DD281117A5 - HAIR REMOVAL FOR HUMAN AND ANIMALS - Google Patents

Abstract

The invention relates to the use of physiological salts of thiocyanic acid in humans as cosmetic agent for hair care, for maintaining and promoting hair growth and for increasing the resistance of the hair to injurious effects. The composition and the process can likewise be used in productive livestock to increase yields and improve quality (gloss, skin texture, hair strength and elasticity, density and uniformity of the hair coat, softness and strength when processing) in the production of wool, furs, leather or feathers. Sodium thiocyanate or potassium thiocyanate or mixtures of these substances are preferably used. In humans, use is predominantly external (as additive to bath water, to hair lotions, shampoos or cosmetics), and in productive livestock it is predominantly oral by admixture with the feed or by administration with thiocyanate-supplemented feedstuffs.

Description

Field of application of the invention

The invention relates to a means for promoting hair growth in humans and livestock and to improve the quality of the formation of hair, wool, fur, fur and feathers.

Characteristic of the known state of the art

It is generally known that illness-related damage and also in everyday life typical manipulations such as hair washing, brushing, blow-dyeing and -forming can lead to premature hair loss and inhibition of hair growth. Such caused superficial loss of substance on the hair man tries to compensate through hair packs and hair fixatives. The damaged scalp is treated with scalp packs and ointments. Often, prophylactic treatment measures such as hair tinctures and spa packs for the scalp and hair are applied, but based on no specific mechanism of action, but only increase the well-being of the treated. For the health care and hair care or promotion of hair growth, however, it is important to have a hair restorer, which is already at undgeschädigton hair to a; Ositive influence in terms of hair growth and quality improvement of hair formation leads.

The previously known for this means have not been able to prevail in practice. On the one hand, they are not suitable in their application to stimulate hair growth by physiological means, on the other hand, the desired effects were not clinically reproducible or even associated with undesirable side effects.

This concerns the most diverse plant extracts, oils or preparations, animal extracts, ammion fluids and hormones, vasodilating and skin-irritating active substances such as isothiocyanates, alcohols, ethers, phenol derivatives or carbon dioxide, natural fatty acids, sulfur and thiosulphates, gibberellins, elastase or Collagen extracts and microbial extracts.

In the case of illness-related hair loss, the hair growth can be increased by successful treatment of the underlying disease. It has long been known that hair growth can be temporarily increased by effective drugs such as adrenocortical hormones, sex hormones or their antagonists. Because of hardly avoidable severe side effects such treatments are rarely and only under strict medical control.

Recently, in some countries, the application of the drug minoxidil, which is mentioned in PCT patents WO 83/02558 and WO 87/00427 and in Japanese Patent Laid-Open Nos. 61/165411 and 61/165312, has been requested for the external stimulation of hair growth. After twice daily use of a minoxidil solution, hair growth had improved cosmetically acceptable in about one year of all male hair loss subjects. As hair growth is not stimulated physiologically when using a drug such as Minoxidil, side effects are to be expected, which were initially expressed in a lowering of blood pressure and an increase in heart rate (Olsen, EA, MS Weiner, ER Delong and SR Tinell: Topical Minoxidil in early male pattern baldness, J. Amer. Acad. Derm. 13 [1985] 185-192).

In addition, depending on the agents used or drug preparations further disadvantages, such as the possibility of long-term mocrotoxic effects with constant use, unpleasant effects on the hair such as sticking and unpleasant odor, local irritation, increased sensitivity to UV radiation, so that only a kurzzoitige application in the winter months deteriorated properties such as poor combability, reduced elasticity, reduced gloss, increased brittleness and sensitivity, decreased resistance and adaptation to the drug, which is not expected to be stimulated physiologically only in a physiological manner.

