CN2281761Y

CN2281761Y - Micro dialysis probe

Info

Publication number: CN2281761Y
Application number: CN 96228271
Authority: CN
Inventors: 郭述苏; 赵玉武
Original assignee: Individual
Current assignee: Individual
Priority date: 1996-07-09
Filing date: 1996-07-09
Publication date: 1998-05-20
Anticipated expiration: 2006-07-09

Abstract

The utility model relates to a micro dialysis probe, which is composed of an inner tube, an outer sleeve tube, a dialysis membrane tube and a right-angle bent outflow tube. The utility model changes many defects that the micro dialysis probe leaves the body, and the inner and the outer components of a cell can not be distinguished exist in the method of collecting the specimen sample with tissue homogenate. By combining the micro dialysis probe with a stereotactic apparatus, hands can be directly extended into each of different positions of the bodies of human bodies, animal bodies, plant bodies, etc. sampling is quick and exact, and the desired component analysis is obtained at the quickest speed; The utility model can be used for the analysis and the investigation in many fields of biology, medicine, botany, environmental protection science, etc., has the advantages of convenient use and accurate and quick sampling and makes the delightful contribution to the sampling of the living body.

Description

Microdialysis probe

This utility model is an analytical sampling gathering-device from goal object, particularly be to be used for biomedicine, botany and environmental protection scientific research to need the key device of collected specimens-a kind of microdialysis probe.

This utility model microdialysis probe is through Shandong Province's Searches of Patent Literature centre retrieves: " ended in by the end of June, 1996 from 1985 to, in the patent application of all bulletins, identical with above-mentioned technology is zero piece of writing in domestic Chinese patent data CDRO M storehouse.”

For example medical science use or research in, the past is during pathophysiological change in the various tissues of analyzing human body and animal model, the resourcefulness of institute's collected specimens is with " tissue homogenate method ".The living tissue that is about to desired area cuts off, and chopping, grinding, filtration obtain filtrate, go out the various compositions that wherein contain with Instrumental Analysis.Component analysis after this method can only exsomatize in the tissue, and the inside and outside Composition Region of cell in the tissue can not be distinguished one from the other, such sample data is unsafty.

The purpose of this utility model provides a kind of can directly the insertion in the different parts of human body, animal and plant body or some other goal object, obtains the microdialysis probe of existing various compositions in the goal object fast.

The purpose of this utility model is achieved in that accompanying drawings is as follows:

A kind of microdialysis probe, its construction features is:

1. the effuser 13 that is provided with interior pipe 6, trocar sheath 5, dialyzer pipe 3 and the right angle bending of side opening 2 by vertical lower end sidewall is formed;

2. be provided with trocar sheath 5 outside the stage casing of pipe 6 in; The vertical tube portions down of effuser 13 insert in trocar sheaths 5 suitable for reading, and between the outer wall of the outer wall of trocar sheath 5 inwall suitable for reading and effuser 13 vertical tube end openings and interior pipe 6 for being tightly connected; The lower port of trocar sheath 5 is communicated with the upper port sealing of dialyzer pipe 3; The lower port of the lower port of dialyzer pipe 3 and interior pipe 6 is by sealing compound 1 sealing.

In the above-mentioned microdialysis probe, install an outer shell 8 additional in the outside of interior pipe 6 and the vertical lower nozzle three's of trocar sheath 5 upper port and effuser 13 junction.

In the above-mentioned microdialysis probe, around the epimere outer wall of interior pipe 6, fit and install a sleeve pipe 9 additional, sleeve pipe 9, overcoat 12 of peripheral applying socket.

In the above-mentioned microdialysis probe, fitting around the outer wall of the horizontal pipeline section of effuser 13 adds sleeve pipe 14 of cover, the outside of sleeve pipe 14 encased 17.

Accompanying drawing 1 is the microdialysis probe cross-sectional view;

Accompanying drawing 2 is microdialysis probe embodiment 1 cross-sectional view;

Accompanying drawing 3 is microdialysis probe embodiment 2 cross-sectional view.

Description of drawings and embodiment:

1 is sealing compound, and 2 is side opening, and 3 is the dialyzer pipe, and 4 is binding agent, 5 is trocar sheath, and 6 is interior pipe, and 7 is adhesive layer, and 8 is outer shell, 9 is sleeve pipe, and 10 is adhesive layer, and 11 is the dialysis solution import, 12 is overcoat, and 13 is effuser, and 14 is sleeve pipe, 15 are the dialysis solution outlet, and 16 is adhesive layer, and 17 is overcoat, 18 is adhesive layer, and 19 is exhaust chamber, and 20 is clamp.

Can find out that by accompanying drawing 1 this utility model microdialysis probe mainly comprises upper and lower straight-through interior pipe 6, trocar sheath 5, dialyzer pipe 3, effuser 13; Interior pipe 6 middle part peripheral hardware trocar sheaths 5, one lateral surface of interior pipe 6 and a medial surface of trocar sheath 5 fit together with binding agent 7, cavity between interior pipe 6 another lateral surface and trocar sheath 5 inwalls is an exhaust chamber 19, the vertical port of effuser 13 inserts in trocar sheath 5 suitable for reading, and is fitted and connected by adhesive layer 7 between the outer wall of the inwall of trocar sheath 5 and interior pipe 6; Be fitted and connected by adhesive layer 18 between the vertical pipe outer wall down of interior pipe 6 outer walls and effuser 13 and trocar sheath 5 inwalls; The lower port of trocar sheath 5 is communicated with by binding agent 4 bondings with the upper port of dialysis mould 3; The lower port of the lower port of dialyzer pipe 3 and interior pipe 6 is jointly by sealing compound 1 sealing; In pipe 6 lower end sidewalls be provided with side opening 2, it is that a cavity is an exhaust chamber 19 that the inwall chamber of trocar sheath 5 communicates with inwall chamber in the dialyzer pipe 3; Make the lower ends that interior pipe 6 suitable for reading 11 leads to interior pipe 6 lead to exhaust chamber 19, upwards pass to perpendicular section end opening of effuser 13, feed the effuser crosspiece through the effuser end opening again, lead to the outside by the horizontal mouth 15 that brings out of effuser again through side opening 2.

