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CR8769A - Sistemas y procedimientos para unos bioreactores desechables - Google Patents

Sistemas y procedimientos para unos bioreactores desechables

Info

Publication number
CR8769A
CR8769A CR8769A CR8769A CR8769A CR 8769 A CR8769 A CR 8769A CR 8769 A CR8769 A CR 8769A CR 8769 A CR8769 A CR 8769A CR 8769 A CR8769 A CR 8769A
Authority
CR
Costa Rica
Prior art keywords
procedures
systems
disposable bioreactors
disposable
disposable reservoir
Prior art date
Application number
CR8769A
Other languages
English (en)
Inventor
Hodge Geoffrey
Galliher Parrish
Fisher Michael
Original Assignee
Xcellerex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35197799&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR8769(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Xcellerex Inc filed Critical Xcellerex Inc
Publication of CR8769A publication Critical patent/CR8769A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00Bioreactors or fermenters specially adapted for specific uses
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50Mixing receptacles
    • B01F35/513Flexible receptacles, e.g. bags supported by rigid containers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50Mixing receptacles
    • B01F35/53Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
    • B01F35/531Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom
    • B01F35/5312Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom with vertical baffles mounted on the walls
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/14Bags
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02Stirrer or mobile mixing elements
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18Flow directing inserts
    • C12M27/20Baffles; Ribs; Ribbons; Auger vanes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48Automatic or computerized control
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/44Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Computer Hardware Design (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Packages (AREA)

Abstract

Por lo tanto, en una realizacion de la invencion, un sistema bioreactor esta presente e incluye un deposito desechable para alojar biomateriales para su procesamiento, incluyendo el deposito desechable, al menos un puerto de entrada , al menos, un puerto de escape, al menos un puerto de recoleccioon, y la integridad del medio esterilizado esta protegida con unos filtros esterilizados acoplados a todos los puertos externos abiertos.
CR8769A 2004-06-04 2006-11-23 Sistemas y procedimientos para unos bioreactores desechables CR8769A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57714304P 2004-06-04 2004-06-04
US66925205P 2005-04-07 2005-04-07

Publications (1)

Publication Number Publication Date
CR8769A true CR8769A (es) 2007-08-28

Family

ID=35197799

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8769A CR8769A (es) 2004-06-04 2006-11-23 Sistemas y procedimientos para unos bioreactores desechables

Country Status (14)

Country Link
US (1) US7629167B2 (es)
EP (1) EP1773976B2 (es)
JP (1) JP4680990B2 (es)
KR (1) KR101021203B1 (es)
CN (2) CN102492607B (es)
AU (1) AU2005250500B2 (es)
BR (1) BRPI0510648B1 (es)
CA (1) CA2569405C (es)
CR (1) CR8769A (es)
DK (1) DK1773976T4 (es)
ES (1) ES2612212T5 (es)
MX (1) MXPA06014099A (es)
NO (1) NO20070069L (es)
WO (1) WO2005118771A2 (es)

