CN2768663Y - Automatic feedback control administration therapeutical instrument for cardiovascular - Google Patents

Abstract

The utility model discloses a cardiovascular automatic feedback control medicine treatment instrument, which is composed of two pressure sensors, a preamplifier, an A/D conversion, calculation and program center control device, a D/A conversion and a micropump infusion set. The utility model collects important physiological parameters such as blood pressure and heart rate through the pressure sensor directly, rapidly, continuously and with high density, and inputs them into the computer in real time and continuously through the A/D converter, and sets up a user interface window to allow the doctor to select and transform different parameters through man-machine dialogue. The medicine, through the specific mathematical model and the operation of the program, through the D/A converter output command to control an automatic control infusion device to control the speed and dose of drug administration. It absorbs the best clinically proven experience, can take advantage of the characteristics of timely, accurate, fast and accurate computer sampling, and can also avoid some human errors and long sampling intervals, etc. It has strong practicability and technological content. High, reliability and accuracy are much higher than traditional methods.

Description

Cardiovascular Automatic Feedback Control Medication Therapy Apparatus

technical field

This instrument involves comprehensive disciplines such as clinical medicine, biomedical engineering, computer, and electromechanical engineering, especially a high-tech cardiovascular automatic feedback control drug delivery treatment instrument.

Instrument background

The activity and regulation of the human cardiovascular system is a complex positive and negative feedback dynamic automatic balance regulation system. When the body is in a pathological state, especially a serious morbid imbalance (such as acute massive myocardial infarction, hypertensive crisis shock, etc.), the body has lost the ability of self-feedback regulation. The current traditional method for hospitals to deal with this emergency is: medical staff repeatedly measure various vital parameters such as blood pressure and heart rate, and use this as a basis for continuously adjusting the type and dosage of medication. Any delay and inaccuracy in treatment and processing will endanger the life of the patient and affect the body's reconstruction of the self-balance feedback system. Traditional treatment methods are affected by the experience of medical staff, the frequency and accuracy of clinical measurements, and the timely and precise adjustment of the dosage and speed of medication. Cause the success rate of present clinical rescue this type of patient is extremely low.

The development of medical instruments at home and abroad is moving in the direction of automation, intelligence, modularization and serialization, but now there are not many of them that mainly focus on diagnosis and are directly used for treatment, especially automated and intelligent treatment instruments.

Contents of the invention

The purpose of this cardiovascular automatic feedback control medication treatment instrument is to provide automatic cardiovascular feedback control for cardiovascular patients through the characteristics of automatic signal reception, analysis and processing, monitoring, alarm, fault self-diagnosis, intelligent operation and other online closed-loop automatic detection feedback control treatment. Medicine treatment instrument, so that it partially replaces traditional clinical treatment measures.

The utility model is composed of two pressure sensors, a preamplifier, an A/D conversion, calculation and program center control device, a D/A conversion and a micropump infusion set. Preamplifiers include ECG preamplifiers and invasive blood pressure preamplifiers. The calculation and program center control device is composed of a PC with RS232 standard interface and a single-chip microcomputer. The preamplifier includes an ECG preamplifier and an invasive blood pressure preamplifier.

The ECG preamplifier and the invasive blood pressure preamplifier described in the utility model both consist of several resistors, three integrated amplifiers, several capacitors and several voltage regulator tubes.

The utility model integrates rich and successful clinical experience, combines the model in the experiment to compile the data into a program, fully utilizes the advantages of the computer, and collects important physiological parameters such as blood pressure and heart rate through the pressure sensor directly, rapidly, continuously and with high density. The A/D converter continuously inputs into the computer in real time, and sets up a user interface window to allow the doctor to select and change different drugs through man-machine dialogue. Through specific mathematical models and program operations, the D/A converter outputs instructions to control An automatic control infusion set to control the rate and dose of drug administration. The reaction of the drug in the body is timely and rapidly fed back to the computer through the detection system, and the latter constantly updates the calculation results to continuously adjust the type of drug, the rate and dosage of the drug. This instrument absorbs the best experience that has been proven clinically, and at the same time, it can take advantage of the characteristics of timely, accurate, fast and accurate computer sampling. In addition, it can also avoid some human errors and long sampling intervals. . Therefore, this instrument has strong practicability and high technological content. Using it to rescue critically ill patients is much more reliable and accurate than traditional methods, and its response speed is beyond the reach of manpower.