In healthy livestock, optimal nutrition is considered to be the primary effective influencing factor for hair growth in order to achieve higher quality in wool, fur, fur, leather and feathers. When feeding proteinaceous feeds, e.g. increased the wool synthesis and biomass in sheep. The result is a dense, soft and shiny fleece. An increase in the carbohydrate content of feeds leads to the increase of SH-groups in the skin, which also results in a promotion of hair growth. At the same time, the structure and physical properties are improved. After Doehner, H., Handbi'ch sheep breeding and sheep husbandry, Volume IV, Parey Berlin Hamburg, 1954; Gebhard, G., Animal Production-Animal Nutrition, VEB German Agricultural Publishing Berlin, 1981 and Schwark, H.J., Jankowskv St., Veress, L., International Handbook of Animal Production - Sheep, VEB Deutscher Landw! tschaftsverlag Berlin, 1981, there are further possibilities for promoting hair growth in an additional administration of sulfur and sulfur-containing amino acids, in particular of cystine, but also of methionine. Similar effects are known of calcium, sodium and ammonium sulfate. However, Kiok, P., describes the influence of diet on the quality of wool yield in merino sheep without special consideration of the addition of sulfur-containing amino acids and pure sulfur in protein-rich concentrated feed, Diss. Vet. Med. Fak. Berlin, 1969 ", that with optimal alimentary supply of stimulants no stimulating effects on growth and quality of the coat can be determined.

Another way to increase hair growth is by hormonal means. However, this is long term koine improvement achievable. Another disadvantage is the residual contamination of the slaughtered meat with hormone residues. The various options for optimizing animal nutrition all have the disadvantage that they are economically complex measures, which are also difficult to control, since they are each dependent on the current food supply and the composition of the food ingredients.

Object of the invention

The aim of the invention is a cost-producible agent which is effective in humans and animals and both promotes hair growth and positively affects the quality of hair formation. The physiologically acceptable agent for humans and animals should continue to produce favorable cosmetic effects and be distinguished by a high utility value.

Explanation of the essence of the invention The invention has for its object to find a physiological hair restorer for humans and farm animals on Reason of its physicochemical and biochemical properties is able to improve hair growth and quality Improve hair formation without causing a toxic burden on the organism or an environmental impact,

and e'ne increased resistance of hair, wool, fur, fur, leather or feathers against environmental influences or in the

Induced processing process. Erfin.iungsgomäß the object is achieved that the hair restorer for human or livestock orally, alimentary and / or

is supplied episomatically.

Oral or alimentary, the hair restorer is used in human or farm animal physiologically adapted dosages. For humans, this means a daily maintenance dose of EOmg after initial administration of 100mg NaSCN Depending on the necessary duration of application is reduced to 20mg / d. The total duration of treatment depends on this

from the individual requirements of the individual as well as from other factors, eg. B. previous toxic

Stress with subsequent hair loss. An interval application of 10-20 days application and 10-30 days

and more application-free interval represents a variant.

The oral delivery also allows a suitably compiled diet, eg. B. under preferred use of Cabbage and dairy products, ensuring adequate intake of thiocyanate. The episomatic application takes place in the form of rubbings after shampooing with hair lotions on alcoholic Basis, as an additive to the bath water, to shampoos, cosmetics or health care products. The Application concentration is 0.001-1% thiocyanate content. In case of hair loss, the invention also provides for the local application of thiocyanate with vegetable

to carry out thiocyanate-rich raw materials and at the same time to ensure a corresponding alimentäro thiocyanatreiche diet.

The use of the remedy is intended both to maintain and promote the growth of hash

as well as for special load situation to raise the resistance of the hair formation to growth-inhibiting

Compensate for influences, eg. B. at increased load by dusts, toxic environmental influences or radiation or Chemotherapy forms of cancer with increased hair loss. Even with pathologically disturbed hair growth is a Hair growth promotion achievable. In livestock, the application is to increase and improve quality of WoII- or fur production at the same time Promotion of the state of health of the animals primarily by oral intake by admixture with food or production

enriched with the active ingredient feed, z. B. in pelleting provided.

Also for whole-body baths, the Thiocyanatanwendung is suitable. This applies to fur animals, z. B. for mink, as well as for the People, with the whole-body bath the hair now and then must be dipped with. As application concentration

comes the range 3-150mg / l ^! n question. In exceptional cases, z. As in fur animals, higher concentrations up to 1 g / langewendet should be.

