CU20180014A7 - Inhibidor de la isocitrato deshidrogenasa mutada idh1 r132h - Google Patents
Inhibidor de la isocitrato deshidrogenasa mutada idh1 r132hInfo
- Publication number
- CU20180014A7 CU20180014A7 CUP2018000014A CU20180014A CU20180014A7 CU 20180014 A7 CU20180014 A7 CU 20180014A7 CU P2018000014 A CUP2018000014 A CU P2018000014A CU 20180014 A CU20180014 A CU 20180014A CU 20180014 A7 CU20180014 A7 CU 20180014A7
- Authority
- CU
- Cuba
- Prior art keywords
- idh1
- inhibitor
- muted
- isocitrate
- dehydrogenase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
<p>La presente invención se refiere al adcuto del ácido (2E)-but-2-enedioico y ácido 3-(2-{[4- (trifluorometoxi)fenil] amino}-1-[(1R,5R)-3,3,5-trimetilciclohexil]-1 H-benzimidazol-5- il)propanoico (1:4) y a su forma cristalina, a un método para preparar este aducto, y a medicamentos que comprenden este aducto, el cual es un inhibidor de la isocitrato deshidrogenasa mutada IDH1 R132H útil para el tratamiento de tumores.</p>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15178419 | 2015-07-27 | ||
| PCT/EP2016/067477 WO2017016992A1 (en) | 2015-07-27 | 2016-07-22 | Inhibitor of the mutated isocitrate dehydrogenase idh1 r132h |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20180014A7 true CU20180014A7 (es) | 2018-06-05 |
Family
ID=53758092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CUP2018000014A CU20180014A7 (es) | 2015-07-27 | 2016-07-22 | Inhibidor de la isocitrato deshidrogenasa mutada idh1 r132h |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10344004B2 (es) |
| EP (1) | EP3328837B1 (es) |
| JP (1) | JP6804516B2 (es) |
| KR (1) | KR20180030789A (es) |
| CN (1) | CN107810181B (es) |
| AR (1) | AR105493A1 (es) |
| AU (1) | AU2016300980B2 (es) |
| BR (1) | BR112018001534A2 (es) |
| CA (1) | CA2993473A1 (es) |
| CL (1) | CL2018000249A1 (es) |
| CO (1) | CO2018000793A2 (es) |
| CR (1) | CR20180053A (es) |
| CU (1) | CU20180014A7 (es) |
| DO (1) | DOP2018000027A (es) |
| EA (1) | EA201890386A1 (es) |
| EC (1) | ECSP18006465A (es) |
| ES (1) | ES2860693T3 (es) |
| HK (1) | HK1252449A1 (es) |
| IL (1) | IL256024A (es) |
| MX (1) | MX2018001205A (es) |
| NI (1) | NI201800014A (es) |
| PE (1) | PE20181038A1 (es) |
| SV (1) | SV2018005621A (es) |
| TN (1) | TN2018000038A1 (es) |
| TW (1) | TW201708193A (es) |
| WO (1) | WO2017016992A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6534675B2 (ja) | 2014-02-11 | 2019-06-26 | バイエル・ファルマ・アクティエンゲゼルシャフト | ｍＩＤＨ１阻害剤としてのベンズイミダゾール−２−アミン |
| US9951027B2 (en) | 2014-02-11 | 2018-04-24 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as MIDH1 inhibitors |
| CN107108554B (zh) | 2014-10-23 | 2020-11-06 | 德国癌症研究中心 | 作为midh1抑制剂用于治疗肿瘤的1-环己基-2-苯基氨基苯并咪唑 |
