CS269952B2 - Method of enduracidine production - Google Patents

Method of enduracidine production Download PDF

Info

Publication number: CS269952B2
Authority: CS; Czechoslovakia
Prior art keywords: enduracidin; fluoro; tyrosine; broth; strain
Prior art date: 1980-10-31

Application number

CS817970A

Other languages

Czech (cs)

English (en)

Other versions

CS797081A2 (en

Inventor

Ikuo Nogami

Hideo Shirafuji

Shigeo Matsumura

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-10-31

Filing date

1981-10-29

Publication date

1990-05-14

1981-10-29 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1989-09-12 Publication of CS797081A2 publication Critical patent/CS797081A2/cs

1990-05-14 Publication of CS269952B2 publication Critical patent/CS269952B2/cs

Links

238000000034 method Methods 0.000 title claims description 13
238000004519 manufacturing process Methods 0.000 title claims description 5
241000971005 Streptomyces fungicidicus Species 0.000 claims abstract description 27
VIIAUOZUUGXERI-UHFFFAOYSA-N 3-fluorotyrosine Chemical compound OC(=O)C(N)CC1=CC=C(O)C(F)=C1 VIIAUOZUUGXERI-UHFFFAOYSA-N 0.000 claims abstract description 17
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 16
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
229910052799 carbon Inorganic materials 0.000 claims description 5
230000003115 biocidal effect Effects 0.000 claims description 4
229910052757 nitrogen Inorganic materials 0.000 claims description 4
238000012258 culturing Methods 0.000 claims description 3
150000003839 salts Chemical class 0.000 claims description 3
239000002253 acid Substances 0.000 claims 1
244000005700 microbiome Species 0.000 abstract description 19
241000187747 Streptomyces Species 0.000 abstract description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 39
235000010633 broth Nutrition 0.000 description 24
229920001817 Agar Polymers 0.000 description 21
239000008272 agar Substances 0.000 description 21
239000000725 suspension Substances 0.000 description 18
239000000203 mixture Substances 0.000 description 16
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 14
239000002609 medium Substances 0.000 description 13
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
239000000243 solution Substances 0.000 description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
238000001914 filtration Methods 0.000 description 11
238000000855 fermentation Methods 0.000 description 10
230000004151 fermentation Effects 0.000 description 10
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
240000008042 Zea mays Species 0.000 description 9
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 9
235000002017 Zea mays subsp mays Nutrition 0.000 description 9
235000005822 corn Nutrition 0.000 description 9
230000003248 secreting effect Effects 0.000 description 9
244000063299 Bacillus subtilis Species 0.000 description 7
235000014469 Bacillus subtilis Nutrition 0.000 description 7
239000013078 crystal Substances 0.000 description 7
239000000284 extract Substances 0.000 description 6
239000002689 soil Substances 0.000 description 6
239000002585 base Substances 0.000 description 5
239000001963 growth medium Substances 0.000 description 5
235000012054 meals Nutrition 0.000 description 5
238000011084 recovery Methods 0.000 description 5
239000011780 sodium chloride Substances 0.000 description 5
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
239000008367 deionised water Substances 0.000 description 4
229910021641 deionized water Inorganic materials 0.000 description 4
108010012631 enduracidin A Proteins 0.000 description 4
239000011521 glass Substances 0.000 description 4
235000015097 nutrients Nutrition 0.000 description 4
238000011218 seed culture Methods 0.000 description 4
108010068370 Glutens Proteins 0.000 description 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
238000002835 absorbance Methods 0.000 description 3
238000005273 aeration Methods 0.000 description 3
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
229910052921 ammonium sulfate Inorganic materials 0.000 description 3
235000011130 ammonium sulphate Nutrition 0.000 description 3
239000003242 anti bacterial agent Substances 0.000 description 3
229940088710 antibiotic agent Drugs 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
239000000706 filtrate Substances 0.000 description 3
239000012458 free base Substances 0.000 description 3
235000021312 gluten Nutrition 0.000 description 3
238000002955 isolation Methods 0.000 description 3
230000035772 mutation Effects 0.000 description 3
230000005855 radiation Effects 0.000 description 3
239000013049 sediment Substances 0.000 description 3
239000007787 solid Substances 0.000 description 3
238000001179 sorption measurement Methods 0.000 description 3
239000008223 sterile water Substances 0.000 description 3
238000003756 stirring Methods 0.000 description 3
239000000126 substance Substances 0.000 description 3
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N Lactic Acid Natural products CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
229910021380 Manganese Chloride Inorganic materials 0.000 description 2
GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
239000000654 additive Substances 0.000 description 2
230000000996 additive effect Effects 0.000 description 2
229910000019 calcium carbonate Inorganic materials 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
229920001429 chelating resin Polymers 0.000 description 2
239000012141 concentrate Substances 0.000 description 2
238000011033 desalting Methods 0.000 description 2