Families Citing this family (239)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL155588A0 (en) * 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
WO2003028869A2 (en) 2001-10-03 2003-04-10 Levtech, Inc. Mixing bag or vessel having a receiver for a fluid-agitating element
US7086778B2 (en) * 2000-10-09 2006-08-08 Levtech, Inc. System using a levitating, rotating pumping or mixing element and related methods
US8182137B2 (en) 2000-10-09 2012-05-22 Atmi Packaging, Inc. Mixing bag or vessel with a fluid-agitating element
US20030100945A1 (en) 2001-11-23 2003-05-29 Mindguard Ltd. Implantable intraluminal device and method of using same in treating aneurysms
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
EP2813281B1 (en) * 2004-01-07 2016-08-17 Pall Technology UK limited Bioprocessing vessel
WO2005108546A2 (en) 2004-04-27 2005-11-17 Baxter International Inc. Stirred-tank reactor system
EP1778390A4 (en) * 2004-06-23 2011-05-25 Levtech Inc MIXER CONTAINER SYSTEMS, DEVICES AND RELATED METHODS
US8603805B2 (en) 2005-04-22 2013-12-10 Hyclone Laboratories, Inc. Gas spargers and related container systems
WO2006119622A1 (en) 2005-05-09 2006-11-16 Saxonia Biotec Gmbh. Apparatus for providing media to cell culture modules
WO2008040568A1 (en) 2006-10-03 2008-04-10 Artelis Mixing system including a flexible bag, specific flexible bag and locating system for the mixing system
WO2008040567A1 (en) * 2006-10-03 2008-04-10 Artelis Flexible mixing bag, mixing device and mixing system
US8790913B2 (en) 2005-10-26 2014-07-29 Pbs Biotech, Inc. Methods of using pneumatic bioreactors
US7628528B2 (en) * 2005-10-26 2009-12-08 PRS Biotech, Inc. Pneumatic bioreactor
DE102006001623B4 (de) * 2006-01-11 2009-05-07 Sartorius Stedim Biotech Gmbh Behälter und Verfahren zum Mischen von Medien
SE531572C2 (sv) * 2006-04-05 2009-05-26 Millipore Ab Engångsenhet för processa produkter
DE102006018824A1 (de) 2006-04-22 2007-10-25 Bayer Technology Services Gmbh Einweg-Bioreaktor
DE102006022307A1 (de) * 2006-05-11 2007-11-15 Respironics Novametrix, LLC, Wallingford Einwegbioreaktor mit Sensoranordnung
CN101460605B (zh) 2006-05-13 2017-09-08 Atmi有限责任公司 一次性生物反应器
EP2044190B1 (en) 2006-06-16 2017-09-13 GE Healthcare Bio-Sciences Corp. Gas delivery configurations, foam control systems, and bag molding methods and articles for collapsible bag vessels and bioreactors
FR2902799B1 (fr) * 2006-06-27 2012-10-26 Millipore Corp Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
EP2049646A2 (en) * 2006-07-14 2009-04-22 Xcellerex, Inc. Environmental containment systems
US8846382B2 (en) 2006-08-01 2014-09-30 Oliver Muecke Airlift bioreactor
US20080032396A1 (en) * 2006-08-02 2008-02-07 Becton, Dickinson And Company Bioreactor and Method
US11827875B2 (en) 2006-08-02 2023-11-28 Finesse Solutions, Inc. Method for manufacturing a composite sensor
US9267100B2 (en) 2006-08-02 2016-02-23 Finesse Solutions, Inc. Composite sensor assemblies for single use bioreactors
US8008065B2 (en) 2006-08-02 2011-08-30 Finesse Solutions, Llc. Disposable bioreactor vessel port
US10227555B2 (en) 2006-08-02 2019-03-12 Finesse Solutions, Inc. Composite sensor assemblies for single use bioreactors
US20080151683A1 (en) * 2006-11-14 2008-06-26 Charles Meadows Stir-bag system with stand and turbulence member
US9658178B2 (en) 2012-09-28 2017-05-23 General Electric Company Sensor systems for measuring an interface level in a multi-phase fluid composition
US10018613B2 (en) 2006-11-16 2018-07-10 General Electric Company Sensing system and method for analyzing a fluid at an industrial site
US9589686B2 (en) 2006-11-16 2017-03-07 General Electric Company Apparatus for detecting contaminants in a liquid and a system for use thereof
US10260388B2 (en) 2006-11-16 2019-04-16 General Electric Company Sensing system and method
US9538657B2 (en) 2012-06-29 2017-01-03 General Electric Company Resonant sensor and an associated sensing method
US10914698B2 (en) 2006-11-16 2021-02-09 General Electric Company Sensing method and system
US9536122B2 (en) 2014-11-04 2017-01-03 General Electric Company Disposable multivariable sensing devices having radio frequency based sensors
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
WO2008079280A1 (en) 2006-12-21 2008-07-03 Millipore Corporation Purification of proteins
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
WO2008101124A1 (en) * 2007-02-15 2008-08-21 Broadley-James Corporation Sterile bioreactor bag with integrated drive unit
US20100075405A1 (en) * 2007-02-15 2010-03-25 Broadley-James Corporation Bioreactor jacket
EP2132534A1 (en) * 2007-02-28 2009-12-16 Xcellerex, Inc. Weight measurements of liquids in flexible containers
US7713730B2 (en) 2007-04-24 2010-05-11 Pbs Biotech, Inc. Pneumatic bioreactor
US9868095B2 (en) 2007-05-02 2018-01-16 Finesse Solutions, Inc. Disposable bioreactor system
US9090398B2 (en) 2007-05-04 2015-07-28 Emd Millipore Corporation Disposable processing bag with alignment feature
KR101553040B1 (ko) * 2007-05-07 2015-09-14 프로탈릭스 리미티드 대규모 폐기 가능한 바이오리액터
CN101743302B (zh) * 2007-06-15 2013-11-13 塞卢升生物技术有限公司 改进的柔性的生物反应器
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
