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CR7899A - Compuestos de triciclicos inhbidores de proteina quinasa para mejorar la eficacia de agentes antienoplasticos y derivados de diazenpamdionilo como inhibidores de quinasa - Google Patents

Compuestos de triciclicos inhbidores de proteina quinasa para mejorar la eficacia de agentes antienoplasticos y derivados de diazenpamdionilo como inhibidores de quinasa

Info

Publication number
CR7899A
CR7899A CR7899A CR7899A CR7899A CR 7899 A CR7899 A CR 7899A CR 7899 A CR7899 A CR 7899A CR 7899 A CR7899 A CR 7899A CR 7899 A CR7899 A CR 7899A
Authority
CR
Costa Rica
Prior art keywords
diazenpamdionilo
antienoplastic
inhibiting
effectiveness
derivatives
Prior art date
Application number
CR7899A
Other languages
English (en)
Inventor
Ninkovic Sacha
John Bennett Michael
Yuanjin Rui Eugene
Wang Fen
Pritchett Benedict Suzanne
Teng Min
Wang Yong
Zhu Jinjiang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CR7899A publication Critical patent/CR7899A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Proteina quinasas, tales como CHK-1, que inhiben compuestos triciclicos de la siguiente formula (en la que R2, R3 y R4 son como se han definido en la memoria descriptiva) composiciones farmaceuticas que contienen cantidades eficaces de dichos compuestos o sus sales son utiles como un unico agente o en combinacion con un agente anti-neoplasico o radiacion que tienen un efecto antineoplasico para tratar enfermedades o afecciones tales como canceres.
CR7899A 2003-01-09 2005-07-08 Compuestos de triciclicos inhbidores de proteina quinasa para mejorar la eficacia de agentes antienoplasticos y derivados de diazenpamdionilo como inhibidores de quinasa CR7899A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43939603P 2003-01-09 2003-01-09

Publications (1)

Publication Number Publication Date
CR7899A true CR7899A (es) 2005-08-05

Family

ID=32713475

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7899A CR7899A (es) 2003-01-09 2005-07-08 Compuestos de triciclicos inhbidores de proteina quinasa para mejorar la eficacia de agentes antienoplasticos y derivados de diazenpamdionilo como inhibidores de quinasa

Country Status (34)

Country Link
US (3) US6967198B2 (es)
EP (2) EP1585749B1 (es)
JP (1) JP3990718B2 (es)
KR (1) KR100697746B1 (es)
CN (1) CN1759118B (es)
AP (1) AP2048A (es)
AT (1) ATE404564T1 (es)
AU (1) AU2004203977B2 (es)
BR (1) BRPI0406701A (es)
CA (1) CA2512683C (es)
CR (1) CR7899A (es)
CY (1) CY1108408T1 (es)
DE (1) DE602004015724D1 (es)
DK (1) DK1585749T3 (es)
EA (1) EA009337B1 (es)
EC (1) ECSP055911A (es)
ES (1) ES2309484T3 (es)
GE (1) GEP20084367B (es)
HR (1) HRP20050624A2 (es)
IL (1) IL169082A (es)
IS (1) IS7884A (es)
MA (1) MA27703A1 (es)
MX (1) MXPA05007352A (es)
NO (1) NO20053775L (es)
NZ (1) NZ540638A (es)
OA (1) OA13017A (es)
PL (1) PL378372A1 (es)
PT (1) PT1585749E (es)
RS (1) RS20050522A (es)
SI (1) SI1585749T1 (es)
TN (1) TNSN05176A1 (es)
UA (1) UA80733C2 (es)
WO (1) WO2004063198A1 (es)
ZA (1) ZA200504674B (es)

