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CU22500A1 - MONOCLONAL ANTIBODIES ANTI-GANGLIOSIDOS, MONOCLONAL ANTIBODIES ANTIIDIOTIPOS, PRODUCING HYBRIDOMES AND PROCEDURE OF OBTAINING THE SAME - Google Patents

MONOCLONAL ANTIBODIES ANTI-GANGLIOSIDOS, MONOCLONAL ANTIBODIES ANTIIDIOTIPOS, PRODUCING HYBRIDOMES AND PROCEDURE OF OBTAINING THE SAME

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Publication number
CU22500A1
CU22500A1 CU11493A CU11493A CU22500A1 CU 22500 A1 CU22500 A1 CU 22500A1 CU 11493 A CU11493 A CU 11493A CU 11493 A CU11493 A CU 11493A CU 22500 A1 CU22500 A1 CU 22500A1
Authority
CU
Cuba
Prior art keywords
mabs
monoclonal antibodies
immunization
response
idiotype
Prior art date
Application number
CU11493A
Other languages
Spanish (es)
Inventor
Ruiz Maria Eliana Lanio
Valcarcel Carlos Manuel Alvarez
Abraham Amparo Emilia Macias
Lopez Ana Maria Vazquez
Fernandez Angel Mauro Alfonso
Rodriguez Rolando Perez
Original Assignee
Centro Inmunologia Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro Inmunologia Molecular filed Critical Centro Inmunologia Molecular
Priority to CU11493A priority Critical patent/CU22500A1/en
Publication of CU22500A1 publication Critical patent/CU22500A1/en

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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se relaciona con la rama de la Inmunología y en particular con la generación y selección de anticuerpos monoclonales (AcM) contra gangliósidos (Ab1s), que poseen la característica de ser específicos, de portar idiotipos recurrentes y que tienen valor como inmunoreguladores de la respuesta inmune contra estos antígenos; y con la obtención de AcM anti-idiotipos (Ab2s) generados a partir de la inmunización con dichos AcM anti-gangliósidos. De acuerdo con lo expuesto, un objeto de esta invención es proporcionar AcMs contra gangliósidos (Ab1s), portadores de idiotipos capaces de inducir una respuesta antígeno específica (Ab1´) en ausencia del antígeno, y los métodos para su generación. Otro objeto de esta invención es proveer de AcMs anti-idiotipo (Ab2s), generados mediante la inmunización con AcM antigangliósidos poseedores de las propiedades antes expuestas, que tienen la capacidad también de producir respuesta Ab1´. Otro importante objetivo de la invención consiste en generar AcM específicos contra gangliósidos (Ab1), inmunizar ratones y otras especies con dichos anticuerpos y seleccionar aquellos capaces de generar una respuesta antígeno específica (Ab1´). Generar AcM anti-idiotipo a partir de la inmunización de ratones u otras especies animales con los AcM anti-gangliósidos antes mencionados.The present invention is related to the branch of Immunology and in particular to the generation and selection of monoclonal antibodies (mAbs) against gangliosides (Ab1s), which have the characteristic of being specific, of carrying recurrent idiotypes and that have value as immunoregulators of the immune response against these antigens; and with obtaining anti-idiotype mAbs (Ab2s) generated from immunization with said anti-ganglioside mAbs. In accordance with the foregoing, an object of this invention is to provide mAbs against gangliosides (Ab1s), carriers of idiotypes capable of inducing a specific antigen response (Ab1´) in the absence of the antigen, and the methods for its generation. Another object of this invention is to provide anti-idiotype mAbs (Ab2s), generated by immunization with antiganglioside mAbs possessing the above properties, which also have the ability to produce an Ab1 'response. Another important objective of the invention is to generate specific mAbs against gangliosides (Ab1), immunize mice and other species with said antibodies and select those capable of generating a specific antigen response (Ab1´). Generate anti-idiotype mAbs from the immunization of mice or other animal species with the aforementioned anti-ganglioside mAbs.

CU11493A 1993-12-09 1993-12-09 MONOCLONAL ANTIBODIES ANTI-GANGLIOSIDOS, MONOCLONAL ANTIBODIES ANTIIDIOTIPOS, PRODUCING HYBRIDOMES AND PROCEDURE OF OBTAINING THE SAME CU22500A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CU11493A CU22500A1 (en) 1993-12-09 1993-12-09 MONOCLONAL ANTIBODIES ANTI-GANGLIOSIDOS, MONOCLONAL ANTIBODIES ANTIIDIOTIPOS, PRODUCING HYBRIDOMES AND PROCEDURE OF OBTAINING THE SAME

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU11493A CU22500A1 (en) 1993-12-09 1993-12-09 MONOCLONAL ANTIBODIES ANTI-GANGLIOSIDOS, MONOCLONAL ANTIBODIES ANTIIDIOTIPOS, PRODUCING HYBRIDOMES AND PROCEDURE OF OBTAINING THE SAME

Publications (1)

Publication Number Publication Date
CU22500A1 true CU22500A1 (en) 1997-12-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CU11493A CU22500A1 (en) 1993-12-09 1993-12-09 MONOCLONAL ANTIBODIES ANTI-GANGLIOSIDOS, MONOCLONAL ANTIBODIES ANTIIDIOTIPOS, PRODUCING HYBRIDOMES AND PROCEDURE OF OBTAINING THE SAME

Country Status (1)

Country Link
CU (1) CU22500A1 (en)

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