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CU24425B1 - Amino-heteroaril-benzamidas como inhibidores de cinasa - Google Patents

Amino-heteroaril-benzamidas como inhibidores de cinasa

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Publication number
CU24425B1
CU24425B1 CU2016000052A CU20160052A CU24425B1 CU 24425 B1 CU24425 B1 CU 24425B1 CU 2016000052 A CU2016000052 A CU 2016000052A CU 20160052 A CU20160052 A CU 20160052A CU 24425 B1 CU24425 B1 CU 24425B1
Authority
CU
Cuba
Prior art keywords
benzamidas
heteroaril
amino
inhibitors
cinasa
Prior art date
Application number
CU2016000052A
Other languages
English (en)
Other versions
CU20160052A7 (es
Inventor
Jeffrey T Bagdanoff
Yu Ding
Wooseok Han
Zilin Huang
Qun Jiang
Jeff Xianming Jin
Xiang Kou
Patrick Lee
Mika Lindvall
Zhongcheng Min
Yue Pan
Sabina Pecchi
Keith Bruce Pfister
Daniel Poon
Vivek Rauniyar
Xiaojing Michael Wang
Qiong Zhang
Jianguang Zhou
Shejin Zhu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20160052A7 publication Critical patent/CU20160052A7/es
Publication of CU24425B1 publication Critical patent/CU24425B1/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

<p>La presente invención proporciona un compuesto de Ia formula (1), </p> <p>ESPACIO PARA FÓRMULA</p> <p>útil en condiciones asociadas con niveles excesivos o indeseados de actividad de ERK1 y/o ERK2, particularmente cánceres que responden a inhibidores de ERK1 y/o ERK2.</p>
CU2016000052A 2013-11-01 2014-10-29 Amino-heteroaril-benzamidas como inhibidores de cinasa CU24425B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361898761P 2013-11-01 2013-11-01
CN2014088409 2014-10-11
PCT/US2014/062913 WO2015066188A1 (en) 2013-11-01 2014-10-29 Aminoheteroaryl benzamides as kinase inhibitors

Publications (2)

Publication Number Publication Date
CU20160052A7 CU20160052A7 (es) 2017-02-02
CU24425B1 true CU24425B1 (es) 2019-06-04

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CU2016000052A CU24425B1 (es) 2013-11-01 2014-10-29 Amino-heteroaril-benzamidas como inhibidores de cinasa

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US (4) US9242996B2 (es)
EP (1) EP3063143B1 (es)
JP (2) JP6219507B2 (es)
KR (1) KR101910720B1 (es)
CN (1) CN105658646B (es)
AP (1) AP2016009099A0 (es)
AU (1) AU2014342338B2 (es)
BR (1) BR112016008133B1 (es)
CA (1) CA2922532C (es)
CL (1) CL2016000807A1 (es)
CU (1) CU24425B1 (es)
CY (1) CY1120635T1 (es)
DK (1) DK3063143T3 (es)
DO (1) DOP2016000085A (es)
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