US7832922B2 (en) 2007-11-30 2010-11-16 Levitronix Gmbh Mixing apparatus and container for such
WO2009093997A1 (en) * 2008-01-25 2009-07-30 Xcellerex, Inc. Information acquisition and management systems and methods in bioreactor systems and manufacturing facilities
JP5148718B2 (ja) * 2008-01-25 2013-02-20 エクセレレックス インク. 袋体の皴除去及び漏れ検知システム、及び液体収容のための電磁攪拌システム
CN101977674B (zh) * 2008-03-19 2013-06-19 赛多利斯司特蒂姆生物工艺公司 一次性混合容器
US10767154B2 (en) 2008-03-25 2020-09-08 Global Life Sciences Solutions Usa Llc Temperature controlling surfaces and support structures
US9534196B2 (en) 2009-03-25 2017-01-03 Ge Healthcare Bio-Sciences Corp. Temperature controlled support surfaces for single use flexible wall systems
WO2013106809A1 (en) * 2012-01-13 2013-07-18 Xcellerex, Inc. Temperature controlled support surfaces for single use flexible wall systems
US9340763B2 (en) 2008-03-25 2016-05-17 Ge Healthcare Bio-Sciences Corp. Temperature controlling surfaces and support structures
US20090242173A1 (en) * 2008-03-25 2009-10-01 Peter Mitchell Temperature control system
WO2009132192A2 (en) * 2008-04-25 2009-10-29 Pbs Biotech, Inc. Bioreactor apparatus
US8381780B2 (en) * 2008-05-22 2013-02-26 Xcellerex, Inc. Lift and support assemblies and methods for collapsible bag containers of vessels and bioreactors
DE102008025507A1 (de) 2008-05-28 2009-12-03 Sartorius Stedim Biotech Gmbh Mischsystem
DE102008025968B4 (de) * 2008-05-30 2014-08-21 Sartorius Stedim Biotech Gmbh Bioreaktor mit Kondensator
EP2130905A1 (en) 2008-06-04 2009-12-09 Pharmacell B.V. Method for culturing eukaryotic cells
WO2009151514A1 (en) * 2008-06-11 2009-12-17 Millipore Corporation Stirred tank bioreactor
US8192071B2 (en) 2008-07-16 2012-06-05 Sartorius Stedim Biotech Gmbh Agitator apparatus with collapsible impeller
FR2934371B1 (fr) * 2008-07-25 2012-06-08 Nanotec Solution Dispositif capteur de biomasse a usage unique, procede de realisation de ce dispositif et bioreacteur a usage unique integrant ce capteur
CA2738981C (en) 2008-09-30 2018-07-31 Toray Industries, Inc. Method for producing a chemical product and continuous fermentation apparatus
NZ593235A (en) 2008-11-03 2013-02-22 Crucell Holland Bv Method for the production of recombinant adenovirus serotype 35
GB0820779D0 (en) 2008-11-13 2008-12-17 Artelis S A Cell culture device and method of culturing cells
DK2370561T3 (da) 2008-12-16 2019-10-21 Emd Millipore Corp Omrøringstankreaktor og fremgangsmåde
US20110236932A1 (en) 2008-12-19 2011-09-29 Stobbe Tech A/S Biopharmaceutical plant in a column
DE102009005962A1 (de) 2009-01-23 2010-07-29 Bayer Technology Services Gmbh Begasungssystem
PL2408401T3 (pl) 2009-03-03 2016-10-31 Sposoby, urządzenia i układy dla inżynierii tkanki kostnej z wykorzystaniem bioreaktora
FR2943355B1 (fr) * 2009-03-18 2011-04-08 Sartorius Stedim Biotech Sa Recipient-melangeur avec palier d'arbre en partie superieure
EP2409130B1 (en) * 2009-03-20 2013-12-04 Pbs Biotech, Inc. Automatable aseptic sample withdrawal system
FR2943560B1 (fr) * 2009-03-24 2011-05-27 Jean Pascal Zambaux Bioreacteur jetable et systeme d'agitation a usage unique
DE102009019697A1 (de) * 2009-05-05 2010-11-18 Bayer Technology Services Gmbh Container
EP2251407B1 (en) * 2009-05-12 2016-06-29 Eppendorf AG Disposable bioreactor and method for its production
DE102009050448A1 (de) * 2009-06-19 2011-12-08 Sartorius Stedim Biotech Gmbh Sensorvorrichtung, aufweisend einen optischen Sensor, einen Behälter und ein Kompartimentierungsmittel
AU2010270726A1 (en) 2009-07-06 2012-02-02 Genentech, Inc. Method of culturing eukaryotic cells
AU2010300549B2 (en) 2009-09-30 2014-09-11 Ge Healthcare Bio-Sciences Corp Disposable bioreactor condenser bag and filter heater
US9719705B2 (en) * 2009-09-30 2017-08-01 Ge Healthcare Bio-Sciences Corp. Disposable bioreactor condenser bag and filter heater
FR2950802B1 (fr) * 2009-10-02 2012-02-03 Sartorius Stedim Biotech Sa Elaboration et/ou conservation d'un produit biopharmaceutique.
DE102009052670B4 (de) * 2009-11-12 2017-10-05 Sartorius Stedim Biotech Gmbh Begasungsvorrichtung für Bioreaktoren
AU2010322460B2 (en) * 2009-11-17 2015-05-28 Harvard Apparatus Regenerative Technology, Inc. Bioreactors, systems, and methods for producing and/or analyzing organs
US11773358B2 (en) 2009-12-22 2023-10-03 Cytiva Sweden Ab Method for controlling culture parameters in a bioreactor
WO2011078773A1 (en) 2009-12-22 2011-06-30 Ge Healthcare Bio-Sciences Ab A method for controlling culture parameters in a bioreactor
US8455242B2 (en) 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
CA2790819A1 (en) * 2010-02-25 2011-09-01 Jere Northrop Process and method for optimizing production of food and feed
EP2544809B1 (en) 2010-03-09 2014-10-08 EMD Millipore Corporation Process bag container with sensors
US20130115588A1 (en) * 2010-04-15 2013-05-09 G & G Technologies, Inc. Integrated bioreactor and separation system and methods of use therof
EP3597671B1 (en) 2010-05-17 2022-09-21 EMD Millipore Corporation Stimulus responsive polymers for the purification of biomolecules
US8480292B2 (en) * 2010-06-01 2013-07-09 Boris Dushine Systems, apparatus and methods to reconstitute dehydrated drinks
EP2591088B1 (en) * 2010-07-05 2021-04-21 BPC Instruments AB System for biological fermentation
