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CU20160189A7 - Ácidos grasos útiles en la conjugación con biomoléculas - Google Patents

Ácidos grasos útiles en la conjugación con biomoléculas

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Publication number
CU20160189A7
CU20160189A7 CUP2016000189A CU20160189A CU20160189A7 CU 20160189 A7 CU20160189 A7 CU 20160189A7 CU P2016000189 A CUP2016000189 A CU P2016000189A CU 20160189 A CU20160189 A CU 20160189A CU 20160189 A7 CU20160189 A7 CU 20160189A7
Authority
CU
Cuba
Prior art keywords
disease
conjugate
fatty acid
alcoholic
metabolic disorders
Prior art date
Application number
CUP2016000189A
Other languages
English (en)
Other versions
CU24455B1 (es
Inventor
David Weninger Barnes
Ken Yamada
Chikwendu Ibebunjo
Alokesh Duttaroy
Louise Clare Kirman
Alexandra Marshall Bruce
Aimee Richardson Usera
Frederic Zecri
Jun Yuan
Changgang Lou
Aaron Kanter
Avirup Bose
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53491695&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU20160189(A7) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CU20160189A7 publication Critical patent/CU20160189A7/es
Publication of CU24455B1 publication Critical patent/CU24455B1/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K38/095—Oxytocins; Vasopressins; Related peptides
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Abstract

La invención proporciona un conjugado, el cual comprende una biomolécula enlazada a un ácido graso por medio de un enlazador, en donde el ácido graso tiene las siguientes fórmulas A1, A2 o A3: ESPACIO PARA FÓRMULA en donde R1, R2, R3, R4, Ak, n, m y p se definen en Ia presente. La invención también se refiere a un método para Ia elaboración del conjugado de Ia invención tal como el conjugado de GDF15, y a sus usos terapéuticos, tales como el tratamiento o Ia prevención de trastornos o enfermedades metabólicas, diabetes mellitus tipo 2, obesidad, pancreatitis, dislipidemia, enfermedad de hígado graso alcohólico y no aIcohóIico/esteatohepatitis y otras enfermedades progresivas del hígado, resistencia a Ia insulina, hiperinsulinemia, intolerancia a Ia glucosa, hiperglucemia, síndrome metabólico, hipertensión, enfermedad cardiovascular, ateroesclerosis, enfermedad de arterias periféricas, embolia, insuficiencia cardíaca, enfermedad cardíaca coronaria, complicaciones diabéticas (incluyendo, pero no limitándose a, enfermedad crónica del riñón), neuropatía, gastroparesis y otros trastornos metabólicos. La presente invención proporciona además una combinación farmacológicamente activos y una composición farmacéutica.
CU2016000189A 2014-06-23 2015-06-18 Ácidos grasos útiles en la conjugación con biomoléculas CU24455B1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462015862P 2014-06-23 2014-06-23
US201462082327P 2014-11-20 2014-11-20
US201562107016P 2015-01-23 2015-01-23
PCT/US2015/036328 WO2015200078A1 (en) 2014-06-23 2015-06-18 Fatty acids and their use in conjugation to biomolecules

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CU20160189A7 true CU20160189A7 (es) 2017-04-05
CU24455B1 CU24455B1 (es) 2019-11-04

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TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
US10752664B2 (en) 2011-04-08 2020-08-25 Amgen Inc. Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (GDF-15)
MX369152B (es) 2013-07-31 2019-10-30 Amgen Inc Construcciones del factor de diferenciación de crecimiento 15 (gdf-15).
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
WO2016088059A1 (en) 2014-12-04 2016-06-09 Novartis Ag Methods and compositions using klotho variant polypeptides
CR20170338A (es) 2015-01-23 2017-09-12 Novartis Ag Conjugados de ácidos grasos y apelina sintética con mayor vida media
EP3277811B1 (en) 2015-04-03 2020-12-23 University of Massachusetts Fully stabilized asymmetric sirna
US10633653B2 (en) 2015-08-14 2020-04-28 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
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