[go: up one dir, main page]

CO2019002123A2 - Plantas y métodos para aumentar y disminuir la síntesis de cannabinoides - Google Patents

Plantas y métodos para aumentar y disminuir la síntesis de cannabinoides

Info

Publication number
CO2019002123A2
CO2019002123A2 CONC2019/0002123A CO2019002123A CO2019002123A2 CO 2019002123 A2 CO2019002123 A2 CO 2019002123A2 CO 2019002123 A CO2019002123 A CO 2019002123A CO 2019002123 A2 CO2019002123 A2 CO 2019002123A2
Authority
CO
Colombia
Prior art keywords
plants
cannabinoids
methods
synthesis
decrease
Prior art date
Application number
CONC2019/0002123A
Other languages
English (en)
Inventor
Robert F Roscow
Original Assignee
Canopy Growth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Canopy Growth Corp filed Critical Canopy Growth Corp
Publication of CO2019002123A2 publication Critical patent/CO2019002123A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nutrition Science (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Esta divulgación se refiere a nuevas plantas y métodos para aumentar y disminuir la síntesis de cannabinoides. Las plantas descritas en este documento comprenden proporciones y concentraciones no naturales de cannabinoides en plantas del género cannabis. Los métodos descritos en el presente documento comprenden la manipulación de la ruta biosintética de los cannabinoides para producir plantas del género cannabis con proporciones y concentraciones de cannabinoides no naturales.
CONC2019/0002123A 2016-08-18 2019-03-06 Plantas y métodos para aumentar y disminuir la síntesis de cannabinoides CO2019002123A2 (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201662376521P 2016-08-18 2016-08-18
US201662385102P 2016-09-08 2016-09-08
US201662416098P 2016-11-01 2016-11-01
US201662416084P 2016-11-01 2016-11-01
US201662429046P 2016-12-01 2016-12-01
US201662429039P 2016-12-01 2016-12-01
US201662429049P 2016-12-01 2016-12-01
PCT/US2017/047587 WO2018035450A1 (en) 2016-08-18 2017-08-18 Plants and methods for increasing and decreasing synthesis of cannabinoids

Publications (1)

Publication Number Publication Date
CO2019002123A2 true CO2019002123A2 (es) 2019-05-31

Family

ID=61197425

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2019/0002123A CO2019002123A2 (es) 2016-08-18 2019-03-06 Plantas y métodos para aumentar y disminuir la síntesis de cannabinoides

Country Status (12)

Country Link
US (1) US11466283B2 (es)
EP (1) EP3500090A4 (es)
CN (1) CN109890202A (es)
AU (1) AU2017313843A1 (es)
BR (1) BR112019003024A8 (es)
CA (1) CA3033875A1 (es)
CL (1) CL2019000434A1 (es)
CO (1) CO2019002123A2 (es)
MX (1) MX2019001968A (es)
PE (1) PE20190654A1 (es)
WO (1) WO2018035450A1 (es)
ZA (1) ZA201900986B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
US11202771B2 (en) 2018-01-31 2021-12-21 Treehouse Biotech, Inc. Hemp powder
CA3120993C (en) * 2018-02-20 2022-06-21 Supera Pharmaceuticals, Inc. Genetically modified cannabis sativa plants and modified cannabinoid compounds for treatment of substance addiction and other disorders
CA3105433C (en) * 2018-08-17 2023-07-11 Canbreed Ltd. Cannabis plant cells with reduced delta-9-tetrahydrocannabinol (thc) content
EP3864000A4 (en) 2018-10-10 2022-08-10 Treehouse Biosciences, Inc. CANNABIGEROL SYNTHESIS
CN113227353A (zh) * 2018-11-14 2021-08-06 马努斯生物合成股份有限公司 用于产生大麻素的微生物细胞及方法
CA3130763A1 (en) 2019-02-25 2020-09-03 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
GB2597189B (en) * 2019-04-11 2024-06-05 Meng Lim Kah Process for producing a genetically modified seed
AU2020267673B2 (en) * 2019-05-09 2024-06-20 New West Genetics Inc. Methods for production of low cost terpenoids, including cannabinoids, and varieties adapted for large-scale planting and density optimization including cannabinoid preservation
WO2020240560A1 (en) * 2019-05-29 2020-12-03 Canbreed Ltd. Cannabis plants with improved yield
JP7684945B2 (ja) * 2019-07-12 2025-05-28 キャノピー グロウス コーポレイション カンナビノイド誘導体
EP4004212A1 (en) * 2019-07-30 2022-06-01 The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Institute) Methods of controlling cannabinoid synthesis in plants or cells and plants and cells produced thereby
CN112441952B (zh) * 2019-08-28 2021-08-06 析木津生物医药(广州)有限公司 一种大麻二酚-3-磺酸及其制备方法和应用、大麻二酚衍生物
US20220356484A1 (en) * 2019-09-06 2022-11-10 Dr. James Berman Genetic modification of plants
CN115298200A (zh) * 2019-10-01 2022-11-04 恩派瑞安神经科学公司 经遗传修饰的植物以及其制造方法
WO2021067645A1 (en) * 2019-10-01 2021-04-08 Intima Bioscience, Inc. Genetically modified plants and methods of making the same
JP2022551066A (ja) * 2019-10-02 2022-12-07 キャノピー グロウス コーポレイション カンナビノイド誘導体
US20240084337A1 (en) * 2019-10-11 2024-03-14 National University Of Singapore Biosynthesis of cannabinoid precursors using novel aromatic prenyl transferases
WO2021087551A1 (en) * 2019-11-04 2021-05-14 Agriculture Victoria Services Pty Ltd A method to produce targeted gene editing constructs
AU2021264520B2 (en) 2020-04-30 2025-05-22 Hydro Dynamics, Inc. System and method for treatment of plants for synthesis of compounds therefrom
EP4156912A4 (en) * 2020-05-27 2024-01-03 Canbreed Ltd. CANNABIS PLANTS WITH IMPROVED AGRONOMIC CHARACTERISTICS
CA3179868A1 (en) * 2020-07-13 2022-01-20 Betterseeds Ltd Cannabis with altered cannabinoid content
US20240102034A1 (en) * 2020-07-16 2024-03-28 Daniel Kevin FOWLER Cannabis plant with increased cannabigerolic acid
WO2022081681A1 (en) * 2020-10-13 2022-04-21 Canopy Growth Corporation Cannabis plant with increased cannabichromenic acid
US20230265444A1 (en) * 2022-02-24 2023-08-24 Canopy Growth Corporation Gene-editing in cannabis plant
KR20230143960A (ko) * 2022-04-05 2023-10-13 주식회사 진코어 유전자 교정 단백질을 포함하는 대마 유전자 교정용 조성물 및 이를 이용한 대마 유전자 교정 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011017798A1 (en) * 2009-08-12 2011-02-17 National Research Council Of Canada Aromatic prenyltransferase from cannabis
CA3130705A1 (en) 2010-04-15 2011-10-20 National Research Council Of Canada Genes and proteins for aromatic polyketide synthesis
US20160177404A1 (en) 2011-08-18 2016-06-23 Courtagen Life Sciences Inc. Cannabis genomes and uses thereof
US20140245494A1 (en) * 2013-02-25 2014-08-28 Ytzchak Cohen Cannabis plant named erez
US10441617B2 (en) * 2013-03-15 2019-10-15 Biotech Institute, Llc Breeding, production, processing and use of medical cannabis
CA2959070C (en) * 2014-08-27 2020-11-10 Caribou Biosciences, Inc. Methods for increasing cas9-mediated engineering efficiency
EP3302033A4 (en) * 2015-05-28 2018-10-31 Tweed Inc. Cannabis plants having modified expression of thca synthase