DE102010036193A1 (de) * 2010-09-02 2012-03-08 Sartorius Stedim Biotech Gmbh Vorrichtung zur kontaktlosen Übertragung elektrischer Energie für Bioreaktorbauteile
WO2012040574A1 (en) 2010-09-23 2012-03-29 Xcellerex, Inc. Single use slurrying and chromatography systems
CN102559491A (zh) * 2010-10-14 2012-07-11 杨凯 一种用于百合籽球培养的鼓泡式生物反应器
US8542023B2 (en) 2010-11-09 2013-09-24 General Electric Company Highly selective chemical and biological sensors
JP2014501537A (ja) * 2011-01-11 2014-01-23 エクセラレックス,インコーポレーテッド 直線的拡張性を有する使い捨て型バイオリアクタシステム
MY148876A (en) * 2011-01-14 2013-06-14 Univ Sains Malaysia A cell culture tank.
EP2484750A1 (en) * 2011-02-07 2012-08-08 Ecole Polytechnique Fédérale de Lausanne (EPFL) Monitoring system for cell culture
JP5923529B2 (ja) * 2011-03-18 2016-05-24 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 細胞培養用可撓性バッグ
WO2012130334A1 (de) 2011-04-01 2012-10-04 Siemens Aktiengesellschaft Einweg-bioreaktor und sensorsystem für einen bioreaktor
DE102011007013B4 (de) 2011-04-07 2015-08-27 Siemens Aktiengesellschaft Einweg-Bioreaktor
US8668886B2 (en) * 2011-04-24 2014-03-11 Therapeutic Proteins International, LLC Separative bioreactor
US9284841B1 (en) * 2011-07-14 2016-03-15 Julie C. Vickers Disposable heat exchanger assembly for sterile and aseptic biotechnology and pharmaceutical manufacturing applications
CN202786257U (zh) * 2011-08-31 2013-03-13 通用电气健康护理生物科学股份公司 用于生物反应器的排气过滤装置
US9732312B2 (en) * 2011-09-01 2017-08-15 Gicon Grossmann Ingenieur Consult Gmbh Method and device for feeding gases or gas mixtures into a liquid, suspension or emulsion in a reactor in a specific manner
US8183035B1 (en) * 2011-09-07 2012-05-22 Therapeutic Proteins International, LLC Single container manufacturing of biological product
US9376655B2 (en) 2011-09-29 2016-06-28 Life Technologies Corporation Filter systems for separating microcarriers from cell culture solutions
JP6101698B2 (ja) 2011-09-30 2017-03-22 ライフ テクノロジーズ コーポレイション フィルムスパージャを有する容器
CN104105788B (zh) * 2011-10-07 2016-09-21 帕尔技术英国有限公司 流体工艺控制系统及相关方法
CN103975055B (zh) * 2011-10-10 2016-05-04 德国达斯其普信息与程序技术有限公司 包括生物反应器的生物技术装置、用于生物反应器的排出气体温度控制装置以及用于处理生物技术装置中的排出气流的方法
JP6133883B2 (ja) 2011-11-04 2017-05-24 日東電工株式会社 薬物送達用の脂質ナノ粒子の生成方法
US9475686B2 (en) * 2012-03-07 2016-10-25 Ge Healthcare Bio-Sciences Corp. Disposable valve and flexible containers for pressurized bioreactors
US9339764B2 (en) * 2012-03-12 2016-05-17 Uchicago Argonne, Llc Internal gas and liquid distributor for electrodeionization device
US9284521B2 (en) 2012-03-24 2016-03-15 Therapeutic Proteins International, LLC Pivoting pressurized single-use bioreactor
US9339026B2 (en) 2012-06-14 2016-05-17 Therapeutic Proteins International, LLC Pneumatically agitated and aerated single-use bioreactor
US10598650B2 (en) 2012-08-22 2020-03-24 General Electric Company System and method for measuring an operative condition of a machine
US9746452B2 (en) 2012-08-22 2017-08-29 General Electric Company Wireless system and method for measuring an operative condition of a machine
US10684268B2 (en) 2012-09-28 2020-06-16 Bl Technologies, Inc. Sensor systems for measuring an interface level in a multi-phase fluid composition
KR101247515B1 (ko) * 2012-10-15 2013-03-26 김창수 버섯종균 배양장치
EP2926076B1 (en) * 2012-12-03 2020-06-03 Global Life Sciences Solutions USA LLC Temperature controlling surfaces and support structures
CN103028336A (zh) * 2012-12-29 2013-04-10 上海乐纯生物技术有限公司 配液袋子
HK1219964A1 (zh) 2013-03-08 2017-04-21 Genzyme Corporation 治疗性蛋白药物物质的整合连续制造
KR101948536B1 (ko) * 2013-04-19 2019-04-22 이엠디 밀리포어 코포레이션 일회용 바이오리액터 내의 신축성 필름 배플
JP6454694B2 (ja) 2013-06-05 2019-01-16 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 使い捨て容器及び容器を含む混合システム
US10076753B2 (en) * 2013-06-12 2018-09-18 Ge Healthcare Bio-Sciences Corp. Disposable container and mixing system comprising the container
CN105683356B (zh) * 2013-06-17 2019-06-25 通用电气健康护理生物科学股份公司 带有温度传感器的生物反应器系统
AU2014302144B2 (en) 2013-06-28 2017-08-17 Saint-Gobain Performance Plastics Corporation Mixing assemblies including magnetic impellers
US11944946B2 (en) 2013-06-28 2024-04-02 Saint-Gobain Performance Plastics Corporation Mixing assemblies including magnetic impellers
EP3041927B1 (en) 2013-09-06 2018-02-28 GE Healthcare Bio-Sciences AB Cell culture bag with internal dialysis membrane
EP3046644A4 (en) * 2013-09-16 2017-08-09 F. Hoffmann-La Roche AG Bioreactors with multiple or adjustable -position agitator designs
EP3031901B1 (en) * 2013-10-11 2017-09-27 Panasonic Healthcare Holdings Co., Ltd. Culture apparatus
US20160272930A1 (en) * 2013-10-14 2016-09-22 Algalo Industries Ltd. Algae growth system and method
DK3065691T3 (da) 2013-12-10 2021-02-01 Abec Inc Steril engangsbeholder med en aftagelig fastgørelsesindretning
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
DE102014101839B4 (de) * 2014-02-13 2018-03-15 Sartorius Stedim Biotech Gmbh Verpackung für einen flexiblen Behälter und Transporteinheit
WO2015142405A1 (en) 2014-03-21 2015-09-24 Life Technologies Corporation Gas filter systems for fluid processing systems
EP3868856B1 (en) 2014-03-21 2023-10-25 Life Technologies Corporation Condenser systems for fluid processing systems
