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CO4520281A1 - Antifungicos de tetrahidrofurano - Google Patents

Antifungicos de tetrahidrofurano

Info

Publication number
CO4520281A1
CO4520281A1 CO94057442A CO94057442A CO4520281A1 CO 4520281 A1 CO4520281 A1 CO 4520281A1 CO 94057442 A CO94057442 A CO 94057442A CO 94057442 A CO94057442 A CO 94057442A CO 4520281 A1 CO4520281 A1 CO 4520281A1
Authority
CO
Colombia
Prior art keywords
independently
antifungics
tetrahydrofuran
same
ester
Prior art date
Application number
CO94057442A
Other languages
English (en)
Inventor
K Saksena Anil
M Girijavallab Viyyor
Raymond G Lovey
Russell E Pike
Wang Haiyan
Liu Yi-Tsung
K Ganguly Ashit
Frank Bennett
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22622452&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO4520281(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of CO4520281A1 publication Critical patent/CO4520281A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)
  • Lubricants (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)

Abstract

SE DESCRIBE UN COMPUESTO REPRESENTADO POR LA FOR- MULA FIGURA 1 DONDE X ES INDEPENDIENTEMENTE AMBOS F O AMBOS Cl o UN X ES INDEPENDIENTEMENTE F Y EL OTRO ES INDEPEN- DIENTEMENTE Cl: R1 ES UN GRUPO ALQUILO (C3 A C8) DE CADENA LINEAL O RAMIFICADA SUSTITUIDO POR UNO O DOS RESTOS HIDROXI, UN ETER ESTER (POR EJ., UN POLIERESTER O ESTER FOSFATO) DEL MISMO O UNA SAL FARMACEUTICAMENTE ACCEPTABLE DEL MISMO Y COMPOSI- CIONES FARMACEUTICAS DEL MISMO UTILES PARA EL TRATAMIENTO Y/O PREVENCION DE LAS INFECCIONES FUNGICAS.
CO94057442A 1993-12-21 1994-12-20 Antifungicos de tetrahidrofurano CO4520281A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17108393A 1993-12-21 1993-12-21

Publications (1)

Publication Number Publication Date
CO4520281A1 true CO4520281A1 (es) 1997-10-15

Family

ID=22622452

Family Applications (1)

Application Number Title Priority Date Filing Date
CO94057442A CO4520281A1 (es) 1993-12-21 1994-12-20 Antifungicos de tetrahidrofurano

Country Status (28)