Description of drawings

Fig. 1 is a block diagram of the utility model;

Fig. 2 is the circuit diagram of the invasive blood pressure preamplifier of the utility model;

Fig. 3 is utility model ECG preamplifier circuit diagram;

Fig. 4 is a schematic diagram of the composition of the calculation and program center control device and the micropump infusion set of the utility model.

Detailed ways

The utility model is described in detail below in conjunction with accompanying drawing.

The utility model is composed of two pressure sensors 1, a preamplifier 2, an A/D converter 3, a calculation and program center control device 4, a D/A converter 5 and a micropump infusion set 6. The preamplifier 2 includes an ECG preamplifier and an invasive blood pressure preamplifier.

The ECG preamplifier consists of resistors R1-18, integrated amplifiers A1-A3, capacitors C1-10, and regulator tubes DW1-DW4. The ECG lead signal is connected to one end of the resistors R2 and R3, the ECG lead signal is connected to the resistors R2 and R3, the other end of R2 is connected to the inverting input of the amplifier A1, and the other end of the resistor R3 is connected to the non-inverting input of the amplifier A1 Terminal "+", capacitor C2 is connected between the non-inverting and inverting input terminals of the integrated amplifier A1. Resistor R4 is a gain adjustment resistor of the integrated amplifier A1. The output terminal of the integrated amplifier A1 is connected in series with capacitors C4 and C5 and then connected to the non-inverting input terminal "+" of the integrated amplifier A2, and the resistor R6 is connected between the non-inverting input terminal of the integrated amplifier A2 and the ground. The output terminal of the integrated amplifier A2 is connected to R8, R12 and C7. R9 is connected between R8 and the ground. At the same time, the connection point of R8 and R9 is connected to a resistor R7, and the other end of the resistor R7 is connected to the inverting input terminal of the integrated amplifier A2. One end of the resistor R13 is connected to one end of the resistor R12, and the other end is connected to the non-inverting input end of the integrated amplifier A3. One end of the capacitor C9 is connected to one end of the capacitor C7, and the other end is connected to the non-inverting input end of the integrated amplifier A3. The output terminal of the integrated amplifier A3 is connected with the resistor R18, and the signal is output through the resistor R18. At the same time, the output terminal of the integrated amplifier A3 is connected with series voltage dividing resistors R15, R16, R17 and ground. The connection point of the resistors R15 and R16 is connected with the inverting input terminal of the integrated amplifier A3. The connection point of resistors R16 and R17 is connected with capacitor C8 and resistor R14 again, the other end of capacitor C8 is connected with the connection point of resistors R12 and R13, and the other end of resistor R14 is connected with the connection point of capacitors C7 and C9.

The external +12V DC power supply is connected with the regulator DW1 and the capacitor C1 through the resistor R1, and the +9V power supply is output. The other ends of the regulator tube DW1 and the capacitor C1 are connected to the ground. The external +12V DC power supply is connected with the voltage regulator tube DW3 and the capacitor C6 after passing through the resistor R10, and outputs +6V power supply. The other ends of the regulator tube DW3 and the capacitor C6 are connected to the ground. The external -12V DC power supply is connected with the regulator tube DW2 and the capacitor C3 through the resistor R5, and the -9V power supply is output. The other ends of the regulator tube DW2 and the capacitor C3 are connected to the ground. The external -12V DC power supply is connected with the voltage regulator tube DW4 and the capacitor C10 through the resistor R11, and the -6V power supply is output. The other end of the regulator tube DW4 and the capacitor C10 is connected to the ground.

