CO5261627A1 - Derivados de aminometil-fenil-ciclohexanona, procedimiento para su preparacion, el uso de los derivados de aminometil- fenil-ciclohexanona para la preparacion de medicamentos y medicamentos que contienen los derivados de aminometil- fenil-ciclohexano - Google Patents
Derivados de aminometil-fenil-ciclohexanona, procedimiento para su preparacion, el uso de los derivados de aminometil- fenil-ciclohexanona para la preparacion de medicamentos y medicamentos que contienen los derivados de aminometil- fenil-ciclohexanoInfo
- Publication number
- CO5261627A1 CO5261627A1 CO01000529A CO01000529A CO5261627A1 CO 5261627 A1 CO5261627 A1 CO 5261627A1 CO 01000529 A CO01000529 A CO 01000529A CO 01000529 A CO01000529 A CO 01000529A CO 5261627 A1 CO5261627 A1 CO 5261627A1
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- Colombia
- Prior art keywords
- polysubstituted
- mono
- unsubstituted
- alkyl
- unbranched
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
- C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
- C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C225/18—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings the carbon skeleton containing also rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Derivados de aminometil-fenil-ciclohexanona de la fórmula general I o Ia también en forma de sus diastereómeros o enantiómeros, su base libre o una sal con un ácido fisiológicamente tolerable particularmente clorhidrato.<EMI FILE="01000529_1" ID="1" IMF=JPEG >en las cualesR1 y R2 independientemente entre sí representan R5 o YR5 estando elegido Y del grupo que comprende C1-C10-alquilo, C2-C10-alquenilo, o C2-C10-alquinilo, ramificado o no ramificado, no sustituido o mono o polisustituido y estando elegido R5 del grupo que comprendeH, F, Cl, Br, I, CN, NO2, C1-C8-alquilo, C2-C8-alquenilo o C2-C8-alquinilo, ramificados o no ramificados, no sustituidos o mono o polisustituidos, C3-C7-cicloalquilo saturado o insaturado, no sustituido o mono o polisustituido o un heterociclo correspondiente en el cual un átomo de carbono en el ciclo está sustituido por S, O o NR6, estando elegido R6 entreH, C1-C10-alquilo, C2-C10-alquenilo o C2-C10-alquinilo, ramificados o no ramificados, no sustituidos o mono o polisustituidos;arilo o heteroarilo, no sustituidos o mono o polisustituidos;OR7, OC(O)R7, OC(O)OR7, OC(S) R7, C(O)R7, C(O)OR7, C(S)R7, C(S)OR7, SR7, S(O)R7 o S(O2)R7, comprendiendo R7H, C1-C18-alquilo, C2-C18-alquenilo o C2-C18-alquinilo, ramificado o no ramificado, no sustituido o mono o polisustituido: C3-C7-cicloalquilo, saturado o insaturado, no sustituido o mono o polisustituido, o un heterociclo correspondiente, en el cual un átomo de carbono en el ciclo está sustituido por S, O o NR8, siendo R8 - 2 -H, C1-C10-alquilo, C2-C10-alquenilo o C2-C10-alquinilo, ramificados o no ramificados, no sustituidos o mono o polisustituidos;alquilarilo saturado o insaturado, no sustituido o mono o polisustituidos; arilo o heteroarilo, no sustituidos o mono o polisustituidos; oNR9R10, C(O)NR9R10 o S(O2)NR9R10, estando elegidos R9 y R10 independientemente entre sí entreH, C1-C18-alquilo, C2-C18-alquenilo o C2-C18-alquinilo, ramificado o no ramificado, no sustituidos o mono o polisustituidos, C3-C7-cicloalquilo, saturado o insaturado, no sustituido o mono o polisustituidos, o un heterociclo correspondiente en que un átomo de carbono en el ciclo está sustituido por S, O o NR11, siendo R11H, C1-C10-alquilo, C2-C10-alquenilo o C2-C10-alquinilo, ramificado o no ramificado, no sustituido o mono o polisustituido;alquilarilo saturado o insaturado, no sustituido o monosustituido, arilo o heteroarilo no sustituido o mono o polisustituidooR9 y R10 en conjunto representan C3-C7-cicloalquilo, saturado o insaturado, no sustituido o mono o polisustituido o un heterociclo correspondiente en que un átomo de carbono en el ciclo está sustituido por S, O o NR12, siendo R12H, C1-C10-alquilo, C2-C10-alquenilo o C2-C10-alquinilo, ramificado o no ramificado, no sustituido o mono o polisustituido;oR1 y R2 en conjunto forman -CH=CH-CH=CH-, pudiendo estar mono o polisustituido el sistema naftílico resultante,X está elegido entreH, F, Cl, Br, I, CF3, O-S(O2)-C6H4-pCH3, OR13 u OC(O)R13, representando