CY1115626T1 - NEW PRODUCTS (6-oxo-1,6-dihydro-pyrimidin-2-yl) -amide, their preparation and pharmaceutical use as unrestricted phosphorus - Google Patents
NEW PRODUCTS (6-oxo-1,6-dihydro-pyrimidin-2-yl) -amide, their preparation and pharmaceutical use as unrestricted phosphorusInfo
- Publication number
- CY1115626T1 CY1115626T1 CY20141100419T CY141100419T CY1115626T1 CY 1115626 T1 CY1115626 T1 CY 1115626T1 CY 20141100419 T CY20141100419 T CY 20141100419T CY 141100419 T CY141100419 T CY 141100419T CY 1115626 T1 CY1115626 T1 CY 1115626T1
- Authority
- CY
- Cyprus
- Prior art keywords
- optionally substituted
- pyrimidin
- unrestricted
- dihydro
- oxo
- Prior art date
Links
- XQCZBXHVTFVIFE-UHFFFAOYSA-N 2-amino-4-hydroxypyrimidine Chemical compound NC1=NC=CC(O)=N1 XQCZBXHVTFVIFE-UHFFFAOYSA-N 0.000 title 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title 1
- 229910052698 phosphorus Inorganic materials 0.000 title 1
- 239000011574 phosphorus Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αφορά τα νέα προϊόντα του χημικού τύπου (I) στον οποίο το R1 αντιπροσωπεύει ένα αρυλ ή ετεροαρυλ ενδεχομένως υποκατεστημένα · το R αντιπροσωπεύει το Η ή σχηματίζει μαζί με το R1 έναν κύκλο 5 ή 6 συντηγμένων αλυσίδων σε ένα υπολειπόμενο αρυλ ή ετεροαρυλ που περιλαμβάνουν ενδεχομένως ένα ή περισσότερα Ο, S, Ν, ΝΗ και Nalk, ενδεχομένως υποκατεστημένα · τα R2 και R3 αντιπροσωπεύουν ανεξάρτητα τα Η, Hal ή αλκυλ, ενδεχομένως υποκατεστημένα από ένα ή περισσότερα Hal · το R4 αντιπροσωπεύει το Η · το R5 αντιπροσωπεύει ένα Η ή αλκυλ ενδεχομένως υποκατεστημένο από ένα ή περισσότερα άτομα αλογόνου · τα εν λόγω προϊόντα βρίσκονται υπό κάθε μορφή ισομερών και αλάτων, εν είδει φαρμάκων κυρίως ως αναστολείς φωσφορυλίωσης της ΑΚΤ(ΡΚΒ).The present invention relates to novel products of formula (I) in which R1 represents an aryl or heteroaryl optionally substituted; R represents H or forms together with R1 a 5 or 6 fused chain in a residual aryl or heteroaryl which optionally include one or more O, S, N, NH and Nalk, optionally substituted; R2 and R3 independently represent H, Hal or alkyl, optionally substituted by one or more Hal; R4 represents H; R5 represents an H or alkyl optionally substituted put up by one or more halogen atoms; these products are in all forms of isomers and salts, with medicinal products mainly as AKT phosphorylation inhibitors (PKB).
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0903239A FR2947547B1 (en) | 2009-07-02 | 2009-07-02 | NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB) |
| US24110009A | 2009-09-10 | 2009-09-10 | |
| FR0957070A FR2951169B1 (en) | 2009-10-09 | 2009-10-09 | NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB) |
| EP10742014.3A EP2448927B1 (en) | 2009-07-02 | 2010-07-01 | Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1115626T1 true CY1115626T1 (en) | 2017-01-04 |
Family
ID=58461617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20141100419T CY1115626T1 (en) | 2009-07-02 | 2014-06-11 | NEW PRODUCTS (6-oxo-1,6-dihydro-pyrimidin-2-yl) -amide, their preparation and pharmaceutical use as unrestricted phosphorus |
Country Status (1)
| Country | Link |
|---|---|
| CY (1) | CY1115626T1 (en) |
-
2014
- 2014-06-11 CY CY20141100419T patent/CY1115626T1/en unknown
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