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CR7431A - Proceso para la sintesis de piperazinas n-arilicas quirales - Google Patents

Proceso para la sintesis de piperazinas n-arilicas quirales

Info

Publication number
CR7431A
CR7431A CR7431A CR7431A CR7431A CR 7431 A CR7431 A CR 7431A CR 7431 A CR7431 A CR 7431A CR 7431 A CR7431 A CR 7431A CR 7431 A CR7431 A CR 7431A
Authority
CR
Costa Rica
Prior art keywords
aryl
chiral
piperazins
synthesis
preparation
Prior art date
Application number
CR7431A
Other languages
English (en)
Inventor
Ivo Jirkovsky
Gregg Brian Feigelson
Joseph Zeldis
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR7431A publication Critical patent/CR7431A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Un proceso para la preparacion de piperazinas N-arilicas con cadenas laterales quirales que tienen la estructura que se muestra en la formula abajo, y para la preparacion de compuestos intermedios para las mismas: (Formula I). En este proceso, se introduce la quiralidad en el paso de formacion del anillo de piperazina y la sustitucion de 2-aminopiridilo se incorpora mediante desplazamiento. Las piperazinas N, N-disustituidas resultantes actuan en el sistema nervioso central en los receptores de 5HT.
CR7431A 2002-03-12 2004-08-24 Proceso para la sintesis de piperazinas n-arilicas quirales CR7431A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36343102P 2002-03-12 2002-03-12

Publications (1)

Publication Number Publication Date
CR7431A true CR7431A (es) 2008-07-29

Family

ID=28041762

Family Applications (1)

Application Number Title Priority Date Filing Date
CR7431A CR7431A (es) 2002-03-12 2004-08-24 Proceso para la sintesis de piperazinas n-arilicas quirales

Country Status (23)

Country Link
US (1) US6713626B2 (es)
EP (1) EP1483255B1 (es)
JP (1) JP4391241B2 (es)
KR (1) KR20040105765A (es)
CN (2) CN1304388C (es)
AR (1) AR038930A1 (es)
AT (1) ATE439356T1 (es)
AU (1) AU2003220094B2 (es)
BR (1) BR0308377A (es)
CA (1) CA2477892C (es)
CR (1) CR7431A (es)
DE (1) DE60328756D1 (es)
EC (1) ECSP045290A (es)
ES (1) ES2329122T3 (es)
IL (1) IL163827A0 (es)
MX (1) MXPA04008729A (es)
NO (1) NO20044050L (es)
NZ (1) NZ535168A (es)
RU (1) RU2315762C2 (es)
TW (1) TW200403231A (es)
UA (1) UA79273C2 (es)
WO (1) WO2003078417A1 (es)
ZA (1) ZA200408202B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060223824A1 (en) * 2000-11-28 2006-10-05 Wyeth Serotonergic agents
US20060287335A1 (en) * 2000-11-28 2006-12-21 Wyeth Serotonergic agents for treating sexual dysfunction
ATE424825T1 (de) 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
JP4397693B2 (ja) * 2002-03-12 2010-01-13 ワイス Ｎ１−（２’−ピリジル）−１，２−アルカンジアミンスルファミン酸の合成および生物学的に活性なピペラジンの合成におけるその使用
US7091349B2 (en) * 2002-03-12 2006-08-15 Wyeth Process for synthesizing N-aryl piperazines with chiral N′-1-[benzoyl(2-pyridyl)amino]-2-propane substitution
US7361773B2 (en) * 2002-03-12 2008-04-22 Wyeth Preparation of N1-(2'-pyridyl)-1,2-propanediamine sulfamic acid and its use in the synthesis of biologically active piperazines
CA2477906A1 (en) * 2002-03-12 2003-09-25 Ivo Jirkovsky Process for making chiral 1,4-disubstituted piperazines
US20050209245A1 (en) * 2004-03-19 2005-09-22 Wyeth Process for preparing N-aryl-piperazine derivatives
US20050215561A1 (en) * 2004-03-19 2005-09-29 Krishnendu Ghosh Pharmaceutical dosage forms and compositions
US20070099931A1 (en) * 2004-03-19 2007-05-03 Wyeth Pharmaceutical dosage forms and compositions
EP1853593A1 (en) * 2005-03-01 2007-11-14 Wyeth Crystalline and amorphous 4-cyano-n{(2r)-2-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-propyl}-n-pyridin-2-yl-benzamide hydrochloride
CN117003693B (zh) * 2022-05-05 2026-01-30 四川大学华西医院 一类哌啶衍生物及其制备方法和用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE81975T1 (de) 1984-12-21 1992-11-15 Duphar Int Res Arzneimittel mit psychotroper wirkung.
JPH01125357A (ja) 1987-11-06 1989-05-17 Dainippon Pharmaceut Co Ltd トリペプチドの誘導体
AU645681B2 (en) * 1991-05-02 1994-01-20 John Wyeth & Brother Limited Piperazine derivatives
GB9125900D0 (en) * 1991-12-05 1992-02-05 Wyeth John & Brother Ltd Piperazine derivatives
WO1994024115A1 (fr) * 1993-04-16 1994-10-27 Santen Pharmaceutical Co., Ltd. Nouveau derive de piperazine
GB9411099D0 (en) * 1994-06-03 1994-07-27 Wyeth John & Brother Ltd Piperazine derivatives
ES2180638T3 (es) 1994-06-03 2003-02-16 Wyeth John & Brother Ltd Nuevos procedimientos e intermediarios para la preparacion de derivados de piperazina.
GB9413772D0 (en) * 1994-07-08 1994-08-24 Wyeth John & Brother Ltd 5-HT1A ligands
GB9514901D0 (en) * 1995-07-20 1995-09-20 American Home Prod Piperazine derivatives
DE69716900T2 (de) 1996-04-10 2003-07-03 Merck & Co., Inc. Alpha v Beta 3 ANTAGONISTEN
US6469007B2 (en) 2000-11-28 2002-10-22 Wyeth Serotonergic agents

Also Published As

Publication number Publication date
BR0308377A (pt) 2005-01-11
US6713626B2 (en) 2004-03-30
AU2003220094A1 (en) 2003-09-29
AR038930A1 (es) 2005-02-02
ATE439356T1 (de) 2009-08-15
MXPA04008729A (es) 2005-07-13
ES2329122T3 (es) 2009-11-23
AU2003220094B2 (en) 2009-04-23
KR20040105765A (ko) 2004-12-16
JP4391241B2 (ja) 2009-12-24
CN1982307A (zh) 2007-06-20
WO2003078417A1 (en) 2003-09-25
TW200403231A (en) 2004-03-01
DE60328756D1 (de) 2009-09-24
JP2005526775A (ja) 2005-09-08
US20030187265A1 (en) 2003-10-02
CN1304388C (zh) 2007-03-14
UA79273C2 (en) 2007-06-11
EP1483255B1 (en) 2009-08-12
RU2004130300A (ru) 2005-04-10
ZA200408202B (en) 2007-03-28
IL163827A0 (en) 2005-12-18
ECSP045290A (es) 2004-10-26
EP1483255A1 (en) 2004-12-08
NZ535168A (en) 2006-03-31
NO20044050L (no) 2004-09-24
CA2477892C (en) 2010-11-23
RU2315762C2 (ru) 2008-01-27
CN1642936A (zh) 2005-07-20
CA2477892A1 (en) 2003-09-25

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)