R13H, C1-C10-alquilo, C2-C10-alquenilo o C2-C10-alquinilo, ramificados o no ramificados, no sustituidos o mono o polisustituidos, C3-C7-cicloalquilo, saturado o insaturado, no sustituido o mono o polisustituido o un heterociclo correspondiente en que un átomo de carbono en el ciclo está sustituido por N, S u O, alquilarilo saturado o insaturado, no sustituido o mono o polisustituido, arilo o heteroarilo, no sustituido o mono o polisustituido;ocuando el compuesto carece de X según la fórmula Ia está formada una doble ligadura entre los átomos de carbono A y B o entre los átomos de carbono B y C;yR3, R4 están elegidos independientemente entre sí del grupo que comprende H, C1-C10-alquilo, C2-C10-alquenilo o C2-C10-alquinilo, ramificados o no ramificados, no sustituidos o mono o polisustituidos, C3-C7-cicloalquilo, saturado o insaturado, no sustituido o mono o polisustituido, o un heterociclo correspondiente en que un átomo de carbono en el ciclo está sustituido por N, S u O; alquilarilo saturado o insaturado, no sustituido o mono o polisustituido; arilo o heteroarilo no sustituido o mono o polisustituido;oR3 y R4 conjuntamente forman C3-C7-cicloalquilo, saturado o insaturado, no sustituido o mono o polisustituido, o un heterociclo correspondiente en que un átomo de carbono en el ciclo está sustituido por S, O o NR14, siendo R14 H, C1-C10-alquilo, C2-C10-alquenilo o C2-C10-alquinilo, ramificado o no ramificado, o sustituido o mono o polisustituido.Con la condición que cuando X representa OH, R2 representa H, R3 y R4 representan CH3, R1 no puede tener simultáneamente con R5 los significados R5 = OR7 en donde R7 representa H, CH3 o un radical piridilo, tienilo, tiazolilo o fenilo, sustituido o no sustituido, o R5 = OC(O)OR7 con R7 representando C1-5-alquilo, NH-C6H4-C1-3-alquilo, C6H4-OC(O)C1-3-alquilo, C6H4-CH2N(C1-4-alquilo)2, C6H4-CH2-(N-4-morfolino) o CHZ'-NHZ" con Z' y Z" iguales o distintos entre sí y representando H o C1-6-alquilo,o que cuando X representa H o conforme a la fórmula Ia está formada una doble ligadura entre los átomos de carbono A y B, R2 representa H, R3 y R4 representan C1-6-alquilo, arilo o C3-7-cicloalquilo y R1 no puede simultáneamente representar H, C1-6-alcoxi, O-C3-7-cicloalquilo, O-arilo u O-heterociclilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10000311A DE10000311A1 (de) | 2000-01-05 | 2000-01-05 | Aminomethyl-Phonyl-Cyclohexanonderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5261627A1 true CO5261627A1 (es) | 2003-03-31 |
Family
ID=7626852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO01000529A CO5261627A1 (es) | 2000-01-05 | 2001-01-04 | Derivados de aminometil-fenil-ciclohexanona, procedimiento para su preparacion, el uso de los derivados de aminometil- fenil-ciclohexanona para la preparacion de medicamentos y medicamentos que contienen los derivados de aminometil- fenil-ciclohexano |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6890959B2 (es) |
| EP (1) | EP1246791B1 (es) |
| JP (1) | JP2003519209A (es) |
| KR (1) | KR100748378B1 (es) |
| CN (1) | CN100467441C (es) |
| AR (1) | AR030683A1 (es) |
| AT (1) | ATE280752T1 (es) |
| AU (1) | AU782862B2 (es) |
| BR (1) | BR0016941A (es) |
| CA (1) | CA2396310A1 (es) |
| CO (1) | CO5261627A1 (es) |
| CZ (1) | CZ20022338A3 (es) |
| DE (2) | DE10000311A1 (es) |
| DK (1) | DK1246791T3 (es) |
| ES (1) | ES2231304T3 (es) |
| HU (1) | HUP0203859A3 (es) |
| IL (2) | IL150558A0 (es) |
| MX (1) | MXPA02006697A (es) |
| NO (1) | NO20022983L (es) |
| NZ (1) | NZ520468A (es) |
| PE (1) | PE20011043A1 (es) |
| PL (1) | PL356642A1 (es) |
| PT (1) | PT1246791E (es) |
| RU (1) | RU2002120897A (es) |
| SI (1) | SI1246791T1 (es) |
| SK (1) | SK286799B6 (es) |
| WO (1) | WO2001049651A2 (es) |
| ZA (1) | ZA200206150B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7457762B2 (en) * | 2001-09-04 | 2008-11-25 | Accenture Global Services Gmbh | Optimization of management of maintenance, repair and overhaul of equipment in a specified time window |
| DE10326097A1 (de) * | 2003-06-06 | 2005-01-05 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen |
| DE10328316A1 (de) | 2003-06-23 | 2005-01-20 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| US7260408B2 (en) * | 2004-02-20 | 2007-08-21 | Airespace, Inc. | Wireless node location mechanism using antenna pattern diversity to enhance accuracy of location estimates |
