[go: up one dir, main page]

CR8980A - Nuevas composiciones farmaceuticas que comprenden acido 4- (4-(3-(4-cloro-3-trifluorometil-fenil)-ureido)-3-fluoro-fenoxi)-piridin-2-carboxilico para el tratamiento de trasntornos hiperproliferativos - Google Patents

Nuevas composiciones farmaceuticas que comprenden acido 4- (4-(3-(4-cloro-3-trifluorometil-fenil)-ureido)-3-fluoro-fenoxi)-piridin-2-carboxilico para el tratamiento de trasntornos hiperproliferativos

Info

Publication number
CR8980A
CR8980A CR8980A CR8980A CR8980A CR 8980 A CR8980 A CR 8980A CR 8980 A CR8980 A CR 8980A CR 8980 A CR8980 A CR 8980A CR 8980 A CR8980 A CR 8980A
Authority
CR
Costa Rica
Prior art keywords
pharmaceutical compositions
treatment
hyperproliferative
phenoxi
carboxilico
Prior art date
Application number
CR8980A
Other languages
English (en)
Inventor
Jacques Dumas
Paul Ehrlich
Susanne Zuleger
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35517032&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR8980(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of CR8980A publication Critical patent/CR8980A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

Esta invencion se relaciona con composiciones farmaceuticas novedosas que comprenden una dispersion solida del compuesto de la formula (I), procesos para preparar estas nuevas composiciones farmaceuticas y su uso en el tratamiento de trastornos hiperproliferatios, tal como cancer, ya sea como unico agente o en combinacion con otras terapias.
CR8980A 2004-08-27 2007-03-07 Nuevas composiciones farmaceuticas que comprenden acido 4- (4-(3-(4-cloro-3-trifluorometil-fenil)-ureido)-3-fluoro-fenoxi)-piridin-2-carboxilico para el tratamiento de trasntornos hiperproliferativos CR8980A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60475204P 2004-08-27 2004-08-27

Publications (1)

Publication Number Publication Date
CR8980A true CR8980A (es) 2007-10-22

Family

ID=35517032

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8980A CR8980A (es) 2004-08-27 2007-03-07 Nuevas composiciones farmaceuticas que comprenden acido 4- (4-(3-(4-cloro-3-trifluorometil-fenil)-ureido)-3-fluoro-fenoxi)-piridin-2-carboxilico para el tratamiento de trasntornos hiperproliferativos

Country Status (41)

