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CU24568B1 - Anticuerpo inhibidor de masp-3 - Google Patents

Anticuerpo inhibidor de masp-3

Info

Publication number
CU24568B1
CU24568B1 CU2019000006A CU20190006A CU24568B1 CU 24568 B1 CU24568 B1 CU 24568B1 CU 2019000006 A CU2019000006 A CU 2019000006A CU 20190006 A CU20190006 A CU 20190006A CU 24568 B1 CU24568 B1 CU 24568B1
Authority
CU
Cuba
Prior art keywords
masp
inhibitor antibody
antibody
antigen
seq
Prior art date
Application number
CU2019000006A
Other languages
English (en)
Other versions
CU20190006A7 (es
Inventor
W Jason Cummings
Gregory A Demopulos
Thomas Dudler
Hans-Wilhelm Schwaeble
Larry W Tjoelker
Christi L Wood
Munehisa Yabuki
Original Assignee
Omeros Corp
Univ Leicester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Corp, Univ Leicester filed Critical Omeros Corp
Publication of CU20190006A7 publication Critical patent/CU20190006A7/es
Publication of CU24568B1 publication Critical patent/CU24568B1/es

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Abstract

<p>La presente invención se refiere a un anticuerpo, o fragmento de unión a antígeno del mismo, que se une a MASP-3 en el que dicho anticuerpo o fragmento de unión a antígeno del mismo comprende una región variable de cadena pesada que comprende las SEQ ID Nos: 30, 254 o 255 y una región variable de cadena ligera que comprende las SEQ ID Nos: 45, 256 o 280.</p>
CU2019000006A 2016-08-01 2017-07-31 Anticuerpo inhibidor de masp-3 CU24568B1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662369674P 2016-08-01 2016-08-01
US201662419420P 2016-11-08 2016-11-08
US201762478336P 2017-03-29 2017-03-29
PCT/US2017/044714 WO2018026722A1 (en) 2016-08-01 2017-07-31 Compositions and methods of inhibiting masp-3 for the treatment of various diseases and disorders

Publications (2)

Publication Number Publication Date
CU20190006A7 CU20190006A7 (es) 2019-09-04
CU24568B1 true CU24568B1 (es) 2022-01-13

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US (5) US10639369B2 (es)
EP (2) EP3490603A4 (es)
JP (3) JP6971306B2 (es)
KR (3) KR102382804B1 (es)
CN (4) CN116333146A (es)
AU (4) AU2017306069B2 (es)
CA (3) CA3173979A1 (es)
CL (3) CL2019000230A1 (es)
CO (1) CO2019001212A2 (es)
CR (1) CR20190105A (es)
CU (1) CU24568B1 (es)
EC (1) ECSP19015192A (es)
GE (1) GEP20247593B (es)
IL (3) IL264592B2 (es)
JO (6) JOP20170154B1 (es)
MA (1) MA45798A (es)
MX (3) MX2019000965A (es)
PE (3) PE20250416A1 (es)
PH (1) PH12019500204A1 (es)
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TW (4) TWI861458B (es)
UA (1) UA124674C2 (es)
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WO (1) WO2018026722A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014031522A2 (pt) * 2012-06-18 2017-08-01 Omeros Corp métodos para inibir a ativação de complemento dependente de masp-3, para inibir a ativação de complemento dependente de masp-2 e para fabricar um medicamento
WO2017035401A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Amide compounds for treatment of immune and inflammatory disorders
WO2017035405A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Amino compounds for treatment of immune and inflammatory disorders
WO2017035409A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
WO2018160891A1 (en) 2017-03-01 2018-09-07 Achillion Pharmaceutical, Inc. Pharmaceutical compounds for treatment of medical disorders
PL3985002T3 (pl) 2017-03-01 2025-09-15 Achillion Pharmaceuticals, Inc. Arylowe, heteroarylowe i heterocykliczne związki farmaceutyczne do leczenia zaburzeń medycznych
US20190038623A1 (en) 2017-08-02 2019-02-07 Achillion Pharmaceuticals, Inc. Therapeutic regimens for treatment of paroxysmal nocturnal hemoglobinuria
JP2021525860A (ja) * 2018-05-25 2021-09-27 アキリオン ファーマシューティカルズ，インコーポレーテッド 補体代替経路関連腎症バイオマーカー
WO2020051532A2 (en) 2018-09-06 2020-03-12 Achillion Pharmaceuticals, Inc. Macrocyclic compounds for the treatment of medical disorders
WO2020051538A1 (en) 2018-09-06 2020-03-12 Achillion Pharmaceuticals, Inc. Morphic forms of complement factor d inhibitors
AU2019346464A1 (en) 2018-09-25 2021-04-08 Achillion Pharmaceuticals, Inc. Morphic forms of complement factor D inhibitors
CA3123583A1 (en) 2018-12-17 2020-06-25 Achillion Pharmaceuticals, Inc. Targeted dosing for the treatment of complement mediated disorders
KR20220004024A (ko) 2019-03-22 2022-01-11 아칠리온 파르마세우티칼스 인코포레이티드 보체 매개 장애의 치료를 위한 약제학적 조성물
CN110244053B (zh) * 2019-05-09 2022-03-11 北京大学第三医院（北京大学第三临床医学院） 用于诊断狼疮肾炎并肺动脉高压疾病的分子标志物及其用途
CN112812182B (zh) * 2019-11-15 2023-01-06 深圳宾德生物技术有限公司 一种靶向fgfr4的单链抗体、嵌合抗原受体、嵌合抗原受体t细胞及其制备方法和应用
KR20220131233A (ko) * 2020-01-21 2022-09-27 상하이 바이오트로이 바이오테크니크 컴퍼니, 리미티드 Semg2 항체 및 이의 용도
WO2022040149A1 (en) * 2020-08-18 2022-02-24 Omeros Corporation Monoclonal antibodies, compositions and methods for detecting complement factor d
CN112950324B (zh) * 2021-03-15 2022-06-03 重庆邮电大学 一种知识图谱辅助的成对排序个性化电商推荐方法及系统
CN115304670B (zh) * 2021-05-07 2024-07-30 华南农业大学 一种猫冠状病毒核衣壳蛋白的鼠源单克隆抗体及其编码基因和应用
EP4489782A2 (en) * 2022-03-10 2025-01-15 Omeros Corporation Masp-2 and masp-3 inhibitors, and related compositions and methods, for treatment of sickle cell disease
EP4611892A1 (en) * 2022-11-02 2025-09-10 Omeros Corporation Therapeutic methods and uses for antibodies to human masp-3
WO2024163530A2 (en) * 2023-02-01 2024-08-08 Crown Bioscience Inc. Novel anti-ccr4 antibodies and derivative products
CN121311247A (zh) 2023-06-09 2026-01-09 舒泰神（北京）生物制药股份有限公司 特异性结合masp3的抗体以及特异性结合masp3和masp2的多特异性抗体

