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CZ220099A3 - Nové sloučeniny s analgetickým účinkem - Google Patents

Nové sloučeniny s analgetickým účinkem

Info

Publication number
CZ220099A3
CZ220099A3 CZ992200A CZ220099A CZ220099A3 CZ 220099 A3 CZ220099 A3 CZ 220099A3 CZ 992200 A CZ992200 A CZ 992200A CZ 220099 A CZ220099 A CZ 220099A CZ 220099 A3 CZ220099 A3 CZ 220099A3
Authority
CZ
Czechia
Prior art keywords
novel compounds
compounds exhibiting
analgetic activity
analgetic
activity
Prior art date
Application number
CZ992200A
Other languages
English (en)
Inventor
Benjamin Pelcman
Edward Roberts
Original Assignee
Astra Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Inc. filed Critical Astra Pharma Inc.
Publication of CZ220099A3 publication Critical patent/CZ220099A3/cs

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
CZ992200A 1996-12-20 1997-12-09 Nové sloučeniny s analgetickým účinkem CZ220099A3 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9604786A SE9604786D0 (sv) 1996-12-20 1996-12-20 New compounds

Publications (1)

Publication Number Publication Date
CZ220099A3 true CZ220099A3 (cs) 1999-11-17

Family

ID=20405139

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ992200A CZ220099A3 (cs) 1996-12-20 1997-12-09 Nové sloučeniny s analgetickým účinkem

Country Status (31)

Country Link
US (3) US6153626A (cs)
EP (2) EP1428821A1 (cs)
JP (1) JP2001507021A (cs)
KR (1) KR20000069600A (cs)
CN (2) CN1154635C (cs)
AR (1) AR010378A1 (cs)
AT (1) ATE266638T1 (cs)
AU (1) AU738002B2 (cs)
BR (1) BR9713785A (cs)
CA (1) CA2274117A1 (cs)
CZ (1) CZ220099A3 (cs)
DE (1) DE69729115T2 (cs)
DK (1) DK0946510T3 (cs)
EE (1) EE03966B1 (cs)
ES (1) ES2219783T3 (cs)
HU (1) HUP0000613A3 (cs)
ID (1) ID21662A (cs)
IL (1) IL130536A0 (cs)
IS (1) IS5078A (cs)
MY (1) MY132705A (cs)
NO (1) NO313632B1 (cs)
NZ (1) NZ336028A (cs)
PL (1) PL188945B1 (cs)
PT (1) PT946510E (cs)
RU (1) RU2193030C2 (cs)
SE (1) SE9604786D0 (cs)
SK (1) SK283300B6 (cs)
TR (1) TR199901411T2 (cs)
UA (1) UA54481C2 (cs)
WO (1) WO1998028270A1 (cs)
ZA (1) ZA9711049B (cs)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
AU2003220725B2 (en) * 1997-12-24 2006-06-01 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor
JP4754068B2 (ja) * 1997-12-24 2011-08-24 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド δ−オピオイドレセプターに結合する4−[アリール(ピペリジン−4−イル)]アミノベンズアミド類
US6900228B1 (en) * 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
EP1512683B1 (en) * 1998-03-10 2011-08-31 Research Triangle Institute Novel opiate compounds, methods of making and methods of use
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides
SE9904674D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904675D0 (sv) 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
CA2395471A1 (en) 1999-12-22 2001-06-28 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(8-azabicyclo[3.2.1]octan-3-yl)]aminobenzoic acid derivatives
AU2001232319B2 (en) * 2000-02-18 2005-01-13 Meiji Seika Kaisha, Ltd. Phenoxyalkylamine derivates useful as opioid delta receptor ligands
US6552036B2 (en) 2000-03-03 2003-04-22 Ortho-Mcneil Pharmaceutical, Inc. 3-(Diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives
AU2001242744B2 (en) 2000-03-24 2005-07-21 Meiji Seika Kaisha Ltd Diphenylalkylamine derivatives useful as opioid delta receptor ligands
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
WO2002048122A2 (en) * 2000-12-14 2002-06-20 Ortho-Mcneil Pharmaceutical, Inc. Benzamidine derivatives
CA2436263A1 (en) * 2000-12-15 2002-06-20 Astrazeneca Ab New process for the preparation diaryl-4-amino-piperidinyl compounds
SE0101769D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
AR035974A1 (es) 2001-05-18 2004-07-28 Astrazeneca Ab Derivados de diarilmetil piperazina, procesos para su preparacion, uso de estos derivados para la elaboracion de medicamentos y composicion farmaceutica
SE0101773D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101770D0 (sv) 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101771D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
ATE347549T1 (de) 2001-10-15 2006-12-15 Janssen Pharmaceutica Nv Neue substituierte 4-phenyl-4-(1h-imidazo-2-yl)- piperidin-derivate und ihre anwendung als selective delta-opioid-agonisten
ATE521592T1 (de) * 2002-03-13 2011-09-15 Janssen Pharmaceutica Nv Histone-deacetylase-inhibitoren
CA2485681C (en) 2002-05-24 2012-10-16 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
ATE363470T1 (de) 2002-11-18 2007-06-15 Chemocentryx Inc Arylsulfonamide
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
CN1816524B (zh) * 2003-01-16 2012-06-27 阿卡蒂亚药品公司 用于神经退行性疾病的治疗的选择性五羟色胺2a/2c受体反向激动剂
WO2005003131A1 (en) * 2003-06-27 2005-01-13 Janssen Pharmaceutica N.V. Tricyclic delta opioid modulators
WO2005075472A1 (en) 2004-02-03 2005-08-18 Janssen Pharmaceutica, N.V. 3-(diheteroarylnethylene)-8-azabicyclo[3.2.1]octane and 3-(aryl)(heteroaryl)methylene)-8-azabicyclo[3.2.1]octane derivatives
HRP20120343T1 (hr) 2004-08-02 2012-05-31 Astrazeneca Ab Derivati diarilmetil piperazina, njihovi pripravci i njihova uporaba
CA2574768A1 (en) * 2004-08-05 2006-02-05 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
AU2005319060A1 (en) * 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. Tricyclic delta-opioid modulators
BRPI0519198A2 (pt) * 2004-12-22 2008-12-30 Janssen Pharmaceutica Nv moduladores de delta-opiàide tricÍclicos
CA2592464A1 (en) * 2004-12-22 2006-06-29 Janssen Pharmaceutica N.V. Tricyclic .delta.-opioid modulators
CA2594347A1 (en) * 2005-01-06 2006-07-13 Janssen Pharmaceutica N.V. Tricyclic d-opioid modulators
TWI410406B (zh) 2005-05-13 2013-10-01 Otsuka Pharma Co Ltd 吡咯烷化合物
CN101243079A (zh) * 2005-06-16 2008-08-13 詹森药业有限公司 三环阿片调节剂
JP5219465B2 (ja) * 2006-11-10 2013-06-26 大塚製薬株式会社 医薬

