DD160453A5 - Verfahren zur herstellung von benzopyranverbindungen - Google Patents

Verfahren zur herstellung von benzopyranverbindungen Download PDF

Info

Publication number: DD160453A5
Authority: DD; German Democratic Republic
Prior art keywords: group; compound; dihydro; benzopyran; formula
Prior art date: 1980-06-17

Application number

DD81230894A

Other languages

German (de)

English (en)

Inventor

Masami Shiratsuchi

Noboru Shimizu

Hiromichi Shigyo

Yoshinori Kyotani

Hisashi Kunieda

Kiyoshi Kawamura

Seiichi Sato

Toshihiro Akashi

Mashiko Nagakura

Naotoshi Sawada

Yasumi Uchida

Original Assignee

Kowa Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-06-17

Filing date

1981-06-17

Publication date

1983-08-03

1980-06-17 Priority claimed from JP8084180A external-priority patent/JPS6054317B2/ja

1980-12-25 Priority claimed from JP55182854A external-priority patent/JPS57106619A/ja

1981-06-17 Application filed by Kowa Co filed Critical Kowa Co

1983-08-03 Publication of DD160453A5 publication Critical patent/DD160453A5/de

Links

238000004519 manufacturing process Methods 0.000 title abstract description 3
150000001562 benzopyrans Chemical class 0.000 title description 4
150000001875 compounds Chemical class 0.000 claims abstract description 149
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 25
125000000217 alkyl group Chemical group 0.000 claims abstract description 17
125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 17
239000002253 acid Substances 0.000 claims abstract description 11
150000003839 salts Chemical class 0.000 claims abstract description 11
125000002947 alkylene group Chemical group 0.000 claims abstract description 10
125000005843 halogen group Chemical group 0.000 claims abstract description 9
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 9
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract description 6
125000002768 hydroxyalkyl group Chemical group 0.000 claims abstract description 3
125000003545 alkoxy group Chemical group 0.000 claims description 8
125000005529 alkyleneoxy group Chemical group 0.000 claims description 4
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 3
125000003884 phenylalkyl group Chemical group 0.000 claims description 3
239000003814 drug Substances 0.000 abstract description 29
230000000694 effects Effects 0.000 abstract description 28
230000017531 blood circulation Effects 0.000 abstract description 11
230000009467 reduction Effects 0.000 abstract description 7
230000001800 adrenalinergic effect Effects 0.000 abstract description 4
230000000903 blocking effect Effects 0.000 abstract description 2
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210000000748 cardiovascular system Anatomy 0.000 abstract description 2
201000010099 disease Diseases 0.000 abstract description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
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238000006243 chemical reaction Methods 0.000 description 48
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CHNUOJQWGUIOLD-NFZZJPOKSA-N epalrestat Chemical compound C=1C=CC=CC=1\C=C(/C)\C=C1/SC(=S)N(CC(O)=O)C1=O CHNUOJQWGUIOLD-NFZZJPOKSA-N 0.000 description 28
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238000012360 testing method Methods 0.000 description 17
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229910002651 NO3 Inorganic materials 0.000 description 15
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230000000052 comparative effect Effects 0.000 description 7
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ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 6
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JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 6
239000008194 pharmaceutical composition Substances 0.000 description 6
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239000011591 potassium Substances 0.000 description 6
238000002360 preparation method Methods 0.000 description 6
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FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 6
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229910001961 silver nitrate Inorganic materials 0.000 description 5
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JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 3
GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 description 3
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RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 3
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HUHXLHLWASNVDB-UHFFFAOYSA-N 2-(oxan-2-yloxy)oxane Chemical compound O1CCCCC1OC1OCCCC1 HUHXLHLWASNVDB-UHFFFAOYSA-N 0.000 description 2
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QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 2
BUDQDWGNQVEFAC-UHFFFAOYSA-N Dihydropyran Chemical compound C1COC=CC1 BUDQDWGNQVEFAC-UHFFFAOYSA-N 0.000 description 2
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NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 2
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KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 description 2
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239000011230 binding agent Substances 0.000 description 2
239000011575 calcium Substances 0.000 description 2
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OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
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NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
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235000000346 sugar Nutrition 0.000 description 1
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238000007070 tosylation reaction Methods 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DD81230894A 1980-06-17 1981-06-17 Verfahren zur herstellung von benzopyranverbindungen DD160453A5 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP8084180A JPS6054317B2 (ja)	1980-06-17	1980-06-17	新規ベンゾピラン誘導体
JP55182854A JPS57106619A (en)	1980-12-25	1980-12-25	Remedy for circulatory disease