Country Link
US (2) US20060058358A1 (es)
EP (2) EP2589384A1 (es)
JP (1) JP5017115B2 (es)
KR (1) KR101336737B1 (es)
CN (2) CN101287463A (es)
AR (1) AR050616A1 (es)
AU (1) AU2005279996A1 (es)
BR (1) BRPI0514715B1 (es)
CA (1) CA2578438C (es)
CL (1) CL2010001484A1 (es)
CR (1) CR8980A (es)
CY (1) CY2017038I1 (es)
DK (1) DK1793824T3 (es)
EA (1) EA010832B1 (es)
EC (1) ECSP077299A (es)
ES (1) ES2561618T3 (es)
GT (1) GT200500230A (es)
HN (1) HN2005000484A (es)
HR (1) HRP20160156T1 (es)
HU (2) HUE026654T2 (es)
IL (1) IL181590A (es)
LT (1) LTC1793824I2 (es)
LU (1) LUC00047I2 (es)
MA (1) MA28911B1 (es)
ME (2) MEP35808A (es)
MX (1) MX2007002397A (es)
MY (1) MY191349A (es)
NI (1) NI200700064A (es)
NO (2) NO343937B1 (es)
NZ (1) NZ553557A (es)
PE (2) PE20100432A1 (es)
PL (1) PL1793824T3 (es)
PT (1) PT1793824E (es)
RS (1) RS54580B1 (es)
SI (1) SI1793824T1 (es)
TN (1) TNSN07076A1 (es)
TW (1) TWI369987B (es)
UA (1) UA92472C2 (es)
UY (1) UY29086A1 (es)
WO (1) WO2006026500A1 (es)
ZA (1) ZA200702392B (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
HK1042251B (en) * 1999-01-13 2012-07-20 Bayer Healthcare Llc Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
US20080108672A1 (en) * 2002-01-11 2008-05-08 Bernd Riedl Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors
EP1478358B1 (en) 2002-02-11 2013-07-03 Bayer HealthCare LLC Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis
UY28213A1 (es) * 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
PT1626714E (pt) * 2003-05-20 2007-08-24 Bayer Pharmaceuticals Corp Diarilureias para doenças mediadas por pdgfr
DE602004010407T2 (de) * 2003-07-23 2008-10-16 Bayer Pharmaceuticals Corp., West Haven Fluorsubstituierter omega-carboxyaryldiphenylharnstoff zur behandlung und prävention von krankheiten und leiden
PL1797038T3 (pl) * 2004-09-29 2012-11-30 Bayer Healthcare Llc Termodynamicznie trwała postać tosylanu bay 43-9006
MX2007010856A (es) * 2005-03-07 2007-11-12 Bayer Healthcare Ag Composicion farmaceutica que comprende una difenilurea sustituida con omega-carboxiarilo para el tratamiento del cancer.
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US20080026038A1 (en) * 2006-07-26 2008-01-31 Remington Direct Lp No laxation, low flatulence bulking system
US20090074917A2 (en) * 2006-07-26 2009-03-19 Remington Direct Lp Low-calorie, no laxation bulking system
BRPI0719883A2 (pt) 2006-10-09 2015-05-05 Takeda Pharmaceutical Inibidores de quinase
AR062927A1 (es) * 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
EP1920767A1 (en) * 2006-11-09 2008-05-14 Abbott GmbH & Co. KG Melt-processed imatinib dosage form
CA2667720A1 (en) * 2006-11-09 2008-05-15 Abbott Gmbh & Co. Kg. Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor
CL2008000746A1 (es) 2007-03-14 2008-09-22 Tibotec Pharm Ltd Composicion farmaceutica en solucion que comprende tmc278 y un polimero soluble en agua; proceso de preparacion de dicha composicion; y uso de un polvo que comprende tmc278 para tratar sida.
CN101702878B (zh) * 2007-05-11 2012-11-28 弗·哈夫曼-拉罗切有限公司 可溶性差的药物的药物组合物
US20110033461A1 (en) * 2008-03-12 2011-02-10 Vladimir Ratushny Combination Therapy for the Treatment of Cancer
UA107186C2 (xx) * 2008-12-03 2014-12-10 Тверді форми дозування бендамустину
WO2010068951A1 (en) * 2008-12-12 2010-06-17 Fox Chase Cancer Center Combination therapy based on src and aurora kinase inhibition for the treatment of cancer
JO3112B1 (ar) * 2010-03-29 2017-09-20 Ferring Bv تركيبة دوائية سريعة التحلل
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
KR20130109092A (ko) * 2010-06-09 2013-10-07 아보트 러보러터리즈 키나제 억제제를 함유하는 고체 분산물
SG186981A1 (en) 2010-07-12 2013-02-28 Salix Pharmaceuticals Ltd Formulations of rifaximin and uses thereof
US20130183268A1 (en) 2010-07-19 2013-07-18 Bayer Healthcare Llc Drug combinations with fluoro-substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
MX2013003695A (es) 2010-10-01 2013-05-20 Bayer Ip Gmbh Combinaciones que contienen n-(2-arilamino) arilsulfonamida sustituida.
EP2632436B1 (en) 2010-10-29 2018-08-29 Abbvie Inc. Solid dispersions containing an apoptosis-inducing agent
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
CN103301066B (zh) * 2012-03-15 2018-12-07 苏州泽璟生物制药有限公司 一种改善吸收性能的固体分散体及其制备
JO3479B1 (ar) * 2012-09-06 2020-07-05 Bayer Healthcare Llc تركيبة دوائية مغلفة تحتوي على ريجورافنيب
US9211290B2 (en) * 2012-12-31 2015-12-15 Noven Therapeutics, Llc Solid dispersions of amorphous paroxetine mesylate
IN2013CH04511A (es) * 2013-10-04 2015-04-10 Hetero Research Foundation
CN104721142B (zh) * 2013-12-18 2020-04-28 山东新时代药业有限公司 一种利伐沙班固体分散体及其制备方法
US9790185B2 (en) 2014-07-09 2017-10-17 Shilpa Medicare Limited Process for the preparation of regorafenib and its crystalline forms
CN105267167A (zh) * 2015-09-11 2016-01-27 江苏嘉逸医药有限公司 一种瑞戈非尼口服固体药物组合物的制备方法
CN105330600B (zh) * 2015-11-30 2018-05-22 山东罗欣药业集团股份有限公司 一种瑞戈菲尼的制备方法
CN105879049B (zh) * 2016-05-13 2019-03-26 浙江大学 一种瑞戈非尼与β-环糊精的包合物及其制备方法
CN107661296A (zh) * 2016-07-27 2018-02-06 江苏先声药业有限公司 一种瑞戈非尼固体分散体及其制备方法
KR102494049B1 (ko) 2016-09-30 2023-01-31 샐릭스 파마슈티컬스 인코포레이티드 리팍시민의 고체 분산물 형태
CN111166724A (zh) * 2018-11-09 2020-05-19 北京化工大学 一种瑞戈非尼纳米分散体、片剂及其制备方法
EP3861989A1 (en) 2020-02-07 2021-08-11 Bayer Aktiengesellschaft Pharmaceutical composition containing regorafenib and a stabilizing agent
BR112022017758A2 (pt) * 2020-03-05 2022-11-29 Aurigene Discovery Tech Ltd Composições farmacêuticas de um inibidor de quinase
CN112587485A (zh) * 2021-01-08 2021-04-02 湖南南新制药股份有限公司 一种药物固体分散体及其制备方法
CN112842998A (zh) * 2021-01-19 2021-05-28 深圳市简一生物科技有限公司 一种瑞戈非尼分散剂及其制备方法
FR3123358B1 (fr) * 2021-05-25 2024-05-10 Vecormat Bfc Procédé d’élaboration d’un matériau naturel composite à faible emprunte carbone et fort taux de matière naturelle.
WO2022253945A1 (en) 2021-06-04 2022-12-08 Bayer Aktiengesellschaft Pharmaceutical dosage forms comprising 3-(5-methyl-1,3-thiazol-2-yl)-5-[(3r)-tetrahydrofuran-3-yloxy]-n-{(1r)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}-benzamide
CN114767633B (zh) * 2022-04-07 2023-03-31 郑州大学第一附属医院 含抗乳腺癌药物他莫昔芬的固体分散体、制备方法及制剂
WO2025242583A1 (en) 2024-05-24 2025-11-27 Bayer Consumer Care Ag Novel formulation comprising elinzanetant in a solid dispersion

