CU20090151A7 - ADDITION SALTS OF ACID, HYDRATES AND POLYMORPHES OF ETHYL-AMIDA ACID 5- (2,4-DIHIDROXI-5-ISOPROPIL-PHENYL) -4- (4-MORFOLIN-4-IL-METHYL-PHENYL) -ISOXAZOL- 3-CARBOXYL, AND FORMULATIONS THAT UNDERSTAND THESE FORMS - Google Patents
ADDITION SALTS OF ACID, HYDRATES AND POLYMORPHES OF ETHYL-AMIDA ACID 5- (2,4-DIHIDROXI-5-ISOPROPIL-PHENYL) -4- (4-MORFOLIN-4-IL-METHYL-PHENYL) -ISOXAZOL- 3-CARBOXYL, AND FORMULATIONS THAT UNDERSTAND THESE FORMSInfo
- Publication number
- CU20090151A7 CU20090151A7 CU20090151A CU20090151A CU20090151A7 CU 20090151 A7 CU20090151 A7 CU 20090151A7 CU 20090151 A CU20090151 A CU 20090151A CU 20090151 A CU20090151 A CU 20090151A CU 20090151 A7 CU20090151 A7 CU 20090151A7
- Authority
- CU
- Cuba
- Prior art keywords
- phenyl
- acid
- forms
- isoxazol
- formulations
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 150000004677 hydrates Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 5
- -1 2,4-dihydroxy-5-isopropyl-phenyl Chemical group 0.000 abstract 2
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 abstract 2
- 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- JLLYLQLDYORLBB-UHFFFAOYSA-N 5-bromo-n-methylthiophene-2-sulfonamide Chemical compound CNS(=O)(=O)C1=CC=C(Br)S1 JLLYLQLDYORLBB-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical class CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000011521 glass Substances 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a nuevas formas de sal etil-amida del ácido 5-(2,4-dihidroxi-5-isopropil-fenil(-4-(4-morfolin-4-il-metil-fenil)-isoxazol-3-carboxílico, en particular la sal de mesilato, clorhidrato, tartrato, fosfato, y hemi-fumarato de la misma; a formas cristalinas de estas sales; a polimorfos de la etil-amida del ácido 5-(2,4-dihidroxi-5-isopropil-fenil(-4-(4-morfolin-4-il-metil-fenil)-isoxazol-3-carboxílico; a hidratos y polimorfos de las nuevas formas de sal mencionadas anteriormente; al uso de las nuevas formas de sal mencionadas anteriormente; para la fabricación de un medicamento para el tratamiento de un trastorno mediado por Hsp90; a un método para el tratamiento de un trastorno mediado por Hsp90, utilizando las nuevas formas de sal; a formulaciones que comprenden estas formas de sal, en particular soluciones acuosas adecuadas para administración intravenosa; y a recipientes de vidrio ámbar que se rellenan con estas formulaciones.The present invention relates to novel forms of 5- (2,4-dihydroxy-5-isopropyl-phenyl (-4- (4-morpholin-4-yl-methyl-phenyl) -isoxazol-3) ethyl-amide salt -carboxylic acid, in particular the mesylate, hydrochloride, tartrate, phosphate, and hemi-fumarate salt thereof; to crystalline forms of these salts; to polymorphs of 5- (2,4-dihydroxy-5 acid ethyl amide) -isopropyl-phenyl (-4- (4-morpholin-4-yl-methyl-phenyl) -isoxazol-3-carboxylic acid; to hydrates and polymorphs of the new salt forms mentioned above; to the use of the new salt forms mentioned above; for the manufacture of a medicament for the treatment of an Hsp90 mediated disorder; to a method for the treatment of an Hsp90 mediated disorder, using the new salt forms; to formulations comprising these salt forms, in particular solutions aqueous suitable for intravenous administration; and amber glass containers that are filled with these formulations.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20090151A CU20090151A7 (en) | 2009-08-31 | 2009-08-31 | ADDITION SALTS OF ACID, HYDRATES AND POLYMORPHES OF ETHYL-AMIDA ACID 5- (2,4-DIHIDROXI-5-ISOPROPIL-PHENYL) -4- (4-MORFOLIN-4-IL-METHYL-PHENYL) -ISOXAZOL- 3-CARBOXYL, AND FORMULATIONS THAT UNDERSTAND THESE FORMS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20090151A CU20090151A7 (en) | 2009-08-31 | 2009-08-31 | ADDITION SALTS OF ACID, HYDRATES AND POLYMORPHES OF ETHYL-AMIDA ACID 5- (2,4-DIHIDROXI-5-ISOPROPIL-PHENYL) -4- (4-MORFOLIN-4-IL-METHYL-PHENYL) -ISOXAZOL- 3-CARBOXYL, AND FORMULATIONS THAT UNDERSTAND THESE FORMS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20090151A7 true CU20090151A7 (en) | 2011-04-26 |
Family
ID=44303527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20090151A CU20090151A7 (en) | 2009-08-31 | 2009-08-31 | ADDITION SALTS OF ACID, HYDRATES AND POLYMORPHES OF ETHYL-AMIDA ACID 5- (2,4-DIHIDROXI-5-ISOPROPIL-PHENYL) -4- (4-MORFOLIN-4-IL-METHYL-PHENYL) -ISOXAZOL- 3-CARBOXYL, AND FORMULATIONS THAT UNDERSTAND THESE FORMS |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU20090151A7 (en) |
-
2009
- 2009-08-31 CU CU20090151A patent/CU20090151A7/en unknown
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