CY1108878T1 - Παραγωγα αμινο-τροπανης, η παρασκευη τους και οι εφαρμογες τους στη θεραπευτικη - Google Patents
Παραγωγα αμινο-τροπανης, η παρασκευη τους και οι εφαρμογες τους στη θεραπευτικηInfo
- Publication number
- CY1108878T1 CY1108878T1 CY20091100292T CY091100292T CY1108878T1 CY 1108878 T1 CY1108878 T1 CY 1108878T1 CY 20091100292 T CY20091100292 T CY 20091100292T CY 091100292 T CY091100292 T CY 091100292T CY 1108878 T1 CY1108878 T1 CY 1108878T1
- Authority
- CY
- Cyprus
- Prior art keywords
- denotes
- alkyl
- formula
- nrr
- cycloalkyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- FHPZUVVXVRYZAS-SFYZADRCSA-N (1r,5s)-8-methyl-8-azabicyclo[3.2.1]octan-5-amine Chemical class C1CC[C@@]2(N)CC[C@]1([H])N2C FHPZUVVXVRYZAS-SFYZADRCSA-N 0.000 abstract 1
- -1 alkoxy atom Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Addiction (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Η εφεύρεση αφορά τα παράγωγα αμινο- τροπάνης του γενικού τύπου (I): όπου : To Ra Ra, ∙και το R5 δηλώνουν άτομα υδρογόνου ή ομάδες αλκυλίου, το R1 δηλώνει ένα άτομο υδρογόνου ή μια ομάδα αλκυλίου, κυκλοαλκυλίου, ετεροκυκλοαλκυλίου ή αρυλίου, το R2 δηλώνει ένα άτομο του τύπου - (CH2)x-(CO)y- Υ ή -(CO)y-(CH2)x- Υ, όπου το Υ δηλώνει ένα άτομο υδρογόνου ή ένα άτομο υδροξέος, αλκυλίου, κυκλοαλκυλίου, αλκοξέος, αρυλίου, ετεροαρυλίου ή – NR11R12, το R3 δηλώνει 1 έως 3 ομάδες επιλεγμένες μεταξύ των ατόμων αλογόνου και των ομάδων αλκυλίου, κυκλοαλκυλίου, - OR, - NRR', - CO-NRR', - NR-CO-R', -NR-CO- NRR', - NR-COOR', - ΝO2, -CN et - COOR, το R4 επιλέγεται ανάμεσα σε μια ομάδα του τύπου (a), (b), (c) ή (d): ή μια ομάδα του τύπου - A- R18, - A- CH = Ν- R19, -A- N(R20)- Α'-R19, - A-CO-N(R20)- A'- R19, - A-CH(NH2)- R19, - A-N(R20)-COO- A' ή - (CH2)r- ετεροαρυλίου. Διαδικασία παρασκευής και εφαρμογή στη θεραπευτική.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0408372A FR2873693B1 (fr) | 2004-07-29 | 2004-07-29 | Derives d'amino-tropane, leur preparation et leur application en therapeutique |
| EP05790816A EP1773829B1 (fr) | 2004-07-29 | 2005-07-20 | Derives d'amino-tropane, leur preparation et leurs applications en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1108878T1 true CY1108878T1 (el) | 2014-07-02 |
Family
ID=34947491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100292T CY1108878T1 (el) | 2004-07-29 | 2009-03-17 | Παραγωγα αμινο-τροπανης, η παρασκευη τους και οι εφαρμογες τους στη θεραπευτικη |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7569582B2 (el) |
| EP (1) | EP1773829B1 (el) |
| JP (1) | JP2008508242A (el) |
| KR (1) | KR20070047803A (el) |
| CN (1) | CN101010320B (el) |
| AR (1) | AR050019A1 (el) |
| AT (1) | ATE417846T1 (el) |
| AU (1) | AU2005276355B2 (el) |
| BR (1) | BRPI0513923A (el) |
| CA (1) | CA2574517A1 (el) |
| CY (1) | CY1108878T1 (el) |
| DE (1) | DE602005011818D1 (el) |
| DK (1) | DK1773829T3 (el) |
| ES (1) | ES2319918T3 (el) |
| FR (1) | FR2873693B1 (el) |
| HR (1) | HRP20090160T1 (el) |
| IL (1) | IL180797A (el) |
| MX (1) | MX2007001023A (el) |
| PE (1) | PE20060575A1 (el) |
| PL (1) | PL1773829T3 (el) |
| PT (1) | PT1773829E (el) |
| RU (1) | RU2389727C2 (el) |
| SI (1) | SI1773829T1 (el) |
| TW (1) | TW200617005A (el) |
| UY (1) | UY29040A1 (el) |
| WO (1) | WO2006021657A1 (el) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2873690B1 (fr) * | 2004-07-29 | 2006-10-13 | Sanofi Synthelabo | Derives d'oxopiperidine, leur preparation et leur application en therapeutique |
| FR2873691B1 (fr) * | 2004-07-29 | 2006-10-06 | Sanofi Synthelabo | Derives d'amino-piperidine, leur preparation et leur application en therapeutique |
| WO2007028770A1 (en) * | 2005-09-05 | 2007-03-15 | Neurosearch A/S | Monoamine neurotransmitter re-uptake inhibitors for neuroprotection in patients suffering from an advanced stage of a mental disease |
| DK2305263T3 (da) * | 2007-06-07 | 2012-10-22 | Novartis Ag | Stabiliserede amorfe former af imatinibmesylat |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EA018999B1 (ru) * | 2007-10-25 | 2013-12-30 | Экселиксис, Инк. | Соединения тропана |
