CY1752A - 8a-Acylaminoergoline its preparation and pharmaceutical compositions containing it - Google Patents

8a-Acylaminoergoline its preparation and pharmaceutical compositions containing it Download PDF

Info

Publication number: CY1752A
Authority: CY; Cyprus
Prior art keywords: compound; formula; acid addition; addition salt; pharmaceutically acceptable
Prior art date: 1987-06-23

Application number

CY175294A

Other languages

English (en)

Original Assignee

Sandoz Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-23

Filing date

1994-06-03

Publication date

1994-06-03

1994-06-03 Application filed by Sandoz Ltd filed Critical Sandoz Ltd

1994-06-03 Publication of CY1752A publication Critical patent/CY1752A/en

Links

239000008194 pharmaceutical composition Substances 0.000 title claims description 9
238000002360 preparation method Methods 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims description 62
150000003839 salts Chemical class 0.000 claims description 27
239000002253 acid Substances 0.000 claims description 23
239000012458 free base Substances 0.000 claims description 11
238000000034 method Methods 0.000 claims description 10
FWWOWPGPERBCNJ-UHFFFAOYSA-N 2-hydroxy-4-(2-hydroxyethoxy)-4-oxobutanoic acid Chemical compound OCCOC(=O)CC(O)C(O)=O FWWOWPGPERBCNJ-UHFFFAOYSA-N 0.000 claims description 7
238000004519 manufacturing process Methods 0.000 claims description 7
208000028017 Psychotic disease Diseases 0.000 claims description 5
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239000000939 antiparkinson agent Substances 0.000 claims description 3
239000003176 neuroleptic agent Substances 0.000 claims description 3
239000003937 drug carrier Substances 0.000 claims description 2
239000008024 pharmaceutical diluent Substances 0.000 claims description 2
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LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
238000012360 testing method Methods 0.000 description 11
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
230000000694 effects Effects 0.000 description 8
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
229960004046 apomorphine Drugs 0.000 description 7
VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 description 7
239000002775 capsule Substances 0.000 description 7
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Substances [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 7
210000002966 serum Anatomy 0.000 description 7
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
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QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 4
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RKZACOKFBAFYPQ-PSOPSSQASA-N (6ar,9s,10ar)-5,7-dimethyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-amine Chemical compound C1=CC([C@H]2C[C@H](N)CN([C@@H]2C2)C)=C3C2=C(C)NC3=C1 RKZACOKFBAFYPQ-PSOPSSQASA-N 0.000 description 2
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LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 2
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JBFYUZGYRGXSFL-UHFFFAOYSA-N imidazolide Chemical compound C1=C[N-]C=N1 JBFYUZGYRGXSFL-UHFFFAOYSA-N 0.000 description 2
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GOTMKOSCLKVOGG-OAHLLOKOSA-N (5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol Chemical compound C1([C@@H]2C3=CC(O)=C(Cl)C=C3CCN(C2)C)=CC=CC=C1 GOTMKOSCLKVOGG-OAHLLOKOSA-N 0.000 description 1
SKYZYDSNJIOXRL-BTQNPOSSSA-N (6ar)-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-10,11-diol;hydrochloride Chemical compound Cl.C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 SKYZYDSNJIOXRL-BTQNPOSSSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
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CY175294A 1987-06-23 1994-06-03 8a-Acylaminoergoline its preparation and pharmaceutical compositions containing it CY1752A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3720656		1987-06-23

Publications (1)

Publication Number	Publication Date
CY1752A true CY1752A (en)	1994-06-03

Family

ID=6330087

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY175294A CY1752A (en)	1987-06-23	1994-06-03	8a-Acylaminoergoline its preparation and pharmaceutical compositions containing it

Country Status (28)