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151273A (en) * 1974-10-31 1979-04-24 The Regents Of The University Of California Increasing the absorption rate of insoluble drugs
US4220302A (en) 1978-07-21 1980-09-02 Hampton Diane M Nursing bottle holder
JP2527107B2 (ja) * 1991-04-16 1996-08-21 日本新薬株式会社 固体分散体の製造方法
KR100704977B1 (ko) * 1997-12-22 2007-04-09 바이엘 코포레이션 대칭성 및 비대칭성 치환디페닐우레아를 이용한 ｒａｆ키나제의 저해
HUP0004426A3 (en) * 1997-12-22 2001-07-30 Bayer Corp Pittsburgh Inhibition of raf kinase using aryl and heteroaryl substituted heterocyclic ureas
IL136767A0 (en) * 1997-12-22 2001-06-14 Bayer Ag Inhibition of raf kinase using substituted heterocyclic ureas
DZ3004A1 (fr) * 1999-01-13 2004-03-27 Bayer Corp Omega-carboxyaryl diphényl urées substitués comme inhibiteurs de raf kinase.
HK1042251B (en) * 1999-01-13 2012-07-20 Bayer Healthcare Llc Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
WO2000042012A1 (en) * 1999-01-13 2000-07-20 Bayer Corporation φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
JP3789066B2 (ja) 1999-12-08 2006-06-21 三菱電機株式会社 液晶表示装置
RU2002130822A (ru) * 2000-04-19 2004-03-27 Фудзисава Фармасьютикал Ко., Лтд. (JP) Твердая дисперсия с улучшенной абсорбируемостью
US8725620B2 (en) 2000-07-10 2014-05-13 Nobuyoshi Morimoto System and method for negotiating improved terms for products and services being purchased through the internet
CA2418490A1 (en) * 2000-08-11 2002-02-21 Eisai Co., Ltd. Drug-containing solid dispersion having improved solubility
US20040058956A1 (en) 2000-12-11 2004-03-25 Yohko Akiyama Pharmaceutical composition having an improved water solubility
US7235576B1 (en) * 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
CA2434542A1 (en) * 2001-02-13 2002-08-22 Anne Juppo Novel modified release formulation
SE0103838D0 (sv) * 2001-11-16 2001-11-16 Astrazeneca Ab Pharmaceutical formulation & product
US7307071B2 (en) * 2001-12-04 2007-12-11 Onyx Pharmaceuticals, Inc RAF-MEK-ERK pathway inhibitors to treat cancer
US20030207872A1 (en) * 2002-01-11 2003-11-06 Bayer Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
JP2005517690A (ja) * 2002-02-01 2005-06-16 ファイザー・プロダクツ・インク 固体薬物分散物を含有する即時放出剤形
EP1478358B1 (en) * 2002-02-11 2013-07-03 Bayer HealthCare LLC Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis
CA2430180C (en) 2003-05-21 2010-03-16 Royal Group Technologies Limited Cascade shade
DE602004010407T2 (de) * 2003-07-23 2008-10-16 Bayer Pharmaceuticals Corp., West Haven Fluorsubstituierter omega-carboxyaryldiphenylharnstoff zur behandlung und prävention von krankheiten und leiden
WO2006026501A1 (en) * 2004-08-27 2006-03-09 Bayer Pharmaceuticals Corporation New pharmaceutical compositions for the treatment of cancer