Publications (1)

Publication Number	Publication Date
DD160453A5 true DD160453A5 (de)	1983-08-03

Family

ID=26421809

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD81230894A DD160453A5 (de)	1980-06-17	1981-06-17	Verfahren zur herstellung von benzopyranverbindungen

Country Status (16)

Country	Link
US (1)	US4394382A (no)
EP (1)	EP0042299B1 (no)
KR (1)	KR850000193B1 (no)
AU (1)	AU543347B2 (no)
CA (1)	CA1178598A (no)
CS (1)	CS226731B2 (no)
DD (1)	DD160453A5 (no)
DE (1)	DE3166300D1 (no)
DK (1)	DK154557C (no)
ES (1)	ES8300104A1 (no)
FI (1)	FI79307C (no)
IE (1)	IE52067B1 (no)
NO (1)	NO154495C (no)
PL (1)	PL130537B1 (no)
SU (1)	SU1212325A3 (no)
ZA (1)	ZA814042B (no)

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JPS5965076A (ja) *	1982-10-05	1984-04-13	Kowa Co	新規なキノリン誘導体
JPS60181083A (ja) *	1984-02-29	1985-09-14	Kowa Co	新規ラセミ体及びその変換方法
JPS60208973A (ja) *	1984-03-31	1985-10-21	Kowa Co	循環系疾患治療剤
GB8730051D0 (en) *	1987-12-23	1988-02-03	Beecham Group Plc	Novel compounds
WO1997043272A2 (en) *	1996-05-14	1997-11-20	Glaxo Group Limited	Benzofurans and benzopyrans as chronobiological agents
JP4000505B2 (ja)	1999-12-01	2007-10-31	第一三共株式会社	緑内障を治療するための併用剤
BR0313593A (pt)	2002-08-19	2005-07-12	Pfizer Prod Inc	Terapia de combinação para doenças hiperproliferativas
AU2003275609A1 (en) *	2002-10-24	2004-05-13	Kowa Co., Ltd.	Nerve fiber regeneration accelerator
US20050037063A1 (en) *	2003-07-21	2005-02-17	Bolton Anthony E.	Combined therapies
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
TWI646091B (zh) *	2012-12-28	2019-01-01	日商衛斯克慧特股份有限公司	鹽類及晶形
JP2016516804A (ja)	2013-04-17	2016-06-09	ファイザー・インク	心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
AU2020209215B2 (en)	2019-01-18	2023-02-02	Astrazeneca Ab	PCSK9 inhibitors and methods of use thereof

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Publication number	Priority date	Publication date	Assignee	Title
GB1493998A (en) *	1975-06-03	1977-12-07	Beecham Group Ltd	Propanolamine derivatives
JPS54106476A (en) *	1978-01-04	1979-08-21	Merck & Co Inc	Multiisubstituted 2233lower alkylaminoo22 r100propoxypyridine
DE2804625A1 (de) *	1978-02-03	1979-08-09	Thomae Gmbh Dr K	Neue 4-acylamino-phenyl-aethanolamine
DE2805404A1 (de) *	1978-02-09	1979-08-16	Merck Patent Gmbh	1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung

1981
- 1981-06-09 US US06/271,927 patent/US4394382A/en not_active Expired - Lifetime
- 1981-06-11 AU AU71652/81A patent/AU543347B2/en not_active Expired
- 1981-06-12 IE IE1312/81A patent/IE52067B1/en not_active IP Right Cessation
- 1981-06-12 CA CA000379656A patent/CA1178598A/en not_active Expired
- 1981-06-15 FI FI811856A patent/FI79307C/fi not_active IP Right Cessation
- 1981-06-16 EP EP81302700A patent/EP0042299B1/en not_active Expired
- 1981-06-16 ZA ZA814042A patent/ZA814042B/xx unknown
- 1981-06-16 KR KR1019810002196A patent/KR850000193B1/ko not_active Expired
- 1981-06-16 CS CS814509A patent/CS226731B2/cs unknown
- 1981-06-16 ES ES503091A patent/ES8300104A1/es not_active Expired
- 1981-06-16 SU SU813300799A patent/SU1212325A3/ru active
- 1981-06-16 DK DK264181A patent/DK154557C/da not_active IP Right Cessation
- 1981-06-16 DE DE8181302700T patent/DE3166300D1/de not_active Expired
- 1981-06-16 NO NO812042A patent/NO154495C/no not_active IP Right Cessation
- 1981-06-17 PL PL1981231734A patent/PL130537B1/pl unknown
- 1981-06-17 DD DD81230894A patent/DD160453A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
US4394382A (en)	1983-07-19
PL130537B1 (en)	1984-08-31
KR850000193B1 (ko)	1985-03-05
DK154557C (da)	1989-04-17
DK264181A (da)	1981-12-18
EP0042299A1 (en)	1981-12-23
KR830006268A (ko)	1983-09-20
ES503091A0 (es)	1982-10-01
NO154495B (no)	1986-06-23
FI79307C (fi)	1989-12-11
DK154557B (da)	1988-11-28
FI811856L (fi)	1981-12-18
IE811312L (en)	1981-12-17
NO812042L (no)	1981-12-18
AU543347B2 (en)	1985-04-18
NO154495C (no)	1986-10-01
AU7165281A (en)	1981-12-24
SU1212325A3 (ru)	1986-02-15
EP0042299B1 (en)	1984-09-26
ES8300104A1 (es)	1982-10-01
ZA814042B (en)	1982-06-30
PL231734A1 (no)	1982-08-16
DE3166300D1 (en)	1984-10-31
CS226731B2 (en)	1984-04-16
CA1178598A (en)	1984-11-27
IE52067B1 (en)	1987-06-10
FI79307B (fi)	1989-08-31

