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CU24555B1 - Combinación a dosis fija de paracetamol:amitriptilina - Google Patents

Combinación a dosis fija de paracetamol:amitriptilina

Info

Publication number
CU24555B1
CU24555B1 CU2018000037A CU20180037A CU24555B1 CU 24555 B1 CU24555 B1 CU 24555B1 CU 2018000037 A CU2018000037 A CU 2018000037A CU 20180037 A CU20180037 A CU 20180037A CU 24555 B1 CU24555 B1 CU 24555B1
Authority
CU
Cuba
Prior art keywords
paracetamol
amitriptyline
fixed
dose combination
synergy
Prior art date
Application number
CU2018000037A
Other languages
English (en)
Other versions
CU20180037A7 (es
Inventor
Fernández Pedro Gilberto Bárzaga
Menéndez Addis Bellma
La Paz Martín-Viaña Nilia De
Suárez Bárbara Beatriz Garrido
Cortezón Ania González
Yaquis Alejandro Saúl Padrón
Morales Rolando Perdomo
Original Assignee
Centro De Investig Y Desarrollo De Medicamentos Cidem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro De Investig Y Desarrollo De Medicamentos Cidem filed Critical Centro De Investig Y Desarrollo De Medicamentos Cidem
Priority to CU2018000037A priority Critical patent/CU24555B1/es
Priority to KR1020207034822A priority patent/KR20210013573A/ko
Priority to US17/052,578 priority patent/US11590091B2/en
Priority to AU2019263876A priority patent/AU2019263876A1/en
Priority to CN201980029184.5A priority patent/CN112055585A/zh
Priority to CA3094488A priority patent/CA3094488A1/en
Priority to EP19727583.7A priority patent/EP3789020A1/en
Priority to EA202092145A priority patent/EA202092145A1/ru
Priority to JP2020560464A priority patent/JP2021521253A/ja
Priority to BR112020019985-0A priority patent/BR112020019985A2/pt
Priority to PCT/CU2019/050002 priority patent/WO2019210889A1/es
Publication of CU20180037A7 publication Critical patent/CU20180037A7/es
Priority to CL2020002632A priority patent/CL2020002632A1/es
Publication of CU24555B1 publication Critical patent/CU24555B1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<p>La presente invención describe una combinación farmacéutica a dosis fija de paracetamol y<br /> amitriptilina que muestran su sinergia para la reducción del dolor persistente inflamatorio y de la hipersensibilidad mecánica tras el daño neural, proporciones, seguridad y capacidad neuroprotectora.</p>
CU2018000037A 2018-05-03 2018-05-07 Combinación a dosis fija de paracetamol:amitriptilina CU24555B1 (es)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CU2018000037A CU24555B1 (es) 2018-05-07 2018-05-07 Combinación a dosis fija de paracetamol:amitriptilina
CA3094488A CA3094488A1 (en) 2018-05-03 2019-05-03 Fixed dose composition of paracetamol: amitriptyline and method for the treatment of mixed cancer pain
US17/052,578 US11590091B2 (en) 2018-05-03 2019-05-03 Fixed dose composition of paracetamol: amitriptyline and method for the treatment of mixed cancer pain
AU2019263876A AU2019263876A1 (en) 2018-05-03 2019-05-03 Fixed dose composition of paracetamol: amitriptyline and method for the treatment of mixed cancer pain
CN201980029184.5A CN112055585A (zh) 2018-05-03 2019-05-03 固定剂量的对乙酰氨基酚：阿米替林组合物和混合型癌症疼痛的治疗方法
KR1020207034822A KR20210013573A (ko) 2018-05-03 2019-05-03 파라세타몰: 아미트리프틸린의 고정 용량 조성물 및 혼합 암 통증의 치료방법
EP19727583.7A EP3789020A1 (en) 2018-05-07 2019-05-03 Fixed dose composition of paracetamol: amitriptyline and method for the treatment of mixed cancer pain
EA202092145A EA202092145A1 (ru) 2018-05-07 2019-05-03 Композиция парацетамола: амитриптилина с фиксированной дозой и способ лечения смешанной раковой боли
JP2020560464A JP2021521253A (ja) 2018-05-03 2019-05-03 パラセタモール：アミトリプチリンの固定用量組成物および混合型がん性疼痛を治療するための方法
BR112020019985-0A BR112020019985A2 (pt) 2018-05-03 2019-05-03 composição farmacêutica, uso de uma composição farmacêutica, e, kit
PCT/CU2019/050002 WO2019210889A1 (es) 2018-05-03 2019-05-03 Composición a dosis fija de paracetamol:amitriptilina y método para el tratamiento del dolor mixto por cáncer
CL2020002632A CL2020002632A1 (es) 2018-05-07 2020-10-13 Composición a dosis fija de paracetamol:amitriptilina y método para el tratamiento del dolor mixto por cáncer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU2018000037A CU24555B1 (es) 2018-05-07 2018-05-07 Combinación a dosis fija de paracetamol:amitriptilina

Publications (2)

Publication Number Publication Date
CU20180037A7 CU20180037A7 (es) 2019-12-03
CU24555B1 true CU24555B1 (es) 2021-12-08

Family

ID=66676966

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2018000037A CU24555B1 (es) 2018-05-03 2018-05-07 Combinación a dosis fija de paracetamol:amitriptilina

Country Status (12)

Country Link
US (1) US11590091B2 (es)
EP (1) EP3789020A1 (es)
JP (1) JP2021521253A (es)
KR (1) KR20210013573A (es)
CN (1) CN112055585A (es)
AU (1) AU2019263876A1 (es)
BR (1) BR112020019985A2 (es)
CA (1) CA3094488A1 (es)
CL (1) CL2020002632A1 (es)
CU (1) CU24555B1 (es)
EA (1) EA202092145A1 (es)
WO (1) WO2019210889A1 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050176809A1 (en) * 2004-02-05 2005-08-11 Rodlen Laboratories, Inc. Method and compositions for treatment of painful disorders
WO2005115360A2 (en) * 2004-05-11 2005-12-08 Becton, Dickinson And Company Formulations of anti-pain agents and methods of using the same
GB0501809D0 (en) * 2005-01-28 2005-03-09 Pharmakodex Ltd Anti-migraine formulations
US20130189354A1 (en) * 2010-10-07 2013-07-25 Trinity Laboratories, Inc., Novel Pharmaceutical Compositions for Treating Chronic Pain and Pain Associated with Neuropathy
CA2891855A1 (en) * 2012-12-21 2014-06-26 Sykehuset Sorlandet Hf Egfr targeted therapy of neurological disorders and pain

Also Published As

Publication number Publication date
BR112020019985A2 (pt) 2021-01-26
AU2019263876A1 (en) 2020-11-26
CU20180037A7 (es) 2019-12-03
CN112055585A (zh) 2020-12-08
WO2019210889A1 (es) 2019-11-07
US11590091B2 (en) 2023-02-28
KR20210013573A (ko) 2021-02-04
EP3789020A1 (en) 2021-03-10
EA202092145A1 (ru) 2021-02-11
JP2021521253A (ja) 2021-08-26
CL2020002632A1 (es) 2021-02-19
US20210236440A1 (en) 2021-08-05
CA3094488A1 (en) 2019-11-07

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