DD276032A5 - METHOD FOR PRODUCING MEDICAMENTAL CARE FOR THE TREATMENT OF VENEER EXPANSIONS - Google Patents

Abstract

The invention relates to a process for the preparation of a preparation for the treatment of vein dilations, in particular for the treatment of haemorrhoids, or occurring on the lower limbs, possibly entzuendeten varicose veins and to reduce the pain caused by them. According to the invention, the preparations are prepared by mixing aluminum potassium sulfate and / or one or more of its hydrates with physiologically acceptable carriers, excipients and possibly fragrances and preparing from the mixture in a known manner liquid or solid preparations, preferably ointments, creams, lotions, pastes ,

Description

Field of application of the invention

The invention relates to a process for the preparation of medicaments for the treatment of venous veins. The preparations are particularly suitable for the treatment of hemorrhoids, occurring especially on the lower limbs, sometimes inflamed (phlebitis) varicose veins (phlebectasia) and to reduce the pain caused by them (phlebalgia) and contain as active ingredients natural mineral substances. Under hemorrhoids are in the following understood the extensions of the lowermost portion of the rectum located, small valves containing venous network (nodi haemorrhoidales).

Characteristic of the known state of the art

For a long time, those skilled in the art have endeavored to treat hemorrhoids in a manner other than surgical because the surgical procedure involves prolonged disability, can only be performed in hospital, and the rate of infection is generally about 10% in the case of thickening and endoscopy (Pharrn (6 |, 142 (1986)). At an advanced age and in the presence of other diseases, the surgical procedure may also cause other problems.

The healing of the vein dilations occurring mainly in the limbs is also a frequent therapeutic task, the surgical procedure can also have the above-mentioned disadvantages, although the risk of infection is lower.

Both hemorrhoids and vein dilations are very common in all age groups of the adult population.

Therefore, there is a great need for top long-term locally applicable Präp & raten, which are analgesic, free of side effects and said pathological Ve. to induce or eliminate changes to the regression.

From the literature it is known to use metal salts locally to alleviate the discomfort caused by hemorrhoids. Such salts are, for example, the basic bismuth gallate, the basic bismuth iodogallate.

The metal salts were always used together with plant-extracts, oils, corticoids or other active pharmaceutical ingredients (Rote Liste 1983, 46, main group, Editio Cantor Aulendorf / Wuertt., FRG).

On the use of alums, ie of double salts dev general formula Me ¹ Mo ¹¹ ISO ^) ₂ · 12 H ₂ O (where Me ^{1 is} potassium, sodium, ammonium, thallium, rubidium or CSsiumion and Me ¹ " Aluminum, iron, chromium, cobalt or manganese ion means), in particular of Ali imlnh'mkalium sulfate as an active ingredient in one-component preparations for the treatment of vein dilation has not been disclosed in the literature.

The oral preparations generally have several undesirable side effects when used for short periods of time, but the treatment of hemorrhoiclan and other venous reactions takes less time.

Venoruton (active ingredient: (M-hydroxyethyl) rutoside), for example, may cause redness and edema swelling of the face after 6 to 8 days of use.

Object of the invention

The aim of the invention is to provide a novel pharmaceutical preparation which can be applied externally to the treatment of Vonenweitorungon, in particular for the treatment of hemorrhoids and varicose veins and which causes no undesirable side effects.

Explanation of the essence of the invention The object of the invention is to develop a preparation while eliminating the deficiency of the known solutions,

which can be produced easily and cheaply and contains only a single active substance.

It has now been found that by local application of an exclusively Aluminiumkaliunsulfat or its Hydrate (alum) containing preparations the vein dilations, especially hemorrhoidone, on the lower limbs

occurring, sometimes inflamed (phlebitis) varicose veins (phlebectasia) and caused by these pain (phlebalgia) can be significantly improved or eliminated altogether.