| US20050236892A1 (en) * | 2004-04-27 | 2005-10-27 | Akihito Kusano | Hydraulic braking pressure generating apparatus for vehicles |
| DE102005052588A1 (de) | 2005-11-02 | 2007-05-10 | Grünenthal GmbH | Verfahren zur Herstellung substituierter Dimethyl-(3-aryl-butyl)-amin-Verbindungen mittels homogener Katalyse |
| TWI496762B (zh) | 2006-07-24 | 2015-08-21 | 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法 | |
| JP5009736B2 (ja) * | 2007-10-15 | 2012-08-22 | 日本曹達株式会社 | 環状アミノエーテルを用いたマンニッヒ反応 |
| CN102026959A (zh) * | 2008-02-29 | 2011-04-20 | 格吕伦塔尔有限公司 | 制造(1rs，3rs，6rs)-6-二甲基氨基甲基-1-(3-甲氧基苯基)-环己烷-1，3-二醇的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1518663A1 (de) * | 1965-08-02 | 1969-12-18 | Gruenenthal Chemie | Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung |
| US3652589A (en) * | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| US3974157A (en) * | 1974-03-04 | 1976-08-10 | Pennwalt Corporation | 1-(Amino-alkyl)-2-aryl-cyclohexane alcohols and esters |
| JPS51143650A (en) * | 1975-06-06 | 1976-12-10 | Takeda Chem Ind Ltd | A process for preparing cyclohexanol derivatives |
| DE69029668T2 (de) | 1989-03-08 | 1997-08-07 | Merck Sharp & Dohme | Tetrahydroquinolin-Derivate, verwendbar bei neurodegenerativen Krankheiten |
| IL112569A (en) * | 1994-02-10 | 1999-12-22 | Wyeth John & Brother Ltd | Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation |
| DE19525137C2 (de) | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
| DE19547766A1 (de) | 1995-12-20 | 1997-06-26 | Gruenenthal Gmbh | 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-verbindungen als pharmazeutische Wirkstoffe |
| DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| MY125037A (en) | 1998-06-10 | 2006-07-31 | Glaxo Wellcome Spa | 1,2,3,4 tetrahydroquinoline derivatives |
| DE19830105C1 (de) * | 1998-07-06 | 2000-02-17 | Gruenenthal Gmbh | Acridinderivate |
-
2000
- 2000-01-05 DE DE10000311A patent/DE10000311A1/de not_active Withdrawn
- 2000-12-27 SI SI200030587T patent/SI1246791T1/xx unknown
- 2000-12-27 EP EP20000990824 patent/EP1246791B1/de not_active Expired - Lifetime
- 2000-12-27 PL PL00356642A patent/PL356642A1/xx unknown
- 2000-12-27 SK SK980-2002A patent/SK286799B6/sk not_active IP Right Cessation
- 2000-12-27 DE DE50008447T patent/DE50008447D1/de not_active Expired - Lifetime
- 2000-12-27 NZ NZ520468A patent/NZ520468A/en unknown
- 2000-12-27 DK DK00990824T patent/DK1246791T3/da active
- 2000-12-27 BR BR0016941-2A patent/BR0016941A/pt not_active Application Discontinuation
- 2000-12-27 CN CNB008192669A patent/CN100467441C/zh not_active Expired - Fee Related
- 2000-12-27 HU HU0203859A patent/HUP0203859A3/hu unknown
- 2000-12-27 AU AU30169/01A patent/AU782862B2/en not_active Ceased
- 2000-12-27 AT AT00990824T patent/ATE280752T1/de active
- 2000-12-27 MX MXPA02006697A patent/MXPA02006697A/es active IP Right Grant
- 2000-12-27 CZ CZ20022338A patent/CZ20022338A3/cs unknown
- 2000-12-27 CA CA002396310A patent/CA2396310A1/en not_active Abandoned
- 2000-12-27 PT PT00990824T patent/PT1246791E/pt unknown
- 2000-12-27 RU RU2002120897/04A patent/RU2002120897A/ru unknown
- 2000-12-27 WO PCT/EP2000/013282 patent/WO2001049651A2/de not_active Ceased
- 2000-12-27 JP JP2001550191A patent/JP2003519209A/ja active Pending
- 2000-12-27 KR KR1020027008706A patent/KR100748378B1/ko not_active Expired - Fee Related
- 2000-12-27 IL IL15055800A patent/IL150558A0/xx active IP Right Grant
- 2000-12-27 ES ES00990824T patent/ES2231304T3/es not_active Expired - Lifetime
-
2001
- 2001-01-02 AR ARP010100008A patent/AR030683A1/es unknown
- 2001-01-04 CO CO01000529A patent/CO5261627A1/es not_active Application Discontinuation
- 2001-01-04 PE PE2001000012A patent/PE20011043A1/es not_active Application Discontinuation
-
2002
- 2002-06-20 NO NO20022983A patent/NO20022983L/no not_active Application Discontinuation
- 2002-07-03 IL IL150558A patent/IL150558A/en not_active IP Right Cessation
- 2002-07-05 US US10/189,184 patent/US6890959B2/en not_active Expired - Fee Related
- 2002-08-01 ZA ZA200206150A patent/ZA200206150B/xx unknown
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