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CU23235A1 - POXVIRUS RECOMBINANTES PARA PROTEINAS QUIMéRICAS DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA Y SU APLICACION EN LA TERAPéUTICA Y LA PREVENCION DEL SIDA - Google Patents

POXVIRUS RECOMBINANTES PARA PROTEINAS QUIMéRICAS DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA Y SU APLICACION EN LA TERAPéUTICA Y LA PREVENCION DEL SIDA

Info

Publication number
CU23235A1
CU23235A1 CU20010057A CU20010057A CU23235A1 CU 23235 A1 CU23235 A1 CU 23235A1 CU 20010057 A CU20010057 A CU 20010057A CU 20010057 A CU20010057 A CU 20010057A CU 23235 A1 CU23235 A1 CU 23235A1
Authority
CU
Cuba
Prior art keywords
hiv
therapeutics
application
immunodeficiency virus
human immunodeficiency
Prior art date
Application number
CU20010057A
Other languages
English (en)
Inventor
Cano Carlos A Duarte
Blomquist Dania Marcia Vazquez
Perez Enrique Iglesias
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40091626&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU23235(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Priority to CU20010057A priority Critical patent/CU23235A1/es
Priority to EP02703488A priority patent/EP1371730B1/en
Priority to CN028034139A priority patent/CN1526018B/zh
Priority to AU2002237195A priority patent/AU2002237195B2/en
Priority to BRPI0206823-0A priority patent/BRPI0206823B1/pt
Priority to AT02703488T priority patent/ATE435916T1/de
Priority to CA2430702A priority patent/CA2430702C/en
Priority to PCT/CU2002/000001 priority patent/WO2002068654A2/es
Priority to KR1020037009273A priority patent/KR100920141B1/ko
Priority to BR0206823-0A priority patent/BR0206823A/pt
Priority to JP2002568748A priority patent/JP4125128B2/ja
Priority to ES02703488T priority patent/ES2329768T3/es
Priority to DE60232862T priority patent/DE60232862D1/de
Priority to RU2003128991/13A priority patent/RU2302461C2/ru
Priority to US10/469,256 priority patent/US7318927B2/en
Priority to ARP020100686A priority patent/AR032871A1/es
Priority to ZA200304387A priority patent/ZA200304387B/en
Priority to US11/486,535 priority patent/US20080280354A1/en
Publication of CU23235A1 publication Critical patent/CU23235A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se describen y reivindican genes quimÉricos del VIH formados por la union de fragmentos de diferentes genes de este virus, donde estos fragmentos contienen epítopos para cÉlulas T citotoxicas (CTL) o T auxiliadoras del VIH-1, los cuales son presentados por una amplia gama de antígenos del Sistema Principal de Histocompatibilidad Humano tipo 1 (HLA-1). A partir de estos genes se obtienen poxvirus recombinantes Utiles en la vacunacion profilActica y terapÉutica contra la infeccion por VIH/SIDA capaces de generar una respuesta inmune celular protectora en animales de laboratorio inmunizados y siendo reconocidos por los infocitos CTL de pacientes de VIH/SIDA.
CU20010057A 2001-02-28 2001-02-28 POXVIRUS RECOMBINANTES PARA PROTEINAS QUIMéRICAS DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA Y SU APLICACION EN LA TERAPéUTICA Y LA PREVENCION DEL SIDA CU23235A1 (es)

Priority Applications (18)