Also Published As

Publication number Publication date
EA200700501A1 (ru) 2007-08-31
CA2578438A1 (en) 2006-03-09
PT1793824E (pt) 2016-03-11
CN101287463A (zh) 2008-10-15
US20060058358A1 (en) 2006-03-16
LUC00047I1 (es) 2017-11-15
PL1793824T3 (pl) 2016-06-30
TW200616627A (en) 2006-06-01
IL181590A0 (en) 2007-07-04
JP5017115B2 (ja) 2012-09-05
HN2005000484A (es) 2010-06-08
US20170165243A1 (en) 2017-06-15
SI1793824T1 (sl) 2016-03-31
ES2561618T3 (es) 2016-02-29
UA92472C2 (ru) 2010-11-10
HRP20160156T1 (hr) 2016-03-11
TWI369987B (en) 2012-08-11
DK1793824T3 (en) 2016-02-01
ZA200702392B (en) 2008-11-26
NZ553557A (en) 2010-08-27
MY191349A (en) 2022-06-17
LTC1793824I2 (lt) 2017-06-12
CY2017038I2 (el) 2018-06-27
CA2578438C (en) 2015-10-06
MA28911B1 (fr) 2007-10-01
CN102885813A (zh) 2013-01-23
NO2019033I1 (no) 2019-08-05
HUS1700047I1 (hu) 2017-12-28
EP2589384A1 (en) 2013-05-08
EP1793824B1 (en) 2015-11-18
KR101336737B1 (ko) 2013-12-04
IL181590A (en) 2013-04-30
HUE026654T2 (en) 2016-07-28
KR20070067104A (ko) 2007-06-27
LUC00047I2 (es) 2018-01-10
GT200500230A (es) 2006-03-28
CY2017038I1 (el) 2018-06-27
BRPI0514715B1 (pt) 2021-11-03
PE20060505A1 (es) 2006-06-18
AU2005279996A1 (en) 2006-03-09
UY29086A1 (es) 2006-03-31
ECSP077299A (es) 2007-04-26
NI200700064A (es) 2008-03-03
CL2010001484A1 (es) 2011-04-25
ME00152B (me) 2010-10-10
PE20100432A1 (es) 2010-07-21
EA010832B1 (ru) 2008-12-30
NO20071584L (no) 2007-05-24
MEP35808A (en) 2010-06-10
AR050616A1 (es) 2006-11-08
BRPI0514715A (pt) 2008-06-24
WO2006026500A1 (en) 2006-03-09
MX2007002397A (es) 2007-05-15
EP1793824A1 (en) 2007-06-13
NO343937B1 (no) 2019-07-15
RS54580B1 (sr) 2016-06-30
JP2008511685A (ja) 2008-04-17
TNSN07076A1 (en) 2008-06-02