Country	Link
US (1)	US5075318A (fi)
JP (1)	JPH0670052B2 (fi)
KR (1)	KR970001527B1 (fi)
AT (1)	AT395242B (fi)
AU (1)	AU615657B2 (fi)
BE (1)	BE1004034A3 (fi)
CA (1)	CA1302404C (fi)
CH (1)	CH674646A5 (fi)
CY (1)	CY1752A (fi)
DK (1)	DK169335B1 (fi)
ES (1)	ES2010282A6 (fi)
FI (1)	FI88302C (fi)
FR (1)	FR2617166B1 (fi)
GB (1)	GB2206115B (fi)
GR (1)	GR1002318B (fi)
HK (1)	HK2794A (fi)
HU (2)	HU203097B (fi)
IE (1)	IE60550B1 (fi)
IL (1)	IL86820A (fi)
IT (1)	IT1219652B (fi)
LU (1)	LU87251A1 (fi)
MY (1)	MY103584A (fi)
NL (1)	NL8801597A (fi)
NZ (1)	NZ225112A (fi)
PH (1)	PH24690A (fi)
PT (1)	PT87781B (fi)
SE (1)	SE467925B (fi)
ZA (1)	ZA884505B (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH664568A5 (de) *	1984-01-12	1988-03-15	Sandoz Ag	8-alpha-acylaminoergoline.
JP3630888B2 (ja) *	1996-10-31	2005-03-23	株式会社ニデック	レンズ搬送装置と眼鏡レンズを搬送するための眼鏡レンズ用固定カップ及びレンズ搬送方法
AU2009303389B2 (en)	2008-10-17	2014-10-16	Wisconsin Alumni Research Foundation	Method of making biologically active alpha-beta peptides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH664568A5 (de) *	1984-01-12	1988-03-15	Sandoz Ag	8-alpha-acylaminoergoline.
CH666035A5 (de) *	1984-12-24	1988-06-30	Sandoz Ag	8-alpha-acylaminoergolene.

1988
- 1988-06-17 IT IT48097/88A patent/IT1219652B/it active
- 1988-06-20 GB GB8814615A patent/GB2206115B/en not_active Expired - Lifetime
- 1988-06-20 FR FR888808357A patent/FR2617166B1/fr not_active Expired - Lifetime
- 1988-06-20 BE BE8800702A patent/BE1004034A3/fr not_active IP Right Cessation
- 1988-06-20 LU LU87251A patent/LU87251A1/fr unknown
- 1988-06-21 SE SE8802323A patent/SE467925B/sv not_active IP Right Cessation
- 1988-06-21 NZ NZ225112A patent/NZ225112A/en unknown
- 1988-06-21 DK DK340188A patent/DK169335B1/da not_active IP Right Cessation
- 1988-06-21 AU AU18194/88A patent/AU615657B2/en not_active Ceased
- 1988-06-21 HU HU883159A patent/HU203097B/hu not_active IP Right Cessation
- 1988-06-21 PT PT87781A patent/PT87781B/pt not_active IP Right Cessation
- 1988-06-21 MY MYPI88000682A patent/MY103584A/en unknown
- 1988-06-21 CH CH2387/88A patent/CH674646A5/de not_active IP Right Cessation
- 1988-06-21 IE IE186788A patent/IE60550B1/en not_active IP Right Cessation
- 1988-06-21 GR GR880100401A patent/GR1002318B/el unknown
- 1988-06-21 IL IL86820A patent/IL86820A/xx not_active IP Right Cessation
- 1988-06-22 KR KR1019880007511A patent/KR970001527B1/ko not_active Expired - Fee Related
- 1988-06-22 PH PH37103A patent/PH24690A/en unknown
- 1988-06-22 AT AT0161788A patent/AT395242B/de not_active IP Right Cessation
- 1988-06-22 FI FI883008A patent/FI88302C/fi not_active IP Right Cessation
- 1988-06-22 JP JP63154570A patent/JPH0670052B2/ja not_active Expired - Lifetime
- 1988-06-22 CA CA000570102A patent/CA1302404C/en not_active Expired - Lifetime
- 1988-06-23 NL NL8801597A patent/NL8801597A/nl active Search and Examination
- 1988-06-23 ZA ZA884505A patent/ZA884505B/xx unknown
- 1988-06-23 ES ES8801948A patent/ES2010282A6/es not_active Expired
1990
- 1990-11-02 US US07/608,454 patent/US5075318A/en not_active Expired - Lifetime
1994
- 1994-01-13 HK HK27/94A patent/HK2794A/xx not_active IP Right Cessation
- 1994-06-03 CY CY175294A patent/CY1752A/en unknown
1995
- 1995-06-15 HU HU95P/P00209P patent/HU211651A9/hu unknown