For easy to use, and reinforce tubule in the path, so outside the junction of suitable for reading and the interior pipe 6 of trocar sheath 5 and effuser 13, install an outer shell 8 additional; Outside the epimere of interior pipe 6, install additional between sleeve pipe 9, two pipes and be fitted and connected by adhesive layer 10; Outside the transverse pipe of effuser 13, install additional between sleeve pipe 14, two pipes and be fitted and connected by adhesive layer 16; Add overcoat 17 of cover at sleeve pipe 9; Add overcoat 17 of cover in the outside of sleeve pipe 9.For easy to use and reinforcing also can be installed in whole tubular type microdialysis probe on the housing that is designed beautifully.

Accompanying drawing 2 is to make the embodiment profile, and on the make, the bad sealing in junction of trocar sheath 5 and dialyzer pipe 3 in this microdialysis probe adds binding agent if probe turned around, and binding agent can flow to intracavity, is difficult for bonding.For this reason, the bottom of trocar sheath 5 can be divided into two sections,, two sections trocar sheaths, 5 usefulness binding agents be docked get final product again earlier with trocar sheath 5 and dialyzer pipe 3 usefulness binding agents 4 good seals.

Can find out also that by accompanying drawing 2 effuser 13 can be vertical pipe lengthening down, through to the following bounding point near trocar sheath 5.The vertical pipe down of this section effuser 13 can replace the exhaust chamber 19 in the accompanying drawing 1.

Can find out another embodiment of microdialysis probe by accompanying drawing 3, among this figure effuser 13 and trocar sheath 5 and in combining of pipe 6 can its knot mouthful be tightly connected with clamp 20.

Work process is: the position of the dialyzer pipe 3 of microdialysis probe being inserted required analytical sampling, again with the connection microperfusion pump suitable for reading of the interior pipe 6 in the microdialysis probe, again will be according to the different material of being analyzed, the dialysis solution that the needs of different parts etc. are prepared is sent into the dialysis solution import 11 of pipe 6 in the microdialysis probe with microperfusion pump, side opening 2 by interior pipe 6 lower ends enters in the dialysis mould pipe 3 again, the outer material of dialyzer pipe 3 can enter in the dialysis solution in the dialyzer pipe 3 by film, enter in the effuser 13 through exhaust chamber 19 with dialysis solution then, flow out by the outlet 15 of effuser 13 again, thereby obtain required sampling, analyze again, promptly get required result.

Advantage of the present utility model is a lot, illustrates as follows:

In medical science, can insert the variant section of animal, human body in conjunction with stereotactic apparatus with microdialysis probe The position can be used for organizing the various biochemicals of aqueous humor etc. of outer liquid, blood, eyeball at various pathology The analysis that changes under the physiological status, and can add medicine in dislysate is to observe straight to the part of medicine Connect effect, have live body, dynamically, accurate positioning and can the material that cell is inside and outside make a distinction excellent Point, therefore closer to the functional status of body, the application in botany is also a lot, can be with microdialysis Probe inserts in the various fruit of just having taken off, and by the dialysis sampling, carries out various Analysis of Nutritive Compositions; In the application of environmental protection, can be used for the sample analysis of contained various chemical substances in soil and the moisture. In a word Having many uses of microdialysis probe just can in time be taken a sample as long as insert microdialysis probe, full out obtains it In composition and variation thereof.

Claims

1, a kind of microdialysis probe is characterized in that:

1. the effuser (13) that is provided with interior pipe (6), trocar sheath (5), dialyzer pipe (3) and the right angle bending of side opening (2) by vertical lower end sidewall is formed;

2. be provided with trocar sheath (5) outside the stage casing of pipe (6) in; Effuser (13) vertically descends tube portion to insert in trocar sheath (5) suitable for reading, and between the outer wall of the outer wall of trocar sheath (5) inwall suitable for reading and effuser (13) vertical tube end opening and interior pipe (6) for being tightly connected; The lower port of trocar sheath (5) is communicated with the upper port sealing of dialyzer pipe (3); The lower port of the lower port of dialyzer pipe (3) and interior pipe (6) is by sealing compound 1 sealing.

2, microdialysis probe according to claim 1 is characterized in that: the outside in the vertical lower nozzle three's of interior pipe (6) and trocar sheath (5) upper port and effuser (13) junction installs an outer shell (8) additional.

3, microdialysis probe according to claim 1 is characterized in that: fit around the epimere outer wall of interior pipe (6) and install a sleeve pipe (9) additional, sleeve pipe (9), an overcoat of peripheral applying socket (12).

4, microdialysis probe according to claim 1 is characterized in that: fitting around the outer wall of the horizontal pipeline section of effuser (13) adds a cover sleeve pipe (14), the outside of sleeve pipe (14) encased (17).