In livestock or fur animal, the hair restorer is preferably administered orally or aliment. Depending on species comes

while a concentration range of 0.5-30 mg SCN ~ / kg KM in question. In adaptation to the diet of each

Animal species, the dose is either continuously, z. As fur animal, poultry, or discontinuous, z. B. 1-3 times / week, z. B. Sheep, administered. The duration of application depends on the keeping conditions. In sheep, the gift is recommended after

the 1st Schur and / or in the winter months over a period of 30-5Od or 4-5 months. In the fur animal, the feed is advantageous,

as soon as the young are separated from the mother. After administration for 4-8 weeks, the interposition of an application-free interval is recommended for about 4 weeks. Thereafter, thiocyanate is administered in cycles of about 4 weeks each with about 2 weeks application-free intervals to the furone.

According to the invention, it has been found that the growth of hair is promoted by salts of thiocyanic acid in the physiological concentration range for human and livestock in the case of local and / or oral or alimentary use, and the quality of the hair formation is improved. This has an advantageous effect on the properties of hair, wool, fur, fur, leather or feathers (improved gloss, improved coat structure, hair strength and elasticity, density and uniformity of the coat, softness and increased strength in the processing process or increased resistance to environmental influences.

embodiments example 1

Long-term use for 15 years in male adult adults in the form of once-weekly full-body baths with repeated dipping of the hair during bathing resulted in dense hair growth with firm hair and a strikingly low sensitivity to a sensation of pain, if pulled by the hair , If a longer interval (> 3 months) is inserted between this form of thiocyanate application, the normal sensitivity of the hair to tension becomes clear again. The graying of the hair is obviously not affected.

The dose was about 3 mg NaSCN / l bathwater in the first 5 years of use. Thereafter, it was increased to 30-60mg NaSCN / L bath water without affecting hair growth. Differences were detectable. The general condition was subjectively significantly improved and indeed at the higher dosages with higher subjective effect.

Example 2

When toxic hair loss, caused by contact with a algicidem and molluscucidem paint, with a large area of more than vertust Vj of the head hair, 30 mg NaSCN / l bath water Gamkörperbäder were carried out according to Example 1 with the dosage. In addition, headbaths were added. This was done daily, then twice a week for a total of more than 1 year. Adivans were taken Vit.-B complex dragee and Panthenolspray applied to the scalp. Already after about 8-14 days started a re-hairing with the original natural hair color.

Example 3

In the industrial lamb fattening (merino sheep fed with pellet concentrate), a mixture of KSCN / NaSCN (3: 2) was administered orally twice a week with the drinking water in a single dose of 12 mg SCN "/ kg KM each Stabling after compilation of the experimental and Kor.trollgruppen made.

The other gifts took place alternately at intervals of 3 to 4 days in total 4 times. On the 10th day after the stabling, the animals were shorn.

In accordance with the invention with SCN ^- care group, a surplus of greasy wool by 6% (Table 1.) Was detectable.

Table 1

Wool yield in lamb intensive fattening with Schur on the 11th day of the stabling

KM (kg) / wool yield (g) / animal animal group η animal ix) (x)

Experimental group 99 26 1495

Control group 99 26 1415

Example 4

The experimental conditions correspond to Example 3, it was only the application time increased to 9 doses. In the group supplied with SCN according to the invention, an additional amount of welding wool was achieved by 9% in the selected extended application phase, and the staple length was increased by 3.4% (Table 2).

Table 2

Wool yield in lamb intensive fattening with Schur on day 34 of stabling

animal group η KM (kg) / animal (χ) Wool yield (girier (χ) Staple length (mm) / animal (X) Experimental group control group 98 98 23.0 22.7 932 855 43.2 41.8

In addition, the wool quality was improved, as determined by the fineness (Table 3).

