CR20170371A - Compuestos de benzoxaboral 4-sustituidos y uso de los mismos - Google Patents
Compuestos de benzoxaboral 4-sustituidos y uso de los mismosInfo
- Publication number
- CR20170371A CR20170371A CR20170371A CR20170371A CR20170371A CR 20170371 A CR20170371 A CR 20170371A CR 20170371 A CR20170371 A CR 20170371A CR 20170371 A CR20170371 A CR 20170371A CR 20170371 A CR20170371 A CR 20170371A
- Authority
- CR
- Costa Rica
- Prior art keywords
- compounds
- substituted
- benzoxaboral
- same
- ch2ch2ch3
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010062207 Mycobacterial infection Diseases 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000002179 anti-microbacterial effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000027531 mycobacterial infectious disease Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se proporcionan benzoxaboroles sustituidos cuya est ructura comprende la fórmula I I I : en donde R3 se selecciona a part ir de ¿CH3 , ¿CH2CH3 , ¿CH2 =CH2 ,¿CH2CH2CH3, ¿CH(CH3 )2, ¿CH2CH2 =CH2 y ciclopropilo, R1 y R2 se seleccionan cada uno independientemente a partir de H, -CH3 ,-CH2CH3 , ¿CH2CH2CH3 y ¿CH(CH3 ) 2 ; composiciones que contienen estos compuestos, su uso en terapia, incluyendo su uso como agentes anti -micobacterianos, por ejemplo, en el tratamiento de una infección micobacteriana en un mamífero, y los métodos para la preparación de estos compuestos.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15382056 | 2015-02-12 | ||
| EP15382054 | 2015-02-12 | ||
| EP15382055 | 2015-02-12 | ||
| PCT/IB2016/050775 WO2016128948A1 (en) | 2015-02-12 | 2016-02-12 | 4 -substituted benzoxaborole compounds and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20170371A true CR20170371A (es) | 2018-01-22 |
Family
ID=55409879
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20170372A CR20170372A (es) | 2015-02-12 | 2016-02-12 | Compuestos de benzoxaborol y usos de los mismos |
| CR20170371A CR20170371A (es) | 2015-02-12 | 2016-02-12 | Compuestos de benzoxaboral 4-sustituidos y uso de los mismos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20170372A CR20170372A (es) | 2015-02-12 | 2016-02-12 | Compuestos de benzoxaborol y usos de los mismos |
Country Status (36)
| Country | Link |
|---|---|
| US (3) | US10774096B2 (es) |
| EP (2) | EP3256480A1 (es) |
| JP (2) | JP2018506540A (es) |
| KR (2) | KR20170117158A (es) |
| CN (2) | CN107531730B (es) |
| AU (3) | AU2016217507B2 (es) |
| BR (2) | BR112017017213A2 (es) |
| CA (2) | CA2976308A1 (es) |
| CL (2) | CL2017002059A1 (es) |
| CO (2) | CO2017008816A2 (es) |
| CR (2) | CR20170372A (es) |
| CY (1) | CY1123687T1 (es) |
| DK (1) | DK3256479T3 (es) |
| DO (2) | DOP2017000188A (es) |
| EA (2) | EA036516B1 (es) |
| ES (1) | ES2821951T3 (es) |
| HR (1) | HRP20201597T1 (es) |
| HU (1) | HUE051113T2 (es) |
| IL (2) | IL253865A0 (es) |
| LT (1) | LT3256479T (es) |
| MA (2) | MA41494B1 (es) |
| MX (2) | MX379057B (es) |
| MY (1) | MY194004A (es) |
| NZ (1) | NZ734379A (es) |
| PE (2) | PE20171432A1 (es) |
| PH (2) | PH12017501428A1 (es) |
| PL (1) | PL3256479T3 (es) |
| PT (1) | PT3256479T (es) |
| RS (1) | RS60885B1 (es) |
| SG (2) | SG11201706510YA (es) |
| SI (1) | SI3256479T1 (es) |
| SM (1) | SMT202000565T1 (es) |
| TW (2) | TW201702250A (es) |
| UA (1) | UA120527C2 (es) |
| WO (2) | WO2016128949A1 (es) |
| ZA (1) | ZA201705456B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY175823A (en) * | 2013-08-09 | 2020-07-10 | Glaxosmithkline Ip No 2 Ltd | Tricyclic benzoxaborole compounds and uses thereof |
| HUE059818T2 (hu) * | 2017-05-08 | 2022-12-28 | Glaxosmithkline Intellectual Property Dev | Szenfetrinem vagy annak sója vagy észtere a mikrobakteriális fertõzés kezelésében való felhasználásra |
| EP3716766A4 (en) | 2017-11-30 | 2021-12-22 | Boragen, Inc. | BENZOXABOROLE COMPOUNDS AND THEIR FORMULATIONS |
| EP3836938A4 (en) | 2018-08-18 | 2022-05-11 | Boragen, Inc. | SOLID FORMS OF SUBSTITUTED BENZOXAZOLE AND COMPOSITIONS THEREOF |
| CN110441344B (zh) * | 2019-06-25 | 2020-09-29 | 北京大学 | 一种基于固体核磁共振技术检测rna结构的方法 |
| AU2023287063A1 (en) * | 2022-06-23 | 2024-05-30 | Shanghai Micurx Pharmaceutical Co., Ltd. | Prodrugs of boron compounds and their use in treating bacterial infections |
| CN119233823A (zh) * | 2022-06-23 | 2024-12-31 | 上海盟科药业股份有限公司 | 硼化合物治疗非结核分枝杆菌感染的方法和用途及用于治疗相同疾病的药物组合物 |
| KR20240150582A (ko) | 2023-04-08 | 2024-10-15 | 김태서 | 맥세이프 배터리팩을 포함한 아이폰 케이스 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9411587D0 (en) * | 1994-06-09 | 1994-08-03 | Zeneca Ltd | Compound, composition and use |
| US6632955B1 (en) | 1996-12-02 | 2003-10-14 | Chisso Corporation | Optically active nitro alcohol derivatives, optically active amino alcohol derivatives, and process for preparing the same |
| AU2003298328A1 (en) | 2002-12-02 | 2004-06-23 | Solvias Ag | Catalytic hydrogeneration of carbon-heteroatom double bonds |
| KR101456815B1 (ko) | 2005-02-16 | 2014-10-31 | 아나코르 파마슈티칼스 인코포레이티드 | 보론함유 소분자 |
| JP5084717B2 (ja) | 2005-03-08 | 2012-11-28 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | キラル・ビスオキサゾリン触媒 |
| CN106008583A (zh) | 2005-12-30 | 2016-10-12 | 安纳考尔医药公司 | 含硼的小分子 |
| TWM325238U (en) * | 2006-12-29 | 2008-01-11 | Universal Scient Ind Co Ltd | Voltage regulator and voltage regulating system |
| KR100848491B1 (ko) | 2007-01-16 | 2008-07-28 | 영진약품공업주식회사 | 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법 |
| JO3396B1 (ar) | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| CA2744231A1 (en) | 2008-12-17 | 2010-07-15 | Anacor Pharmaceuticals, Inc. | Polymorphs of (s)-3-aminomethyl-7-(3-hydroxy-propoxy)-3h-benzo[c][1,2] oxaborol-1-ol |
| WO2011037731A1 (en) * | 2009-09-25 | 2011-03-31 | Anacor Pharmaceuticals, Inc. | Boron containing small molecules |
| ES2710105T3 (es) * | 2010-04-07 | 2019-04-23 | Glaxosmithkline Llc | Proceso para preparar benzoxaboroles |
| WO2012033858A2 (en) * | 2010-09-07 | 2012-03-15 | Anacor Pharmaceuticals, Inc. | Boron-containing small molecules |
| CN104136032B (zh) * | 2011-12-22 | 2018-11-13 | 盟科医药技术公司 | 可用于抗菌治疗的三环类硼化合物 |
| CN102739587B (zh) | 2012-06-16 | 2014-05-21 | 天地融科技股份有限公司 | 音频数据传输方法 |
| KR101636431B1 (ko) | 2013-07-30 | 2016-07-05 | 동아에스티 주식회사 | 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도 |
| MY175823A (en) | 2013-08-09 | 2020-07-10 | Glaxosmithkline Ip No 2 Ltd | Tricyclic benzoxaborole compounds and uses thereof |
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2016
- 2016-02-11 MA MA41494A patent/MA41494B1/fr unknown
- 2016-02-11 MA MA041495A patent/MA41495A/fr unknown
- 2016-02-12 LT LTEP16706002.9T patent/LT3256479T/lt unknown
- 2016-02-12 RS RS20201204A patent/RS60885B1/sr unknown
- 2016-02-12 CN CN201680021538.8A patent/CN107531730B/zh active Active
- 2016-02-12 CR CR20170372A patent/CR20170372A/es unknown
- 2016-02-12 BR BR112017017213-5A patent/BR112017017213A2/pt not_active Application Discontinuation
- 2016-02-12 SG SG11201706510YA patent/SG11201706510YA/en unknown
- 2016-02-12 DK DK16706002.9T patent/DK3256479T3/da active
