CR9669A - Proceso para producir 3-oxo-pregn-4-eno-21, 17 carbolactonas por oxidacion libre de metales de 17-(3-hidroxipropil)-3,17-dihicroxiandrostanos - Google Patents
Proceso para producir 3-oxo-pregn-4-eno-21, 17 carbolactonas por oxidacion libre de metales de 17-(3-hidroxipropil)-3,17-dihicroxiandrostanosInfo
- Publication number
- CR9669A CR9669A CR9669A CR9669A CR9669A CR 9669 A CR9669 A CR 9669A CR 9669 A CR9669 A CR 9669A CR 9669 A CR9669 A CR 9669A CR 9669 A CR9669 A CR 9669A
- Authority
- CR
- Costa Rica
- Prior art keywords
- oxo
- carbolactones
- pregn
- eno
- produce
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000003647 oxidation Effects 0.000 title abstract 2
- 238000007254 oxidation reaction Methods 0.000 title abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- BMAXQBBOPJUDSD-OHPXTLHMSA-N (5S,8R,9S,10S,13S,14S)-17-(3-hydroxypropyl)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol Chemical class OCCCC1(CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@H]2CC(CC[C@]12C)O)O BMAXQBBOPJUDSD-OHPXTLHMSA-N 0.000 abstract 1
- ROTZYFNEYFKWQU-DUGPHZPDSA-N (8R,9S,10S,13S,14S,17S)-10,13-dimethylspiro[2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione Chemical class C([C@H]1[C@H]2[C@@H]([C@]3(CCC(=O)CC3CC2)C)CC[C@@]11C)C[C@]11CCC(=O)O1 ROTZYFNEYFKWQU-DUGPHZPDSA-N 0.000 abstract 1
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 abstract 1
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 abstract 1
- 229960004845 drospirenone Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Este invento se refiere a procesos para producir 3-oxo-pregnano-21,17- carbolactonas de formula II, asi como 3-oxo-pregn-4-eno-21, 17- carbolactonas de formula III por oxidacion libre de metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos de formula I Ademas, la invencion se refiere al hemisolvato en diclorometano de 6b, 7b;15b,16b-dimetileno-3-oxo-17a-pregnan-5b-ol-21, 17- carbolactona (iv) asi como un proceso para producir drospirenona
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/185,984 US7319154B2 (en) | 2005-07-21 | 2005-07-21 | Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes |
| EP05090214.7A EP1746101B2 (de) | 2005-07-21 | 2005-07-21 | Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR9669A true CR9669A (es) | 2008-02-20 |
Family
ID=37434272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR9669A CR9669A (es) | 2005-07-21 | 2008-01-17 | Proceso para producir 3-oxo-pregn-4-eno-21, 17 carbolactonas por oxidacion libre de metales de 17-(3-hidroxipropil)-3,17-dihicroxiandrostanos |
Country Status (22)
| Country | Link |
|---|---|
| EP (2) | EP2527356B1 (es) |
| KR (1) | KR101410583B1 (es) |
| AU (1) | AU2006271885B8 (es) |
| BR (1) | BRPI0613679A2 (es) |
| CA (1) | CA2614804C (es) |
| CR (1) | CR9669A (es) |
| DK (2) | DK2527356T3 (es) |
| EA (1) | EA016411B1 (es) |
| EC (1) | ECSP088124A (es) |
| ES (2) | ES2581735T3 (es) |
| HR (2) | HRP20160853T1 (es) |
| HU (2) | HUE027858T2 (es) |
| IL (1) | IL188619A (es) |
| LT (1) | LT2527356T (es) |
| MX (1) | MX2008000936A (es) |
| NO (1) | NO344680B1 (es) |
| NZ (1) | NZ565247A (es) |
| PL (2) | PL2527356T3 (es) |
| PT (2) | PT2527356T (es) |
| RS (2) | RS54927B1 (es) |
| SI (2) | SI2527356T1 (es) |
| WO (1) | WO2007009821A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0803102A2 (pt) | 2007-05-01 | 2011-11-01 | Sicor Inc | um processo para preparar drospirenona e intermediários da mesma |
| DE102007030596B3 (de) * | 2007-06-28 | 2009-03-12 | Bayer Schering Pharma Aktiengesellschaft | Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden |
| ES2432063T3 (es) * | 2009-06-16 | 2013-11-29 | Crystal Pharma, S.A.U. | Procedimiento para la obtención de 17-espirolactonas en esteroides |
| CN102040650B (zh) * | 2010-10-26 | 2014-03-26 | 西安科技大学 | 串联反应构建甾体-6β,7β-亚甲基结构的方法 |
| ITMI20111383A1 (it) * | 2011-07-25 | 2013-01-26 | Ind Chimica Srl | Processo per la preparazione di drospirenone |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069219A (en) | 1976-12-27 | 1978-01-17 | G. D. Searle & Co. | 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters |
| DE3026783C2 (de) | 1980-07-11 | 1982-07-29 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5β-Hydroxy-δ↑6↑-steroiden |
| DE3042136A1 (de) | 1980-11-03 | 1982-06-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden |
| DE3265852D1 (en) | 1981-09-21 | 1985-10-03 | Schering Ag | 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation |
| DE19633685C1 (de) | 1996-08-12 | 1997-10-09 | Schering Ag | Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens |
| ES2271636T3 (es) * | 2002-08-16 | 2007-04-16 | PHARMACIA & UPJOHN COMPANY LLC | Intermediarios de 5 androsten-3-ol esteroides y procedimientos para su preparacion. |
