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CY1119290T1 - CLAUDIN-18 MONOCLONE ANTIBODIES FOR CANCER TREATMENT - Google Patents

CLAUDIN-18 MONOCLONE ANTIBODIES FOR CANCER TREATMENT

Info

Publication number
CY1119290T1
CY1119290T1 CY20171100941T CY171100941T CY1119290T1 CY 1119290 T1 CY1119290 T1 CY 1119290T1 CY 20171100941 T CY20171100941 T CY 20171100941T CY 171100941 T CY171100941 T CY 171100941T CY 1119290 T1 CY1119290 T1 CY 1119290T1
Authority
CY
Cyprus
Prior art keywords
cancer
claudin
cancer treatment
monoclone antibodies
monoclone
Prior art date
Application number
CY20171100941T
Other languages
Greek (el)
Inventor
Ugur Sahin
Özlem Türeci
Dirk Usener
Stefan Fritz
Christoph Uherek
Gunda Brandenburg
Harald - Gerhard Geppert
Anja Kristina Schröder
Philippe Thiel
Original Assignee
Ganymed Pharmaceuticals Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ganymed Pharmaceuticals Ag filed Critical Ganymed Pharmaceuticals Ag
Publication of CY1119290T1 publication Critical patent/CY1119290T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1063—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from stomach or intestines
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

Η παρούσα εφεύρεση παρέχει αντισώματα χρήσιμα ως θεραπευτικά για τη θεραπεία ή/και πρόληψη ασθενειών που σχετίζονται με κύτταρα που εκφράζουν CLD18, συμπεριλαμβανομένων των ασθενειών που σχετίζονται με όγκους όπως ο γαστρικός καρκίνος, ο καρκίνος το οισοφάγου, καρκίνος του παγκρέατος, καρκίνος του πνεύμονα, καρκίνος των ωοθηκών, καρκίνος του ήπατος, καρκίνος της κεφαλής-αυχένα και καρκίνος της χοληδόχου κύστης.The present invention provides antibodies useful as therapeutics for the treatment and / or prevention of diseases related to cells expressing CLD18, including diseases associated with tumors such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, liver cancer, head-neck cancer and gall bladder cancer.

CY20171100941T 2005-11-24 2017-09-06 CLAUDIN-18 MONOCLONE ANTIBODIES FOR CANCER TREATMENT CY1119290T1 (en)

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EP05025657A EP1790664A1 (en) 2005-11-24 2005-11-24 Monoclonal antibodies against claudin-18 for treatment of cancer
EP06818817A EP1948693B1 (en) 2005-11-24 2006-11-24 Monoclonal antibodies against claudin-18 for treatment of cancer
EP10011776.1A EP2311879B1 (en) 2005-11-24 2006-11-24 Monoclonal antibodies against claudin-18 for treatment of cancer

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CY20151100985T CY1116964T1 (en) 2005-11-24 2015-11-05 CLAUDIN-18 Monoclonal Antibodies In Cancer Treatment
CY20151101128T CY1117031T1 (en) 2005-11-24 2015-12-10 CLAUDIN-18 Monoclonal Antibodies In Cancer Treatment
CY20171100941T CY1119290T1 (en) 2005-11-24 2017-09-06 CLAUDIN-18 MONOCLONE ANTIBODIES FOR CANCER TREATMENT
CY181101025T CY1121002T1 (en) 2005-11-24 2018-10-05 MONOCLONE ANTIBODIES AGAINST CLAUDINIS-18 FOR THE TREATMENT OF CANCER
CY20191101176T CY1122346T1 (en) 2005-11-24 2019-11-08 MONOCLONAL ANTIBODIES AGAINST CLAUDIN 18 FOR THE TREATMENT OF CANCER
CY20221100092T CY1124965T1 (en) 2005-11-24 2022-02-02 ANTI-CLAUDIN-18 MONOCLONAL ANTIBODIES FOR THE TREATMENT OF CANCER
CY20221100167T CY1125027T1 (en) 2005-11-24 2022-02-28 MONOCLONAL ANTIBODIES AGAINST CLAUDIN-18 FOR THE TREATMENT OF CANCER

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CY20221100092T CY1124965T1 (en) 2005-11-24 2022-02-02 ANTI-CLAUDIN-18 MONOCLONAL ANTIBODIES FOR THE TREATMENT OF CANCER
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