Application Number Priority Date Filing Date Title
CU20010057A CU23235A1 (es) 2001-02-28 2001-02-28 POXVIRUS RECOMBINANTES PARA PROTEINAS QUIMéRICAS DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA Y SU APLICACION EN LA TERAPéUTICA Y LA PREVENCION DEL SIDA
US10/469,256 US7318927B2 (en) 2001-02-28 2002-02-22 Recombinant poxvirus for chimeric proteins of the human immunodeficiency virus
KR1020037009273A KR100920141B1 (ko) 2001-02-28 2002-02-22 인간 면역결핍 바이러스의 키메릭 단백질용 재조합폭스바이러스
JP2002568748A JP4125128B2 (ja) 2001-02-28 2002-02-22 ヒト免疫不全ウイルスのキメラタンパク質用組換えポックスウイルス
AU2002237195A AU2002237195B2 (en) 2001-02-28 2002-02-22 Recombinant poxvirus for chimeric proteins of the human immunodeficiency virus
BRPI0206823-0A BRPI0206823B1 (pt) 2001-02-28 2002-02-22 Gene quimérico, proteína quimérica, vírus recombinante, e, composição de vacina
AT02703488T ATE435916T1 (de) 2001-02-28 2002-02-22 Rekombinantes pockenvirus für chimäre proteine des menschlichen immunschwächevirus
CA2430702A CA2430702C (en) 2001-02-28 2002-02-22 Recombinant poxvirus for chimeric proteins of the human immunodeficiency virus
PCT/CU2002/000001 WO2002068654A2 (es) 2001-02-28 2002-02-22 Poxvirus recombinantes para proteinas quimericas del virus de la inmunodeficiencia humana
EP02703488A EP1371730B1 (en) 2001-02-28 2002-02-22 Recombinant poxvirus for chimeric proteins of the human immunodeficiency virus
BR0206823-0A BR0206823A (pt) 2001-02-28 2002-02-22 Gene quimérico, proteìna quimérica, vìrus recombinante, composição de vacina, uso de uma composição de vacina, combinação terapêutica ou preventiva, e, plasmìdeo
CN028034139A CN1526018B (zh) 2001-02-28 2002-02-22 人类免疫缺陷病毒嵌合蛋白质的重组痘病毒
ES02703488T ES2329768T3 (es) 2001-02-28 2002-02-22 Poxvirus recombinantes para las proteinas quimericas del virus de inmunodeficiencia humana.
DE60232862T DE60232862D1 (de) 2001-02-28 2002-02-22 Rekombinantes pockenvirus für chimäre proteine des menschlichen immunschwächevirus
RU2003128991/13A RU2302461C2 (ru) 2001-02-28 2002-02-22 Химерный ген cr3 и кодируемый им химерный белок cr3 (варианты), индуцирующий иммунный ответ против вич-1
ARP020100686A AR032871A1 (es) 2001-02-28 2002-02-27 Poxvirus recombinantes para proteinas quimericas del virus de la inmunodeficiencia humana
ZA200304387A ZA200304387B (en) 2001-02-28 2003-06-04 Recombinant poxvirus for chimeric proteins of the human immunodeficiency virus.
US11/486,535 US20080280354A1 (en) 2001-02-28 2006-07-14 Recombinant poxvirus for chimeric proteins of the human immunodeficiency virus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20010057A CU23235A1 (es) 2001-02-28 2001-02-28 POXVIRUS RECOMBINANTES PARA PROTEINAS QUIMéRICAS DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA Y SU APLICACION EN LA TERAPéUTICA Y LA PREVENCION DEL SIDA

Publications (1)

Publication Number Publication Date
CU23235A1 true CU23235A1 (es) 2007-09-26

Family

ID=40091626

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20010057A CU23235A1 (es) 2001-02-28 2001-02-28 POXVIRUS RECOMBINANTES PARA PROTEINAS QUIMéRICAS DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA Y SU APLICACION EN LA TERAPéUTICA Y LA PREVENCION DEL SIDA

Country Status (16)