Also Published As

Publication number	Publication date
ZA884505B (en)	1990-02-28
SE8802323L (sv)	1988-12-24
AU615657B2 (en)	1991-10-10
IT1219652B (it)	1990-05-24
SE467925B (sv)	1992-10-05
LU87251A1 (fr)	1989-03-08
HUT50174A (en)	1989-12-28
DK340188D0 (da)	1988-06-21
IL86820A0 (en)	1988-11-30
CH674646A5 (fi)	1990-06-29
IL86820A (en)	1991-07-18
DK340188A (da)	1988-12-24
DK169335B1 (da)	1994-10-10
US5075318A (en)	1991-12-24
FI883008L (fi)	1988-12-24
FR2617166A1 (fr)	1988-12-30
KR970001527B1 (ko)	1997-02-11
HU211651A9 (en)	1995-12-28
GB2206115A (en)	1988-12-29
ES2010282A6 (es)	1989-11-01
PH24690A (en)	1990-09-07
HK2794A (en)	1994-01-21
JPH0670052B2 (ja)	1994-09-07
GB2206115B (en)	1991-04-03
KR890000479A (ko)	1989-03-14
AT395242B (de)	1992-10-27
IT8848097A0 (it)	1988-06-17
HU203097B (en)	1991-05-28
IE881867L (en)	1988-12-23
JPS6422876A (en)	1989-01-25
AU1819488A (en)	1989-01-05
MY103584A (en)	1993-08-28
IE60550B1 (en)	1994-07-27
PT87781A (pt)	1989-05-31
FI88302C (fi)	1993-04-26
ATA161788A (de)	1992-03-15
CA1302404C (en)	1992-06-02
FR2617166B1 (fr)	1992-07-17
SE8802323D0 (sv)	1988-06-21
FI883008A0 (fi)	1988-06-22
FI88302B (fi)	1993-01-15
NZ225112A (en)	1991-03-26
GB8814615D0 (en)	1988-07-27
GR1002318B (el)	1996-05-13
GR880100401A (el)	1989-03-08
NL8801597A (nl)	1989-01-16
BE1004034A3 (fr)	1992-09-15
PT87781B (pt)	1992-10-30

Publication	Publication Date	Title
KR100247121B1 (ko)	2000-08-01	헤테로시클릭 화합물과 그의 제조방법 및 용도
HU211575A9 (en)	1995-12-28	2-methyl-thieno-benzodiazepine
NO327896B1 (no)	2009-10-12	Tricykliske benzodiazepiner, farmasoytisk sammensetning, anvendelse av forbindelsene samt mellomprodukter som er nyttige ved syntese av forbindelsene
DK156001B (da)	1989-06-12	Analogifremgangsmaade til fremstilling af mercaptosubstituerede 2,3,4,5-tetrahydro-1h-3-benzazepiner
GB2071095A (en)	1981-09-16	Heterocyclic compounds processes for their preparation and pharmaceutical compositions containing them
FI84173C (fi)	1991-10-25	Foerfarande foer framstaellning av farmakologiskt aktiva 2,3,4,5-tetrahydro-1h-3-benzazepinderivat.
FI97806C (fi)	1997-02-25	Menetelmä terapeuttisesti aktiivisten dihydrobentsofuraanikarboksamidien valmistamiseksi
US3636045A (en)	1972-01-18	Thiepino and oxepino(4 5-c)pyrrol derivatives
CS247094B2 (en)	1986-11-13	Preparation method of 5,11-dihydro-11-(((methyl-4-piperidinyl)amino)carbonyl)-6h-dibenz(b,e)-azepin-6-on
US5075318A (en)	1991-12-24	8α-acylaminoergoline, its preparation and pharmaceutical compositions containing it
JPH08507498A (ja)	1996-08-13	複素環式化合物、それらの使用および製法
US5637596A (en)	1997-06-10	Azabicycloalkyl derivatives of imidazo[1,5-a]indol-3-one and process for their preparation
US4424225A (en)	1984-01-03	Thienobenzodiazepinones, pharmaceutical compositions thereof and method of use thereof
DK162050B (da)	1991-09-09	Pyrazolderivater med ergolinskelet eller salte deraf, deres fremstilling, farmaceutiske praeparater indeholdende disse og fremgangsmaade til fremstilling af de farmaceutiske praeparater
US4032640A (en)	1977-06-28	4H-Benzo[4,5]cyclohepta[1,2-b]thiophenes
HU201759B (en)	1990-12-28	Process for producing new condensed diazepinones and pharmaceutical compositions comprising same
US4410527A (en)	1983-10-18	Substituted thienobenzodiazepinones and salts thereof
US4673674A (en)	1987-06-16	Diazepinoindoles useful for treating depression, schizophrenia, social withdrawal or anxiety and pharmaceutical compositions containing them
HU206214B (en)	1992-09-28	Process for producing pyrido/63,4-b//1,4/benzoxazepine derivatives and pharmaceutical compositions comprising same
NZ203216A (en)	1985-09-13	Pyridobenzodiazepinone derivatives and pharmaceutical compositions
RU2043991C1 (ru)	1995-09-20	Дигидробензофурановые карбоксамиды или его фармацевтически приемлемые соли и способ их получения
NZ203194A (en)	1985-09-13	Dibenzodiazepinone derivatives and pharmaceutical compositions
DK157925B (da)	1990-03-05	2,3,4,5-tetrahydro-1h-3-benzazepinderivater og farmaceutiske praeparater indeholdende disse
PL157529B1 (en)	1992-06-30	Method for manufacturing 8 alfa-acyloaminergoline