Publication	Publication Date	Title
DD160453A5 (de)	1983-08-03	Verfahren zur herstellung von benzopyranverbindungen
EP0026317B1 (de)	1985-10-16	Optisch aktive 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US4034009A (en)	1977-07-05	4-Ureido-2-acyl phenoxypropanolamine
EP0039892B1 (de)	1986-12-30	Substituierte Phenyläther
EP0192829B1 (de)	1990-09-26	Amino-propanol-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel sowie Zwischenprodukte
US4059622A (en)	1977-11-22	Alkanolamine derivatives
EP0004532A1 (de)	1979-10-17	1-Aryloxy-3-nitratoalkylamino-2-propanole, Verfahren zu ihrer Herstellung und ihre pharmazeutischen Zubereitungen
EP0410208B1 (de)	1994-06-22	Chromanderivate
DE2830884C2 (no)	1990-01-11
EP0400430A2 (de)	1990-12-05	Chromanderivate
EP0271013A2 (de)	1988-06-15	Basisch substituierte Phenylacetonitrile, ihre Herstellung und diese enthaltende Arzneimittel
EP0074014A1 (de)	1983-03-16	2-(2'-Hydroxy-3'-(1,1-dimethylpropylamino)-propoxy)-beta-phenylpropiophenon, seine Säureadditionssalze, Verfahren zu seiner Herstellung und Arzneimittel
CH640227A5 (de)	1983-12-30	Aminoalkoxyphenyl-derivate.
DD145104B3 (de)	1990-07-18	Verfahren zur herstellung von polyalkoxyphenylpyrrolidone
DD148215A5 (de)	1981-05-13	Verfahren zur herstellung von bicyclo eckige klammer auf 3.1.0 eckige klammer zu hexyl-substituierten carbonylaminophenoxyverbindungen
HU188061B (en)	1986-03-28	Process for the preparation of benzopyrane derivatives and pharmaceutical compositions containing said compounds as active ingredients
DE3014813A1 (de)	1980-11-13	2-hydroxy-5-(1-hydroxy-2-piperazinylethyl)benzoesaeure-derivate
DD157796A5 (de)	1982-12-08	Verfahren zur herstellung neuer derivate des 2-amino-aethanols
DE2923817B1 (de)	1980-08-14	(3-Alkylamino-2-hydroxypropoxy)-furan-2-carbonsaeureanilide und deren physiologisch vertraegliche Saeureadditionssalze und Verfahren zu deren Herstellung sowie Arzneimittel mit einem Gehalt dieser Verbindungen
EP0308792A2 (de)	1989-03-29	Azachromanderivate
EP0096006A2 (de)	1983-12-07	3-(Ureidocyclohexylamino)-propan-1,2-diolderivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie ihre therapeutische Verwendung
DE3104785A1 (de)	1982-02-25	Basische ether der 4-hydroxy-benzophenone, die als (beta)-blocker wirksam sind, und verfahren zu ihrer herstellung
EP0038936A1 (de)	1981-11-04	Neue 1-Aryloxy-3-alkylamino-2-propanole und Verfahren zu ihrer Herstellung
DE1795060C3 (de)	1976-11-18	Morpholin- und N-Methyl-piperazinderivate und Arzneimittel
DE2943406A1 (de)	1981-05-07	Aminoderivate des 2-methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazols

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2001-02-01	ENJ	Ceased due to non-payment of renewal fee