JP6020513B2 (ja) * 2014-05-29 2016-11-02 横河電機株式会社 細胞培養バッグおよび細胞培養バッグの製造方法
US9079690B1 (en) 2014-06-26 2015-07-14 Advanced Scientifics, Inc. Freezer bag, storage system, and method of freezing
US9587215B2 (en) 2014-08-07 2017-03-07 General Electric Company Devices, systems and methods for automated transfer of a sample
US9457306B2 (en) * 2014-10-07 2016-10-04 Life Technologies Corporation Regulated vacuum off-gassing of gas filter for fluid processing system and related methods
DE102014117658B4 (de) * 2014-12-02 2023-02-16 Sartorius Stedim Biotech Gmbh Mischvorrichtung mit Strömungsbrecher
CA2979723A1 (en) * 2015-04-13 2016-10-20 Rosemount Analytical Inc. Single-use bioreactor port with multiple sensors
JP6723563B2 (ja) * 2015-04-20 2020-07-15 グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー ウイルスの不活性化
US11052165B2 (en) 2015-04-20 2021-07-06 Global Life Sciences Solutions Usa Llc Method for virus clearance
DE102015007061B4 (de) * 2015-06-02 2023-12-14 Sartorius Stedim Biotech Gmbh System, Vorrichtung und Verfahren zum Aufnehmen eines Einwegbeutels
DE102015110894B3 (de) * 2015-07-06 2016-09-01 Sartorius Stedim Biotech Gmbh Verfahren zum Messen einer Mehrzahl von Zustandsparametern eines in einem Behälter enthaltenen Fluids
JP6764221B2 (ja) * 2015-07-22 2020-09-30 株式会社日立製作所 攪拌装置
US10047596B2 (en) 2015-07-23 2018-08-14 General Electric Company System and method for disposal of water produced from a plurality of wells of a well-pad
US10323494B2 (en) 2015-07-23 2019-06-18 General Electric Company Hydrocarbon production system and an associated method thereof
US10077646B2 (en) 2015-07-23 2018-09-18 General Electric Company Closed loop hydrocarbon extraction system and a method for operating the same
US9920292B2 (en) 2015-08-31 2018-03-20 General Electric Company System and method for initiating a cell culture
CN115029246B (zh) * 2015-10-01 2025-06-03 思拓凡瑞典有限公司 过滤器保持装置
US10836989B2 (en) * 2015-10-16 2020-11-17 Global Life Sciences Solutions Usa Llc Disposable container, mixing system and packaging
KR20180074775A (ko) 2015-10-26 2018-07-03 론자 리미티드 생물약제의 생산을 위한 제조 설비
EP3374501B1 (en) 2015-11-11 2023-07-12 Lonza Ltd Crispr-associated (cas) proteins with reduced immunogenicity
US10576393B2 (en) * 2015-12-18 2020-03-03 General Electric Company System and method for condensing moisture in a bioreactor gas stream
CN105413554B (zh) * 2015-12-25 2018-09-18 奥星制药设备(石家庄)有限公司 基于一次性无菌袋的配液平台及其搅拌配制和转运方法
WO2017116910A1 (en) 2015-12-29 2017-07-06 Life Technologies Corporation Flexible bioprocessing container with partial dividing partition
WO2017123788A2 (en) * 2016-01-12 2017-07-20 Sarfaraz Niazi Multipurpose bioreactor
KR102593407B1 (ko) 2016-03-02 2023-10-24 론자 리미티드 개선된 발효 공정
US10689873B2 (en) 2016-03-10 2020-06-23 Lonza Ltd Customizable facility
BR112018068281A2 (pt) 2016-03-10 2019-04-02 Lonza Ag instalação personalizável
US20180010082A1 (en) * 2016-06-03 2018-01-11 Lonza Ltd Bioreactor With Higher Agitation Rates
SG11201810780XA (en) 2016-06-03 2018-12-28 Lonza Ag Single use bioreactor
JP2019517272A (ja) 2016-06-10 2019-06-24 ロンザ リミテッドLonza Limited タンパク質の安定化方法
SG11201810286WA (en) 2016-06-24 2018-12-28 Lonza Ag Variable diameter bioreactors
US11359176B2 (en) 2016-07-12 2022-06-14 Global Life Sciences Solutions Usa Llc Microfluidic device for cell culture monitoring
IL264374B2 (en) 2016-08-02 2024-03-01 Lonza Ag Customizable facility
EP3485280A1 (en) 2016-08-12 2019-05-22 Lonza Ltd Proteomic analysis of host cell proteins
US10808216B2 (en) 2016-10-05 2020-10-20 Lonza Ltd Reactor surface finish remediation
US20200054972A1 (en) 2016-11-17 2020-02-20 Andrew Bryce Filter assembly with filter lock design
WO2018092000A1 (en) 2016-11-17 2018-05-24 Lonza Ltd. Filter moving device
US10589197B2 (en) 2016-12-01 2020-03-17 Life Technologies Corporation Microcarrier filter bag assemblies and methods of use
US10436338B2 (en) 2016-12-09 2019-10-08 Lonza Ltd Rupture disks for bioreactors and methods of using same
WO2018107099A1 (en) 2016-12-09 2018-06-14 Lonza Ltd Method for the reduction of viral titer in pharmaceuticals
US11643627B2 (en) 2016-12-29 2023-05-09 Cytiva Sweden Ab Housing for holding a flexible bioprocess bag
CA3050477A1 (en) 2017-01-18 2018-07-26 Lonza Ltd Methods for evaluating monoclonality
US20190360980A1 (en) 2017-02-03 2019-11-28 Lonza Ltd Methods of analyzing pluralities of cells and detecting protein sequence variants in biological product manufacturing
JP2020505940A (ja) 2017-02-10 2020-02-27 ロンザ リミテッドLonza Limited 細胞培養システム及び方法
KR102701102B1 (ko) 2017-02-17 2024-08-29 론자 리미티드 생물학적 생성물 변이체의 생산 방법
EP3583205A1 (en) 2017-02-17 2019-12-25 Lonza Ltd Mammalian cells for producing adeno-associated viruses
CN119242587A (zh) 2017-02-17 2025-01-03 隆萨有限公司 难以表达的蛋白质的多位点特异性整合细胞
US10244406B2 (en) 2017-03-07 2019-03-26 Lonza Ltd. Wireless sensor information monitoring
ES2684630B2 (es) * 2017-03-30 2019-07-02 Inversiones Hiki6 S L Método, programa informático y planta multifuncional, modular y móvil de mezcla y envasado
KR102447734B1 (ko) 2017-04-07 2022-09-28 에피본, 인크. 접종 및 배양용 시스템 및 방법
US11054362B2 (en) * 2017-04-10 2021-07-06 David Robert Howland System and method for bacterial detection using film formation promotion with enhanced corrosion imbalance
