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CR20110089A - Compuestos macrociclicos de quinoxalina como inhibidores de la proteasa ns3 de vhc - Google Patents

Compuestos macrociclicos de quinoxalina como inhibidores de la proteasa ns3 de vhc

Info

Publication number
CR20110089A
CR20110089A CR20110089A CR20110089A CR20110089A CR 20110089 A CR20110089 A CR 20110089A CR 20110089 A CR20110089 A CR 20110089A CR 20110089 A CR20110089 A CR 20110089A CR 20110089 A CR20110089 A CR 20110089A
Authority
CR
Costa Rica
Prior art keywords
macrociclic
quinoxaline
inhibitors
compounds
hcv protease
Prior art date
Application number
CR20110089A
Other languages
English (en)
Inventor
Harper Steven
Summa Vincenzo
J Liverton Nigel
A Mccauley John
Original Assignee
Angeletti P Ist Richerche Bio
Merck Sharp & Dhome Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41130248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20110089(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Angeletti P Ist Richerche Bio, Merck Sharp & Dhome Corp filed Critical Angeletti P Ist Richerche Bio
Publication of CR20110089A publication Critical patent/CR20110089A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a un compuesto macrocíclico con la fórmula (I) y a su uso como inhibidor de la proteasa NS3 del virus de la hepatitis C (HCV), y en el tratamiento o prevención de infecciones por HCV.
CR20110089A 2008-07-22 2011-02-15 Compuestos macrociclicos de quinoxalina como inhibidores de la proteasa ns3 de vhc CR20110089A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13555908P 2008-07-22 2008-07-22

Publications (1)

Publication Number Publication Date
CR20110089A true CR20110089A (es) 2011-04-27

Family

ID=41130248

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20110089A CR20110089A (es) 2008-07-22 2011-02-15 Compuestos macrociclicos de quinoxalina como inhibidores de la proteasa ns3 de vhc

Country Status (43)

Country Link
US (2) US7973040B2 (es)
EP (3) EP2540350B1 (es)
JP (1) JP4920797B2 (es)
KR (1) KR101313675B1 (es)
CN (1) CN102159285B (es)
AR (1) AR072588A1 (es)
AU (1) AU2009274190B2 (es)
BR (1) BRPI0916235B8 (es)
CA (1) CA2731177C (es)
CL (1) CL2011000145A1 (es)
CO (1) CO6351757A2 (es)
CR (1) CR20110089A (es)
CY (3) CY1113752T1 (es)
DK (2) DK2540350T3 (es)
DO (1) DOP2011000023A (es)
EA (1) EA019327B1 (es)
EC (1) ECSP11010777A (es)
ES (2) ES2392611T3 (es)
FR (1) FR16C1027I2 (es)
HN (1) HN2011000209A (es)
HR (2) HRP20120866T1 (es)
HU (1) HUS1700001I1 (es)
IL (1) IL210580A (es)
LT (1) LTC2310095I2 (es)
LU (1) LUC00002I2 (es)
MA (1) MA32502B1 (es)
ME (2) ME02024B (es)
MX (1) MX2011000826A (es)
MY (1) MY152070A (es)
NI (1) NI201100023A (es)
NL (1) NL300857I2 (es)
NO (1) NO2017004I2 (es)
NZ (1) NZ590638A (es)
PE (1) PE20110212A1 (es)
PL (2) PL2540350T3 (es)
PT (2) PT2310095E (es)
RS (2) RS53420B (es)
SI (2) SI2540350T1 (es)
SV (1) SV2011003813A (es)
TN (1) TN2011000014A1 (es)
TW (1) TWI441638B (es)
UA (1) UA100436C2 (es)
WO (1) WO2010011566A1 (es)

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