Also Published As

Publication number Publication date
BR112019003024A8 (pt) 2019-09-10
EP3500090A1 (en) 2019-06-26
EP3500090A4 (en) 2020-01-08
WO2018035450A1 (en) 2018-02-22
CA3033875A1 (en) 2018-02-22
AU2017313843A1 (en) 2019-03-07
PE20190654A1 (es) 2019-05-08
CN109890202A (zh) 2019-06-14
US20200181631A1 (en) 2020-06-11
CL2019000434A1 (es) 2019-05-24
US11466283B2 (en) 2022-10-11
ZA201900986B (en) 2019-12-18
BR112019003024A2 (pt) 2019-05-14
MX2019001968A (es) 2019-10-02

Similar Documents

Publication Publication Date Title
CO2019002123A2 (es) Plantas y métodos para aumentar y disminuir la síntesis de cannabinoides
ECSP20033467A (es) Compuestos macrocíclicos para tratar enfermedades
CL2020000632A1 (es) Composición y método para el tratamiento del autismo.
CO2018001115A2 (es) Composiciones ingeribles por abejas, procedimientos para el uso de las mismas para producir miel y miel producida de esta manera
MX2019003735A (es) Formulaciones diluibles de cannabinoides y procesos para su preparacion.
CO2017008437A2 (es) Métodos de purificación de cannabinoides, composiciones y kits de los mismos
UY35507A (es) Composiciones y métodos para mejorar el crecimiento de plantas
PE20200338A1 (es) Composiciones cannabinoides novedosas y metodos para tratar la epilepsia infantil
CL2017001893A1 (es) Uso de prg4 como agente antiinflamatorio
MX381724B (es) Cadenas ligeras comunes y metodos de uso.
DOP2015000246A (es) Derivados de oxopiridina sustituida y usos de los mismos en el tratamiento de trastornos cardiovasculares
CL2015002239A1 (es) Moduladores de las enzimas modificadoras de los metilos, composiciones que los comprenden y sus usos
PE20160123A1 (es) Metodos para mejorar la calidad de la composicion del meibo de las glandulas de meibomio
CL2016000009A1 (es) Tratamiento de rosacea papulopustular con ivermectina.
CL2017002170A1 (es) Desacetoxitubulisina h y análogos de esta.
BR112015031392A2 (pt) estrutura óptica para processamento da saída de luz por uma unidade de iluminação, unidade de iluminação, e método de fabricação de uma estrutura óptica para processamento da saída de luz por uma unidade de iluminação
CL2018003028A1 (es) Loci genéticos asociados con una mayor fertilidad en el maíz (divisional de la solicitud n° 2071-2016).
AR105894A1 (es) Composición para aplicación tópica que comprende dimetil isosorbida, un poliol, y un antioxidante fenólico o polifenólico
TWD188095S (zh) 照明燈
MX2019008725A (es) Sistemas y métodos para mejorar la formación y densidad de los tricomas en la cannabis.
MX2016015092A (es) Inhibidor de proliferacion de celulas madre cancerosas.
MX2017013137A (es) Derivados de cromeno como inhibidores de las fosfoinositido-3-cina sas.
DOP2016000064A (es) Derivados de fenilalanina sustituidos
AU359842S (en) Housing for light
DOP2018000034A (es) Combinaciones de un anticuerpo ox40 y un modulador de tlr4 y usos de las mismas