Country Link
EP (1) EP0736030B1 (es)
JP (1) JP2834889B2 (es)
KR (1) KR0179990B1 (es)
CN (1) CN1064685C (es)
AT (1) ATE204875T1 (es)
AU (1) AU681753B2 (es)
BR (1) BR1100154B1 (es)
CA (1) CA2179396C (es)
CO (1) CO4520281A1 (es)
CZ (1) CZ294823B6 (es)
DE (2) DE122006000004I2 (es)
DK (1) DK0736030T3 (es)
ES (1) ES2159623T3 (es)
FI (1) FI118470B (es)
FR (1) FR06C0009I2 (es)
HU (1) HU225062B1 (es)
IL (1) IL112081A (es)
LU (1) LU91216I2 (es)
MY (1) MY130217A (es)
NL (1) NL300219I2 (es)
NO (2) NO316173B1 (es)
NZ (1) NZ278713A (es)
PL (1) PL181193B1 (es)
PT (1) PT736030E (es)
SK (1) SK283035B6 (es)
TW (1) TW377349B (es)
WO (1) WO1995017407A1 (es)
ZA (1) ZA9410142B (es)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3764750B2 (ja) * 1994-01-24 2006-04-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 水溶性アゾール抗真菌剤
DE69628117T2 (de) * 1995-06-02 2004-04-01 Schering Corp. Antifungale tetrahydrofurane
US5698557A (en) * 1995-06-19 1997-12-16 Schering Corporation Hydroxy-substituted antifungals
EP0837859B1 (en) * 1995-06-19 2003-08-13 Schering Corporation Tetrahydrofuran antifungals
NZ324616A (en) * 1995-12-20 1999-05-28 Schering Corp Process for preparation of hydrazides using hydrazones and grignard reagents
US5834472A (en) * 1996-05-24 1998-11-10 Schering Corporation Antifungal composition with enhanced bioavailability
HU221371B1 (en) * 1996-05-24 2002-09-28 Schering Corp Antifungal pharmaceutical composition with enhanced bioavailability
AU3483497A (en) * 1996-06-28 1998-01-21 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability
EP0914100A1 (en) * 1996-06-28 1999-05-12 Schering Corporation Oral composition comprising a triazole antifungal compound
US5846971A (en) * 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
US5972381A (en) * 1996-06-28 1999-10-26 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability
US5952502A (en) * 1996-11-12 1999-09-14 Sepracor Inc. 2R,4S,R, S- and 2S,4R,R,S-hydroxyitraconazole
AU5251398A (en) * 1996-11-12 1998-06-03 Sepracor, Inc. (2r,4s,r,r-) and (2s,4r,r,r-)hydroxyitraconazole
EP0937071A1 (en) * 1996-11-12 1999-08-25 Sepracor, Inc. 2r,4s,s,s- and 2s,4r,s,s-hydroxyitraconazole
WO1998021203A1 (en) * 1996-11-12 1998-05-22 Sepracor, Inc. 2r,4s,s,r- and 2s,4r,s,r-hydroxyitraconazole
US5684197A (en) * 1996-12-12 1997-11-04 Schering Corporation Process for preparation of hydrazides
SI0958289T1 (en) 1997-02-11 2004-12-31 Janssen Pharmaceutica N.V. Amino acid ester containing azole antifungals
WO1999015522A1 (en) * 1997-09-25 1999-04-01 Schering Corporation Tetrahydrofuran phosphate- and hydroxy esters, as prodrugs for the corresponding antifungal agent
US6043245A (en) * 1997-09-25 2000-03-28 Schering Corporation Tetrahydrofuran antifungal phosphate
WO1999018111A1 (en) * 1997-10-07 1999-04-15 Schering Corporation Crystalline antifungal glycine ester polymorph
AR015947A1 (es) * 1997-10-07 2001-05-30 Schering Corp Una forma 1 polimorfica (-)-4-[4-[4-[4-[[(2r-cis]-5-(2,4-difluorfenil)tetrahidro-5-(1h-1,2,4-triazol-1-ilmetil)furan-3-il]-metoxi]fenil]-1-piperazinil]fenil-2,4-dihidro-2-[(s)-1-etil-2-(s)-hidroxipropil]-3h-1,2,4-triazol-3-ona, composicion farmaceutica que la contiene y su uso para preparar un medic
US6713481B1 (en) * 1997-10-17 2004-03-30 David R. Andrews Crystalline antifungal polymorph
US5883097A (en) * 1998-04-16 1999-03-16 Schering Corporation Soluble azole antifungal salt
EP0957101A1 (en) 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
US6147077A (en) * 1999-04-29 2000-11-14 Sepracor Inc. 2R,4S-hydroxyitraconazole isomers
EP1177192B1 (en) * 1999-05-04 2003-03-19 Janssen Pharmaceutica N.V. Antifungal ethers
US6362172B2 (en) 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6448401B1 (en) 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
US20030055067A1 (en) * 2001-04-03 2003-03-20 Schering Corporation Antifungal composition with enhanced bioavailability
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
EP2316469A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