- 2016-02-12 EA EA201791671A patent/EA036516B1/ru unknown
- 2016-02-12 JP JP2017542053A patent/JP2018506540A/ja active Pending
- 2016-02-12 ES ES16706002T patent/ES2821951T3/es active Active
- 2016-02-12 WO PCT/IB2016/050776 patent/WO2016128949A1/en not_active Ceased
- 2016-02-12 MX MX2017010413A patent/MX379057B/es unknown
- 2016-02-12 JP JP2017541999A patent/JP6771472B2/ja active Active
- 2016-02-12 US US15/550,693 patent/US10774096B2/en active Active
- 2016-02-12 HR HRP20201597TT patent/HRP20201597T1/hr unknown
- 2016-02-12 UA UAA201708405A patent/UA120527C2/uk unknown
- 2016-02-12 NZ NZ734379A patent/NZ734379A/en not_active IP Right Cessation
- 2016-02-12 PE PE2017001400A patent/PE20171432A1/es not_active Application Discontinuation
- 2016-02-12 EP EP16706003.7A patent/EP3256480A1/en not_active Withdrawn
- 2016-02-12 CA CA2976308A patent/CA2976308A1/en not_active Abandoned
- 2016-02-12 CN CN201680021488.3A patent/CN107548398A/zh active Pending
- 2016-02-12 CA CA2976030A patent/CA2976030C/en active Active
- 2016-02-12 MY MYPI2017702943A patent/MY194004A/en unknown
- 2016-02-12 CR CR20170371A patent/CR20170371A/es unknown
- 2016-02-12 EP EP16706002.9A patent/EP3256479B1/en active Active
- 2016-02-12 EA EA201791667A patent/EA201791667A1/ru unknown
- 2016-02-12 PE PE2017001401A patent/PE20171348A1/es not_active Application Discontinuation
- 2016-02-12 SG SG11201706511TA patent/SG11201706511TA/en unknown
- 2016-02-12 US US15/550,658 patent/US20180037595A1/en not_active Abandoned
- 2016-02-12 AU AU2016217507A patent/AU2016217507B2/en not_active Ceased
- 2016-02-12 SM SM20200565T patent/SMT202000565T1/it unknown
- 2016-02-12 KR KR1020177025539A patent/KR20170117158A/ko not_active Ceased
- 2016-02-12 BR BR112017017211-9A patent/BR112017017211B1/pt active IP Right Grant
- 2016-02-12 PT PT167060029T patent/PT3256479T/pt unknown
- 2016-02-12 PL PL16706002T patent/PL3256479T3/pl unknown
- 2016-02-12 AU AU2016217508A patent/AU2016217508A1/en not_active Abandoned
- 2016-02-12 MX MX2017010414A patent/MX2017010414A/es unknown
- 2016-02-12 WO PCT/IB2016/050775 patent/WO2016128948A1/en not_active Ceased
- 2016-02-12 HU HUE16706002A patent/HUE051113T2/hu unknown
- 2016-02-12 SI SI201630941T patent/SI3256479T1/sl unknown
- 2016-02-12 KR KR1020177025535A patent/KR20170117156A/ko not_active Withdrawn
- 2016-02-15 TW TW105104422A patent/TW201702250A/zh unknown
- 2016-02-15 TW TW105104376A patent/TWI730953B/zh not_active IP Right Cessation
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2017
- 2017-08-07 IL IL253865A patent/IL253865A0/en unknown
- 2017-08-07 IL IL253864A patent/IL253864B/en unknown
- 2017-08-09 PH PH12017501428A patent/PH12017501428A1/en unknown
- 2017-08-09 PH PH12017501427A patent/PH12017501427A1/en unknown
- 2017-08-10 DO DO2017000188A patent/DOP2017000188A/es unknown
- 2017-08-10 DO DO2017000189A patent/DOP2017000189A/es unknown
- 2017-08-11 CL CL2017002059A patent/CL2017002059A1/es unknown
- 2017-08-11 CL CL2017002060A patent/CL2017002060A1/es unknown
- 2017-08-11 ZA ZA201705456A patent/ZA201705456B/en unknown
- 2017-08-29 CO CONC2017/0008816A patent/CO2017008816A2/es unknown
- 2017-08-29 CO CONC2017/0008809A patent/CO2017008809A2/es unknown
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2020
- 2020-09-11 US US17/018,301 patent/US11214582B2/en active Active
- 2020-10-14 AU AU2020256369A patent/AU2020256369A1/en not_active Abandoned
- 2020-10-15 CY CY20201100978T patent/CY1123687T1/el unknown
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