Table 3 Fineness of wool in lamb intensive fattening with shearing on the 34th day of the stabling

mace x (mm) Fineness iM) m) X (mm) shoulder 'atf X (mm) animal group η flank η 22.9 η 22.6 22.2 experimental group 47 23.9 23.4 41 23.2 Day of the stabling 47 61 41 Day of the shearing 61 (34th day) 24.3 22.3 24.3 control group 74 24.1 22.3 56 23.0 Day of the stabling 74 55 56 Day of the shearing 05 (34th day) Difference (%) 4.5 3.4 4.7 Initial and final value -0.5 -0.1 -0.6 Gruppo attempt Kontrolfgruppe

At the same time, a larger body mass gain was observed in the experimental group than in the control group (Table 4). Table 4 Body mass development in lamb intensive fattening within 34 days

animal group Stabling Body mass (g, x) 23050 Schur (34th day) experimental group 22727 32348 control group 31211 Difference (%) Initial and final value Versuchsgruppa 40.3 control group 37.3

Biologically significant with regard to the overall classification of the SCN effect on the stimulation of wool yield is the higher SCN ~ content in the wool fiber at the time of shearing in the experimental animals compared to the control animals (Table 5). The findings are also noteworthy in that with increasing fineness of the wool (increase in the fineness of club from flank to scapula) the SCN ~ level in the experimental group is higher. In contrast, no differences are noticeable in the control group.

Table 5 Thiocyanate content in wool samples from various body regions in intensive gymnastic hammers

SCN "content (mg / kg wool) Group of animals Scapula Flank Club

Experimental group 18.6 16.8 15.3 Control group 13.0 13.3 13.1 Example 5 The experimental conditions correspond to Example 4 with an application of 9 doses. The experimental and control groups were formed by pairs of twins, with one twin each of the experimental and the Was assigned to the control group. The SCN ^- supplied twins produced an 18% increase in welding wool. The staple length increased by 3% (Tab.6). Table 6 Wool yield in intensive mast lambs with Schur on the 34th day of stabling at twin comparison Animal group η KM (kg) / animal Wool yield (g) / animal staple length

mm (animal) (χ) (X) (x)

Experimental group 9 20 889 45.8 Control Group 9 20 756 43.2 Example 6

In conventional sheep husbandry (crossbred Cstfriesian dairy sheep / merino sheep), during the breeding season in the housing period (feeding with barley bran, Runkelschnitzel and hay) a mixture of

KSCN / NaSCN (3: 2) twice a week in a dose of 12mg SCN ~ / kg KM orally with the concentrates. The Applications were carried out as described in Example 3 over 128 stable days in 256 individual doses. This SCN was from The beginning of the high-grade pregnancy including the lation phase is administered, that is, the lambs of the ewes have indirect

over the mother's milk until 2 months after the birth in addition SCN ~ added. The shearing was carried out in the old animals 13 months after the start of the additional SCN ~ supply, in the lambs 11 months after the birth.

In accordance with the invention with SCN ^- care group was an increase of greasy wool mass in the AlUieren by 12%

observed (Table 7). In lambs, the wool yield was 15% (Table 8).

Table 7 Wool yield in conventional sheep farming (old animals) Animal group η KM (kg) / animal Wool yield (g) animal

xvorderSchur χ

Experimental group 9 09 5326 Control group 9 61.6 4762 Table 8 Wool yield in conventional sheep farming (Ltimmer) Animal Group η Wool yield (g) / animal Experimental Group "8 4501 Kontrojlgruppe 5 3910

"indirect additional SCN supply in utero (3 months) or via breastmilk (2 months)

Examination of body mass development and length at the end of the stabling period and at the end of additional SCN ~ care (2 months postpartum) resulted in a greater increase in BM (8%) and a larger (28) length in the experimental group %, Tab.9).

Table 9 Body mass intake and staple length in conventional sheep farming (lambs) Animal Group η Increase (g / d animal) Batch length (mm) / animal

χ χ

Experimental group 14 112 33 Control group 14 104 26

As a side effect of the additional supply of SCN ~ to the dams during high-risk and lactation, lower lamb mortality was observed (Table 10).