JP7780858B2 (ja) 2017-06-16 2025-12-05 ロンザ リミテッド 生物製剤の製造のためのユニバーサル自己調節性哺乳動物細胞株プラットフォーム
US11788048B2 (en) 2017-09-19 2023-10-17 Life Technologies Corporation Systems and methods for a collapsible chamber with foldable mixing element
JP7335873B2 (ja) 2017-09-29 2023-08-30 ロンザ リミテッド バイオリアクターシステムにおいて使用するための灌流装置
US11623200B2 (en) 2017-10-03 2023-04-11 Abec, Inc. Reactor systems
CN111344558A (zh) 2017-10-06 2020-06-26 龙沙有限公司 使用拉曼光谱法自动控制细胞培养
WO2019077623A1 (en) * 2017-10-17 2019-04-25 Shree Biocare Solutions Pvt. Ltd. An improved disposable bioreactor
KR102589415B1 (ko) 2017-11-20 2023-10-16 론자 리미티드 락테이트 축적을 방지하면서 세포 배양물을 증식하는 방법 및 시스템
WO2019113050A1 (en) 2017-12-05 2019-06-13 Lonza Ltd Methods of assaying tropolone
MX2020006860A (es) 2017-12-28 2020-11-11 Locus Ip Co Llc Reactores y metodos de fermentacion sumergida para producir productos a base de microbios.
ES2871818T3 (es) 2018-02-02 2021-11-02 Lonza Ag Métodos de selección celular y modificación del metabolismo celular
US12152227B2 (en) 2018-04-20 2024-11-26 Global Life Sciences Solutions Usa Llc Multiport plate for a bioprocess bag
WO2019209805A1 (en) * 2018-04-27 2019-10-31 Baxter International Inc. Method of mixing a pharmaceutical solution and mixing system
US11447730B2 (en) 2018-05-30 2022-09-20 Global Life Sciences Solutions Usa Llc Bioreactor system and method of bioprocessing
US20210230531A1 (en) * 2018-06-05 2021-07-29 Vbc Holdings Llc Automated and dynamically adjustable gas mixer for bioreactor system
CN120174006A (zh) 2018-07-13 2025-06-20 隆萨有限公司 用于通过降低内源性蛋白质的水平来改善生物产物的生产的方法
WO2020028616A1 (en) 2018-08-02 2020-02-06 Lonza Ltd Methods for manufacturing recombinant protein comprising a disulfide bond
US10220361B1 (en) 2018-08-03 2019-03-05 Boris Dushine Magnetic stirring system for the automated and optimized reconstitution of powdered infant formulations and methods of using same
US10350561B1 (en) 2018-08-03 2019-07-16 Boris Dushine Magnetic stirring system for wine aeration and method of using same
WO2020041454A1 (en) 2018-08-21 2020-02-27 Lonza Ltd A process for creating reference data for predicting concentrations of quality attributes
EP3843869A1 (en) 2018-08-31 2021-07-07 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
EP3844288A1 (en) 2018-10-01 2021-07-07 Lonza Ltd. Ssi cells with predictable and stable transgene expression and methods of formation
GB201816897D0 (en) * 2018-10-17 2018-11-28 Ge Healthcare Bio Sciences Corp A Bioreactor System
KR102076363B1 (ko) * 2018-10-29 2020-02-11 바이오퍼스글로벌(주) 일회용 생물 발효기
US11065589B2 (en) 2018-12-10 2021-07-20 Pall Corporation Radially driven agitator
GB201900741D0 (en) 2019-01-18 2019-03-06 Synpromics Ltd Liver-specifc inducible prometers and methods of use thereof
EP3914691A1 (en) * 2019-01-25 2021-12-01 Enzene Biosciences Ltd. Automated integrated continuous system and bioprocess for producing therapeutic protein
EP3917661A4 (en) * 2019-02-01 2022-12-14 Abec, Inc. REACTOR SYSTEMS
US12188002B2 (en) * 2019-02-08 2025-01-07 Georgia Tech Research Corporation Sensing systems
US11965152B2 (en) 2019-02-11 2024-04-23 Lonza Ltd. Buffer formulation method and system
DE102019110061B4 (de) * 2019-04-16 2023-11-30 Sartorius Stedim Biotech Gmbh Bioprozessbeutel für eine bioprozesstechnische Anlage
EP3963044A2 (en) * 2019-05-02 2022-03-09 Global Life Sciences Solutions USA LLC Bioprocessing system and consumable bag for a bioprocessing system
US20210016287A1 (en) * 2019-07-16 2021-01-21 Ge Healthcare Bio-Sciences Corp. Reinforced bioreactor component structure system for cell cultivation
KR20220097910A (ko) 2019-11-14 2022-07-08 론자 리미티드 세포 선택 방법
US11535421B2 (en) * 2019-12-30 2022-12-27 Global Life Sciences Solutions Usa Llc System and method for packaging a bioprocessing bag and associated components, and packaging for a bioprocessing bag
KR20220123463A (ko) 2020-01-10 2022-09-06 론자 워커스빌 아이엔씨. 생물학적 공정 및 세포 집단을 정제하기 위한 필터 장치 및 방법
JP2023519925A (ja) 2020-03-26 2023-05-15 アスクレピオス バイオファーマシューティカル, インコーポレイテッド フォルスコリン誘導性プロモーター及び低酸素誘導性プロモーター
EP4136237A1 (en) 2020-04-15 2023-02-22 Asklepios Biopharmaceutical, Inc. Forskolin-inducible promoters and hypoxia-inducible promoters
JP2024501109A (ja) * 2020-11-30 2024-01-11 コーニング インコーポレイテッド 細胞培養培地調整容器および灌流バイオリアクタシステム
EP4244330B1 (en) 2020-12-18 2025-02-19 Lonza Biologics Inc. Sterile disconnect for bioprocess systems and method for using same
NL2027815B1 (en) 2021-03-23 2022-10-07 Academisch Ziekenhuis Leiden Genomic integration
US11752509B2 (en) 2021-06-17 2023-09-12 Upside Foods, Inc. Fluid dispenser for recovering material from a surface
KR20240074761A (ko) 2021-09-15 2024-05-28 사니슈어, 인크. 저용량 자기 혼합 시스템
JP2025522723A (ja) 2022-06-28 2025-07-17 アムジエン・インコーポレーテツド 治療用製品製造のためのフレキシブルな施設構成
DE102022117005A1 (de) * 2022-07-07 2024-01-18 Bausch + Ströbel SE + Co. KG Pumpvorrichtung und Pumpanordnung mit mindestens einer Pumpvorrichtung
EP4655378A1 (en) * 2023-01-26 2025-12-03 Metabogal Scientific Consulting Ltd. Bioreactor bag and systems and methods of using same
KR20250160929A (ko) * 2023-03-13 2025-11-14 글로벌 라이프 사이언시즈 솔루션즈 유에스에이 엘엘씨 선형 스케일 가능 바이오반응기 시스템
CN116948817A (zh) * 2023-05-06 2023-10-27 四川大学 一次性生物安全型生物反应器以及监测方法