Similar Documents

Publication Publication Date Title
CR8980A (es) Nuevas composiciones farmaceuticas que comprenden acido 4- (4-(3-(4-cloro-3-trifluorometil-fenil)-ureido)-3-fluoro-fenoxi)-piridin-2-carboxilico para el tratamiento de trasntornos hiperproliferativos
UY31080A1 (es) Derivados de pirazol sustituidos con heteroarilo utiles para tratar trastornos hiperproliferativos y enfermedades asociadas con angiogénesis
CR20190212A (es) 1,2,4-triazolonas 2,4,5-trisustituidas
UY33598A (es) Imidazopiridazinas sustituidas
UY28213A1 (es) Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
UY35040A (es) Pirrolopirimidinilamino-benzotiazolonas sustituidas
MX2007002398A (es) Nuevas composiciones farmaceuticas para el tratamiento de cancer.
HN2012002664A (es) Compuestos, composiciones de tioacetato y metodos de uso
TN2017000467A1 (en) Amido-substituted cyclohexane derivatives
EA201400311A1 (ru) Аминозамещенные имидазопиридазины
CR9034A (es) Preparacion y uso de derivados de acido bifenil-4-il-carbonilamino para el tratamiento de la obesidad
NO20073068L (no) Stereoisomere anrikete 3-aminokarbonylbisykloheptenpyrimidindiaminforindelser og deres anvendelse
ECSP10010615A (es) Derivados de benzofurano, benzotiofeno, benzotiazol como moduladores de fxr
SV2008003045A (es) Aminotetrahidropiranos como inhibidores de dipertidil, peptidasa-iv para el tratamiento o prevencion de diabetes
BR112014000792A2 (pt) compostos de piperidinila para uso como inibidores da tanquirase
UY30220A1 (es) Compuestos de tetrahidropiridotienopirimidina y metodos para su empleo
CO6270298A2 (es) Composiciones para el cuidado del cabello/cuero cabelludo que comprende un surfactante y una mezcla eutecnica
CR20200057A (es) Dihidrooxadiazinonas
UY31780A (es) Fenoxibenzamidas sustituidas
CR9663A (es) Heterociclos de 1,4-dihidropiridina-condensados, procesos para preparar los mismos, uso y composiciones que los contienen
CO7131368A2 (es) (r)-nifuratel, su uso para el tratamiento de infecciones y síntesis de (r) y (s)-nifuratel
DOP2017000146A (es) Pirazolpiridinaminas como inhibidores de mknk1 y mknk2
NI201600006A (es) Pirazolo-piridinaminas sustituidas
CL2011002617A1 (es) Compuestos derivados de arilsulfonamidas 2,5-disustituidas, moduladores del receptor ccr3; composicion farmaceutica que los comprende; y uso del compuesto o de la composicion para prevenir y/o tratar un trastorno inflamatorio o inmunoregulador tal como asma, rinitis, vih, enfermedad de alzheimer, entre otros.
PH12016501932A1 (en) Amido-substituted azole compounds