The invasive blood pressure preamplifier is composed of resistors R21-R219, integrated amplifiers A21-A23, capacitors C21-29, and regulator tubes DW21-DW24. The ECG lead signal is connected across one end of the resistors R22 and R23, the other end of the resistor R22 is connected to the inverting input of the amplifier A21, the other end of the resistor R23 is connected to the non-inverting input of the integrated amplifier A21, and the capacitor C22 is connected to the non-inverting input of the amplifier A21 and the inverting input. Resistor R24 is A21 for gain adjustment resistor. The signal output by the integrated amplifier A21 is connected in series with R26 and then connected to the non-inverting input terminal of the integrated amplifier A22, and the resistors R27 and C24 are connected between the non-inverting input terminal of A22 and the ground. The output terminal of the integrated amplifier A22 is connected to resistors R29, R213, and capacitor C26. The resistor R210 is connected between the resistor R29 and the ground. At the same time, the connecting point of the resistors R29 and R210 is connected with a resistor R28, and the other end of R28 is connected to the inverting input terminal of the integrated amplifier A22. One end of the resistor R214 is connected to the other end of the resistor R213, and the other end is connected to the non-inverting input end of the integrated amplifier A23. One end of the capacitor C27 is connected to the other end of the capacitor C26, and the other end is connected to the non-inverting input end of the integrated amplifier A23. The output terminal of the integrated amplifier A23 outputs a signal through R219. At the same time, the output terminal of the integrated amplifier A23 is connected with series voltage dividing resistors R216, R217, R218 and ground. The connection point of the resistor R216 and the resistor R217 is connected with the inverting input terminal of the integrated amplifier A23. The connection point of resistors R217 and R218 is connected with capacitor C28 and resistor R215, the other end of capacitor C28 is connected with the connection point of resistors R213 and R214, and the other end of resistor R215 is connected with the connection point of capacitors C26 and C27.

The external +12V DC power supply is connected with the voltage regulator tube DW21 and the capacitor C21 through the resistor R21 to output +9V power supply. The other ends of the regulator tube DW21 and the capacitor C21 are connected to the ground. The external +12V DC power supply is connected with the voltage regulator tube DW213 and the capacitor C25 through the resistor R211 to output +6V power supply. The other ends of the regulator tube DW23 and the capacitor C25 are connected to the ground. The external -12V DC power supply is connected with the voltage regulator tube DW22 and the capacitor C23 after passing through the resistor R25, and the -9V power supply is output. The other ends of the regulator tube DW22 and the capacitor C23 are connected to the ground. The external -12V DC power supply is connected to the voltage regulator DW24 and C29 after passing through the resistor R212, and the -6V power supply is output, and the other end of the voltage regulator DW24 and the capacitor C29 are connected to the ground.

The calculation and program center control device 4 is composed of a PC with RS232 standard interface, single-chip microcomputer IC1, light-emitting diodes LED1, LED2 and resistors R31, R32, and the P1 port is connected to the four-bus three-state output buffer IC2 (74LS244) input pin: P _1.0 -P _1.3 of microcontroller IC ₁ is connected to 1A _1-4 of four-bus three-state output buffer IC ₂ , P _1.4 -P _1.7 of IC ₁ is connected to 2A _1-4 of IC ₂ , four-bus three-state output buffer IC 1Y _1-4 of ₂ is connected to 4 input terminals of motor 1 drive circuit, four-bus three-state output buffer IC 2Y _1-4 of ₂ is connected to 4 input terminals of motor 2 drive circuit, four-bus three-state output buffer IC The 1G and 2G terminals of ₂ are directly grounded. The negative pole of light-emitting diode LED1 is connected to pin 17 of microcontroller IC1, the positive pole is connected to resistor R31, the other end of resistor R31 is connected to the +5V output line of the micro pump line circuit board, the negative pole of light-emitting diode LED2 is connected to pin 16 of single-chip microcomputer IC1, and the positive pole is connected to resistor R2 , the other end of the resistor R2 is connected to the +5V output line of the micropump circuit board.

The principle of the utility model is: collect important physiological parameters such as arterial blood pressure, pulmonary artery pressure, and heart rate through the pressure sensor, input them into the computer in real time and continuously through the A/D converter, and set up a user interface window to allow the doctor to select and transform different parameters through man-machine dialogue. Through specific mathematical models and program calculations, the D/A converter outputs instructions to control an automatic control infusion device to control the dosage of drugs, and the response of drugs in the body is timely and rapidly passed through the detection system in a timely and continuous manner. The computer is continuously fed back to the computer, and the latter continuously updates the calculation results, so as to continuously adjust the type of drug, the rate and dosage of the drug by controlling the micropump.

The working principle of the micropump infusion set intravenous drug control pump is as follows:

1. The communication method adopts RS232 standard interface, and the PC sends commands to the single-chip microcomputer (89C51) through the RS232 interface, and the single-chip microcomputer completes corresponding operations according to different commands. Such as controlling the start (infusion start) or stop (stop infusion) of motor 1 or motor 2, sending back the current state of the micropump (such as syringe type, whether the pressure is alarming, whether the infusion is over, etc.) to the PC, etc.