238000009792 diffusion process Methods 0.000 description 2
239000011790 ferrous sulphate Substances 0.000 description 2
235000003891 ferrous sulphate Nutrition 0.000 description 2
235000013312 flour Nutrition 0.000 description 2
230000009036 growth inhibition Effects 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
-1 inorganic acid salts Chemical class 0.000 description 2
229910052816 inorganic phosphate Inorganic materials 0.000 description 2
BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
239000008101 lactose Substances 0.000 description 2
239000011565 manganese chloride Substances 0.000 description 2
235000002867 manganese chloride Nutrition 0.000 description 2
229940099607 manganese chloride Drugs 0.000 description 2
229910000403 monosodium phosphate Inorganic materials 0.000 description 2
235000019799 monosodium phosphate Nutrition 0.000 description 2
231100000219 mutagenic Toxicity 0.000 description 2
230000003505 mutagenic effect Effects 0.000 description 2
150000007524 organic acids Chemical class 0.000 description 2
235000005985 organic acids Nutrition 0.000 description 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
239000011591 potassium Substances 0.000 description 2
229910052700 potassium Inorganic materials 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
229920005989 resin Polymers 0.000 description 2
239000011347 resin Substances 0.000 description 2
230000028327 secretion Effects 0.000 description 2
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
230000002269 spontaneous effect Effects 0.000 description 2
239000008107 starch Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
238000005406 washing Methods 0.000 description 2
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
SRKQWNFPTBNUKE-UHFFFAOYSA-N 1-methyl-1,2-dinitroguanidine Chemical compound [O-][N+](=O)N(C)\C(N)=N/[N+]([O-])=O SRKQWNFPTBNUKE-UHFFFAOYSA-N 0.000 description 1
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
241000193830 Bacillus <bacterium> Species 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
241000192125 Firmicutes Species 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
VZUNGTLZRAYYDE-UHFFFAOYSA-N N-methyl-N'-nitro-N-nitrosoguanidine Chemical compound O=NN(C)C(=N)N[N+]([O-])=O VZUNGTLZRAYYDE-UHFFFAOYSA-N 0.000 description 1
239000001888 Peptone Substances 0.000 description 1
108010080698 Peptones Proteins 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
239000002518 antifoaming agent Substances 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
238000004166 bioassay Methods 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
235000013877 carbamide Nutrition 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
239000010941 cobalt Substances 0.000 description 1
229910017052 cobalt Inorganic materials 0.000 description 1
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
235000012343 cottonseed oil Nutrition 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000001599 direct drying Methods 0.000 description 1
238000004821 distillation Methods 0.000 description 1
238000000921 elemental analysis Methods 0.000 description 1
238000010828 elution Methods 0.000 description 1
NJCUSQKMYNTYOW-MWUYRYRWSA-N enramicina Chemical compound O.N1C(=O)NC(=O)C(C=2C=C(Cl)C(O)=C(Cl)C=2)NC(=O)C(CO)NC(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(CC2N=C(N)NC2)NC(=O)C(CCCNC(N)=O)NC(=O)C(C(C)O)NC(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(C(C)O)NC(=O)N(CCCCN)C(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)/C=C/C=C/CCCCC(C)CC)C(C)OC(=O)C(C=2C=CC(O)=CC=2)NC(=O)C(C)NC(=O)C1CC1CNC(N)=N1 NJCUSQKMYNTYOW-MWUYRYRWSA-N 0.000 description 1
108700041171 enramycin Proteins 0.000 description 1
229950003984 enramycin Drugs 0.000 description 1
CCIVGXIOQKPBKL-UHFFFAOYSA-N ethanesulfonic acid Chemical compound CCS(O)(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-N 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
238000000605 extraction Methods 0.000 description 1
239000012634 fragment Substances 0.000 description 1
238000004108 freeze drying Methods 0.000 description 1
239000008103 glucose Substances 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
229910052748 manganese Inorganic materials 0.000 description 1
239000011572 manganese Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
239000003471 mutagenic agent Substances 0.000 description 1
231100000707 mutagenic chemical Toxicity 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
235000014593 oils and fats Nutrition 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
238000009928 pasteurization Methods 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
PHZLMBHDXVLRIX-UHFFFAOYSA-M potassium lactate Chemical compound [K+].CC(O)C([O-])=O PHZLMBHDXVLRIX-UHFFFAOYSA-M 0.000 description 1
239000001521 potassium lactate Substances 0.000 description 1
235000011085 potassium lactate Nutrition 0.000 description 1
229960001304 potassium lactate Drugs 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
230000028070 sporulation Effects 0.000 description 1
239000007362 sporulation medium Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
229910052720 vanadium Inorganic materials 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
229960001763 zinc sulfate Drugs 0.000 description 1
229910000368 zinc sulfate Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Mycology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CS817970A 1980-10-31 1981-10-29 Method of enduracidine production CS269952B2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP55154393A JPS6038120B2 (ja)	1980-10-31	1980-10-31	抗生物質エンジユラサイジンの製造法