EP1494998A2 (en) 2002-03-01 2005-01-12 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
EP1511490A4 (en) 2002-05-31 2009-03-11 Transform Pharmaceuticals Inc NOVEL CONAZOLE CRYSTALLINE FORMS AND RELATED METHODS, PHARMACEUTICAL COMPOSITIONS AND METHODS
JP2006500377A (ja) 2002-06-21 2006-01-05 トランスフォーム・ファーマシューティカルズ・インコーポレイテッド 改善された溶解性を有する医薬組成物
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
ITMI20032020A1 (it) * 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
RU2394573C2 (ru) * 2004-08-13 2010-07-20 Шеринг-Плоу Лтд. Фармацевтическая композиция
JO2691B1 (en) * 2005-05-03 2013-03-03 ايساي آر آند دي مانجمنت كو.، ليمتد Monolysine salts for azole compounds
EP2130540A1 (en) 2008-06-02 2009-12-09 Sandoz AG Pharmaceutical compositions containing a crystalline form of posaconazole
EP2141159A1 (en) * 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
EP2451805A1 (en) 2009-07-09 2012-05-16 Sandoz AG A crystalline form of posaconazole
WO2011158248A2 (en) * 2010-05-12 2011-12-22 Glenmark Generics Limited Process for preparation of posaconazole and crystalline polymorphic form v of posaconazole
CA2798010C (en) 2010-05-19 2018-09-25 Sandoz Ag Purification of posaconazole and of posaconazole intermediates
US9073904B2 (en) 2010-05-19 2015-07-07 Sandoz Ag Preparation of posaconazole intermediates
CN102892750B (zh) * 2010-05-19 2016-03-02 桑多斯股份公司 制备手性酰肼的方法
EP2571871B1 (en) 2010-05-19 2017-06-21 Sandoz AG Process for the preparation of chiral triazolones
ES2893444T3 (es) 2010-06-29 2022-02-09 Merck Sharp & Dohme Formulaciones de posaconazol en solución intravenosa estabilizadas mediante beta-ciclodextrina sustituida
CA2838051C (en) 2011-06-16 2019-09-24 Sandoz Ag Process for the preparation of a chiral compound
EP2789610A1 (en) 2013-04-10 2014-10-15 Sandoz Ag Purification of Posaconazole Intermediates
CA2919290A1 (en) * 2013-07-25 2015-01-29 Sandoz Ag Improved process for the preparation of crystalline form iv of posaconazole
ITMI20132114A1 (it) 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
CN105287403A (zh) * 2014-08-02 2016-02-03 陕西合成药业股份有限公司 一种泊沙康唑前体药物的冻干组合物及其制备方法和用途
CN104370894A (zh) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 无定型泊沙康唑的制备工艺
PL3227277T3 (pl) 2014-12-05 2020-08-10 Pulmocide Limited Związek przeciwgrzybiczy
CN107635988B (zh) 2015-05-21 2021-06-18 普尔莫赛德有限公司 抗真菌的苯甲酰胺类衍生物或其可药用盐
CN106317032A (zh) * 2015-06-15 2017-01-11 重庆圣华曦药业股份有限公司 一种制备高纯度的泊沙康唑的方法
CN106432338A (zh) * 2015-08-08 2017-02-22 陕西合成药业股份有限公司 泊沙康唑衍生物、合成和在长效制剂中的用途
JP7054381B2 (ja) * 2015-09-23 2022-04-13 バイオコン・リミテッド 結晶形態のポサコナゾール中間体および非晶質ポサコナゾールの調製のためのプロセス
CN105606736A (zh) * 2016-01-27 2016-05-25 重庆华邦制药有限公司 分离测定泊沙康唑中间体z1及其有关物质的方法
JP6938831B2 (ja) * 2016-03-04 2021-09-22 ゼァージァン アウスン ファーマシューティカル カンパニー リミテッドＺｈｅｊｉａｎｇ Ａｕｓｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． ポサコナゾール、組成物、中間体、並びにその製造方法及び使用
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
WO2017032908A1 (en) 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
WO2018115319A2 (en) 2016-12-23 2018-06-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
CN106967054A (zh) * 2017-03-30 2017-07-21 成都绿林科技有限公司 一种泊沙康唑的制备方法
CN106883221A (zh) * 2017-04-17 2017-06-23 兰州大学 一种无定形泊沙康唑及其制备方法
CN108341754A (zh) * 2018-03-12 2018-07-31 扬子江药业集团有限公司 泊沙康唑杂质及其制备方法和用途
CN110938093B (zh) * 2018-09-21 2022-08-19 华创合成制药股份有限公司 一种泊沙康唑磷酸酯单胆碱盐及其制备方法和用途
CN112778369B (zh) * 2019-11-05 2024-01-26 华创合成制药股份有限公司 一种三唑类衍生物及其制备方法和用途
GB201917867D0 (en) 2019-12-06 2020-01-22 Pulmocide Ltd Polymorphs
CN113666915B (zh) * 2021-08-27 2022-08-16 江苏海洋大学 一种泊沙康唑中间体的制备方法
CN114315811B (zh) * 2021-11-19 2024-04-30 江苏恒盛药业有限公司 一种三氮唑类似物化合物及其制备方法和应用
CN120794964A (zh) * 2025-07-03 2025-10-17 广州绿十字制药股份有限公司 泊沙康唑脂肪酸酯、泊沙康唑脂肪酸酯脂肪乳及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267179A (en) * 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
ES2065340T3 (es) * 1987-11-20 1995-02-16 Schering Corp Oxetanos y tetrahidrofuranos tri- y tetra-sustituidos y compuestos intermedios para los mismos.
US5039676A (en) * 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals

Also Published As

Publication number Publication date
JPH09500658A (ja) 1997-01-21
NL300219I1 (nl) 2006-04-03
EP0736030B1 (en) 2001-08-29
DE122006000004I2 (de) 2007-03-29
CN1142828A (zh) 1997-02-12
WO1995017407A1 (en) 1995-06-29
FR06C0009I2 (es) 2006-12-29
ZA9410142B (en) 1996-05-02
HK1008820A1 (en) 1999-05-21
NO962616D0 (no) 1996-06-20
NO316173B1 (no) 2003-12-22
ES2159623T3 (es) 2001-10-16
MY130217A (en) 2007-06-29
LU91216I2 (en) 2006-03-27
NL300219I2 (nl) 2006-05-01
DE69428125T2 (de) 2002-05-02
SK82696A3 (en) 1997-03-05
AU1512795A (en) 1995-07-10
PL315169A1 (en) 1996-10-14
ATE204875T1 (de) 2001-09-15
KR0179990B1 (en) 1999-03-20
DE69428125D1 (de) 2001-10-04
SK283035B6 (sk) 2003-02-04
CZ294823B6 (cs) 2005-03-16
FI962577L (fi) 1996-06-20
CA2179396C (en) 2001-04-17
NO2006002I1 (no) 2006-02-20
PT736030E (pt) 2002-01-30
IL112081A0 (en) 1995-03-15
NZ278713A (en) 1997-12-19
HU225062B1 (en) 2006-05-29
DK0736030T3 (da) 2001-10-29
IL112081A (en) 2001-08-26
DE122006000004I1 (de) 2006-04-27
CA2179396A1 (en) 1995-06-29
TW377349B (en) 1999-12-21
CZ180596A3 (en) 1997-01-15
FI118470B (fi) 2007-11-30
FR06C0009I1 (es) 2006-05-19
NO2006002I2 (no) 2011-03-07
JP2834889B2 (ja) 1998-12-14
NO962616L (no) 1996-08-07
HUT75879A (en) 1997-05-28
PL181193B1 (pl) 2001-06-29
HU9601709D0 (en) 1996-08-28
AU681753B2 (en) 1997-09-04
FI962577A0 (fi) 1996-06-20
EP0736030A1 (en) 1996-10-09
BR1100154B1 (pt) 2013-11-26
CN1064685C (zh) 2001-04-18

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