2. After the P1 port of the single-chip microcomputer passes through the 74LS244, it controls the motor drive circuit, and then controls the work of the stepping motor.

3. The detection circuit of the type of syringe, whether the pressure is an alarm, whether the infusion is over, etc. will directly send the detection signal to the single-chip microcomputer, and the single-chip microcomputer will send it to the PC through the RS232 interface.

4. The indicator light is used to indicate the working state. If the indicator light flickers, it means that the corresponding motor is in the state of rotation (infusion).

5. The power circuit is used to provide the power required for the whole machine to work, and the backup battery maintains the power supply when the power fails.

According to the principle of clinical treatment, the utility model uses a pressure sensor, a preamplifier and an analog-to-digital conversion system to receive the patient's pulmonary artery pressure, arterial pressure and electrocardiogram. After the drug system is administered, the patient's parameter changes are fed back to the sensor. Repeatedly, a closed-loop automatic detection feedback control treatment system is formed.

Claims (5)

1, a kind of cardiovascular automatic feedback control drug treatment instrument is characterized in that: be made of two pressure transducers (1), preamplifier (2), A/D conversion (3), calculating and program center control device (4), D/A conversion (5) and micro pump transfusion device (6); Calculating and program center control device (4) are made of (PC) machine with RS232 standard interface, single-chip microcomputer (IC1), and preamplifier (2) comprises ECG preamplifier and invasive blood pressure preamplifier; Two pressure transducers (1) outfan is connected to the ECG preamplifier and the invasive blood pressure preamplifier input of preamplifier (2) respectively, the measured signal of pressure transducer (1) is delivered to preamplifier (2) to be amplified, ECG preamplifier and invasive blood pressure preamplifier outfan are connected to A/D conversion (3) its output signal are carried out the A/D conversion, A/D changes 3 outfans and is connected to single-chip microcomputer (IC1) in calculating and the program center control device (4), single-chip microcomputer (IC1) (P1) mouth meets four bus tristate output buffer (IC2) input feet, the P of single-chip microcomputer (IC1) _1.0-P _1.3Meet (the 1A of four bus tristate output buffers (IC2) _1-4), (P of single-chip microcomputer (IC1) _1.4-P _1.7) meet (2A of tristate output buffer (IC2) _1-4), (1Y of four bus tristate output buffers (IC2) _1-4) connect 4 inputs of motor (M1) drive circuit in the micro pump transfusion device (6), (2Y of four bus tristate output buffers (IC2) _1-4) connect 4 inputs of motor (M2) drive circuit in the micro pump transfusion device (6), (1G, the 2G) of four bus tristate output buffers (IC2) holds direct ground connection.

2, cardiovascular automatic feedback control drug treatment instrument according to claim 1, it is characterized in that: ECG preamplifier and the integral installation of invasive blood pressure preamplifier are on a printed circuit board.

3, according to right 1 or 2 described cardiovascular automatic feedback control drug treatment instrument, it is characterized in that: ECG preamplifier is made of resistance (R1-R18), integrated amplifier (A1-A3), electric capacity (C1-10), stabilivolt (DW1-DW4); The cross-over connection of cardiac diagnosis lead signal is in resistance (R2, a R3) end, the other end of resistance (R2) is connected to the inverting input of amplifier (A1), the other end of resistance (R3) is connected to the in-phase input end of amplifier (A1), electric capacity (C2) is connected between the homophase and inverting input of integrated amplifier (A1), and resistance (R4) is the gain-adjusted resistance of integrated amplifier (A1); Be connected to the in-phase input end of integrated amplifier (A2) behind integrated amplifier (A1) the outfan serial connection electric capacity (C4, C5), resistance (R6) is connected between the in-phase input end and ground of integrated amplifier (A2); The outfan of integrated amplifier (A2) is connected to (R8, R12, C7), resistance (R9) is connected between resistance (R8) and the ground, simultaneously, resistance (R8) connects a resistance (R7) again with the interface of resistance (R9), and the other end of resistance (R7) is connected to the inverting input of integrated amplifier (A2); One end of one end of resistance (R13) and resistance (R12) links, the in-phase input end of the other end and integrated amplifier (A3) joins, one end of one end of electric capacity (C9) and electric capacity (C7) links, the in-phase input end of the other end and integrated amplifier (A3) joins, the outfan of integrated amplifier (A3) links to each other with resistance (R18), by resistance (R18) output signal, the divider resistance of the output termination of integrated amplifier (A3) series connection simultaneously (R15, R16, R17) with ground, the interface of resistance (R15) and resistance (R16) links with the inverting input of integrated amplifier (A3) again, resistance (R16) links with electric capacity (C8) and resistance (R14) with the interface of resistance (R17) again, the other end of electric capacity (C8) and resistance (R12, R13) interface links, the other end of resistance (R14) and electric capacity (C7, C9) interface links; External+12V dc source links with stabilivolt (DW1), electric capacity (C1) by resistance (R1) back, the other end of stabilivolt (DW1), electric capacity (C1) with link, external+12V dc source links with stabilivolt (DW3), electric capacity (C6) by resistance (R10) back, the other end of stabilivolt (DW3), electric capacity (C6) with link, external direct current power supply links output-9V power supply by resistance R 5 backs with stabilivolt DW2, capacitor C 3; The other end of stabilivolt (DW2), electric capacity (C3) links with ground, and external direct current power supply links by resistance (R11) back and stabilivolt (DW4), electric capacity (C10), the other end of stabilivolt (DW4), electric capacity (C10) and link.