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5211657A (en) 1988-11-07 1993-05-18 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5549910A (en) 1989-03-31 1996-08-27 The Regents Of The University Of California Preparation of liposome and lipid complex compositions
JP3218637B2 (ja) 1990-07-26 2001-10-15 大正製薬株式会社 安定なリポソーム水懸濁液
JP2958076B2 (ja) 1990-08-27 1999-10-06 株式会社ビタミン研究所 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法
DK0672142T3 (da) 1992-12-04 2001-06-18 Medical Res Council Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse
US5856121A (en) 1994-02-24 1999-01-05 Case Western Reserve University Growth arrest homebox gene
US6074642A (en) 1994-05-02 2000-06-13 Alexion Pharmaceuticals, Inc. Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
US5741516A (en) 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5738868A (en) 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
US7273925B1 (en) 1998-12-15 2007-09-25 Brigham And Women's Hospital, Inc. Methods and products for regulating lectin complement pathway associated complement activation
US20040031072A1 (en) * 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
WO2001040451A2 (en) 1999-12-02 2001-06-07 Jens Christian Jensenius Masp-3, a complement-fixing enzyme, and uses for it
SG98393A1 (en) 2000-05-19 2003-09-19 Inst Materials Research & Eng Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
ES2601143T3 (es) 2002-07-19 2017-02-14 Omeros Corporation Copolímeros tribloque biodegradables, métodos de síntesis de los mismos, e hidrogeles y biomateriales preparados a partir de los mismos
WO2004022096A1 (en) 2002-09-06 2004-03-18 Alexion Pharmaceuticals, Inc. Method of treatment of asthma using antibodies to complement component c5
CN101897969B (zh) 2003-02-21 2014-04-02 健泰科生物技术公司 补体抑制剂在制备用于预防或抑制组织损伤的药物中的用途
DE102004017370A1 (de) 2004-04-08 2005-10-27 Nutrinova Nutrition Specialties & Food Ingredients Gmbh PUFA-PKS Gene aus Ulkenia
US7919094B2 (en) 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
MY169746A (en) 2005-08-19 2019-05-14 Abbvie Inc Dual variable domain immunoglobulin and uses thereof
US8679845B2 (en) 2007-05-31 2014-03-25 University Of Washington B cells modified to reversibly induce accelerated mutagenesis of target genes
CA2767755C (en) 2009-07-17 2021-10-12 Rigshospitalet Inhibitors of complement activation
ES2624835T3 (es) * 2009-08-06 2017-07-17 Immunas Pharma, Inc. Anticuerpos que se unen específicamente a los oligómeros A beta y uso de los mismos
CA2780713A1 (en) * 2009-09-03 2011-03-10 Vancouver Biotech Ltd. Monoclonal antibodies against gonadotropin-releasing hormone receptor
EP2542588A1 (en) * 2010-03-05 2013-01-09 F. Hoffmann-La Roche AG Antibodies against human csf-1r and uses thereof
US20120122107A1 (en) 2010-11-16 2012-05-17 Aarhus Universitet Homeostatic multidomain protein, and uses for it
CA3025762C (en) * 2011-05-04 2021-11-09 Omeros Corporation Compositions for inhibiting masp-2 dependent complement activation
ES2894944T3 (es) * 2012-04-06 2022-02-16 Omeros Corp Composiciones y métodos para inhibir la MASP-1 y/o la MASP-2 y/o la MASP-3 para el tratamiento de la hemoglobinuria nocturna paroxísmica
BR112014031522A2 (pt) * 2012-06-18 2017-08-01 Omeros Corp métodos para inibir a ativação de complemento dependente de masp-3, para inibir a ativação de complemento dependente de masp-2 e para fabricar um medicamento
KR102685501B1 (ko) * 2013-02-20 2024-07-17 노파르티스 아게 인간화 항-EGFRvIII 키메라 항원 수용체를 사용한 암의 치료
CU24446B1 (es) * 2013-03-13 2019-10-04 Prothena Biosciences Ltd Un anticuerpo monoclonal humanizado que se une a tau
JP6908381B2 (ja) * 2014-01-29 2021-07-28 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｍｕｃ１−ｃ／細胞外ドメイン（ｍｕｃ１−ｃ／ｅｃｄ）に対する抗体

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