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE200792C (es) 1907-09-28
US2793166A (en) * 1952-10-18 1957-05-21 Bristol Lab Inc Stirring device for laboratory fermenters
US2956739A (en) * 1957-02-13 1960-10-18 Tothill Gordon Roy Variable pitch impellers and closure seals therefor
US2958517A (en) * 1958-04-28 1960-11-01 Bellco Glass Inc Vessel for tissue culture and the like comprising a magnetic stirrer
US4162855A (en) * 1974-11-18 1979-07-31 Spectroderm International, Inc. Magnetic stirrer apparatus
SE397637B (sv) * 1976-03-09 1977-11-14 Wik G Magnetomrorare
FR2376898A1 (fr) 1977-01-10 1978-08-04 Schick Josef Procede et installation pour la production microbiologique de proteines d'unicellulaires a partir d'ethanol
JPH0634698B2 (ja) * 1984-02-04 1994-05-11 オリンパス光学工業株式会社 反応分析装置
FR2569994B1 (fr) * 1984-09-13 1986-11-21 Technicatome Dispositif de melange mobile
JPS6350311Y2 (es) 1984-11-16 1988-12-23
US4620794A (en) * 1984-11-20 1986-11-04 Jule Inc. Gradient formers
DE3577578D1 (de) 1985-02-01 1990-06-13 Maerkl Herbert Folienfermenter.
US4668632A (en) 1985-02-06 1987-05-26 Vxr, Inc. Sparger and apparatus for and method of growing cells
JPS62503003A (ja) * 1985-05-29 1987-12-03 モスコフスキ テフノロギチエスキ インステイテユト ミアスノイ イ モロチノイ プロミシユレンノステイ バリ−ク半製品の保存方法
US4882062A (en) * 1986-08-29 1989-11-21 Rainin Instrument Co., Inc. Solvent mixing chamber for a liquid chromatography system
US4830511A (en) * 1986-10-29 1989-05-16 The Coca-Cola Company Postmix juice dispensing system
DE3874532T2 (de) * 1987-03-02 1993-02-04 Ionode Pty Ltd Mischungsgeraet und -verfahren.
GB2202549A (en) 1987-03-20 1988-09-28 Philip John Whitney Foldable fermenter
JPS63233773A (ja) * 1987-03-23 1988-09-29 Reika Kogyo Kk 培養装置
JPS63278539A (ja) * 1987-05-11 1988-11-16 Tosoh Corp 液分注装置
US4808348A (en) * 1987-05-14 1989-02-28 The Coca-Cola Company Microgravity carbonator
JPS63283570A (ja) * 1987-05-15 1988-11-21 Daido Sanso Kk 発酵槽
US5081035A (en) * 1988-04-18 1992-01-14 The University Of Michigan Bioreactor system
IL86442A (en) 1988-05-19 1992-02-16 Plant Biotec Ltd Air lift fermenter formed from flexible plastic sheets
US5075234A (en) * 1988-11-02 1991-12-24 Josefino Tunac Fermentor/bioreactor systems having high aeration capacity
US5028142A (en) * 1989-04-06 1991-07-02 Biotrack, Inc. Reciprocal mixer
JPH03160983A (ja) * 1989-11-21 1991-07-10 Toshiba Corp 培養装置
WO1991019944A1 (fr) * 1990-06-14 1991-12-26 Kiichi Hirata Dispositif pour fabriquer une emulsion et systeme de combustion de celle-ci
US5156701A (en) * 1990-08-20 1992-10-20 Denco Inc. Total containment welding of plastic tubes
US5401212A (en) * 1990-08-29 1995-03-28 Intelligent Enclosures Corporation Environmental control system
US5205783A (en) * 1991-08-22 1993-04-27 Accu*Aire Systems, Inc. Air flow control equipment in chemical laboratory buildings
US5183336A (en) * 1992-01-21 1993-02-02 Kontes Glass Company Stirring assembly
US5664938A (en) * 1992-03-05 1997-09-09 Yang; Frank Jiann-Fu Mixing apparatus for microflow gradient pumping
IT1258959B (it) * 1992-06-09 1996-03-11 Impianto a moduli mobili per lo sviluppo e la produzione di prodotti biotecnologici su scala pilota
US5227138A (en) * 1992-09-09 1993-07-13 Virginia Mason Clinic Blood transport apparatus
US5240322A (en) * 1992-09-23 1993-08-31 Habley Medical Technology Corporation Pharmaceutical mixing container with rotatable vaned internal magnetic mixing element
US5352036A (en) * 1992-09-23 1994-10-04 Habley Medical Technology Corporation Method for mixing and dispensing a liquid pharmaceutical with a miscible component
US5261742A (en) * 1993-02-23 1993-11-16 Eastman Kodak Company Air-powered apparatus and method for mixing a liquefied sample and weighing the sample
US5368390A (en) * 1993-03-01 1994-11-29 General Signal Corporation Mixer systems
JP2663327B2 (ja) * 1993-05-20 1997-10-15 哲夫 西田 培養処理槽及びこれを併設した水処理施設
US5342781A (en) * 1993-07-15 1994-08-30 Su Wei Wen W External-loop perfusion air-lift bioreactor
IL110456A0 (en) * 1993-07-30 1994-10-21 Du Pont Apparatus for multiphase liquid separation
US5591344A (en) 1995-02-13 1997-01-07 Aksys, Ltd. Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof
AU4927496A (en) * 1995-02-21 1996-09-11 Iqbal W. Siddiqi Apparatus and method for mixing and separation employing magnetic particles
US6500343B2 (en) * 1995-02-21 2002-12-31 Iqbal W. Siddiqi Method for mixing and separation employing magnetic particles
US5478149A (en) * 1995-04-24 1995-12-26 Magnetic Mixers, Inc. Magnetic mixer
JPH09141079A (ja) 1995-11-15 1997-06-03 Shiseido Co Ltd 水溶性両親媒性高分子電解質からなる乳化剤、これを配合した乳化組成物及び乳化化粧料
IL119310A (en) 1996-09-26 1999-07-14 Metabogal Ltd Cell/tissue culturing device and method
US5779359A (en) * 1996-12-05 1998-07-14 General Signal Corporation Mixer having exposed clean-in-place bearing assemblies
US5758965A (en) * 1996-12-05 1998-06-02 General Signal Corporation Mixer system
JP3705461B2 (ja) * 1996-12-26 2005-10-12 富士写真フイルム株式会社 ハロゲン化銀乳剤の製造方法及びハロゲン化銀写真乳剤
EP1011752B1 (en) 1997-05-20 2004-10-13 Zymequest, Inc. Cell processing system and method for controlling it
KR100234283B1 (ko) * 1997-08-27 1999-12-15 윤종용 습식현상기의 현상액 공급 시스템
US5939313A (en) * 1997-09-12 1999-08-17 Praxair Technology, Inc. Stationary vortex system for direct injection of supplemental reactor oxygen
CN1064403C (zh) * 1997-12-31 2001-04-11 华南理工大学 管道气升式磁处理光生物反应器微藻生产系统及监控方法
US6247840B1 (en) * 1998-01-15 2001-06-19 Shaik A. Gaffar Dialysis container with sample saver
AU6021699A (en) 1998-09-01 2000-03-21 Penn State Research Foundation Method and apparatus for aseptic growth or processing of biomass
US6086243A (en) * 1998-10-01 2000-07-11 Sandia Corporation Electrokinetic micro-fluid mixer
US8026096B1 (en) 1998-10-08 2011-09-27 Protein Sciences Corporation In vivo active erythropoietin produced in insect cells
US6379625B1 (en) * 1999-12-23 2002-04-30 Peter Zuk, Jr. Apparatus comprising a disposable device and reusable instrument for synthesizing chemical compounds, and for testing chemical compounds for solubility
US6416215B1 (en) * 1999-12-14 2002-07-09 University Of Kentucky Research Foundation Pumping or mixing system using a levitating magnetic element
US6432698B1 (en) * 1999-01-06 2002-08-13 Rutgers, The State University Disposable bioreactor for culturing microorganisms and cells
US6391698B1 (en) * 1999-02-26 2002-05-21 United Microelectronics Corp. Forming complementary metal-oxide semiconductor with gradient doped source/drain
US6132309A (en) * 1999-03-10 2000-10-17 Panelli; Paul Giulo Modular clean room plenum
DE19917398C2 (de) 1999-04-16 2002-06-20 Accoris Gmbh Modulares chemisches Mikrosystem
IL129564A (en) * 1999-04-23 2004-06-20 Atlantium Lasers Ltd A method for disinfecting and purifying liquids and gases and a device for its use
US6357907B1 (en) * 1999-06-15 2002-03-19 V & P Scientific, Inc. Magnetic levitation stirring devices and machines for mixing in vessels
CA2379773C (en) * 1999-07-19 2009-01-20 Organon Teknika B.V. Device and method for mixing magnetic particles with a fluid
FR2799138B1 (fr) 1999-10-05 2002-02-08 Opifex Reacteur pour la realisation de cultures cellulaires ou de micro-organismes ou pour la mise en solution ou en suspension de poudre dans un milieu liquide
US6758593B1 (en) * 2000-10-09 2004-07-06 Levtech, Inc. Pumping or mixing system using a levitating magnetic element, related system components, and related methods
US6402367B1 (en) * 2000-06-01 2002-06-11 Aemp Corporation Method and apparatus for magnetically stirring a thixotropic metal slurry
WO2003028869A2 (en) 2001-10-03 2003-04-10 Levtech, Inc. Mixing bag or vessel having a receiver for a fluid-agitating element
US6837613B2 (en) * 2001-04-10 2005-01-04 Levtech, Inc. Sterile fluid pumping or mixing system and related method
AU783125B2 (en) 2000-10-31 2005-09-29 Dsm Ip Assets B.V. Optimisation of fermentation processes
US6544788B2 (en) 2001-02-15 2003-04-08 Vijay Singh Disposable perfusion bioreactor for cell culture
US6467946B1 (en) * 2001-04-24 2002-10-22 Dade Microscan Inc. Method and apparatus for mixing liquid samples in a container using rotating magnetic fields
JP2002350500A (ja) * 2001-05-24 2002-12-04 Mitsubishi Electric Corp 半導体集積回路装置
US6670171B2 (en) * 2001-07-09 2003-12-30 Wheaton Usa, Inc. Disposable vessel
US20030170810A1 (en) * 2001-09-18 2003-09-11 Masoud Vedadi Methods and apparatuses for purification
US7595043B2 (en) * 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US6736906B2 (en) 2002-04-10 2004-05-18 International Business Machines Corporation Turbine part mount for supercritical fluid processor
US20030198128A1 (en) * 2002-04-19 2003-10-23 Carlson Roger W. Mixing system having non-contacting bearings
US6837610B2 (en) * 2002-09-27 2005-01-04 Ilc Dover Lpp Bioprocess container, bioprocess container mixing device and method of use thereof
US6673598B1 (en) * 2002-10-29 2004-01-06 Synthecon, Inc. Disposable culture bag
US7144727B2 (en) * 2003-04-14 2006-12-05 Synthecon, Inc. Interlinked culture chamber for biologicals
US20040229335A1 (en) * 2003-05-15 2004-11-18 Introgen Therapeutics, Inc. Methods and compositions for the production of adenoviral vectors
US7168848B2 (en) * 2003-07-02 2007-01-30 Spx Corporation Axial-pumping impeller apparatus and method for magnetically-coupled mixer
US20050076076A1 (en) * 2003-08-08 2005-04-07 Liberty Logistics Inc. Collaborative logistics information exchange method and apparatus
EP2813281B1 (en) * 2004-01-07 2016-08-17 Pall Technology UK limited Bioprocessing vessel
WO2005108546A2 (en) * 2004-04-27 2005-11-17 Baxter International Inc. Stirred-tank reactor system