4, according to right 1 or 2 described cardiovascular automatic feedback control drug treatment instrument, it is characterized in that: the invasive blood pressure preamplifier is made of resistance (R21-R219), integrated amplifier (A21-A232), electric capacity (C21-29), stabilivolt (DW21-DW24); The cross-over connection of cardiac diagnosis lead signal is in resistance (R22, R23) end, the other end of resistance R 22 is connected to the inverting input of amplifier A21, the other end of resistance R 23 is connected to the in-phase input end of integrated amplifier (A21), electric capacity (C22) is connected between the homophase and inverting input of integrated amplifier (A21), resistance (R24) is that (A21) is gain-adjusted resistance, be connected to the in-phase input end of integrated amplifier (A22) after the signal serial connection (R26) of integrated amplifier (A21) output, resistance (R27), electric capacity (C24) is connected between the in-phase input end and ground of integrated amplifier (A22), the outfan of integrated amplifier (A22) is connected to resistance (R29, R213) and electric capacity (C26), resistance (R210) is connected between resistance (R29) and the ground, simultaneously, resistance (R29) and interface (R210) connect a resistance (R28) again, and the other end of resistance (R28) is connected to the inverting input of integrated amplifier (A22); The other end of one end of resistance (R214) and resistance (R213) links, and the in-phase input end of the other end and integrated amplifier (A23) joins; The other end of one end of electric capacity (C27) and electric capacity (C26) links, the in-phase input end of the other end and integrated amplifier (A23) joins, the outfan of integrated amplifier (A23) is by (R219) output signal, the divider resistance of the output termination of integrated amplifier (A23) series connection simultaneously (R216, R217, R218) with ground, the interface of resistance (R216) and resistance (R217) links with the inverting input of integrated amplifier (A23) again, resistance (R217) links with electric capacity (C28) and resistance (R215) with the interface of resistance (R218) again, the other end of electric capacity (C28) and resistance (R213, R214) interface links, the other end of resistance (R215) and electric capacity (C26, C27) interface links, and external direct current power supply is by resistance (R21) back and stabilivolt (DW21), electric capacity (C21) links; Stabilivolt (DW21), the other end of electric capacity (C21) with link, external direct current power supply is by resistance (R211) back and stabilivolt (DW213), electric capacity (C25) links, stabilivolt (DW23), the other end of electric capacity (C25) with link, external direct current power supply is by resistance (R25) back and stabilivolt (DW22), electric capacity (C23) links, stabilivolt (DW22), the other end of electric capacity (C23) with link, external direct current power supply is by resistance (R212) back and stabilivolt (DW24), electric capacity (C29) links, stabilivolt (DW24), the other end of electric capacity (C29) with link.

5, according to right 1 or 2 described cardiovascular automatic feedback control drug treatment instrument, it is characterized in that: be provided with light emitting diode (LED1, LED2) and resistance (R31, R32), the negative pole of LED 1 connects the foot 17 of single-chip microcomputer (IC1), anodal connection resistance (R31), the other end connection micro pump line of resistance (R31)+the 5V output lead, the negative pole of LED 2 connects the foot 16 of single-chip microcomputer (IC1), anodal connection resistance (R2), the other end of resistance (R2) join former micro pump wiring board+5V output lead.

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