| CN107810176B (zh) | 2015-06-08 | 2020-10-16 | 德国癌症研究公共权益基金会 | 作为mIDH1抑制剂的N-薄荷基苯并咪唑类化合物 |
| WO2017005674A1 (en) | 2015-07-07 | 2017-01-12 | Bayer Pharma Aktiengesellschaft | 2-aryl- and 2-arylalkyl-benzimidazoles as midh1 inhibitors |
| US10414734B2 (en) | 2015-07-16 | 2019-09-17 | Bayer Pharma Aktiengesellschaft | 5-hydroxyalkylbenzimidazoles as mIDH1 inhibitors |
| EP3121166A1 (en) | 2015-07-21 | 2017-01-25 | Bayer Pharma Aktiengesellschaft | Fused imidazoles as midh1 inhibitors |
| TW201718513A (zh) | 2015-07-27 | 2017-06-01 | 拜耳製藥公司 | 製備經取代之３－（２－苯胺－１－環己基－１ｈ－苯并咪唑－５－基）丙酸衍生物之方法 |
| WO2019015672A1 (zh) * | 2017-07-21 | 2019-01-24 | 南京明德新药研发股份有限公司 | 吡啶并咪唑类化合物及其应用 |
| CN111278465A (zh) * | 2017-08-01 | 2020-06-12 | 德国癌症研究中心 | mIDH1抑制剂和DNA低甲基化剂（HMA）的组合 |
| CN108948205B (zh) * | 2018-07-13 | 2021-09-28 | 北京金岱生物科技有限公司 | 抗idh1r132h单克隆抗体及其应用 |
| TWI760017B (zh) | 2019-12-23 | 2022-04-01 | 大陸商昆藥集團股份有限公司 | 一種ｉｄｈ１突變體抑制劑的鹽型、晶型及其製備方法 |
| AU2021311539A1 (en) | 2020-07-21 | 2023-02-09 | Daiichi Sankyo Company, Limited | Combination drug of temozolomide and inhibitor of mutated IDH1 enzyme |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010151441A1 (en) | 2009-06-23 | 2010-12-29 | Translational Genomics Research Institute | Benzamide derivatives |
| EP2643314B1 (en) * | 2010-11-25 | 2016-07-13 | ratiopharm GmbH | Novel salts and polymorphic forms of afatinib |
| GEP20166432B (en) | 2011-09-27 | 2016-02-10 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| JP6534675B2 (ja) | 2014-02-11 | 2019-06-26 | バイエル・ファルマ・アクティエンゲゼルシャフト | ｍＩＤＨ１阻害剤としてのベンズイミダゾール−２−アミン |
| US9951027B2 (en) * | 2014-02-11 | 2018-04-24 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as MIDH1 inhibitors |
| ES2822654T3 (es) * | 2014-10-23 | 2021-05-04 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Benzimidazol-2-aminas como inhibidores de mIDH1 |
| CN107108554B (zh) * | 2014-10-23 | 2020-11-06 | 德国癌症研究中心 | 作为midh1抑制剂用于治疗肿瘤的1-环己基-2-苯基氨基苯并咪唑 |
| CN107810176B (zh) | 2015-06-08 | 2020-10-16 | 德国癌症研究公共权益基金会 | 作为mIDH1抑制剂的N-薄荷基苯并咪唑类化合物 |
| WO2017005674A1 (en) | 2015-07-07 | 2017-01-12 | Bayer Pharma Aktiengesellschaft | 2-aryl- and 2-arylalkyl-benzimidazoles as midh1 inhibitors |
| US10414734B2 (en) * | 2015-07-16 | 2019-09-17 | Bayer Pharma Aktiengesellschaft | 5-hydroxyalkylbenzimidazoles as mIDH1 inhibitors |
| EP3121166A1 (en) * | 2015-07-21 | 2017-01-25 | Bayer Pharma Aktiengesellschaft | Fused imidazoles as midh1 inhibitors |
| TW201718513A (zh) * | 2015-07-27 | 2017-06-01 | 拜耳製藥公司 | 製備經取代之３－（２－苯胺－１－環己基－１ｈ－苯并咪唑－５－基）丙酸衍生物之方法 |
-
2016
- 2016-07-14 TW TW105122262A patent/TW201708193A/zh unknown
- 2016-07-22 CU CUP2018000014A patent/CU20180014A7/es unknown
- 2016-07-22 TN TNP/2018/000038A patent/TN2018000038A1/en unknown
