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CY1115074T1 - Θεραπεια νευρολογικων διαταραχων βασει βακλοφαινης και ακαμπροσατης - Google Patents

Θεραπεια νευρολογικων διαταραχων βασει βακλοφαινης και ακαμπροσατης

Info

Publication number
CY1115074T1
CY1115074T1 CY20141100159T CY141100159T CY1115074T1 CY 1115074 T1 CY1115074 T1 CY 1115074T1 CY 20141100159 T CY20141100159 T CY 20141100159T CY 141100159 T CY141100159 T CY 141100159T CY 1115074 T1 CY1115074 T1 CY 1115074T1
Authority
CY
Cyprus
Prior art keywords
disease
vaclophine
laboratory
neurological disorder
treatment based
Prior art date
Application number
CY20141100159T
Other languages
English (en)
Inventor
Daniel Cohen
Ilya Chumakov
Serguei Nabirochkin
Emmanuel Vial
Mickaël Guedj
Original Assignee
Pharnext
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharnext filed Critical Pharnext
Publication of CY1115074T1 publication Critical patent/CY1115074T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε συνδυασμούς και μεθόδους για την αγωγή νευρολογικών διαταραχών που σχετίζονται με διεγερτοτοξικότητα γλουταμινικού και τοξικότητα β αμυλοειδούς. Ειδικότερα, η παρούσα εφεύρεση αναφέρεται σε νέες συνδυαστικές θεραπείες της σκληρύνσεως κατά πλάκας, της νόσου Alzheimer, της σχετιζόμενης με νόσο Alzheimer διαταραχής, της αμυοτροφικής πλάγιας σκληρύνσεως, της νόσου Parkinson, της νόσου Huntington, του νευροπαθούς άλγους, της αλκοολικής νευροπάθειας, του αλκοολισμού ή της αλκοολικής στερήσεως ή της κακώσεως του νωτιαίου μυελού βάσει του συνδυασμού βακλοφαίνης και ακαμπροσάτης.
CY20141100159T 2011-03-01 2014-02-27 Θεραπεια νευρολογικων διαταραχων βασει βακλοφαινης και ακαμπροσατης CY1115074T1 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11305217 2011-03-01
US201161468658P 2011-03-29 2011-03-29
US201161493606P 2011-06-06 2011-06-06
EP11305687 2011-06-06
EP12708113.1A EP2560631B1 (en) 2011-03-01 2012-03-01 Baclofen and acamprosate based therapy of neurogical disorders

Publications (1)

Publication Number Publication Date
CY1115074T1 true CY1115074T1 (el) 2016-12-14

Family

ID=46758335

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20141100159T CY1115074T1 (el) 2011-03-01 2014-02-27 Θεραπεια νευρολογικων διαταραχων βασει βακλοφαινης και ακαμπροσατης
CY20181100664T CY1120369T1 (el) 2011-03-01 2018-06-27 Θεραπεια νευρολογικων διαταραχων βασει βακλοφαινης και ακαμπροσατης
CY181101262T CY1120925T1 (el) 2011-03-01 2018-11-28 Θεραπεια νευρολογικων διαταραχων βασει βακλοφαινης και ακαμπροσατης

Family Applications After (2)

Application Number Title Priority Date Filing Date
CY20181100664T CY1120369T1 (el) 2011-03-01 2018-06-27 Θεραπεια νευρολογικων διαταραχων βασει βακλοφαινης και ακαμπροσατης
CY181101262T CY1120925T1 (el) 2011-03-01 2018-11-28 Θεραπεια νευρολογικων διαταραχων βασει βακλοφαινης και ακαμπροσατης

Country Status (26)

Country Link
US (7) US9820978B2 (el)
EP (5) EP2680835B1 (el)
JP (2) JP5987008B2 (el)
KR (2) KR101918745B1 (el)
CN (2) CN103596562B (el)
AU (2) AU2012222351B2 (el)
BR (1) BR112013022112B1 (el)
CA (1) CA2828765C (el)
CY (3) CY1115074T1 (el)
DK (3) DK2796132T3 (el)
EA (2) EA023277B1 (el)
ES (5) ES2665569T3 (el)
HR (1) HRP20140131T1 (el)
HU (1) HUE038653T2 (el)
IL (2) IL228177B (el)
LT (2) LT2727588T (el)
MX (2) MX340568B (el)
PL (3) PL2727588T3 (el)
PT (1) PT2560631E (el)
RS (3) RS53227B (el)
SG (2) SG192968A1 (el)
SI (3) SI2796132T1 (el)
SM (3) SMT201800618T1 (el)
TR (1) TR201809351T4 (el)
WO (2) WO2012117076A2 (el)
ZA (1) ZA201306039B (el)

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EP2263665A1 (en) 2009-06-02 2010-12-22 Pharnext New compositions for treating CMT and related disorders
US9393241B2 (en) 2009-06-02 2016-07-19 Pharnext Compositions for treating CMT and related disorders
EP2322163A1 (en) 2009-11-03 2011-05-18 Pharnext New therapeutics approaches for treating alzheimer disease
US9387206B2 (en) 2009-11-03 2016-07-12 Pharnext Therapeutic approaches for treating Alzheimer's disease
EP2705842A1 (en) * 2012-09-05 2014-03-12 Pharnext Therapeutic approaches for treating parkinson's disease
US9867837B2 (en) * 2011-03-01 2018-01-16 Pharnext Compositions for treating neurological disorders
US9241933B2 (en) 2011-03-01 2016-01-26 Pharnext Compositions for treating amyotrophic lateral sclerosis
US9248111B2 (en) 2011-03-01 2016-02-02 Pharnext Therapeutic approaches for treating parkinson's disease
US10010515B2 (en) 2011-03-01 2018-07-03 Pharnext Therapeutic approaches for treating Parkinson's disease
UA113165C2 (xx) * 2011-03-01 2016-12-26 Застосування комбінації баклофену і акампросату для лікування неврологічних захворювань та композиція, яка містить баклофен і акампросат
JP5987008B2 (ja) 2011-03-01 2016-09-06 ファーネクストＰｈａｒｎｅｘｔ バクロフェンおよびアカンプロセートに基づく神経疾患の治療
CN108057033A (zh) * 2011-03-01 2018-05-22 法耐斯特公司 用于治疗肌萎缩性侧索硬化症的新组合物
US9931326B2 (en) 2011-03-29 2018-04-03 Pharnext Composition comprising torasemide and baclofen for treating neurological disorders
GB2501457A (en) 2012-02-10 2013-10-30 Rational Intellectual Holdings Ltd Assigning player positions in an online table game
HUE034212T2 (en) * 2012-03-01 2018-02-28 Pharnext New compositions for treating amyotrophic lateral sclerosis
AU2013224959B2 (en) * 2012-03-01 2017-12-07 Pharnext New compositions for treating amyotrophic lateral sclerosis
BR112015001090A2 (pt) * 2012-07-18 2017-06-27 Pharnext composição compreendendo baclofeno e acamprosato, ou sal(is) ou pró-fármaco(s) ou derivado(s) ou formulação(ões) de liberação prolongada dos mesmos; e baclofeno, ou um sal, pró-fármaco, derivado, ou formulação de liberação prolongada do mesmo
EP2705841A1 (en) * 2012-09-05 2014-03-12 Pharnext Combinations of nootropic agents for treating cognitive dysfunctions
GB201300684D0 (en) 2013-01-15 2013-02-27 Apitope Int Nv Peptide
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