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CO4480020A1 - PHARMACEUTICAL FORMULATIONS - Google Patents

PHARMACEUTICAL FORMULATIONS

Info

Publication number
CO4480020A1
CO4480020A1 CO96061449A CO96061449A CO4480020A1 CO 4480020 A1 CO4480020 A1 CO 4480020A1 CO 96061449 A CO96061449 A CO 96061449A CO 96061449 A CO96061449 A CO 96061449A CO 4480020 A1 CO4480020 A1 CO 4480020A1
Authority
CO
Colombia
Prior art keywords
formulation according
active drug
molecular weight
aqueous media
active
Prior art date
Application number
CO96061449A
Other languages
Spanish (es)
Inventor
Ross James Macrae
Janet Sarah Smith
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of CO4480020A1 publication Critical patent/CO4480020A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1. UNA FORMULACION FARMACEUTICA DE LIBERACION CONTROLADA PARA LA ADMINISTRACION ORAL, COMPUESTA ESENCIALMENTE POR: UN FARMACO ACTIVO; POLI(OXIDO DE ETILENO) DE BAJO PESO MOLECULAR; HIDROXIPROPIL- METIL CELULOSA; EXCIPIENTES DE COMPRIMIDOS; Y OPCIONALMENTE UNO O MAS POLIMEROS ENTERICOS. 2. UNA FORMULACION SEGUN LA REIVINDICACION 1, EN LA QUE EL FARMACO ACTIVO ES DEBILMENTE BASICO. 3. UNA FORMULACION SEGUN LA REIVINDICACION 1 O LA REIVINDICACION 2, EN LA QUE EL FARMACO ACTIVO ES DOXAZOSINA, O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES. 4. UNA FORMULACION SEGUN LA REIVINDICACION 1, EN LA QUE EL FARMACO ACTIVO TIENE UNA ALTA SOLUBILI- DAD EN MEDIOS ACUOSOS. 5. UNA FORMULACION SEGUN LA REIVINDICACION 1, EN LA QUE EL FARMACO ACTIVO TIENE UNA BAJA SOLUBILI- DAD EN MEDIOS ACUOSOS. 6. UNA FORMULACION SEGUN UNA CUALQUIERA DE LAS REIVINDICACIONES ANTERIORES, EN LA QUE LA HIDROXI- PROPILMETIL CELULOSA TIENE UN PESO MOLECULAR MEDIO NUMERICO EN EL INTERVALO DE 80.000 A 250.000.1. A PHARMACEUTICAL FORMULATION OF CONTROLLED RELEASE FOR THE ORAL ADMINISTRATION, COMPOSED ESSENTIALLY BY: AN ACTIVE PHARMACY; LOW MOLECULAR WEIGHT POLY (ETHYLENE OXIDE); HYDROXIPROPIL-METHYL CELLULOSE; EXCIPIENTS OF TABLETS; AND OPTIONALLY ONE OR MORE ENTERIC POLYMERS. 2. A FORMULATION ACCORDING TO CLAIM 1, IN WHICH THE ACTIVE DRUG IS WEAKLY BASIC. 3. A FORMULATION ACCORDING TO CLAIM 1 OR CLAIM 2, IN WHICH THE ACTIVE DRUG IS DOXAZOSINE, OR ONE OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS. 4. A FORMULATION ACCORDING TO CLAIM 1, IN WHICH THE ACTIVE DRUG HAS A HIGH SOLUBILITY IN AQUEOUS MEDIA. 5. A FORMULATION ACCORDING TO CLAIM 1, IN WHICH THE ACTIVE DRUG HAS A LOW SOLUBILITY IN AQUEOUS MEDIA. 6. A FORMULATION ACCORDING TO ANY OF THE PREVIOUS CLAIMS, IN WHICH THE HYDROXY-PROPYLMETHYL CELLULOSE HAS A NUMERICAL AVERAGE MOLECULAR WEIGHT IN THE INTERVAL OF 80,000 TO 250,000.

CO96061449A 1995-11-21 1996-11-21 PHARMACEUTICAL FORMULATIONS CO4480020A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9523752.5A GB9523752D0 (en) 1995-11-21 1995-11-21 Pharmaceutical formulations

Publications (1)

Publication Number Publication Date
CO4480020A1 true CO4480020A1 (en) 1997-07-09

Family

ID=10784188

Family Applications (1)

Application Number Title Priority Date Filing Date
CO96061449A CO4480020A1 (en) 1995-11-21 1996-11-21 PHARMACEUTICAL FORMULATIONS

Country Status (29)

Country Link
EP (1) EP0862437A1 (en)
JP (1) JPH10513481A (en)
KR (1) KR19990071505A (en)
CN (1) CN1215993A (en)
AP (1) AP718A (en)
AR (1) AR004335A1 (en)
AU (1) AU709560B2 (en)
BG (1) BG102438A (en)
BR (1) BR9611626A (en)
CA (1) CA2232715A1 (en)
CO (1) CO4480020A1 (en)
CZ (1) CZ155498A3 (en)
GB (1) GB9523752D0 (en)
HR (1) HRP960554A2 (en)
HU (1) HUP9903734A3 (en)
IS (1) IS4706A (en)
MA (1) MA26410A1 (en)
MX (1) MX9804008A (en)
NO (1) NO982302L (en)
NZ (1) NZ322053A (en)
OA (1) OA10687A (en)
PE (1) PE22898A1 (en)
PL (1) PL326981A1 (en)
SK (1) SK63098A3 (en)
TN (1) TNSN96141A1 (en)
TR (1) TR199800902T2 (en)
WO (1) WO1997018814A1 (en)
YU (1) YU62096A (en)
ZA (1) ZA969722B (en)

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Also Published As

Publication number Publication date
AR004335A1 (en) 1998-11-04
WO1997018814A1 (en) 1997-05-29
BR9611626A (en) 1999-06-01
MA26410A1 (en) 2004-12-20
HRP960554A2 (en) 1998-02-28
AP718A (en) 1999-01-06
ZA969722B (en) 1998-05-20
CA2232715A1 (en) 1997-05-29
CZ155498A3 (en) 1999-03-17
SK63098A3 (en) 1999-05-07
AP9600883A0 (en) 1997-01-31
EP0862437A1 (en) 1998-09-09
TR199800902T2 (en) 1998-09-21
TNSN96141A1 (en) 2005-03-15
JPH10513481A (en) 1998-12-22
KR19990071505A (en) 1999-09-27
AU7572196A (en) 1997-06-11
IS4706A (en) 1998-03-31
HUP9903734A3 (en) 2000-04-28
GB9523752D0 (en) 1996-01-24
HUP9903734A2 (en) 2000-03-28
YU62096A (en) 1999-03-04
NO982302L (en) 1998-07-17
BG102438A (en) 1999-01-29
NZ322053A (en) 1999-11-29
AU709560B2 (en) 1999-09-02
PL326981A1 (en) 1998-11-09
PE22898A1 (en) 1998-05-07
NO982302D0 (en) 1998-05-20
OA10687A (en) 2002-11-27
CN1215993A (en) 1999-05-05
MX9804008A (en) 1998-09-30

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