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CU23892B1 - CYCLOSPORINE MICROENCAPSULATED PHARMACEUTICAL COMPOSITION A - Google Patents

CYCLOSPORINE MICROENCAPSULATED PHARMACEUTICAL COMPOSITION A

Info

Publication number
CU23892B1
CU23892B1 CUP2007000274A CU20070274A CU23892B1 CU 23892 B1 CU23892 B1 CU 23892B1 CU P2007000274 A CUP2007000274 A CU P2007000274A CU 20070274 A CU20070274 A CU 20070274A CU 23892 B1 CU23892 B1 CU 23892B1
Authority
CU
Cuba
Prior art keywords
cyclosporine
pharmaceutical composition
water
microencapsulated
microencapsulated pharmaceutical
Prior art date
Application number
CUP2007000274A
Other languages
Spanish (es)
Other versions
CU20070274A6 (en
Inventor
Hernández Orestes López
Carril Martha Gómez
Izquierdo Suslebys Salomón
Original Assignee
Ct De Investigación Y Desarrollo De Medicamentos Cidem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40717312&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU23892(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ct De Investigación Y Desarrollo De Medicamentos Cidem filed Critical Ct De Investigación Y Desarrollo De Medicamentos Cidem
Priority to CUP2007000274A priority Critical patent/CU23892B1/en
Priority to ARP080105294A priority patent/AR069578A1/en
Priority to PCT/CU2008/000011 priority patent/WO2009071034A1/en
Publication of CU20070274A6 publication Critical patent/CU20070274A6/en
Publication of CU23892B1 publication Critical patent/CU23892B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Composición farmacéutica de ciclosporina A microencapsulada mediante secado por aspersión, modificando su solubilidad en agua y en fluido gastrointestinal con ayuda de un tensoactivo hidrofílico y uso de una mezcla de polímeros como Dextrana y polietilenglicol 4000 para aumentar su estabilidad en agua contribuyendo a mantenerla estable en agua por más de 24 horas, lo que coadyuva amejorar la absorción de la misma.Pharmaceutical composition of microencapsulated cyclosporine A by spray drying, modifying its solubility in water and in gastrointestinal fluid with the aid of a hydrophilic surfactant and using a mixture of polymers such as Dextrana and polyethylene glycol 4000 to increase its stability in water contributing to keep it stable in water for more than 24 hours, which helps to improve its absorption.

CUP2007000274A 2007-12-07 2007-12-07 CYCLOSPORINE MICROENCAPSULATED PHARMACEUTICAL COMPOSITION A CU23892B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CUP2007000274A CU23892B1 (en) 2007-12-07 2007-12-07 CYCLOSPORINE MICROENCAPSULATED PHARMACEUTICAL COMPOSITION A
ARP080105294A AR069578A1 (en) 2007-12-07 2008-12-04 PHARMACEUTICAL COMPOSITION OF CYCLOSPORIN A AND PROCEDURE TO MODIFY YOUR SOLUBILITY AND STABILITY
PCT/CU2008/000011 WO2009071034A1 (en) 2007-12-07 2008-12-05 Pharmaceutical cyclosporine composition and method for altering the solubility and stability thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CUP2007000274A CU23892B1 (en) 2007-12-07 2007-12-07 CYCLOSPORINE MICROENCAPSULATED PHARMACEUTICAL COMPOSITION A

Publications (2)

Publication Number Publication Date
CU20070274A6 CU20070274A6 (en) 2011-10-31
CU23892B1 true CU23892B1 (en) 2013-04-19

Family

ID=40717312

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2007000274A CU23892B1 (en) 2007-12-07 2007-12-07 CYCLOSPORINE MICROENCAPSULATED PHARMACEUTICAL COMPOSITION A

Country Status (3)

Country Link
AR (1) AR069578A1 (en)
CU (1) CU23892B1 (en)
WO (1) WO2009071034A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0008785D0 (en) * 2000-04-10 2000-05-31 Novartis Ag Organic compounds
EP1539111A1 (en) * 2002-08-05 2005-06-15 DSM IP Assets B.V. Oral dosage forms of water insoluble drugs and methods of making the same
US20070196396A1 (en) * 2004-02-11 2007-08-23 Rubicon Research Private Limited Controlled release pharmaceutical compositions with improved bioavailability

Also Published As

Publication number Publication date
CU20070274A6 (en) 2011-10-31
WO2009071034A1 (en) 2009-06-11
AR069578A1 (en) 2010-02-03

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Legal Events

Date Code Title Description
FG Grant of patent