- 2016-07-22 AU AU2016300980A patent/AU2016300980B2/en not_active Ceased
- 2016-07-22 EA EA201890386A patent/EA201890386A1/ru unknown
- 2016-07-22 EP EP16741332.7A patent/EP3328837B1/en active Active
- 2016-07-22 CR CR20180053A patent/CR20180053A/es unknown
- 2016-07-22 KR KR1020177036977A patent/KR20180030789A/ko not_active Withdrawn
- 2016-07-22 MX MX2018001205A patent/MX2018001205A/es unknown
- 2016-07-22 ES ES16741332T patent/ES2860693T3/es active Active
- 2016-07-22 JP JP2018504187A patent/JP6804516B2/ja not_active Expired - Fee Related
- 2016-07-22 WO PCT/EP2016/067477 patent/WO2017016992A1/en not_active Ceased
- 2016-07-22 CA CA2993473A patent/CA2993473A1/en not_active Abandoned
- 2016-07-22 CN CN201680038633.9A patent/CN107810181B/zh not_active Expired - Fee Related
- 2016-07-22 US US15/748,014 patent/US10344004B2/en not_active Expired - Fee Related
- 2016-07-22 PE PE2018000133A patent/PE20181038A1/es unknown
- 2016-07-22 HK HK18111750.7A patent/HK1252449A1/zh unknown
- 2016-07-22 BR BR112018001534A patent/BR112018001534A2/pt not_active Application Discontinuation
- 2016-07-27 AR ARP160102274A patent/AR105493A1/es unknown
-
2017
- 2017-11-30 IL IL256024A patent/IL256024A/en unknown
-
2018
- 2018-01-26 EC ECIEPI20186465A patent/ECSP18006465A/es unknown
- 2018-01-26 DO DO2018000027A patent/DOP2018000027A/es unknown
- 2018-01-26 CL CL2018000249A patent/CL2018000249A1/es unknown
- 2018-01-26 CO CONC2018/0000793A patent/CO2018000793A2/es unknown
- 2018-01-26 NI NI201800014A patent/NI201800014A/es unknown
- 2018-01-26 SV SV2018005621A patent/SV2018005621A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180030789A (ko) | 2018-03-26 |
| US10344004B2 (en) | 2019-07-09 |
| EA201890386A1 (ru) | 2018-08-31 |
| TN2018000038A1 (en) | 2019-07-08 |
| HK1252449A1 (zh) | 2019-05-24 |
| EP3328837A1 (en) | 2018-06-06 |
| MX2018001205A (es) | 2018-04-24 |
| JP6804516B2 (ja) | 2020-12-23 |
| CR20180053A (es) | 2018-03-20 |
| US20180222870A1 (en) | 2018-08-09 |
| IL256024A (en) | 2018-01-31 |
| CO2018000793A2 (es) | 2018-05-10 |
| BR112018001534A2 (pt) | 2018-09-11 |
| DOP2018000027A (es) | 2018-02-28 |
| ES2860693T3 (es) | 2021-10-05 |
| WO2017016992A1 (en) | 2017-02-02 |
| CN107810181B (zh) | 2021-06-22 |
| NI201800014A (es) | 2018-09-06 |
| JP2018521095A (ja) | 2018-08-02 |
| EP3328837B1 (en) | 2021-01-06 |
| CN107810181A (zh) | 2018-03-16 |
| CA2993473A1 (en) | 2017-02-02 |
| TW201708193A (zh) | 2017-03-01 |
| PE20181038A1 (es) | 2018-07-03 |
| ECSP18006465A (es) | 2018-04-30 |
| SV2018005621A (es) | 2018-12-05 |
| AU2016300980B2 (en) | 2020-12-24 |
| CL2018000249A1 (es) | 2018-07-06 |
| AR105493A1 (es) | 2017-10-11 |
| AU2016300980A1 (en) | 2017-12-21 |
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