CN2616058Y - continuous perfusion cardiac preservation device - Google Patents

Abstract

A continuous perfusion heart preservation device, comprising a heart and a storage container for a preservation solution, a membrane lung, a perfusion pump, a perfusion tube located in the heart and a storage container for a storage solution, a liquid inlet tube, a liquid outlet tube, and a sampling tube. One end of the liquid inlet pipe is connected to the heart and the storage container of the preservation solution, and the other end is connected to the membrane lung; one end of the liquid outlet pipe is connected to the membrane lung, and the other end is connected to the perfusion tube located in the heart and the storage container of the preservation solution; One end is connected with the membrane lung, and the other end is connected with the heart and the preservation solution storage container; the perfusion pump is installed in the pipeline formed by the liquid inlet tube. In this way, a closed circulatory system capable of gas exchange can be formed, so that the isolated heart (donor heart) can not only absorb oxygen and nutrients from the preservation solution, but also maintain the stability of the inner environment of the myocardium, which is beneficial to improve the isolated heart (donor heart). heart) preservation effect.

Description

continuous perfusion cardiac preservation device

1. Technical field

The utility model belongs to an isolated heart (donor heart) preservation device, in particular to a preservation device capable of continuously perfusing a preservation solution to an isolated heart (donor heart).

2. Background technology

At present, heart transplantation has become an effective method for treating end-stage heart disease, and the preservation effect of the isolated heart (donor heart) directly affects the success rate of heart transplantation. It has been more than 30 years since the first human heart transplantation, the design of the donor heart preservation solution has been changing, but the preservation technology of the donor heart has hardly changed. "High potassium arrest, low temperature static preservation" has always been the main method of donor heart preservation. Corresponding to this method, the isolated heart (donor heart) preservation device is a plastic bag and a container containing ice cubes. The isolated heart (donor heart) and its preservation solution are all placed in a plastic bag, and the sealed plastic bag is placed In a container with ice cubes. The disadvantages of the above method and storage device are: 1. It cannot provide the isolated heart with oxygen and nutrients necessary for myocardial metabolism; 2. It cannot regulate the internal environment of myocardial work, and the acidic metabolites generated by anaerobic metabolism of cardiomyocytes 3. Low-temperature storage damages the activity of enzymes and aggravates energy generation disorders; 4. The preservation of the donor heart cannot be monitored. Therefore, using the above-mentioned preservation device, the preservation effect of the isolated heart is poor (high incidence of cardiac insufficiency after transplantation), and the safe preservation time is short (4-6 hours).

3. Contents of the invention

The utility model aims at the deficiencies in the prior art, and provides a preservation device capable of continuously perfusing a preservation solution to the isolated heart (donor heart), so as to improve the preservation effect of the isolated heart (donor heart) and meet the needs of heart transplantation. .

The technical scheme of the utility model is: design a preservation device according to the living environment and conditions of the heart, the preservation device includes a heart and a preservation fluid storage container, a membrane lung provided with an air inlet pipe and an air outlet pipe, a perfusion pump, a heart and a preservation fluid storage container Filling pipe, liquid inlet pipe, liquid outlet pipe and sampling pipe in the container. One end of the liquid inlet pipe is connected with the heart and the preservation solution storage container, and the other end is connected with the membrane lung; one end of the liquid outlet pipe is connected with the membrane lung, and the other end is connected with the perfusion tube located in the heart and the preservation solution storage container; One end is connected with the membrane lung, and the other end is connected with the heart and the preservation solution storage container; the perfusion pump is installed in the pipeline formed by the liquid inlet tube. In this way, a closed circulatory system capable of gas exchange can be formed, so that the isolated heart (donor heart) can not only absorb oxygen and nutrients from the preservation solution, but also maintain the stability of the inner environment of the myocardium.