| US8153653B2 (en) * | 2010-06-22 | 2012-04-10 | Hoffmann-La Roche Inc. | Amido-tropane derivatives |
| EP2683701B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120051A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120057A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968929A (en) * | 1996-10-30 | 1999-10-19 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
| WO1998018788A1 (en) * | 1996-10-30 | 1998-05-07 | Schering Corporation | Piperazino derivatives as neurokinin antagonists |
| FR2762316B1 (fr) * | 1997-04-18 | 1999-12-17 | Sanofi Synthelabo | Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique |
| WO2002059095A1 (en) * | 2001-01-23 | 2002-08-01 | Eli Lilly And Company | Melanocortin receptor agonists |
| CA2453609C (en) * | 2001-07-18 | 2010-05-04 | Merck & Co., Inc. | Bridged piperidine derivatives as melanocortin receptor agonists |
| ES2274201T3 (es) * | 2002-01-23 | 2007-05-16 | Eli Lilly And Company | Agonistas del receptor de melanocortina. |
-
2004
- 2004-07-29 FR FR0408372A patent/FR2873693B1/fr not_active Expired - Fee Related
-
2005
- 2005-07-20 SI SI200530620T patent/SI1773829T1/sl unknown
- 2005-07-20 RU RU2007107372/04A patent/RU2389727C2/ru not_active IP Right Cessation
- 2005-07-20 AU AU2005276355A patent/AU2005276355B2/en not_active Ceased
- 2005-07-20 CA CA002574517A patent/CA2574517A1/fr not_active Abandoned
- 2005-07-20 CN CN2005800292441A patent/CN101010320B/zh not_active Expired - Fee Related
- 2005-07-20 HR HR20090160T patent/HRP20090160T1/xx unknown
- 2005-07-20 PT PT05790816T patent/PT1773829E/pt unknown
- 2005-07-20 PL PL05790816T patent/PL1773829T3/pl unknown
- 2005-07-20 WO PCT/FR2005/001856 patent/WO2006021657A1/fr not_active Ceased
- 2005-07-20 JP JP2007523110A patent/JP2008508242A/ja active Pending
- 2005-07-20 DE DE602005011818T patent/DE602005011818D1/de not_active Expired - Lifetime
- 2005-07-20 DK DK05790816T patent/DK1773829T3/da active
- 2005-07-20 KR KR1020077004658A patent/KR20070047803A/ko not_active Ceased
- 2005-07-20 BR BRPI0513923-6A patent/BRPI0513923A/pt not_active IP Right Cessation
- 2005-07-20 ES ES05790816T patent/ES2319918T3/es not_active Expired - Lifetime
- 2005-07-20 AT AT05790816T patent/ATE417846T1/de active
- 2005-07-20 EP EP05790816A patent/EP1773829B1/fr not_active Expired - Lifetime
- 2005-07-20 MX MX2007001023A patent/MX2007001023A/es active IP Right Grant
- 2005-07-27 AR ARP050103112A patent/AR050019A1/es not_active Application Discontinuation
- 2005-07-28 TW TW094125585A patent/TW200617005A/zh unknown
- 2005-07-28 UY UY29040A patent/UY29040A1/es not_active Application Discontinuation
- 2005-08-01 PE PE2005000887A patent/PE20060575A1/es not_active Application Discontinuation
-
2007
- 2007-01-18 IL IL180797A patent/IL180797A/en not_active IP Right Cessation
- 2007-01-25 US US11/626,973 patent/US7569582B2/en not_active Expired - Fee Related
-
2009
- 2009-03-17 CY CY20091100292T patent/CY1108878T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL180797A0 (en) | 2007-06-03 |
| AR050019A1 (es) | 2006-09-20 |
| DE602005011818D1 (de) | 2009-01-29 |
| FR2873693A1 (fr) | 2006-02-03 |
| HRP20090160T1 (en) | 2009-05-31 |
| JP2008508242A (ja) | 2008-03-21 |
| BRPI0513923A (pt) | 2008-05-20 |
| ES2319918T3 (es) | 2009-05-14 |
| IL180797A (en) | 2011-02-28 |
| CN101010320A (zh) | 2007-08-01 |
| CN101010320B (zh) | 2011-11-16 |
| WO2006021657A1 (fr) | 2006-03-02 |
| EP1773829A1 (fr) | 2007-04-18 |
| US7569582B2 (en) | 2009-08-04 |
| PT1773829E (pt) | 2009-03-26 |
| RU2007107372A (ru) | 2008-09-10 |
| DK1773829T3 (da) | 2009-04-20 |
| PL1773829T3 (pl) | 2009-06-30 |
| MX2007001023A (es) | 2007-04-16 |
| EP1773829B1 (fr) | 2008-12-17 |
| UY29040A1 (es) | 2006-02-24 |
| AU2005276355A1 (en) | 2006-03-02 |
| PE20060575A1 (es) | 2006-08-02 |
| SI1773829T1 (sl) | 2009-06-30 |
| AU2005276355B2 (en) | 2011-08-25 |
| FR2873693B1 (fr) | 2006-09-15 |
| KR20070047803A (ko) | 2007-05-07 |
| TW200617005A (en) | 2006-06-01 |
| US20070191361A1 (en) | 2007-08-16 |
| CA2574517A1 (fr) | 2006-03-02 |
| ATE417846T1 (de) | 2009-01-15 |
| RU2389727C2 (ru) | 2010-05-20 |
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