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CY1110048T1 - METHOD FOR PRODUCTION OF TIOTROPIO SALTS - Google Patents

METHOD FOR PRODUCTION OF TIOTROPIO SALTS

Info

Publication number
CY1110048T1
CY1110048T1 CY20101100435T CY101100435T CY1110048T1 CY 1110048 T1 CY1110048 T1 CY 1110048T1 CY 20101100435 T CY20101100435 T CY 20101100435T CY 101100435 T CY101100435 T CY 101100435T CY 1110048 T1 CY1110048 T1 CY 1110048T1
Authority
CY
Cyprus
Prior art keywords
production
salts
tiotropio
treatment
tiotropium salts
Prior art date
Application number
CY20101100435T
Other languages
Greek (el)
Inventor
Rolf Banholzer
Waldemar Pfrengle
Peter Sieger
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1110048(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of CY1110048T1 publication Critical patent/CY1110048T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση αφορά μια μέθοδο για την παραγωγή νέων αλάτων του τιοτροπίου, όπου Χ σημαίνει ένα ανιόν, αυτά τα νέα άλατα του τιοτροπίου ως τέτοια, φαρμακευτικά σκευάσματα που τα περιέχουν, καθώς και τη χρήση τους για την παραγωγή ενός φαρμάκου για τη θεραπεία παθήσεων των αναπνευστικών οδών, ιδιαιτέρως για τη θεραπεία της ΧΑΠ (COPD = chronic obstructive pulmonary disease = χρόνιας αποφρακτικής πνευμονοπάθειας) και του άσθματος.The invention relates to a method for the production of new tiotropium salts, wherein X means an anion, these new tiotropium salts as such, pharmaceutical preparations containing them, and their use in the manufacture of a medicament for the treatment of respiratory diseases. routes, especially for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.

CY20101100435T 2003-11-03 2010-05-17 METHOD FOR PRODUCTION OF TIOTROPIO SALTS CY1110048T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025075 2003-11-03
EP04791028A EP1682541B1 (en) 2003-11-03 2004-10-29 Method for producing tiotropium salts

Publications (1)

Publication Number Publication Date
CY1110048T1 true CY1110048T1 (en) 2015-01-14

Family

ID=34530660

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20101100435T CY1110048T1 (en) 2003-11-03 2010-05-17 METHOD FOR PRODUCTION OF TIOTROPIO SALTS
CY20131100607T CY1114157T1 (en) 2003-11-03 2013-07-17 TYPES OF SILVER, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL CONTAINERS

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20131100607T CY1114157T1 (en) 2003-11-03 2013-07-17 TYPES OF SILVER, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL CONTAINERS

Country Status (34)

Country Link
US (1) US8686148B2 (en)
EP (3) EP1682541B1 (en)
JP (1) JP5165244B2 (en)
KR (1) KR20060117334A (en)
CN (3) CN100549010C (en)
AR (1) AR046317A1 (en)
AT (1) ATE460414T1 (en)
AU (1) AU2004285683C1 (en)
BR (1) BRPI0416136A (en)
CA (1) CA2544348A1 (en)
CO (1) CO5690553A2 (en)
CY (2) CY1110048T1 (en)
DE (1) DE502004010885D1 (en)
DK (2) DK2067779T3 (en)
EA (1) EA012326B1 (en)
ES (2) ES2342468T3 (en)
HR (1) HRP20100149T1 (en)
IL (1) IL175023A (en)
ME (1) ME00361B (en)
MX (1) MXPA06004697A (en)
MY (1) MY143364A (en)
NO (1) NO335814B1 (en)
NZ (1) NZ547276A (en)
PE (1) PE20050446A1 (en)
PL (2) PL2067779T3 (en)
PT (2) PT1682541E (en)
RS (2) RS51758B (en)
SG (1) SG137859A1 (en)
SI (2) SI2067779T1 (en)
TW (2) TWI435876B (en)
UA (1) UA82413C2 (en)
UY (1) UY28590A1 (en)
WO (1) WO2005042526A1 (en)
ZA (1) ZA200602342B (en)

Families Citing this family (12)