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US7645885B2 (en) * 2005-08-26 2010-01-12 The Regents Of The University Of California Non-steroidal antiandrogens
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ATE542813T1 (de) * 2008-08-06 2012-02-15 Pfizer 6-substituierte 2- heterocyclylaminopyrazinverbindungen als chk-1- inhibitoren
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US8663210B2 (en) 2009-05-13 2014-03-04 Novian Health, Inc. Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy
US8211901B2 (en) 2009-05-22 2012-07-03 Shenzhen Chipscreen Biosciences Ltd. Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
CN101906076B (zh) 2009-06-04 2013-03-13 深圳微芯生物科技有限责任公司 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用
KR20140053013A (ko) 2011-05-06 2014-05-07 자프겐 인크. 삼환식 설폰아마이드 화합물 그리고 그의 제조방법 및 그를 이용하는 방법
WO2013096687A1 (en) * 2011-12-22 2013-06-27 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs in combination with chk1 inhibitors for treating cancer
CA2860340C (en) 2011-12-31 2017-04-25 Beigene, Ltd. Fused tetra or penta-cyclic pyridophthalazinones as parp inhibitors
NZ624063A (en) * 2011-12-31 2016-09-30 Beigene Ltd Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as parp inhibitors
CN102746211B (zh) * 2012-06-27 2015-05-27 上海泰坦化学有限公司 一种取代吲哚-3-甲醛类化合物的制备方法
TWI633107B (zh) * 2013-05-22 2018-08-21 開曼群島商百濟神州生物科技有限公司 作為ｐａｒｐ抑制劑的稠合四或五環二氫二氮呯并咔唑酮
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CN110087730B (zh) 2016-09-27 2023-03-28 百济神州(苏州)生物科技有限公司 使用包含parp抑制剂的组合产品治疗癌症
JP6541635B2 (ja) * 2016-10-28 2019-07-10 ベイジーン リミテッド Ｐａｒｐ阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン
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Also Published As

Publication number Publication date
BRPI0406701A (pt) 2005-12-20
KR100697746B1 (ko) 2007-03-22
RS20050522A (sr) 2007-12-31
PL378372A1 (pl) 2006-04-03
AU2004203977A1 (en) 2004-07-29
MA27703A1 (fr) 2006-01-02
EA009337B1 (ru) 2007-12-28
ES2309484T3 (es) 2008-12-16
NO20053775L (no) 2005-09-16
EA200500893A1 (ru) 2006-02-24
JP3990718B2 (ja) 2007-10-17
US20060004052A1 (en) 2006-01-05
AP2005003353A0 (en) 2005-09-30
ATE404564T1 (de) 2008-08-15
HK1086257A1 (en) 2006-09-15
CA2512683A1 (en) 2004-07-29
AP2048A (en) 2009-09-24
US6967198B2 (en) 2005-11-22
AU2004203977B2 (en) 2010-06-17
US20070135415A1 (en) 2007-06-14
TNSN05176A1 (fr) 2007-06-11
ECSP055911A (es) 2005-11-22
IS7884A (is) 2005-06-09
ZA200504674B (en) 2006-07-26
US7132533B2 (en) 2006-11-07
GEP20084367B (en) 2008-05-13
UA80733C2 (en) 2007-10-25
CN1759118A (zh) 2006-04-12
SI1585749T1 (sl) 2008-10-31
CA2512683C (en) 2010-03-16
DK1585749T3 (da) 2008-09-22
PT1585749E (pt) 2008-10-23
EP1947102A1 (en) 2008-07-23
KR20050092397A (ko) 2005-09-21
MXPA05007352A (es) 2006-02-17
CN1759118B (zh) 2010-12-08
JP2006516274A (ja) 2006-06-29
NZ540638A (en) 2007-12-21
EP1585749A1 (en) 2005-10-19
US7462713B2 (en) 2008-12-09
EP1585749B1 (en) 2008-08-13
OA13017A (en) 2006-11-10
NO20053775D0 (no) 2005-08-08
US20050075499A1 (en) 2005-04-07
HRP20050624A2 (en) 2006-02-28
CY1108408T1 (el) 2014-02-12
WO2004063198A1 (en) 2004-07-29
DE602004015724D1 (de) 2008-09-25
IL169082A (en) 2011-02-28

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