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KR940003491B1 (ko) 1989-08-10 1994-04-23 리히터 게데온 베기에스제티 기아르 알.티 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물
SE8904298D0 (sv) * 1989-12-21 1989-12-21 Astra Ab New compounds
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SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
JP4754068B2 (ja) * 1997-12-24 2011-08-24 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド δ−オピオイドレセプターに結合する4−[アリール(ピペリジン−4−イル)]アミノベンズアミド類
EP1512683B1 (en) 1998-03-10 2011-08-31 Research Triangle Institute Novel opiate compounds, methods of making and methods of use
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides

Also Published As

Publication number Publication date
PL188945B1 (pl) 2005-05-31
DE69729115D1 (de) 2004-06-17
US6153626A (en) 2000-11-28
ATE266638T1 (de) 2004-05-15
AU738002B2 (en) 2001-09-06
EP0946510B1 (en) 2004-05-12
NO313632B1 (no) 2002-11-04
NO993023D0 (no) 1999-06-18
TR199901411T2 (xx) 1999-09-21
SK76399A3 (en) 2000-01-18
EP0946510A1 (en) 1999-10-06
HUP0000613A2 (hu) 2000-09-28
DE69729115T2 (de) 2005-04-28
EE03966B1 (et) 2003-02-17
EE9900261A (et) 2000-02-15
NZ336028A (en) 2001-03-30
HK1022910A1 (en) 2000-08-25
IL130536A0 (en) 2000-06-01
IS5078A (is) 1999-06-11
US6710179B2 (en) 2004-03-23
JP2001507021A (ja) 2001-05-29
HK1023996A1 (en) 2000-09-29
DK0946510T3 (da) 2004-08-09
SE9604786D0 (sv) 1996-12-20
AU5351398A (en) 1998-07-17
CN1154635C (zh) 2004-06-23
EP1428821A8 (en) 2005-01-26
MY132705A (en) 2007-10-31
EP1428821A1 (en) 2004-06-16
ID21662A (id) 1999-07-08
AR010378A1 (es) 2000-06-07
PT946510E (pt) 2004-08-31
SK283300B6 (sk) 2003-05-02
NO993023L (no) 1999-08-12
BR9713785A (pt) 2000-02-08
WO1998028270A1 (en) 1998-07-02
ES2219783T3 (es) 2004-12-01
ZA9711049B (en) 1998-06-22
PL334370A1 (en) 2000-02-28
RU2193030C2 (ru) 2002-11-20
UA54481C2 (uk) 2003-03-17
US6399635B1 (en) 2002-06-04
US20030055045A1 (en) 2003-03-20
CN1539824A (zh) 2004-10-27
KR20000069600A (ko) 2000-11-25
HUP0000613A3 (en) 2002-10-28
CN1241178A (zh) 2000-01-12
CA2274117A1 (en) 1998-07-02

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic