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CU23221A3 - SINTESIS ASIMéTRICA DE PREGABALIN - Google Patents

SINTESIS ASIMéTRICA DE PREGABALIN

Info

Publication number
CU23221A3
CU23221A3 CU20020122A CU20020122A CU23221A3 CU 23221 A3 CU23221 A3 CU 23221A3 CU 20020122 A CU20020122 A CU 20020122A CU 20020122 A CU20020122 A CU 20020122A CU 23221 A3 CU23221 A3 CU 23221A3
Authority
CU
Cuba
Prior art keywords
pregabalin
asymmetric synthesis
provides
useful
aminomethyl
Prior art date
Application number
CU20020122A
Other languages
English (en)
Inventor
James Andrew Ramsden
Thomas Arthur Mulhern
Thomas Frederick Mich
Marvin Simon Hoekstra
Om Prakash Goel
Mark Joseph Burk
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26874236&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU23221(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of CU23221A3 publication Critical patent/CU23221A3/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

este invento proporciona un mÉtodo para preparar (S)-(+)-Acido 3-(aminometil)-5-metil-hexanoico (pregabalin) o una de sus sales por medio de una síntesis de hidrogenacion asimÉtrica. El pregabalin es Util para el tratamiento y la prevencion de trastornos causados por ataques 8accesos), del dolor y trastornos psicoticos. El invento proporciona tambiÉn compuestos intermedios Utiles en la produccion de pregabalin.
CU20020122A 2000-01-27 2002-06-19 SINTESIS ASIMéTRICA DE PREGABALIN CU23221A3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17835900P 2000-01-27 2000-01-27
US19042700P 2000-03-17 2000-03-17

Publications (1)

Publication Number Publication Date
CU23221A3 true CU23221A3 (es) 2007-07-20

Family

ID=26874236

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20020122A CU23221A3 (es) 2000-01-27 2002-06-19 SINTESIS ASIMéTRICA DE PREGABALIN

Country Status (50)

Country Link
US (1) US6891059B2 (es)
EP (1) EP1250311B1 (es)
JP (2) JP4235384B2 (es)
KR (1) KR100549748B1 (es)
CN (1) CN1210253C (es)
AP (1) AP1438A (es)
AR (1) AR028499A1 (es)
AT (1) ATE261930T1 (es)
AU (1) AU777046B2 (es)
BG (1) BG65560B1 (es)
BR (1) BRPI0107863B8 (es)
CA (1) CA2396090C (es)
CO (1) CO5251411A1 (es)
CR (1) CR6703A (es)
CU (1) CU23221A3 (es)
CY (1) CY2004011I1 (es)
CZ (1) CZ302838B6 (es)
DE (1) DE60102356T2 (es)
DK (1) DK1250311T3 (es)
DZ (1) DZ3268A1 (es)
EA (1) EA004934B1 (es)
EE (1) EE05216B1 (es)
EG (1) EG24138A (es)
ES (1) ES2219493T3 (es)
GE (1) GEP20043236B (es)
HN (1) HN2001000010A (es)
HR (1) HRP20020627B1 (es)
HU (1) HU228815B1 (es)
IL (2) IL150633A0 (es)
IS (1) IS2038B (es)
MA (1) MA26869A1 (es)
ME (1) ME00921B (es)
MX (1) MXPA02007307A (es)
MY (1) MY127152A (es)
NO (1) NO327958B1 (es)
NZ (1) NZ519551A (es)
OA (1) OA12167A (es)
PA (1) PA8510501A1 (es)
PE (1) PE20011063A1 (es)
PL (1) PL203985B1 (es)
PT (1) PT1250311E (es)
RS (1) RS50257B (es)
SI (1) SI1250311T1 (es)
SK (1) SK287303B6 (es)
SV (1) SV2002000295A (es)
TN (1) TNSN01016A1 (es)
TR (1) TR200400953T4 (es)
TW (1) TWI288128B (es)
UA (1) UA75584C2 (es)
WO (1) WO2001055090A1 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1094757C (zh) 1996-07-24 2002-11-27 沃尼尔·朗伯公司 用于治疗疼痛的异丁基γ－氨基丁酸及其衍生物
HU228815B1 (en) * 2000-01-27 2013-05-28 Warner Lambert Co Asymmetric synthesis of pregabalin
US6687187B2 (en) * 2000-08-11 2004-02-03 Phonak Ag Method for directional location and locating system
EP1543831A1 (en) * 2003-12-18 2005-06-22 Pfizer GmbH Arzneimittelwerk Gödecke Pregabalin composition
AU2005221401A1 (en) * 2004-03-12 2005-09-22 Warner-Lambert Company Llc C1-symmetric bisphosphine ligands and their use in the asymmetric synthesis of pregabalin
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)
PT1831154E (pt) * 2004-06-21 2010-02-19 Warner Lambert Co Preparação de pregabalina e compostos relacionados
US7417165B2 (en) 2005-04-06 2008-08-26 Teva Pharmaceutical Industries Ltd. Crystalline forms of pregabalin
US7488846B2 (en) 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
US20070066846A1 (en) * 2005-04-11 2007-03-22 Asher Maymon Process for making (S)-Pregabalin
US7763749B2 (en) 2005-05-10 2010-07-27 Teva Pharmaceutical Industries Ltd. Method for the preparation of Pregabalin and salts thereof
US20070043241A1 (en) 2005-05-10 2007-02-22 Lilach Hedvati Optical resolution of 3-carbamoylmethyl-5-methylhexanoic acid
KR20070067077A (ko) 2005-05-10 2007-06-27 테바 파마슈티컬 인더스트리즈 리미티드 이소부틸글루타르산을 함유하지 않는 프레가발린 및 이의제조 방법
US20060270871A1 (en) * 2005-05-30 2006-11-30 Khanduri Chandra H Polymorphic form i of pregabalin and processes for its preparation
CN100410242C (zh) * 2005-06-23 2008-08-13 江苏恩华药业股份有限公司 普瑞巴林中间体及其制备方法
WO2007035789A1 (en) * 2005-09-19 2007-03-29 Teva Pharmaceutical Industries Ltd. Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key intermediates for the new synthesis of (s)-pregabalin
NL2000281C2 (nl) 2005-11-02 2007-08-07 Pfizer Prod Inc Vaste farmaceutische samenstellingen die pregabaline bevatten.
KR20080016658A (ko) * 2006-04-24 2008-02-21 테바 파마슈티컬 인더스트리즈 리미티드 3-이소부틸글루타르산의 합성 방법
WO2007139933A2 (en) 2006-05-24 2007-12-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
US20080015385A1 (en) * 2006-05-31 2008-01-17 Lilach Hedvati Preparation of (S)-pregabalin-nitrile
CA2649117A1 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. The use of enzymatic resolution for the preparation of intermediates of pregabalin
EP1903027A1 (en) * 2006-09-13 2008-03-26 Novartis AG Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors
BRPI0803092A2 (pt) 2007-03-22 2011-08-30 Teva Pharma sìntese de (s)-(+)-3-(aminometil)-5-metil ácido hexanóico, (s)-pregabalina
EP2170813A4 (en) * 2007-06-25 2012-05-16 Reddy Manne Satyanarayana NEW METHOD OF PREPARING PREGABALIN
KR100846419B1 (ko) * 2007-08-10 2008-07-15 한국과학기술원 프레가발린의 신규한 제조 방법
KR20090101462A (ko) * 2007-10-03 2009-09-28 테바 파마슈티컬 인더스트리즈 리미티드 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법
EP2053040A1 (en) * 2007-10-26 2009-04-29 Chemo Ibérica, S.A. Pregabalin intermediates and process for preparing them and Pregabalin
US20100312010A1 (en) * 2007-12-18 2010-12-09 Watson Pharma Private Limited Process for the Preparation of (S)-Pregabalin
CA2710152A1 (en) * 2007-12-26 2009-07-02 Generics (Uk) Limited Processes to pregabalin
JP5526538B2 (ja) * 2008-01-10 2014-06-18 住友化学株式会社 ３−（２−シアノ−１−プロペニル）−２，２−ジメチルシクロプロパンカルボン酸化合物の製造方法およびその中間体
EP2110372A1 (en) 2008-04-16 2009-10-21 Chemo Ibérica, S.A. Intermediates for the preparation of Pregabalin and process for their preparation
EP2116618A1 (en) 2008-05-09 2009-11-11 Agency for Science, Technology And Research Diagnosis and treatment of Kawasaki disease
MX2010012698A (es) 2008-05-21 2011-03-15 Sandoz Ag Proceso para la hidrolisis enzimatica estereoselectiva del ester del acido 5-metil-3-nitro-metil-hexanoico.
WO2009158343A1 (en) * 2008-06-23 2009-12-30 Teva Pharmaceutical Industries, Ltd. Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
CN101987826A (zh) * 2009-08-04 2011-03-23 铜陵凯顺生物科技有限公司 一种(3s)-3-氨甲基-5-甲基己酸的合成方法
WO2011141923A2 (en) 2010-05-14 2011-11-17 Lupin Limited Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
US8212072B2 (en) 2010-08-13 2012-07-03 Divi's Laboratories, Ltd. Process for the preparation of pregabalin
WO2012025861A1 (en) 2010-08-23 2012-03-01 Pfizer Manufacturing Ireland Process for the preparation of ( s ) - 3 - cyano - 5 - methylhexanoic acid derivatives adn of pregabalin
CN102464594B (zh) * 2010-11-17 2014-06-25 凯瑞斯德生化(苏州)有限公司 普瑞巴林的中间体化合物的制备方法
US9422230B2 (en) 2013-05-09 2016-08-23 Council Of Scientific And Industrial Research Process for the preparation of an anticonvulsant agent pregabalin hydrochloride
WO2016075082A1 (en) 2014-11-10 2016-05-19 Sandoz Ag Stereoselective reductive amination of alpha-chiral aldehydes using omega-transaminases for the synthesis of precursors of pregabalin and brivaracetam
WO2017019791A1 (en) 2015-07-27 2017-02-02 Teva Pharmaceuticals International Gmbh Synthesis of (s)-pregabalin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS588390B2 (ja) * 1978-05-23 1983-02-15 住友化学工業株式会社 光学活性ω↓−シアノ↓−α↓−アシルアミノ酸誘導体の製造法
US4939288A (en) * 1989-01-23 1990-07-03 Monsanto Company Method of preparing (R)-succinic acid derivatives
US6197819B1 (en) 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US5171892A (en) 1991-07-02 1992-12-15 E. I. Du Pont De Nemours And Company Chiral phospholanes via chiral 1,4-diol cyclic sulfates
US5616793A (en) * 1995-06-02 1997-04-01 Warner-Lambert Company Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5637767A (en) 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US5840965A (en) * 1996-06-24 1998-11-24 E. I. Du Pont De Nemours And Company Process for the production of purified telephthalic acid
CN1094757C (zh) 1996-07-24 2002-11-27 沃尼尔·朗伯公司 用于治疗疼痛的异丁基γ－氨基丁酸及其衍生物
US6127418A (en) 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
ATE236869T1 (de) 1997-12-17 2003-04-15 Chirotech Technology Ltd Asymmetrische hydrierung
EP1070043B1 (en) 1998-04-09 2004-02-18 Chirotech Technology Limited Asymmetric hydrogenation
HU228815B1 (en) * 2000-01-27 2013-05-28 Warner Lambert Co Asymmetric synthesis of pregabalin