Publications (2)

Publication Number	Publication Date
CS797081A2 CS797081A2 (en)	1989-09-12
CS269952B2 true CS269952B2 (en)	1990-05-14

Family

ID=15583152

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CS817970A CS269952B2 (en)	1980-10-31	1981-10-29	Method of enduracidine production

Country Status (11)

Country	Link
US (1)	US4465771A (es)
EP (1)	EP0055809B1 (es)
JP (1)	JPS6038120B2 (es)
KR (1)	KR870001987B1 (es)
BG (1)	BG44208A3 (es)
BR (1)	BR8107049A (es)
CA (1)	CA1187016A (es)
CS (1)	CS269952B2 (es)
DE (1)	DE3170169D1 (es)
ES (1)	ES506711A0 (es)
HU (1)	HU190358B (es)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4980283A (en) *	1987-10-01	1990-12-25	Merck & Co., Inc.	Renin-inhibitory pepstatin phenyl derivatives
CN101597578B (zh) *	2009-07-01	2011-08-31	南京工业大学	一种安来霉素产生菌及利用大孔树脂提取的方法
CN102391363B (zh) *	2011-09-26	2013-11-13	浙江升华拜克生物股份有限公司	一种恩霉素的提取方法
CN103013977A (zh) *	2012-12-12	2013-04-03	安徽丰原发酵技术工程研究有限公司	一种离子束诱变杀真菌素链霉菌选育恩拉霉素菌株的方法
MX2019006522A (es)	2016-12-06	2020-02-20	Univ Oregon State	Composiciones y metodos para produccion mejorada de enduracidina en una cepa geneticamente modificada de streptomyces fungicidicus.
PE20190967A1 (es) *	2016-12-06	2019-07-08	Intervet Int Bv	Aislados modificados de streptomyces fungicidicus y su uso
CN109266594B (zh) *	2018-09-25	2021-10-26	天津科技大学	一种恩拉霉素高产菌株及其构建方法
CN110157757B (zh) *	2019-02-15	2022-11-25	河北圣雪大成制药有限责任公司	恩拉霉素单组分的产量提高方法、培养基以及分离方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1617881C2 (de) *	1965-10-13	1984-07-05	Takeda Chemical Industries, Ltd., Osaka	Antibiotikum Enduracidin und seine Herstellung
US3697647A (en) *	1967-01-25	1972-10-10	Takeda Chemical Industries Ltd	Feed containing enduracidin

1980
- 1980-10-31 JP JP55154393A patent/JPS6038120B2/ja not_active Expired
1981
- 1981-10-20 CA CA000388357A patent/CA1187016A/en not_active Expired
- 1981-10-22 BG BG053919A patent/BG44208A3/xx unknown
- 1981-10-24 EP EP81108853A patent/EP0055809B1/en not_active Expired
- 1981-10-24 DE DE8181108853T patent/DE3170169D1/de not_active Expired
- 1981-10-29 HU HU813175A patent/HU190358B/hu unknown
- 1981-10-29 CS CS817970A patent/CS269952B2/cs unknown
- 1981-10-30 BR BR8107049A patent/BR8107049A/pt unknown
- 1981-10-30 US US06/316,901 patent/US4465771A/en not_active Expired - Lifetime
- 1981-10-30 ES ES506711A patent/ES506711A0/es active Granted
- 1981-10-31 KR KR1019810004188A patent/KR870001987B1/ko not_active Expired

Also Published As

Publication number	Publication date
US4465771A (en)	1984-08-14
HU190358B (en)	1986-08-28
ES8302097A1 (es)	1983-01-01
ES506711A0 (es)	1983-01-01
BR8107049A (pt)	1982-07-20
KR830007830A (ko)	1983-11-07
CA1187016A (en)	1985-05-14
CS797081A2 (en)	1989-09-12
EP0055809A1 (en)	1982-07-14
EP0055809B1 (en)	1985-04-24
JPS5779896A (en)	1982-05-19
KR870001987B1 (ko)	1987-10-24
JPS6038120B2 (ja)	1985-08-30
BG44208A3 (en)	1988-10-14
DE3170169D1 (en)	1985-05-30

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