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CA2569405A1 (en) 2005-12-15
AU2005250500A1 (en) 2005-12-15
AU2005250500B2 (en) 2011-06-23
JP2008501347A (ja) 2008-01-24
KR20070053200A (ko) 2007-05-23
CN102492607B (zh) 2014-12-10
CA2569405C (en) 2011-05-03
NO20070069L (no) 2007-03-05
HK1112479A1 (en) 2008-09-05
EP1773976A2 (en) 2007-04-18
EP1773976B2 (en) 2020-01-01
BRPI0510648A (pt) 2007-11-20
US20050272146A1 (en) 2005-12-08
EP1773976B1 (en) 2016-12-07
DK1773976T4 (da) 2020-02-10
BRPI0510648B1 (pt) 2016-04-26
MXPA06014099A (es) 2007-05-09
WO2005118771A2 (en) 2005-12-15
ES2612212T3 (es) 2017-05-12
CN101001945B (zh) 2012-02-08
US7629167B2 (en) 2009-12-08
CN101001945A (zh) 2007-07-18
KR101021203B1 (ko) 2011-03-11
ES2612212T5 (es) 2020-06-25
DK1773976T3 (en) 2017-01-30
CN102492607A (zh) 2012-06-13
JP4680990B2 (ja) 2011-05-11

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