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CO6290757A2 - N-(2(hetarl)ari)arilsulfonamidas y n-(2-(hetaril)hetaril)arilsulfonamidas - Google Patents

N-(2(hetarl)ari)arilsulfonamidas y n-(2-(hetaril)hetaril)arilsulfonamidas

Info

Publication number
CO6290757A2
CO6290757A2 CO10005871A CO10005871A CO6290757A2 CO 6290757 A2 CO6290757 A2 CO 6290757A2 CO 10005871 A CO10005871 A CO 10005871A CO 10005871 A CO10005871 A CO 10005871A CO 6290757 A2 CO6290757 A2 CO 6290757A2
Authority
CO
Colombia
Prior art keywords
hetaril
ccr9
compounds
arilsulphonamids
arilsulfonamids
Prior art date
Application number
CO10005871A
Other languages
English (en)
Inventor
Trevor Charvat
Cheng Hu
Anita Melikian
Aaron Novack
Andrew M K Pennell
Jay Powers
Sreenivas Punna
Edward Sullivan
William D Thomas
Solomon Ungashe
Penglie Zhang
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of CO6290757A2 publication Critical patent/CO6290757A2/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Compuestos que actúan como potentes antagonistas del receptor CCR9. Las pruebas en animales demuestran que dichos compuestos son útiles para tratar la inflamación, una indicación distintiva de enfermedad por CCR9. Los compuestos son en general derivados aril sulfonamida y son útiles en composiciones farmacéuticas, métodos para el tratamiento de enfermedades mediadas por CCR9, y como controles en ensayos para la identificación de antagonistas de CCR9.
CO10005871A 2007-06-22 2010-01-21 N-(2(hetarl)ari)arilsulfonamidas y n-(2-(hetaril)hetaril)arilsulfonamidas CO6290757A2 (es)

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