Table 10 Lamb rearing performance Dams (s) live born lambs Lambs / mother animal Lamb interbreeding (s) Rearing rate / dam 8 9 14 14 1.8 1.6 3 4 1.4 1.1 Experimental group control group

Example 7

Albino guinea pigs were depilated with the aid of barium sulphide on their back after previous electric shaving and then 2 experimental and 1 control group were formed. The animals of experimental group were T1 once a day for seven weeks in a NaSCN solution for 10min gebadot (3g NaSCN / 101 water, 37 ⁰ C). The animals of the experimental group T2 received during the same period daily orally by pipette 32 mg NaSCN / kg KM. Following the seven weeks, an experimental Orfanus trichogram was prepared in the experimental and control groups, with the following characteristics:

- Duichschnittlkhe hair thickness in pm hair growth phase (Table 11),

- proportions of the cycle phases within the experimental groups (Table 12),

- growth rate of hair (Table 13),

- Hair density (Table 14).

In addition, the SCN ~ content in hair, skin, adrenal gland, spleen, thyroid, liver and muscle was determined. In the anagen phase, the growth phase of the hair, the hair thickness in both experimental groups is reduced compared to the control group (Table 11).

tables Average hair thickness in different hair growth phases in albino guinea pigs

anagen anagen oral administration of NaSCN anagen number of animals parameter Hair thickness (pm) S % Animal group hairstyle dysplastic dysplastic dysplastic η tested hair X anagen anagen anagen 17 η 14.9 100 control Katag hair Katag hair Katag hair 37.9 14.5 100 telogen hairs telogen hairs telogen hairs 740 28.8 Application of NaSCN 56 17.2 100 as a bath 51.9 24.1 100 296 85.2 577 15 11.8 81 30.9 875 9.9 103 29.8 19.4 116 23 60 23.4 101 154 86.5 16 349 11.3 90 34.3 15 124 840 35.9 36 14 107 55.6 22.8 98 157 83.7 519

Under the influence of SCN * there is a significant increase in the anagen phase, ie the growth phase of the hair. By contrast, the proportion of hair leached in the resting phase decreases. The other growth phases are relatively reduced in favor of the anagen phase (Table 12).

Table 12 Shares of cycle phases within the animal groups in albino guinea pigs

experimental group anagen Dysplast. catagen telogen anagen hair HAARO investigated Hair of the control group η = 1669 740 56 296 577 (17Tiere) 44% 3% 18% 35% Application of NaSCNaIs bath, NaSCN as a bath, examined hair η = 1401 875 23 154 349 (15Tiere) 624 2% 11% 25% oral application from NaSCN, examined hair η = 1552 840 36 157 519 (IBTiere) 54% 2% 10% 34%

Compared to the control group, the increase in anagen phase hair when using NaSCN was considered to be Bath 41%, with oral administration of NaSCN ^- 22%.

Ten days after shaving and depilation, the growth rate of the experimental groups is increased by 5% (Table 13).

Table 13 Growth rate as expression of hair length increase in 10 days in albino guinea pigs Experimental group hair length (cm)

χ% s

Examined hair

the control group

η = 85 7.0 100% 0.75

(17 animals)

application of NaSCN as a bath,

examined hair

η = 90 7.4 105.6% 0.6

(18Tiere)

oral application of NaSCN, examined hair

η = 90 7.4 105.4 0.68

(18Tiere)

Hair density was also increased in the experimental groups (Table 14). Table 14 Hair density in albino guinea pigs

X Number of hairs / cm ² S 8.86 experimental group % Examined hair 49.2 the control group π = 85 100% (17Tiere)

Application of NaSCN as a bath,

examined hair

η = 75 53.3 108.4% 10.32

(15Tiere)

oral administration of NaSCN, examined hair

η = 86 52.0 105.7% 12.6 (16 animals)

In both experimental groups the SCN 'content in the hair was significantly increased. It should be taken into account that the animals before the SCN ~ determination after the bath were rinsed three times under running tap water and then twice in warm tap water were dipped to achieve that as little as possible SCN "directly on the hair Since also in oral administration of SCN ^- the SCN cobalt increases in the hair many times, the results indicate that there is an active accumulation of 3CN "in the hair during hair growth, in connection with the observed promotional effects on hair growth not surprised. Remarkably, there was no change in SCN ~ content in the adrenal, spleen, thyroid, and muscle when NaSCN was used. In the skin, in turn, the SCN ~ concentration was increased.

