CU20100265A7 - CHEMICAL COMPOUNDS 251 - Google Patents
CHEMICAL COMPOUNDS 251Info
- Publication number
- CU20100265A7 CU20100265A7 CU20100265A CU20100265A CU20100265A7 CU 20100265 A7 CU20100265 A7 CU 20100265A7 CU 20100265 A CU20100265 A CU 20100265A CU 20100265 A CU20100265 A CU 20100265A CU 20100265 A7 CU20100265 A7 CU 20100265A7
- Authority
- CU
- Cuba
- Prior art keywords
- pim
- relates
- chemical compounds
- formula
- kinase
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 101100297652 Coturnix japonica PIM3 gene Proteins 0.000 abstract 1
- 101100297651 Mus musculus Pim2 gene Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000009088 enzymatic function Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a compuestos químicos de fórmula I, ESPACIO PARA LA FÓRMULA y sales de los mismos. En algunas realizaciones, la invención se refiere a inhibidores o moduladores de la actividad o función enzimática de la proteína quinasa PIM-I y/o PIM-2 y/o PIM-3. En otras realizaciones adicionales, la invención se refiere a composiciones farmacéuticas que comprenden compuestos descritos en la presente y su uso en la prevención y tratamiento de afecciones y enfermedades relacionadas con la quinasa PIM, preferiblemente cáncer.The invention relates to chemical compounds of formula I, FORMULA SPACE and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of the enzymatic activity or function of the protein kinase PIM-I and / or PIM-2 and / or PIM-3. In other further embodiments, the invention relates to pharmaceutical compositions comprising compounds described herein and their use in the prevention and treatment of conditions and diseases related to PIM kinase, preferably cancer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18327809P | 2009-06-02 | 2009-06-02 | |
| PCT/GB2009/050773 WO2010001169A2 (en) | 2008-07-02 | 2009-07-02 | Chemical compounds 251 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20100265A7 true CU20100265A7 (en) | 2011-11-15 |
| CU23957B1 CU23957B1 (en) | 2013-10-29 |
Family
ID=45000178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2010000265A CU23957B1 (en) | 2009-06-02 | 2010-12-29 | DERIVATIVES OF TIAZOLIDIN-2,4-DIONA |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU23957B1 (en) |
-
2010
- 2010-12-29 CU CU2010000265A patent/CU23957B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CU23957B1 (en) | 2013-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Lapse (for not paying fees) |