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CO2019010117A2 - Process for the separation of optical isomers of racemic ethyl esters of 3-alkylpiperidine carboxylic acid - Google Patents

Process for the separation of optical isomers of racemic ethyl esters of 3-alkylpiperidine carboxylic acid

Info

Publication number
CO2019010117A2
CO2019010117A2 CONC2019/0010117A CO2019010117A CO2019010117A2 CO 2019010117 A2 CO2019010117 A2 CO 2019010117A2 CO 2019010117 A CO2019010117 A CO 2019010117A CO 2019010117 A2 CO2019010117 A2 CO 2019010117A2
Authority
CO
Colombia
Prior art keywords
alkylpiperidine
separation
carboxylic acid
optical isomers
ethyl esters
Prior art date
Application number
CONC2019/0010117A
Other languages
Spanish (es)
Inventor
Ferenc Faigl
Béla Mátravölgyi
Ágnes Mizsák
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of CO2019010117A2 publication Critical patent/CO2019010117A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C07B63/04—Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Un proceso para la separación de isómeros ópticos de etilésteres racémicos del ácido 3-alquilpiperidin-3-carboxílico de la fórmula (rac-I) con el agente de resolución (II) ácido (-)-2,3:4,5-di-O-izopropiliden-2-ceto-L-gulónico (de aquí en adelante: ácido diacetona-L-cetogulónico).A process for the separation of optical isomers of racemic ethyl esters of 3-alkylpiperidine-3-carboxylic acid of the formula (rac-I) with the resolving agent (II) acid (-) - 2,3: 4,5-di -O-Izopropylidene-2-keto-L-gulonic (hereinafter: diacetone-L-ketogulonic acid).

CONC2019/0010117A 2017-03-13 2019-09-18 Process for the separation of optical isomers of racemic ethyl esters of 3-alkylpiperidine carboxylic acid CO2019010117A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1700109A HU231150B1 (en) 2017-03-13 2017-03-13 Process for the separation of optical isomers of racemic ethyl 3-alkylpiperidine-3-carboxylic acid
PCT/IB2018/051600 WO2018167631A1 (en) 2017-03-13 2018-03-12 Process for the separation of optical isomers of racemic 3-alkylpiperidine-carboxylic acid ethyl esters

Publications (1)

Publication Number Publication Date
CO2019010117A2 true CO2019010117A2 (en) 2019-10-09

Family

ID=89992390

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0010117A CO2019010117A2 (en) 2017-03-13 2019-09-18 Process for the separation of optical isomers of racemic ethyl esters of 3-alkylpiperidine carboxylic acid

Country Status (14)

Country Link
US (1) US11091436B2 (en)
EP (1) EP3596048A1 (en)
JP (1) JP2020511453A (en)
KR (1) KR20190128663A (en)
CN (1) CN110402245A (en)
AR (1) AR111273A1 (en)
AU (1) AU2018235267A1 (en)
BR (1) BR112019018847A2 (en)
CA (1) CA3056189A1 (en)
CO (1) CO2019010117A2 (en)
EA (1) EA201992050A1 (en)
HU (1) HU231150B1 (en)
MX (1) MX389165B (en)
WO (1) WO2018167631A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4192833B1 (en) 2020-08-05 2026-01-21 Richter Gedeon Nyrt. Pharmacologically active heterocyclic-substituted pyrazolo[1,5-a]pyrimidine derivatives

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904632A (en) * 1972-05-08 1975-09-09 Hoffmann La Roche (')-di-o-isopropylidene-2-keto-l-gulonates
US5492916A (en) 1993-12-23 1996-02-20 Merck & Co., Inc. Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
KR960705808A (en) 1993-11-09 1996-11-08 조셉 에프. 디프리마 Piperidines, pyrrolidines and hexahydro-1 H-azepines promote release of growth hormone
US5721250A (en) 1993-12-23 1998-02-24 Merck & Co. Inc. Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
US6362188B1 (en) 1998-12-18 2002-03-26 Schering Corporation Farnesyl protein transferase inhibitors
CZ20011900A3 (en) 1998-12-18 2002-02-13 Schering Corporation Substance, treatment method and pharmaceutical preparation in which the substance is comprised as well as use thereof for inhibition of farnesyl protein transferase
CO5150225A1 (en) 1999-03-19 2002-04-29 Merck Sharp & Dohme DERIVATIVES OF TETRAHYDROPIRANE AND ITS USE AS THERAPEUTIC AGENTS
WO2008117982A1 (en) 2007-03-28 2008-10-02 Crystal Genomics, Inc. Heterocyclic carboxylic acid derivatives and pharmaceutical composition for inhibiting lipid accumulation containing same
TW200938200A (en) * 2007-12-28 2009-09-16 Dainippon Sumitomo Pharma Co Methyl-substituted piperidine derivative
CA2711399C (en) 2008-02-06 2016-10-11 Banyu Pharmaceutical Co., Ltd. 3-substituted sulfonylpiperidine derivative

Also Published As

Publication number Publication date
JP2020511453A (en) 2020-04-16
CN110402245A (en) 2019-11-01
AU2018235267A1 (en) 2019-10-17
AR111273A1 (en) 2019-06-26
KR20190128663A (en) 2019-11-18
BR112019018847A2 (en) 2020-04-14
EA201992050A1 (en) 2020-02-06
MX2019011001A (en) 2019-10-17
CA3056189A1 (en) 2018-09-20
MX389165B (en) 2025-03-20
EP3596048A1 (en) 2020-01-22
WO2018167631A1 (en) 2018-09-20
HUP1700109A1 (en) 2018-09-28
US11091436B2 (en) 2021-08-17
HU231150B1 (en) 2021-03-29
US20200131126A1 (en) 2020-04-30

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