Also Published As

Publication number Publication date
EP1250311B1 (en) 2004-03-17
PT1250311E (pt) 2004-07-30
EA200200642A1 (ru) 2002-12-26
TWI288128B (en) 2007-10-11
CN1210253C (zh) 2005-07-13
NO327958B1 (no) 2009-10-26
UA75584C2 (uk) 2006-05-15
BG106849A (en) 2003-03-31
DK1250311T3 (da) 2004-08-16
EE05216B1 (et) 2009-10-15
BR0107863A (pt) 2002-11-05
GEP20043236B (en) 2004-05-25
AP2002002588A0 (en) 2002-09-30
IL150633A0 (en) 2003-02-12
CO5251411A1 (es) 2003-02-28
IS2038B (is) 2005-08-15
JP4886753B2 (ja) 2012-02-29
EA004934B1 (ru) 2004-10-28
JP2009073841A (ja) 2009-04-09
CY2004011I1 (el) 2010-07-28
YU56202A (sh) 2006-01-16
EG24138A (en) 2008-08-06
HU228815B1 (en) 2013-05-28
KR100549748B1 (ko) 2006-02-08
CR6703A (es) 2003-06-24
RS50257B (sr) 2009-07-15
ATE261930T1 (de) 2004-04-15
SK287303B6 (sk) 2010-06-07
HRP20020627A2 (en) 2004-08-31
CZ302838B6 (cs) 2011-12-07
OA12167A (en) 2006-05-08
ME00921B (me) 2012-06-20
HRP20020627B1 (hr) 2011-01-31
DE60102356D1 (de) 2004-04-22
CA2396090C (en) 2006-01-10
PL357077A1 (en) 2004-07-12
KR20020073187A (ko) 2002-09-19
ES2219493T3 (es) 2004-12-01
TR200400953T4 (tr) 2004-07-21
HUP0204307A2 (hu) 2003-06-28
EP1250311A1 (en) 2002-10-23
WO2001055090A1 (en) 2001-08-02
SV2002000295A (es) 2002-06-07
MXPA02007307A (es) 2002-11-29
TNSN01016A1 (fr) 2005-11-10
NO20023582L (no) 2002-09-02
IL150633A (en) 2009-08-03
HN2001000010A (es) 2001-06-13
PA8510501A1 (es) 2002-02-21
US20030212290A1 (en) 2003-11-13
US6891059B2 (en) 2005-05-10
BG65560B1 (bg) 2008-12-30
MY127152A (en) 2006-11-30
BRPI0107863B8 (pt) 2017-04-25
NZ519551A (en) 2004-02-27
AP1438A (en) 2005-05-23
DE60102356T2 (de) 2005-02-17
IS6430A (is) 2002-06-19
HUP0204307A3 (en) 2003-07-28
PL203985B1 (pl) 2009-11-30
SI1250311T1 (en) 2004-10-31
NO20023582D0 (no) 2002-07-26
JP2003520841A (ja) 2003-07-08
AU2213801A (en) 2001-08-07
CA2396090A1 (en) 2001-08-02
CZ20022520A3 (cs) 2002-10-16
PE20011063A1 (es) 2001-10-18
MA26869A1 (fr) 2004-12-20
EE200200403A (et) 2003-10-15
BR0107863B1 (pt) 2013-06-18
AR028499A1 (es) 2003-05-14
CN1396905A (zh) 2003-02-12
DZ3268A1 (fr) 2001-08-02
SK10782002A3 (sk) 2002-11-06
AU777046B2 (en) 2004-09-30
JP4235384B2 (ja) 2009-03-11

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