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ES2342468T3 (en) 2003-11-03 2010-07-07 Boehringer Ingelheim International Gmbh PROCEDURE FOR THE PREPARATION OF TIOTROPE SALTS.
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
MX2007015997A (en) * 2005-06-15 2008-03-07 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof.
DE102005035112A1 (en) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg A new process for the preparation of tiotropium salts using N-methylscopinium salts soluble in organic solvents
TW200738634A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
CN102731494A (en) * 2005-12-19 2012-10-17 西科尔公司 Novel forms of tiotropium bromide and processes for preparation thereof
BRPI0620886A2 (en) * 2006-01-04 2011-11-29 Boehringer Ingelheim Int use of tiotropium salts in the treatment of moderate persistent asthma
EP1953156A1 (en) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Method for manufacturing scopinium salts
CZ201241A3 (en) * 2012-01-20 2013-07-31 Zentiva, K.S. Novel polymorphous forms of thiotropium iodide and process for preparing thereof
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
JP6042197B2 (en) * 2012-12-11 2016-12-14 エア・ウォーター株式会社 Lung disorder treatment

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Also Published As

Publication number Publication date
BRPI0416136A (en) 2007-01-02
JP2007509893A (en) 2007-04-19
ME00361B (en) 2011-10-10
WO2005042526A1 (en) 2005-05-12
US8686148B2 (en) 2014-04-01
RS20060292A (en) 2008-08-07
DE502004010885D1 (en) 2010-04-22
IL175023A0 (en) 2006-08-20
TW201231465A (en) 2012-08-01
TWI363758B (en) 2012-05-11
EP2067779B1 (en) 2013-04-24
TWI435876B (en) 2014-05-01
SI2067779T1 (en) 2013-08-30
UA82413C2 (en) 2008-04-10
HRP20100149T1 (en) 2010-04-30
CO5690553A2 (en) 2006-10-31
UY28590A1 (en) 2005-06-30
CN102070630B (en) 2013-04-17
HK1099748A1 (en) 2007-08-24
AU2004285683A1 (en) 2005-05-12
CN102070630A (en) 2011-05-25
CN101407514A (en) 2009-04-15
CA2544348A1 (en) 2005-05-12
CN101407514B (en) 2013-05-29
NZ547276A (en) 2009-08-28
CN100549010C (en) 2009-10-14
ZA200602342B (en) 2007-06-27
AU2004285683C1 (en) 2011-09-08
ATE460414T1 (en) 2010-03-15
PE20050446A1 (en) 2005-08-02
DK1682541T3 (en) 2010-06-28
KR20060117334A (en) 2006-11-16
SI1682541T1 (en) 2010-06-30
IL175023A (en) 2011-02-28
EP2067779B9 (en) 2013-10-16
PT2067779E (en) 2013-07-25
MXPA06004697A (en) 2006-07-05
NO20061440L (en) 2006-07-12
JP5165244B2 (en) 2013-03-21
PL1682541T3 (en) 2010-08-31
DK2067779T3 (en) 2013-07-29
NO335814B1 (en) 2015-02-23
CN1882582A (en) 2006-12-20
EP1682541B1 (en) 2010-03-10
HK1153409A1 (en) 2012-03-30
EP2336126A1 (en) 2011-06-22
ES2342468T3 (en) 2010-07-07
RS51758B (en) 2011-12-31
AU2004285683B2 (en) 2011-04-21
EA200600886A1 (en) 2006-10-27
MEP51308A (en) 2011-05-10
PT1682541E (en) 2010-04-14
HK1129111A1 (en) 2009-11-20
ES2422729T3 (en) 2013-09-13
CY1114157T1 (en) 2016-08-31
EP1682541A1 (en) 2006-07-26
EP2067779A1 (en) 2009-06-10
AR046317A1 (en) 2005-11-30
PL2067779T3 (en) 2013-09-30
US20050131007A1 (en) 2005-06-16
SG137859A1 (en) 2007-12-28
EA012326B1 (en) 2009-08-28
MY143364A (en) 2011-04-29
TW200526653A (en) 2005-08-16

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