In order to use conveniently and prevent pollution, the blood of the heart donor is directly pumped into the heart and the storage container of the storage solution to prepare the storage solution. It can be equipped with a blood vessel, which is inserted on the heart and the storage solution storage container, and part of it is located in the container. A part is located outside the container.

In order to facilitate transportation and make the sediment produced during the circulation of the preservation solution fall to the bottom of the container, heart placement and preservation solution filter components can be arranged in the heart and the preservation solution storage container.

In order to monitor and adjust the pressure of the preservation solution conveniently, a pressure controller can be provided, and the pressure controller is connected with the perfusion pump and the perfusion tube through a pipe fitting.

In order to monitor and adjust the temperature of the preservation solution conveniently, a temperature monitor can be set, and the temperature monitor is installed in the heart and the preservation solution storage container.

The heart and the preservation solution storage container are composed of a body and a closure. The body is made of plastic or glass. The body wall is a single-layer structure or a sandwich structure that can be installed with a temperature-regulating device. The closure is a flexible cover or a rigid cover. The membrane lung is composed of a shell and multiple rows of hollow fiber tubes installed in the shell; in order to facilitate transportation, the shell of the membrane lung is detachably connected with the heart and the body of the preservation solution storage container, and its combined surface is connected with the heart and the preservation fluid. The shapes of the corresponding combination surfaces of the storage container body are matched.

The method of using the continuous perfusion heart preservation device provided by the utility model: first, put the preservation solution into the heart and the preservation solution storage container, then put the heart taken out from the donor into the above storage container and insert the perfusion tube into the main body of the isolated heart The connection of the perfusion tube at the root of the artery can realize the continuous perfusion of the preservation solution to the isolated heart.

The utility model has the following beneficial effects:

1. It can continuously perfuse the heart with preservation solution, continuously and stably provide the isolated heart with oxygen and nutrients necessary for myocardial metabolism, and meet the energy demand of the isolated heart (donor heart) when it stops beating.

2. Maintain the stability of the internal environment of cardiomyocytes and create good conditions for heart rejuvenation after transplantation.

3. It reduces the damage to cardiomyocytes caused by the acidic metabolites generated by anaerobic metabolism.

4. The storage temperature of the isolated heart (donor heart) can be adjusted by configuring a thermostat, not limited to lower temperatures, so there is no need to worry about energy shortage caused by increased metabolism, and energy shortage caused by decreased enzyme activity can be avoided.

5. It can monitor the preservation of the isolated heart (donor heart) and the change of the preservation solution at any time.

6. The preservation solution can be recycled, which is beneficial to reduce the preservation cost.

7. Simple operation and strong controllability.

8. Small size, easy to transport.

4. Description of drawings

Fig. 1 is the first structure diagram of the continuous perfusion heart preservation device provided by the utility model;

Fig. 2 is the second structure diagram of the continuous perfusion heart preservation device provided by the utility model;

Fig. 3 is the third structure diagram of the continuous perfusion heart preservation device provided by the utility model;

Fig. 4 is the fourth structure diagram of the continuous perfusion heart preservation device provided by the utility model;

Fig. 5 is a fifth structural diagram of the continuous perfusion heart preservation device provided by the utility model;

Fig. 6 is a kind of structural diagram of membrane lung;

Fig. 7 is a structural diagram of heart placement and preservation fluid filter member;

Fig. 8 is a cross-sectional view along line A-A of Fig. 7 .

In the figure, 1-heart and preservation solution storage container, 2-flexible cover, 3-perfusion tube, 4-sampling tube, 5-liquid outlet tube, 6-membrane lung, 7-connecting member, 8-intake tube, 9- Air outlet pipe, 10-perfusion pump, 11-liquid inlet pipe, 12-heart placement and preservation fluid filter member, 13-taking blood vessel, 14-pressure controller, 15-cover plate, 16-temperature monitor, 17-housing, 18-hollow fiber tube, 19-flexible pad, 20-filter.