Country Link
US (2) US7318927B2 (es)
EP (1) EP1371730B1 (es)
JP (1) JP4125128B2 (es)
KR (1) KR100920141B1 (es)
CN (1) CN1526018B (es)
AR (1) AR032871A1 (es)
AT (1) ATE435916T1 (es)
AU (1) AU2002237195B2 (es)
BR (2) BR0206823A (es)
CA (1) CA2430702C (es)
CU (1) CU23235A1 (es)
DE (1) DE60232862D1 (es)
ES (1) ES2329768T3 (es)
RU (1) RU2302461C2 (es)
WO (1) WO2002068654A2 (es)
ZA (1) ZA200304387B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9711957D0 (en) 1997-06-09 1997-08-06 Isis Innovation Methods and reagents for vaccination
GB0118532D0 (en) 2001-07-30 2001-09-19 Isis Innovation Materials and methods relating to improved vaccination strategies
US8637305B2 (en) 2001-11-07 2014-01-28 Mannkind Corporation Expression vectors encoding epitopes of target-associated antigens and methods for their design
WO2003047617A2 (en) 2001-11-30 2003-06-12 Isis Innovation Limited Vaccine
GB0225786D0 (en) * 2002-11-05 2002-12-11 Glaxo Group Ltd Vaccine
GB0225788D0 (en) 2002-11-05 2002-12-11 Glaxo Group Ltd Vaccine
EP1601333B1 (en) * 2003-02-20 2013-01-23 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services Novel insertion sites in pox vectors
GB0417494D0 (en) * 2004-08-05 2004-09-08 Glaxosmithkline Biolog Sa Vaccine
RU2324738C2 (ru) * 2006-06-16 2008-05-20 Федеральное государственное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФГУН ГНЦ ВБ "Вектор" Роспотребнадзора) ГЕНЕТИЧЕСКАЯ КОНСТРУКЦИЯ НА ОСНОВЕ ВЕКТОРНОЙ ПЛАЗМИДЫ pEGFP-N1, ПРОДУЦИРУЮЩАЯ siPHK-ИНГИБИТОРЫ РЕПРОДУКЦИИ ВИРУСА ИММУНОДЕФИЦИТА ЧЕЛОВЕКА 1 ТИПА (ЕЕ ВАРИАНТЫ)
US20080124355A1 (en) 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
EP2620446A1 (en) 2012-01-27 2013-07-31 Laboratorios Del Dr. Esteve, S.A. Immunogens for HIV vaccination
FR2987836A1 (fr) * 2012-03-09 2013-09-13 Biomerieux Sa Peptides d'interference et procede de detection de microorganismes
EP2900259B1 (en) * 2012-09-28 2020-04-15 Kline, Ellis Glycosidase regimen for treatment of infectious disease
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CA3145833A1 (en) * 2019-07-02 2021-01-07 Roman YELENSKY Hiv antigens and mhc complexes
EP4058058A1 (en) 2019-11-14 2022-09-21 Aelix Therapeutics S.L. Dosage regimens for vaccines
CN112852749A (zh) * 2021-03-27 2021-05-28 哈尔滨元亨生物药业有限公司 高效分泌犬细小病毒单克隆抗体杂交瘤细胞株c68及利用生物反应器对其进行生产的方法

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US5174993A (en) * 1981-12-24 1992-12-29 Health Research Inc. Recombinant avipox virus and immunological use thereof
US5505941A (en) * 1981-12-24 1996-04-09 Health Research, Inc. Recombinant avipox virus and method to induce an immune response
GB8918200D0 (en) 1989-08-09 1989-09-20 Medical Res Council The peptide fragments of hiv
US7255862B1 (en) 1996-11-14 2007-08-14 Connaught Technology Corporation ALVAC/FIV constructs

Also Published As

Publication number Publication date
WO2002068654A3 (es) 2003-03-13
WO2002068654A2 (es) 2002-09-06
JP2004518443A (ja) 2004-06-24
ZA200304387B (en) 2004-08-11
KR20030079946A (ko) 2003-10-10
BR0206823A (pt) 2004-02-25
CN1526018A (zh) 2004-09-01
CN1526018B (zh) 2013-04-03
ES2329768T3 (es) 2009-12-01
CA2430702A1 (en) 2002-09-06
US7318927B2 (en) 2008-01-15
EP1371730B1 (en) 2009-07-08
JP4125128B2 (ja) 2008-07-30
CA2430702C (en) 2013-07-09
BRPI0206823B1 (pt) 2018-08-14
AR032871A1 (es) 2003-11-26
DE60232862D1 (de) 2009-08-20
RU2003128991A (ru) 2005-01-20
AU2002237195B2 (en) 2007-01-04
US20040073008A1 (en) 2004-04-15
RU2302461C2 (ru) 2007-07-10
ATE435916T1 (de) 2009-07-15
US20080280354A1 (en) 2008-11-13
KR100920141B1 (ko) 2009-10-08
EP1371730A2 (en) 2003-12-17

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