CR8389A - CD20 ANTIBODIES WITH EFFECTOR FUNCTION AND LINK AFFINITY TO THE IMPROVED FC RECEIVER - Google Patents
CD20 ANTIBODIES WITH EFFECTOR FUNCTION AND LINK AFFINITY TO THE IMPROVED FC RECEIVERInfo
- Publication number
- CR8389A CR8389A CR8389A CR8389A CR8389A CR 8389 A CR8389 A CR 8389A CR 8389 A CR8389 A CR 8389A CR 8389 A CR8389 A CR 8389A CR 8389 A CR8389 A CR 8389A
- Authority
- CR
- Costa Rica
- Prior art keywords
- relates
- abm
- present
- antibodies
- effector function
- Prior art date
Links
- 239000012636 effector Substances 0.000 title abstract 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 title 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000009109 Fc receptors Human genes 0.000 abstract 1
- 108010087819 Fc receptors Proteins 0.000 abstract 1
- 101100495232 Homo sapiens MS4A1 gene Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invencion se refiere a moleculas de enlace a antigenos (ABM). En modalidades particulares, la presente invencion se refiere a anticuerpos monoclonales recombinantes, incluyendo anticuerpos quimericos, primatizados o humanizados especificos para el CD20 humano. Ademas la presente invencion se refiere a moleculas de acidos nucleicos que codifican tales ABM, y vectores y celulas hospederas que comprenden tales moleculas de acidos nucleicos. La invencion se refiere ademas a metodos de uso de estas ABM en el tratamiento de la enfermedad. Ademas, la presente invencion se refiere a ABM con glicosilacion modificada que tiene propiedades terapeuticas modificadas, incluyendo anticuerpos con funcion del efector incrementada y enlace al receptor Fc incrementado.The present invention relates to antigen binding molecules (ABM). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human CD20. In addition, the present invention relates to nucleic acid molecules encoding such ABM, and host vectors and cells comprising such nucleic acid molecules. The invention also relates to methods of use of these ABM in the treatment of the disease. In addition, the present invention relates to ABM with modified glycosylation having modified therapeutic properties, including antibodies with increased effector function and increased Fc receptor binding.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51709604P | 2004-11-05 | 2004-11-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR8389A true CR8389A (en) | 2006-10-05 |
Family
ID=44839338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR8389A CR8389A (en) | 2004-11-05 | 2006-05-10 | CD20 ANTIBODIES WITH EFFECTOR FUNCTION AND LINK AFFINITY TO THE IMPROVED FC RECEIVER |
Country Status (1)
| Country | Link |
|---|---|
| CR (1) | CR8389A (en) |
-
2006
- 2006-05-10 CR CR8389A patent/CR8389A/en unknown
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