5. Specific implementation

Example 1:

The structure of the continuous perfusion heart preservation device in this embodiment is shown in Figure 1, including a heart and a preservation solution storage container 1, a membrane lung 6 provided with an air inlet pipe 8 and an air outlet pipe 9, a perfusion pump 10, inserted in the heart and The blood vessel 13 on the preservation solution storage container 1, the perfusion tube 3 located in the heart and the preservation solution storage container 1, the heart placement and preservation solution filter member 12 installed at the bottom of the heart and the preservation solution storage container 1, the liquid inlet tube 11, Outlet pipe 5, sampling pipe 4. The liquid inlet pipe 11 is a silicone rubber tube, one end of which is connected to the heart and the storage container 1 of the preservation solution, and the other end is connected to the membrane lung 6; the liquid outlet pipe 5 is a silicone rubber tube, one end of which is connected to the membrane lung 6, and the other end is connected to The heart is connected to the perfusion tube 3 in the preservation solution storage container; the sampling tube 4 is a silicone rubber tube, one end of which is connected to the membrane lung 6, and the other end is connected to the heart and the preservation solution storage container 1; the perfusion pump 10 is a flow-adjustable rotor The micropump is installed in the pipeline formed by the liquid inlet pipe 11. The shape and structure of the heart and the preservation solution storage container 1 are shown in Figure 1. It is composed of a single-layer structure rigid body made of transparent plastic and a flexible cover 2 made of plastic film. The composite surface of the lung is a plane. The structure of membrane lung 6 is as shown in Figure 6, and is made up of shell 17 and the multiple rows of hollow fiber tubes 18 installed in the shell; The shell 17 of membrane lung 6 is the columnar body that arc surface and plane form, as shown in Figure 1, The combination surface of the shell 17 and the body of the heart and the preservation solution storage container 1 is a plane, and the combined connection method is bonding, and the connecting member 7 is a self-adhesive set on the combination surface. The heart placed on the lower part of the heart and the preservation solution storage container 1 is placed and the preservation solution filter member 12 is a plate-shaped body whose shape matches the storage container body, the upper layer is a deformable flexible pad (for example, a sponge pad) 19, and the lower layer is a Filter screen 20, as shown in Fig. 7, Fig. 8.

Example 2:

The structure of the continuous perfusion heart preservation device in this embodiment is shown in Figure 2. The difference from Embodiment 1 is: 1. A pressure controller 14 is added, and the pressure controller is connected with the perfusion pump 10 and the perfusion tube 3 through the pipe fittings. connect. 2. The shape and structure of the heart and the preservation solution storage container 1 are as shown in Figure 2. It is composed of a single-layer structure rigid body made of transparent plastic and a rigid cover plate 15 made of plastic. The shape of the body is a trapezoidal groove. The combined surface of the membrane lung is an inclined plane. 3. The shell 17 of the membrane lung 6 is a prism formed by an inclined plane and a plane. As shown in FIG. Component 7 is a hook and a hanging sleeve provided on the combined surface.

Example 3:

The structure of the continuous perfusion heart preservation device in this embodiment is as shown in Figure 3. The difference from Embodiment 1 is: 1. A temperature monitor 16 is added, which is installed in the heart and the preservation solution storage container 1 . 2. The shape and structure of the heart and preservation solution storage container 1 are shown in Figure 3. It is composed of a single-layer structure rigid body made of transparent plastic and a flexible cover 2 made of plastic film. The body is a rectangular groove. 3. The shell 17 of the membrane lung 6 is a cube, as shown in FIG. 3 .

Example 4:

The structure of the continuous perfusion heart preservation device in this embodiment is as shown in Figure 4, and the difference from Embodiment 1 is: 1. The shape and structure of the heart and the preservation solution storage container 1 are as shown in Figure 4, made of transparent plastic The rigid body of the sandwich structure which can be installed with temperature-regulating devices and the flexible cover 2 made of plastic film are combined. The body is a cylinder, and the combined surface with the membrane lung is an arc surface. 2. The shell 17 of the membrane lung 6 is an arc-shaped column. As shown in FIG. It is a hook and a hanging cover arranged on the combination surface.

