Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca AbfiledCriticalAstrazeneca Ab
Priority to CU20100009ApriorityCriticalpatent/CU20100009A7/en
Publication of CU20100009A7publicationCriticalpatent/CU20100009A7/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Un compuesto de fórmula (I) en la que uno de A1, A2 o A3 es N, y los otros se seleccionan independientemente de CH o N; el anillo B es un anillo carbocíclico o heterocíclico de 5 ó 6 miembros condensado que está opcionalmente sustituido como se define en la descripción, y R1, R2, R3 y R4 y n son como se definen en la descripción. Los compuestos son inhibidores de EphB4 o EphA2 y por tanto pueden ser útiles en composiciones farmacéuticas para el tratamiento de enfermedades tales como el cáncer.A compound of formula (I) in which one of A1, A2 or A3 is N, and the others are independently selected from CH or N; Ring B is a condensed 5- or 6-membered carbocyclic or heterocyclic ring that is optionally substituted as defined in the description, and R1, R2, R3 and R4 and n are as defined in the description. The compounds are inhibitors of EphB4 or EphA2 and therefore may be useful in pharmaceutical compositions for the treatment of diseases such as cancer.
DERIVATIVES OF SPIROINDOLINONE, METHODS FOR THEIR PREPARATION, A PHARMACEUTICAL COMPOSITION CONTAINING THEM AND THEIR USE IN THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF CANCER.
ANTAGONISTS OF TIAZOL AND OXAZOL HEPCIDINE, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME FOR THE TREATMENT OF ANEMIAS AND ILLNESSES ASSOCIATED WITH IRON DEFICIENCIES.
USEFUL HETEROCICLIC NITROGEN COMPOUNDS FOR THE TREATMENT OF INFECTIONS BY RESPIRATORY SYNCTIAL VIRUS (RSV), PROCESS TO PREPARE THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM