CR8919A - Analogos de tetrapeptidos - Google Patents
Analogos de tetrapeptidosInfo
- Publication number
- CR8919A CR8919A CR8919A CR8919A CR8919A CR 8919 A CR8919 A CR 8919A CR 8919 A CR8919 A CR 8919A CR 8919 A CR8919 A CR 8919A CR 8919 A CR8919 A CR 8919A
- Authority
- CR
- Costa Rica
- Prior art keywords
- tetrapeptide analogs
- tetrapeptide
- analogs
- cancer
- procedures
- Prior art date
Links
Classifications
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/76—Oxygen atoms attached in position 2 or 6
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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Abstract
Se proporcionan compuestos, composiciones y procedimientos para el tratamiento de enfermedades hiperproliferativas, tales como cancer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58747104P | 2004-07-12 | 2004-07-12 | |
| US68387505P | 2005-05-23 | 2005-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR8919A true CR8919A (es) | 2007-08-31 |
Family
ID=35839791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR8919A CR8919A (es) | 2004-07-12 | 2007-02-12 | Analogos de tetrapeptidos |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20100190688A1 (es) |
| EP (3) | EP1773348A4 (es) |
| JP (2) | JP2008505976A (es) |
| KR (1) | KR20070043831A (es) |
| AU (1) | AU2005271831A1 (es) |
| BR (1) | BRPI0513310A (es) |
| CA (1) | CA2573644A1 (es) |
| CR (1) | CR8919A (es) |
| EA (1) | EA200700225A1 (es) |
| GB (1) | GB2430935A (es) |
| IL (1) | IL180677A0 (es) |
| MA (1) | MA28841B1 (es) |
| MX (1) | MX2007000490A (es) |
| NO (1) | NO20070782L (es) |
| TN (1) | TNSN07005A1 (es) |
| WO (1) | WO2006017295A2 (es) |
| ZA (1) | ZA200700357B (es) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5230865B2 (ja) | 2004-07-15 | 2013-07-10 | テトラロジック ファーマシューティカルズ コーポレーション | Iap結合性化合物 |
| KR20120127754A (ko) | 2004-12-20 | 2012-11-23 | 제넨테크, 인크. | Iap의 피롤리딘 억제제 |
| US7517906B2 (en) | 2005-02-25 | 2009-04-14 | Tetralogic Pharmaceuticals Corporation | Dimeric IAP inhibitors |
| CA2607940C (en) | 2005-05-18 | 2009-12-15 | Aegera Therapeutics Inc. | Bir domain binding compounds |
| BRPI0611922A2 (pt) | 2005-06-08 | 2010-10-05 | Novartis Ag | compostos orgánicos |
| BRPI0617751A2 (pt) | 2005-10-25 | 2011-08-02 | Aegera Therapeutics Inc | compostos de ligação do domìnio iap bir |
| US8247557B2 (en) | 2005-12-19 | 2012-08-21 | Genentech, Inc. | IAP inhibitors |
| WO2007101347A1 (en) * | 2006-03-07 | 2007-09-13 | Aegera Therapeutics Inc. | Bir domain binding compounds |
| TWI504597B (zh) | 2006-03-16 | 2015-10-21 | Pharmascience Inc | 結合於細胞凋亡抑制蛋白(iap)之桿狀病毒iap重複序列(bir)區域之化合物 |
| WO2007133865A2 (en) * | 2006-04-11 | 2007-11-22 | Novartis Ag | Hcv/hiv inhibitors an their uses |
| KR101071516B1 (ko) * | 2006-05-05 | 2011-10-10 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 2가 smac 모방체 및 그의 용도 |
| EP2024362A4 (en) | 2006-05-16 | 2012-01-25 | Pharmascience Inc | BINDING COMPOUNDS TO THE IAP BIR DOMAIN |
| BRPI0715195A2 (pt) | 2006-07-24 | 2013-06-11 | Tetralogic Pharm Corp | composto, mÉtodos para induzir e para estimular a apoptose em uma cÉlula, para intensificar a apoptose de cÉlulas patogÊnicas in vivo em um indivÍduo, e para tratar uma doenÇa, e, composiÇço farmacÊutica |
| CL2007002166A1 (es) | 2006-07-24 | 2008-01-25 | Tetralogic Pharm Corp | Compuestos derivados de heterociclos de nitrogeno, antagonistas de los inhibidores de las proteinas de la apoptosis; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento del cancer. |
| EP2099778A2 (en) * | 2006-11-21 | 2009-09-16 | Smithkline Beecham Corporation | Amido anti-viral compounds |
| MX2009005938A (es) | 2006-12-07 | 2009-06-17 | Novartis Ag | 6-oxo-1,6-dihidro-pirimidin-2-ilos en el tratamiento de enfermedades proliferativas. |
| RU2491276C2 (ru) | 2007-04-30 | 2013-08-27 | Дженентек, Инк. | Ингибиторы iap |
| US8835393B2 (en) | 2008-08-02 | 2014-09-16 | Genentech, Inc. | Inhibitors of IAP |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| US20100317593A1 (en) * | 2009-06-12 | 2010-12-16 | Astrazeneca Ab | 2,3-dihydro-1h-indene compounds |
| US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
| US20110034469A1 (en) | 2009-08-04 | 2011-02-10 | Takeda Pharmaceutical Company Limited | Heterocyclic Compound |
| EP2478358A1 (en) | 2009-09-18 | 2012-07-25 | Novartis AG | Biomarkers for iap inhibitor compounds |
| US9284350B2 (en) | 2010-02-12 | 2016-03-15 | Pharmascience Inc. | IAP BIR domain binding compounds |
| WO2012052758A1 (en) | 2010-10-22 | 2012-04-26 | Astrazeneca Ab | Response biomarkers for iap antagonists in human cancers |
| WO2013045458A1 (en) | 2011-09-26 | 2013-04-04 | Preanalytix Gmbh | Stabilisation and isolation of extracellular nucleic acids |
| US11021733B2 (en) | 2011-09-26 | 2021-06-01 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| AU2012314514B2 (en) | 2011-09-26 | 2018-03-15 | Qiagen Gmbh | Stabilisation and isolation of extracellular nucleic acids |
| EP2766345B1 (en) | 2011-10-14 | 2016-03-16 | Bristol-Myers Squibb Company | Substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| SI2766346T1 (sl) | 2011-10-14 | 2017-05-31 | Bristol-Myers Squibb Company | Substituirane tetrahidroizokinolinske spojine kot faktor xia inhibitorji |
| ES2579832T3 (es) | 2011-10-14 | 2016-08-17 | Bristol-Myers Squibb Company | Compuestos de tetrahidroisoquinolina sustituida como inhibidores del factor XIa |
| UA111756C2 (uk) | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
| BR112014027413A2 (pt) | 2012-05-04 | 2017-06-27 | Novartis Ag | biomarcadores para terapia com inibidor de iap |
| AU2013304214A1 (en) * | 2012-08-15 | 2015-02-12 | F. Hoffmann-La Roche Ag | Azaheterocycles as BIR2 and/or BIR3 inhibitors |
| JP6608280B2 (ja) | 2012-09-25 | 2019-11-20 | キアゲン ゲーエムベーハー | 生物学的試料の安定化 |
| EP2906535B1 (en) * | 2012-10-11 | 2018-08-08 | F.Hoffmann-La Roche Ag | Indolines |
| ES2623304T3 (es) * | 2012-10-11 | 2017-07-10 | F. Hoffmann-La Roche Ag | Azaindolinas |
| CN104640860B (zh) * | 2012-10-11 | 2017-05-31 | 霍夫曼-拉罗奇有限公司 | 氮杂二氢吲哚 |
| WO2014059203A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Crystalline forms of a factor xia inhibitor |
| EP2906552B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| US9403774B2 (en) | 2012-10-12 | 2016-08-02 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| CA2896577C (en) * | 2012-11-30 | 2024-01-23 | Sanford-Burnham Medical Research Institute | Inhibitor of apoptosis protein (iap) antagonists |
| US9498532B2 (en) | 2013-03-13 | 2016-11-22 | Novartis Ag | Antibody drug conjugates |
| CN105007950B (zh) | 2013-03-15 | 2019-01-15 | 诺华股份有限公司 | 抗体药物缀合物 |
| EP3447141B1 (en) | 2013-03-18 | 2020-08-05 | PreAnalytiX GmbH | Stabilisation of biological samples |
| JP6407248B2 (ja) | 2013-03-18 | 2018-10-17 | キアゲン ゲーエムベーハー | 細胞外核酸の安定化および単離 |
| WO2014160668A1 (en) | 2013-03-25 | 2014-10-02 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors |
| EP3071562B1 (en) * | 2013-11-18 | 2020-10-14 | F.Hoffmann-La Roche Ag | Tetrahydro-benzodiazepinones |
| CA2974651A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| NO2760821T3 (es) | 2014-01-31 | 2018-03-10 | ||
| ES2893251T3 (es) | 2014-01-31 | 2022-02-08 | Bristol Myers Squibb Co | Macrociclos con grupos P2 heterocíclicos como inhibidores del factor XIa |
| CN106470679A (zh) | 2014-05-12 | 2017-03-01 | 科内图斯医药公司 | 用半胱天冬酶抑制剂治疗慢性肝脏疾病并发症 |
| EP3151920B1 (en) | 2014-06-04 | 2025-08-06 | Sanford-Burnham Medical Research Institute | Use of inhibitor of apoptosis protein (iap) antagonists in hiv therapy |
| WO2016020791A1 (en) | 2014-08-05 | 2016-02-11 | Novartis Ag | Ckit antibody drug conjugates |
| PE20170903A1 (es) | 2014-08-12 | 2017-07-12 | Novartis Ag | Conjugados de farmacos con anticuerpos anti-cdh6 |
| CN107074821B (zh) | 2014-09-04 | 2020-05-22 | 百时美施贵宝公司 | 为fxia抑制剂的二酰胺大环化合物 |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| GB201506872D0 (en) * | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
| WO2016203432A1 (en) | 2015-06-17 | 2016-12-22 | Novartis Ag | Antibody drug conjugates |
| WO2017044592A1 (en) * | 2015-09-08 | 2017-03-16 | The Regents Of The University Of California | Conjugated anticancer smac analogs |
| MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| EP3377645B1 (en) | 2015-11-20 | 2023-10-04 | Qiagen GmbH | Method of preparing sterilized compositions for stabilization of extracellular nucleic acids |
| WO2017117478A1 (en) | 2015-12-31 | 2017-07-06 | Conatus Pharmaceuticals Inc. | Methods of using caspase inhibitors in treatment of liver disease |
| JP2019530696A (ja) | 2016-10-05 | 2019-10-24 | ノバルティス アーゲー | 線維性、硬変性の疾患もしくは障害を治療または予防するためのfxrアゴニストを含む組合せ組成物 |
| JOP20190187A1 (ar) | 2017-02-03 | 2019-08-01 | Novartis Ag | مترافقات عقار جسم مضاد لـ ccr7 |
| US11179413B2 (en) | 2017-03-06 | 2021-11-23 | Novartis Ag | Methods of treatment of cancer with reduced UBB expression |
| WO2018185618A1 (en) | 2017-04-03 | 2018-10-11 | Novartis Ag | Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment |
| AR111651A1 (es) | 2017-04-28 | 2019-08-07 | Novartis Ag | Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación |
| WO2018213634A1 (en) * | 2017-05-17 | 2018-11-22 | Denali Therapeutics Inc. | Compounds, compositions and methods |
| EA201992765A1 (ru) | 2017-05-24 | 2020-03-25 | Новартис Аг | Белки на основе антител с привитым цитокином и способы их применения в лечении рака |
| WO2018215937A1 (en) | 2017-05-24 | 2018-11-29 | Novartis Ag | Interleukin-7 antibody cytokine engrafted proteins and methods of use in the treatment of cancer |
| CN111107868A (zh) | 2017-05-24 | 2020-05-05 | 诺华股份有限公司 | 抗体细胞因子移植蛋白及使用方法 |
| EP3752145A4 (en) * | 2018-02-13 | 2021-11-17 | Cytosite Biopharma Inc. | GRANZYME B IMAGING AND THERAPY DIRECTED AGAINST GRANZYME B |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| LT3820573T (lt) | 2018-07-10 | 2023-11-10 | Novartis Ag | 3-(5-hidroksi-1-oksoizoindolin-2-il)piperidin-2,6-diono dariniai ir jų naudojimas gydyti nuo ikaros šeimos cinko pirštų 2 (ikzf2) priklausomas ligas |
| EP3873532A1 (en) | 2018-10-31 | 2021-09-08 | Novartis AG | Dc-sign antibody drug conjugates |
| CN113271945A (zh) | 2018-12-20 | 2021-08-17 | 诺华股份有限公司 | 包含3-(1-氧代异吲哚啉-2-基)哌啶-2,6-二酮衍生物的给药方案和药物组合 |
| AU2019409132A1 (en) | 2018-12-21 | 2021-07-15 | Novartis Ag | Antibodies to PMEL17 and conjugates thereof |
| US20230132386A9 (en) * | 2019-02-13 | 2023-04-27 | Cytosite Biopharma Inc. | Granzyme b directed imaging and therapy |
| MX2021009764A (es) | 2019-02-15 | 2021-09-08 | Novartis Ag | Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona sustituidos y usos de los mismos. |
| MX2021009763A (es) | 2019-02-15 | 2021-09-08 | Novartis Ag | Derivados de 3-(1-oxo-5-(piperidin-4-il)isoindolin-2-il)piperidina -2,6-diona y usos de los mismos. |
| WO2021023698A1 (en) | 2019-08-02 | 2021-02-11 | Lanthiopep B.V | Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer |
| JP2023507190A (ja) | 2019-12-20 | 2023-02-21 | ノバルティス アーゲー | 増殖性疾患を治療するための抗TGFβ抗体及びチェックポイント阻害薬の使用 |
| AU2021211871A1 (en) | 2020-01-20 | 2022-09-08 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
| US20230181756A1 (en) | 2020-04-30 | 2023-06-15 | Novartis Ag | Ccr7 antibody drug conjugates for treating cancer |
| IL298473A (en) | 2020-06-11 | 2023-01-01 | Novartis Ag | Zbtb32 inhibitors and uses thereof |
| EP4168007A1 (en) | 2020-06-23 | 2023-04-26 | Novartis AG | Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| EP4188549A1 (en) | 2020-08-03 | 2023-06-07 | Novartis AG | Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| GEAP202516217A (en) * | 2020-09-17 | 2025-02-10 | Novartis Ag | Compounds and compositions as sppl2a inhibitors |
| WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
| US11814367B2 (en) | 2021-03-15 | 2023-11-14 | Maze Therapeutics, Inc. | Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof |
| BR112023018676A2 (pt) | 2021-03-18 | 2023-10-10 | Seagen Inc | Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| CA3235132A1 (en) | 2021-04-16 | 2022-10-20 | Novartis Ag | Antibody drug conjugates and methods for making thereof |
| AR125874A1 (es) | 2021-05-18 | 2023-08-23 | Novartis Ag | Terapias de combinación |
| WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
| CN119301125A (zh) | 2022-07-26 | 2025-01-10 | 诺华股份有限公司 | Akr1c3依赖性kars抑制剂的晶型 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3710795A (en) | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| GB1429184A (en) | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
| US4044126A (en) | 1972-04-20 | 1977-08-23 | Allen & Hanburys Limited | Steroidal aerosol compositions and process for the preparation thereof |
| USRE28819E (en) | 1972-12-08 | 1976-05-18 | Syntex (U.S.A.) Inc. | Dialkylated glycol compositions and medicament preparations containing same |
| US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
| US4358603A (en) | 1981-04-16 | 1982-11-09 | Syntex (U.S.A.) Inc. | Acetal stabilized prostaglandin compositions |
| US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| RU2124503C1 (ru) * | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| CA2265853C (en) * | 1996-09-12 | 2010-08-03 | Idun Pharmaceuticals, Inc. | Inhibition of apoptosis using interleukin-1.beta.-converting enzyme (ice)/ced-3 family inhibitors |
| EP2261235A3 (en) * | 1998-03-19 | 2011-04-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of caspases |
| WO2000020440A1 (en) * | 1998-10-06 | 2000-04-13 | Smithkline Beecham Corporation | Caspases and apoptosis |
| US6235877B1 (en) * | 1999-08-04 | 2001-05-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors |
| AR029851A1 (es) * | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
| US6992063B2 (en) * | 2000-09-29 | 2006-01-31 | The Trustees Of Princeton University | Compositions and method for regulating apoptosis |
| CN101029080A (zh) * | 2001-11-21 | 2007-09-05 | 伯纳姆研究院 | 用于对iap抑制卡斯蛋白酶进行去阻遏的方法及组合物 |
| EP1474093A4 (en) * | 2002-02-04 | 2005-02-16 | Merck & Co Inc | Granzyme B INHIBITORS |
| WO2004096838A1 (en) * | 2003-05-02 | 2004-11-11 | Polyphor Ag | Template-fixed peptidomimetics as medicaments against hiv and cancer |
| WO2005069894A2 (en) * | 2004-01-16 | 2005-08-04 | The Regents Of The University Of Michigan | Conformationally constrained smac mimetics and the uses thereof |
| RS53734B1 (sr) * | 2004-07-02 | 2015-06-30 | Genentech Inc. | Inhibitori iap |
-
2005
- 2005-07-12 EA EA200700225A patent/EA200700225A1/ru unknown
- 2005-07-12 MX MX2007000490A patent/MX2007000490A/es unknown
- 2005-07-12 BR BRPI0513310-6A patent/BRPI0513310A/pt not_active Application Discontinuation
- 2005-07-12 EP EP05771672A patent/EP1773348A4/en not_active Withdrawn
- 2005-07-12 WO PCT/US2005/024700 patent/WO2006017295A2/en not_active Ceased
- 2005-07-12 JP JP2007521572A patent/JP2008505976A/ja active Pending
- 2005-07-12 KR KR1020077003279A patent/KR20070043831A/ko not_active Ceased
- 2005-07-12 AU AU2005271831A patent/AU2005271831A1/en not_active Abandoned
- 2005-07-12 CA CA002573644A patent/CA2573644A1/en not_active Abandoned
- 2005-07-12 EP EP11184396A patent/EP2457895A1/en not_active Withdrawn
- 2005-07-12 EP EP11184402A patent/EP2457896A1/en not_active Withdrawn
- 2005-07-12 US US11/632,441 patent/US20100190688A1/en not_active Abandoned
-
2007
- 2007-01-10 MA MA29613A patent/MA28841B1/fr unknown
- 2007-01-11 IL IL180677A patent/IL180677A0/en unknown
- 2007-01-11 TN TNP2007000005A patent/TNSN07005A1/fr unknown
- 2007-01-12 ZA ZA2007/00357A patent/ZA200700357B/en unknown
- 2007-01-12 GB GB0700629A patent/GB2430935A/en not_active Withdrawn
- 2007-02-09 NO NO20070782A patent/NO20070782L/no not_active Application Discontinuation
- 2007-02-12 CR CR8919A patent/CR8919A/es not_active Application Discontinuation
-
2011
- 2011-01-06 JP JP2011000916A patent/JP2011102312A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006017295A2 (en) | 2006-02-16 |
| EP1773348A2 (en) | 2007-04-18 |
| AU2005271831A1 (en) | 2006-02-16 |
| ZA200700357B (en) | 2008-11-26 |
| WO2006017295A3 (en) | 2007-07-12 |
| MA28841B1 (fr) | 2007-09-03 |
| BRPI0513310A (pt) | 2008-05-06 |
| EP1773348A4 (en) | 2009-05-20 |
| CA2573644A1 (en) | 2006-02-16 |
| NO20070782L (no) | 2007-04-02 |
| EP2457896A1 (en) | 2012-05-30 |
| KR20070043831A (ko) | 2007-04-25 |
| GB0700629D0 (en) | 2007-02-21 |
| JP2008505976A (ja) | 2008-02-28 |
| GB2430935A (en) | 2007-04-11 |
| EA200700225A1 (ru) | 2008-02-28 |
| TNSN07005A1 (fr) | 2008-06-02 |
| JP2011102312A (ja) | 2011-05-26 |
| IL180677A0 (en) | 2008-04-13 |
| US20100190688A1 (en) | 2010-07-29 |
| EP2457895A1 (en) | 2012-05-30 |
| MX2007000490A (es) | 2007-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal (granting procedure) |