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CU24565B1 - 8-cloro-o-quinoleínas y sus derivados como activos anti-inflamatorios - Google Patents

8-cloro-o-quinoleínas y sus derivados como activos anti-inflamatorios

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Publication number
CU24565B1
CU24565B1 CU2019000043A CU20190043A CU24565B1 CU 24565 B1 CU24565 B1 CU 24565B1 CU 2019000043 A CU2019000043 A CU 2019000043A CU 20190043 A CU20190043 A CU 20190043A CU 24565 B1 CU24565 B1 CU 24565B1
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CU
Cuba
Prior art keywords
group
formula
space
derivatives
inflammatory
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CU2019000043A
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English (en)
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CU20190043A7 (es
Inventor
Karim Chebli
Michael Hahne
Florence Mahuteau
Romain Najman
Didier Scherrer
Jamal Tazi
Original Assignee
Abivax
Centre Nat Rech Scient
Inst Curie
Univ Montpellier
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Publication date
Application filed by Abivax, Centre Nat Rech Scient, Inst Curie, Univ Montpellier filed Critical Abivax
Publication of CU20190043A7 publication Critical patent/CU20190043A7/es
Publication of CU24565B1 publication Critical patent/CU24565B1/es

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Abstract

<p>La presente invención se refiere a un compuesto de la fórmula (I)</p> <p>ESPACIO PARA FÓRMULA</p> <p>en donde:</p> <p>ESPACIO PARA FÓRMULA</p> <p>significa un anillo aromático en donde V es C, es decir, forma una piridina, R' representa independientemente un átomo de hidrógeno o un grupo seleccionado entre un grupo alquilo (C1-C3), un átomo de halógeno, un grupo hidroxilo, un grupo-COOR1, un grupo -NO2, un grupo -NR1R2, un grupo morfolinilo o un grupo morfolino, un grupo N-metilpiperazinilo, un grupo fluoroalquilo (C1-C3), un grupo-O-P(=O)-(OR3XOR4), un grupo alcoxi (C1-C4), y un grupo -CN, y además puede ser un grupo seleccionado entre IIa y IIIa:</p> <p>ESPACIO PARA FÓRMULA</p> <p>La presente invención se refiere también a derivados del compuesto de fórmula (I), como activos anti-inflamatorios, útiles en el tratamiento y/o prevención de enfermedades inflamatorias, donde la enfermedad inflamatoria del intestino, la artritis reumatoide y la esclerosis múltiple son de particular interés.</p> <p> </p> <p> </p>
CU2019000043A 2014-07-17 2015-07-17 8-cloro-o-quinoleínas y sus derivados como activos anti-inflamatorios CU24565B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14306164.6A EP2974729A1 (en) 2014-07-17 2014-07-17 Quinoline derivatives for use in the treatment of inflammatory diseases
PCT/EP2015/066458 WO2016009065A2 (en) 2014-07-17 2015-07-17 Quinoline derivatives for the treatment of inflammatory diseases

Publications (2)

Publication Number Publication Date
CU20190043A7 CU20190043A7 (es) 2019-12-03
CU24565B1 true CU24565B1 (es) 2022-01-13

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CU2019000043A CU24565B1 (es) 2014-07-17 2015-07-17 8-cloro-o-quinoleínas y sus derivados como activos anti-inflamatorios
CU2017000004A CU24459B1 (es) 2014-07-17 2015-07-17 8-cloro-n-quinoleínas y sus derivados como activos antiinflamatorios

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CU2017000004A CU24459B1 (es) 2014-07-17 2015-07-17 8-cloro-n-quinoleínas y sus derivados como activos antiinflamatorios

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US (6) US10435370B2 (es)
EP (3) EP2974729A1 (es)
JP (4) JP6884690B2 (es)
KR (3) KR20240161231A (es)
CN (5) CN117281805A (es)
AU (4) AU2015289033A1 (es)
CA (2) CA2954951C (es)
CU (2) CU24565B1 (es)
CY (1) CY1125586T1 (es)
DK (2) DK3169328T3 (es)
ES (2) ES2914066T3 (es)
FI (1) FI3998070T3 (es)
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