| ITMI20040367A1 (it) * | 2004-03-01 | 2004-06-01 | Ind Chimica Srl | Processo per la preparazione di drospirenone |
| ITMI20042338A1 (it) | 2004-12-06 | 2005-03-06 | Ind Chimica Srl | Processo per la preparazione di drospirenone |
-
2006
- 2006-07-20 DK DK12165450.3T patent/DK2527356T3/en active
- 2006-07-20 RS RS20160541A patent/RS54927B1/sr unknown
- 2006-07-20 PT PT121654503T patent/PT2527356T/pt unknown
- 2006-07-20 PT PT67627869T patent/PT1910403T/pt unknown
- 2006-07-20 SI SI200632250T patent/SI2527356T1/en unknown
- 2006-07-20 MX MX2008000936A patent/MX2008000936A/es active IP Right Grant
- 2006-07-20 SI SI200632075A patent/SI1910403T1/sl unknown
- 2006-07-20 EP EP12165450.3A patent/EP2527356B1/en active Active
- 2006-07-20 RS RS20180312A patent/RS56982B1/sr unknown
- 2006-07-20 WO PCT/EP2006/007287 patent/WO2007009821A1/en not_active Ceased
- 2006-07-20 KR KR1020087003999A patent/KR101410583B1/ko active Active
- 2006-07-20 ES ES06762786.9T patent/ES2581735T3/es active Active
- 2006-07-20 AU AU2006271885A patent/AU2006271885B8/en active Active
- 2006-07-20 EP EP06762786.9A patent/EP1910403B1/en active Active
- 2006-07-20 HU HUE06762786A patent/HUE027858T2/en unknown
- 2006-07-20 PL PL12165450T patent/PL2527356T3/pl unknown
- 2006-07-20 DK DK06762786.9T patent/DK1910403T3/en active
- 2006-07-20 LT LTEP12165450.3T patent/LT2527356T/lt unknown
- 2006-07-20 CA CA2614804A patent/CA2614804C/en active Active
- 2006-07-20 EA EA200800326A patent/EA016411B1/ru not_active IP Right Cessation
- 2006-07-20 PL PL06762786.9T patent/PL1910403T3/pl unknown
- 2006-07-20 ES ES12165450.3T patent/ES2663399T3/es active Active
- 2006-07-20 BR BRPI0613679-6A patent/BRPI0613679A2/pt not_active Application Discontinuation
- 2006-07-20 HU HUE12165450A patent/HUE038504T2/hu unknown
- 2006-07-20 NZ NZ565247A patent/NZ565247A/en unknown
- 2006-07-20 HR HRP20160853TT patent/HRP20160853T1/hr unknown
-
2008
- 2008-01-07 IL IL188619A patent/IL188619A/en active IP Right Grant
- 2008-01-17 CR CR9669A patent/CR9669A/es unknown
- 2008-01-18 EC EC2008008124A patent/ECSP088124A/es unknown
- 2008-02-20 NO NO20080894A patent/NO344680B1/no unknown
-
2018
- 2018-03-16 HR HRP20180454TT patent/HRP20180454T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DOP2006000172A (es) | Proceso para producir 3-oxo-pregn-4-eno-21,17-carbolactonas por oxidación libre de metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos | |
| CR9669A (es) | Proceso para producir 3-oxo-pregn-4-eno-21, 17 carbolactonas por oxidacion libre de metales de 17-(3-hidroxipropil)-3,17-dihicroxiandrostanos | |
| UA95490C2 (ru) | Стальной лист для производства легких конструкций, способ изготовления этого листа и его применение | |
| MX2009007146A (es) | Conjugados porcion del factor ix-polimero que tienen ligadura que se puede liberar. | |
| MX2009006433A (es) | Procedimiento para la preparación de fluoroalquenos de 3 a 7 átomos de carbono por deshidrohalogenación mediada por base de fluoroalcanos de 3 a 7 átomos de carbono hidrohalogenados. | |
| TW200626261A (en) | Process for the production of valve metal powders | |
| AR056755A1 (es) | ALEACIoN DE COBRE- ZINC Y ANILLO DE SINCRONIZACIoN FABRICADO DE DICHA ALEACIoN | |
| TW200942627A (en) | Low alloyed steel powder | |
| MX2009005813A (es) | Procedimiento para la preparacion de betamimeticos. | |
| MY157193A (en) | Process for production of olefin | |
| MX2008008298A (es) | Sal de sulfato de hidrogeno novedosa. | |
| BR112013010324A2 (pt) | liga ni-fe-cr-mo | |
| TW200613220A (en) | Complex nanofiber, complex nanofiber association, complex structure, and production method thereof | |
| TW200714632A (en) | Manufacture of polytrimethylene ether glycol | |
| TW200640914A (en) | Novel processes for the preparation of a benzofuran | |
| TW200706493A (en) | Method for producing dodecahydrododecaborates | |
| TW200727908A (en) | Herbal composition for treating cancer | |
| WO2008008744A3 (en) | Synthesis of carbon supported platinum-tungsten electrocatalysts | |
| EP1860103A4 (en) | ANTICANCER COMPOUND, ITS INTERMEDIATE AND METHODS OF PRODUCTION | |
| CU23609B7 (es) | Proceso para producir 3-oxo-pregn-4-eno-21,17-carbolactonas por oxidación libre de metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos | |
| GB2439852A (en) | Antenna structures made of bulk-solidifying amorphous alloys | |
| TW200740739A (en) | Process for preparing ethylcyclohexane by selectively hydrogenating 4-vinylcyclohexene | |
| TW200634178A (en) | A manufacturing method for gold nano-particles | |
| TW200600619A (en) | Single crystal metallic silicide-nanowire and method producing the same | |
| RU2006116621A (ru) | Сплав на основе молибдена |