CZ121694A3 - Dermatological and cosmetic preparations - Google Patents

Abstract

Dermatological and cosmetic compositions having high endermicity and antiageing activity and high stability are herein described consisting of: 1) emulsifying and self-emulsifying agents, having o/w activity formed by a mixture containing (as % w/w); 1') polyethylene glycol mono- or distearate 0.5-5.0 %; 2') polyglycol esters of saturated or unsaturated C14-C20 fatty acids 1.0-10.0 %; 3') cetyl alcohol and optionally other higher alcohols, comprising free or esterified sterols 1.0-16.0 %; 2) sodium versenate and antioxidant agents 0.1-5.0 %; 3) anti-mould and bacteriostatic agents 0.05-0.1 %; 4) active ingredients 1-30 %; 5) purified water F.U. q.s. to 100 %.

Description

The invention relates to dermatological and cosmetic preparations, in particular to anti-aging preparations; they can also be used in the treatment of burns and open wounds. They are highly stable, allowing them to be used to stabilize the active ingredients.

BACKGROUND OF THE INVENTION

The skin is made up of cells whose condition affects the external appearance of the epidermis. Aging of the skin occurs by slowing down its functions, especially as regards nutrition, breathing, hydration, regeneration and protection of skin tissue. Skin aging is a natural phenomenon whose causes have different origins and which can vary from person to person. Usually, there is a decrease in the function of certain cells, which are very important for maintaining the integrity of the skin structure, at about thirty years. Depending on many factors, such as genetic background, general health, or individual lifestyle, this phenomenon may occur at an earlier age.

SUMMARY OF THE INVENTION

The present invention relates to dermatological and cosmetic compositions. effective against aging and highly stable, even in the presence of active ingredients of various types.

The composition according to the invention consists of:

1) O / W emulsifying and self - emulsifying agents (oil in.

water), consisting of mixtures containing (in weight%)

1 ') polyethylene glycol mono- or distearate 2') polyglycol esters of saturated or unsaturated C ₁₄ -C ₂₀ fatty acids 3 ') cetyl alcohol and optionally other higher alcohols, which are understood as free or esterified sterols

2) sodium versenate and antioxidants

3) antifungal and bacteriostatic agents

4) active ingredients

0,5- 5,0%

1,0-10,0

1,0-16,0 0,1- 5,0 0,05-0,1 1,0-30,0

5) Purified water as needed to replenish up to 100%

The polyethylene glycols used have different molecular weights ranging from 200 to 10,000 and preferably from 400 to 2,000, especially equal to 1,000; particularly preferred is polyethylene glycol monostearate (1000) of this molecular weight. ''

The antioxidants are selected from the group consisting of:

(a) unsaturated fatty acids with a higher number of double bonds (polyunsaturated); preferably those belonging to the vitamin F group

b) tocopheryl derivatives, preferably tocopheryl acetate.

Examples of antifungal or bacteriostatic agents are methyl or propyl p-oxobenzoates.

In particular, the active ingredients exhibit skin reconstituting activity. Examples of such additives that are used singly or in combination with one another are collagen in various forms, esurosamine, elastin, amino acids, peptides and mucopolysaccharides.

The preparations according to the invention are distinguished by significant eudermicity, i.e. they have an exceptionally beneficial effect on skin tension and smoothness (anti-wrinkle), on skin translucence, tissue firmness, swelling and elasticity and on irregular fat deposition in the subcutaneous binder (cellulite). Equally beneficial effects are on skin irritation in children caused by wet bedding or sweat, on irritation of the feet after soaking, and on irritation caused by sunbathing.

Furthermore, the compositions of the invention have a surprising dermatological effect on burns, leg ulcer, wound healing and bedsores, since they speed up their treatment.

A particular and surprising aspect of the present invention is the fact that the above-mentioned formulations, excreted as the excretory active agents of item 4), themselves act as stabilizing carriers against individual active ingredients such as vitamins, hormones or antibiotics. Therefore, the present compositions are suitable for the preparation of pharmaceutical compositions containing active ingredients which are degradable due to external conditions (temperature, humidity, oxidizing substances, etc.).

Various stability tests carried out by means of chromatographic analysis have confirmed that the preparations according to the invention maintain at room temperature the titer of the active ingredients added therein within the specified limit; in particular, some vitamins show a decrease in titer not exceeding 10% over two years.

The compositions of the invention are formulated in accordance with dermatology and cosmetic validation procedures and may be in the form of creams, emulsions, lotions, ointments, oils, ampoules, masks, gels, pads or sprays.

Both creams and lotions can be formulated with the same ingredients as an advantage of the invention.

