

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