Example 8 Industrial standard male and female furs (Mustela vision), average age 8 weeks,

average body mass at the beginning of the experiment 73Gg (complaints) or 660g (felling), was from the 3rd month of life with the

Feed mix, depending on supply and availability of different components- mainly from Milk powder, offal of beef and pork and fish consisted daily of KSCN according to the following application scheme

administered:

3. Living Mammal: 5 mg / kg feed,

4th month of life: 3mg / kg feed, 5.-7. Month of life: 5mg / kg feed.

The live evaluation of the animals (TGL 24 300/02) was carried out according to the characteristics Fcllfarbe and Fellstruktur. In the group of animals supplied with KSCN according to the invention, a fur structure better by 6.9% was detectable (Table 15).

Table 15: Live evaluation of the standard mink on the 147th day of the experiment

η score coat structure animal group 99 coat color 1.87 experimental group 97 2.13 1.75 control group 2.13

The better fur structure of KSCN-treated mink was through the results of the fur coverage of the treated hides

confirmed (Table 16).

The assessment was carried out according to the following key:

1. Are the skins of the control and test group different in length from awn hair to hair? These were classified as follows:

- 3 points = average awn, good relation to the length of the undercoat,

- 2 points = a little too long or too short awn in relation to the length of the undercoat,

- 1 point = very long or short awn in relation to the undercoat.

2. Do the skins of the control and test group differ in density and uniformity of the relaxation. The classification was based on the following criteria:

- 2 points = medium,

- 1 point = bad.

3. Does the skins of the control and experimental group differ in hair strength and elasticity? The given points mean:

- 3 points = ideal,

- 2 points = medium,

- 1 point = bad.

It was suggested that the awning hairs in the experimental animals were slightly longer in relation to the undercoat than those of the control animals. The density and uniformity of the relaxation is 5.6% in experimental animals, the hair strength and elasticity 4.8% better than in the control animals (Table 16).

Table 16: Evaluation of the skins of standard mink after processing

animal group η Length of awn hair Score density u. Uniformity of the relaxation Hair strength u. -elasticity experimental group 95 2.55 2.26 2.61 control group 97 2.58 2.14 2.49

Furthermore, a better body mass gain was achieved in the experimental group (Table 17) and, as a consequence, a longer body and coat length (Table 18) than in the control group.

Table 17: Body mass gain of standard mink after 148 days of work

animal group η Housing biomass Body mass Difference outage to installation life mass experimental group 99 668 1813 1145 control group 97 622 1759 1137

Table 18: Body length and fur length of standard mink after processing

animal group η body length Dimension (cm) coat length after processing experimental group 77 44 66 control group 97 42 65

In view of the physiological efficacy of thiocyanate on the structural properties of hair coat in mink, it is important that the SCN ~ serum level of the test animals in the test period with 6-8 mg SCN ~ - / I significantly higher than that of the control animals (4-5 mg SCN "/ I) was.

Claims (5)

1. hair restorer for humans and livestock, characterized in that salts of thiocyanic acid are added locally to the bath water, hair lotions, shampoos, cosmetics or health care products in a concentration of 0.001-1% Thiocyanationen. 2. hair restorer according to claim 1, characterized in that salts of thiocyanic acid orally or in a dose range of 0.2-2 mg / kg KM / d in humans or of 0.2-30 mg / kg KM / d at Livestock are to be administered. 3. hair restorer according to claim 1 and 2, characterized in that a combination of the external application according to claim 1 and the internal application according to claim 2 is made. 4. hair restorer according to claim 1-3, characterized in that a mixture of sodium thiocyanate and potassium thiocyanate is used with a proportion of more than 50% sodium thiocyanate for the application. 5. hair restorer according to claim 1-4, characterized in that their use in addition to the promotion of hair growth improved quality of hair formation and thus improved quality of hair, wool, fur, leather or feathers in terms of shine, coat structure, hair strength and elasticity , Density and uniformity of the hair or feather gown, softness, strength in the processing process causes.