The tolerance tests of the dermatological and cosmetic compositions of the present invention have confirmed that these compositions are fully tolerated and do not cause any irritation, demonstrating their high eudermicity. in '\

DETAILED DESCRIPTION OF THE INVENTION

The following examples further illustrate the invention.

Example 1

To prepare 100 g of base cream purified water hammelis water cetyl alcohol free and esterified sterols methyl p-oxybenzoate polyethylene glycol monostearate (1000) propyl p-oxybenzoate propyl gallate propylene glycol pink essence versenate disodium.

vitamin F 80% polyglycol esters of saturated or unsaturated C ₁₄ -C ₂₀ fatty acids

Example 2

For the preparation of 100 g of elastin cream elastin (anhydrous) linol linoleic acid cetyl alcohol polyethylene glycol monostearate (1000)

43.22 g 27.50 g 16.00 g

1.00 g 0.15 g 3.00 g 0.05 g 0.03 g 7.00 g 0.25 g 0.05 g 1.25 g

0.50 g

- 2 g

1.25 g 12.00 g

2.25 g polyglycol esters of saturated or unsaturated C ₁₄ -C ₂₀ fatty acids free and esterified sterols methyl p-oxybenzoate propyl p-oxybenzoate propyl gallate sodium versenic acid hammelis water propylene glycol purified water pink essence

Example 3

0.75 g 0.13 g 0.07 g 0.30 g 0.05 g

20,50 g 5,25 g

55.975-54.60 g 0.20 g

To prepare 100 g of collagen cream:

soluble collagen (anhydrous) 1.20 g vitamin F (polyunsaturated fatty acids) 1.15 g elastin 0.50 g esurosamine 0.50 g vitamin E (tocopheryl acetate) 0.20 g cetyl alcohol 7.50 g polyethylene glycol monostearate (1,000) 3.00 g polyglycol esters of saturated or unsaturated ^C 20 ^-C i4 ^{fatty .gamma.CH} acids 1.50 g free and esterified sterols 1.50 g methyl p-oxybenzoate 0.10 g propyl p-oxybenzoate 0.01 g propyl gallate 0 02 g versenic acid sodium salt 0.05 g essence Givaudan PCV-1845/2 0.30 g purified water 82.47 g

To prepare 100 g of cleansing milk:

Example 4

purified water 45.05 G hammelis water 27.50 G cetylalkohol _K 2.50 G free and esterified sterols 1.00 G polyglycol esters of saturated or unsaturated ^C 20 ^_C i4 ^fatty acids, Y is ^CH 5.00 G elastin 1.00 G esurosamine 1.00 G methyl p-oxybenzoate 0.13 G polyethylene glycol monostearate (1,000) 0.75 G propyl p-oxybenzoate 0.07 G propygallate 0.30 G propylene glycol 14.00 G essence Givaudan PCV-1845/2 0.20 G sodium versenoic acid 0.05 G Vitamin F 80% 1,25 G Vitamin E (tocopheryl acetate) 0.20 G

Represented by:

Claims (5)

1. Dermatological and cosmetic products consisting of: (1) emulsifying and self-emulsifying agents of the water type), consisting of a mixture which it contains (by weight); 1 ') polyethylene glycol mono- or distearate 2') polyglycol esters of saturated or unsaturated C ₁₄ -C ₂₀ fatty acids 3'j cetyl alcohol and optionally other higher alcohols, which are understood as free or esterified sterols 2) sodium versenate and antioxidants 3) antifungal and bacteriostatic agents of active ingredients are known / in (oil in%) 0,5- 5,0% 1,0-10,0% 4) 5) 1,0-16,0 0.1- 5.0 0.05-0.1 1.0-30.0 purified water as needed to make up to 100 Dermatological and cosmetic preparations according to claim 1, characterized in that the polyunsaturated fatty acids contained therein belong to the group of vitamin F and the antioxidants are tocopherol derivatives; the active ingredients are selected from the group consisting of collagen in various forms, esurosamine, elastin, amino acids, peptides, and wetopolysaccharides. 3. Dermatological and cosmetic products, characterized in that the active ingredients are selected from vitamins, hormones and antibiotics. preparations according to claim m, wherein the groups contained therein, comprising Dermatological and cosmetic preparations according to claims 1 and 2, characterized in that they contain polyethylene glycol monostearate (1000) as an emulsifying agent component. Dermatological and cosmetic preparations according to claims 1-3, wherein the tocopheryl acetate contained therein is a tocopherol derivative. ^to Dermatological and cosmetic preparations according to claims 1 to 4, characterized in that they contain methyl or propyl p-oxybenzoate as an antifungal agent. Dermatological and cosmetic preparations according to claims 1 to 5, characterized in that they are in the form of milk; emulsions, creams, ointments, oils, ampoules, gels, masks, pads, sprays.