Example 5:

The structure of the continuous perfusion heart preservation device in this embodiment is shown in Figure 5. The difference from Embodiment 1 is: 1. A pressure controller 14 is added, and the pressure controller is connected with the perfusion pump 10 and the perfusion tube 3 through the pipe fittings. connect. 2. A temperature monitor 16 is added, which is installed in the heart and the preservation solution storage container 1 . 3. The shape and structure of the heart and preservation solution storage container 1 are shown in Figure 5. It is composed of a sandwich structure rigid body made of transparent plastic that can be installed with a temperature-regulating device and a flexible cover 2 made of plastic film. The body is a cylinder. body, and its combined surface with the membrane lung is an arc surface. 4. The shell 17 of the membrane lung 6 is an arc-shaped column. As shown in FIG. It is a hook and a hanging cover arranged on the combination surface.

Claims (10)

1, a kind of lasting perfused hearts save set, comprise heart and preserve liquid storing containers (1), it is characterized in that also comprising the membrane lung (6) that is provided with air inlet pipe (8) and escape pipe (9), charge pump (10), be positioned at the intrusion pipe (3) of heart and preservation liquid storing containers (1), feed tube (11), drain pipe (5), probe tube (4), one end of feed tube (11) is connected with preservation liquid storing containers (1) with heart, the other end is connected with membrane lung (6), one end of drain pipe (5) is connected with membrane lung (6), the other end be positioned at heart and be connected with the intrusion pipe (3) of preserving the liquid storing containers, one end of probe tube (4) is connected with membrane lung (6), the other end is connected with preservation liquid storing containers (1) with heart, and charge pump (10) is installed in the pipeline of feed tube (11) formation.

2, lasting perfused hearts save set according to claim 1 is characterized in that also being equipped with and gets blood vessel (13), and this is got blood vessel and is inserted on heart and the preservation liquid storing containers (1), and a part is positioned at container, and a part is positioned at outside the container.

3, lasting perfused hearts save set according to claim 1 and 2 is characterized in that heart and preserves being provided with the heart placement in the liquid storing containers (1) and preserving liquid filter element (12).

4, lasting perfused hearts save set according to claim 1 and 2 is characterized in that also being provided with pressure controller (14), and this pressure controller is connected with intrusion pipe (3) with charge pump (10) by pipe fitting.

5, lasting perfused hearts save set according to claim 3 is characterized in that also being provided with pressure controller (14), and this pressure controller is connected with intrusion pipe (3) with charge pump (10) by pipe fitting.

6, lasting perfused hearts save set according to claim 1 and 2 is characterized in that also being provided with temperature monitor (16), and this temperature monitor is installed in heart and preserves in the liquid storing containers (1).

7, lasting perfused hearts save set according to claim 5 is characterized in that also being provided with temperature monitor (16), and this temperature monitor is installed in heart and preserves in the liquid storing containers (1).

8, lasting perfused hearts save set according to claim 7, it is characterized in that heart and preserve liquid storing containers (1) combining by body and closure member, body is made by plastics or glass, body wall is the sandwich that single layer structure maybe can be installed the temperature adjustment device, and closure member is flexible cover (2) or rigid cover plate (15).

9, lasting perfused hearts save set according to claim 8, it is characterized in that membrane lung (6) is made up of shell (17) and many rows hollow fiber conduit (18) of installing in the enclosure, shell (17) is the detachable combination that is connected with heart with the body of preserving liquid storing containers (1), and its combinatorial surface is complementary with the shape of the corresponding combinatorial surface of heart and preservation liquid storing containers (1) body.

10, lasting perfused hearts save set according to claim 9 is characterized in that the shell (17) of membrane lung and the connected mode of heart with the body of preserving liquid storing containers (1) are bonding or articulate.

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