The pharmaceutical preparation according to the invention is preferably prepared as follows. AluminiumkaNumsulfat-dodecahydrate

(Kalialaunaun) is with a hydrophilic, suitable for the production of cosmetics and medicines ointment base (for

Example Hydrogelum methylcellulosi, Unguentum glycerin !, Unguentum stearini, Unguentum hydrophilici anionicum) as Carrier mixed and processed to a homogeneous ointment. The preparation according to the invention may contain further carriers, which are generally used for the preparation of cosmetics and medicaments, Help · and fragrances included. The following literature provides information on these substances: VII. Hungarian Pharmacopoeia; Formulas Normal, Vl. Output; H. Fiedler: Encyclopedia of excipients for pharmacy, cosmetics ..., Editio Contor KG. Aulendorf FRG, 1971, p. 490-494; Applied Biopharmacy, Scientific Publishing House Stuttgart, FRG, 1973, chapters 26 and 28. The preparations which can be prepared according to the invention preferably contain 10-90% by mass, in particular 40-70% by mass. AlumlniumkeHumsulfat-dodecahydrate. Experience has shown that it is sufficient to treat with the 70Ma .-% aluminum potassium sulfate ointment containing behar.delnde Incise vein dilation (varicose knots, hemorrhoids) three times a day. After taking 1-3 treatments Pain, itching and inflammation from strong and finally stop completely. After 3-20 days of treatment is the Resumed working capacity (complete absence of pain), and after further treatment, the extensions disappear

(Varicose node) completely, the bulging vein sections retract to their original position. These

Observations were made on eighteen patients between the ages of 20 and 70 years. AusfOhrungsbelslele The invention is explained in more detail below with reference to some examples. However, the preparation of the preparation of the present invention is not limited to these examples. example 1

1400g of crystalline aluminum potassium sulfate dodecahydrate are pulverized and mixed with 600g of Unguentum glycerin! mixed until the mass is homogeneous. The resulting ointment is filled into tubes of 50g each.

Example 2

1400g aluminum potassium sulfate dodecahydrate and 600g Ung. glycerin! are mixed together in the manner given in Example 1. 60cm ¹ Oleum Chamomillae are added to the mixture. The finished ointment is filled in ointment jar.

Example 3 Made of 210g aluminum potassium sulfate dodecahydrate, 90g Ung. glycerin! and 2g of menthol is preparing a homogeneous mass and in Tubes filled. Example 4 Made from 100g of crystalline aluminum potassium sulfate dodecahydrate, 900g of Unguentum emulsificans aquosum and 7g of menthol

eir.n homogenous mass prepares and filled into tubes of 50g each. The resulting cream is especially suitable for the treatment of varicose veins.

example From 500g cocoa butter and 600g aluminum potassium sulfate dodecahydrate is prepared a homogeneous Krem and 60g each in Tubes filled. The cream is especially suitable for the treatment of hemorrhoids. Examples It works on the catfish described in Example 4 with the difference that as an ointment base 900g Unguentum

hydrophillcum USP.

Claims (4)

1. A process for the preparation of a preparation for the treatment of vein dilations, in particular for the treatment of hemorrhoids or occurring on the lower limb, optionally Entzunosten varicose veins and to reduce the pain caused by these, characterized in that aluminum potassium sulfate and / or one or more of its hydrates mixed with one or more physiologically acceptable carriers, excipients and, where appropriate, fragrances and prepared from the mixture in a known manner liquid or solid preparations, preferably ointment, cream, solution or paste; 2. The method according to claim 1, characterized in that one uses 10-90Ma .-%, preferably 40-70 Ma .-%, Aluminiumkaliumsulf at-dodecahydrate. 3. The method according to claim 1, characterized in that one uses as a carrier hydrophilic ointment base. 4. The method according to claim 1, characterized in that as ointment base ' ^! r.guentum glycerini, Unguentum emulsificans aquosum, cocoa butter, Ungentum hydrophilicum USP is used.