CN211355801U - An embryo loading device - Google Patents
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- CN211355801U CN211355801U CN201922280489.3U CN201922280489U CN211355801U CN 211355801 U CN211355801 U CN 211355801U CN 201922280489 U CN201922280489 U CN 201922280489U CN 211355801 U CN211355801 U CN 211355801U
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- 238000007789 sealing Methods 0.000 claims abstract description 66
- 230000002093 peripheral effect Effects 0.000 claims abstract description 5
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- 238000000034 method Methods 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 description 20
- 230000001681 protective effect Effects 0.000 description 12
- 238000005516 engineering process Methods 0.000 description 6
- 210000002257 embryonic structure Anatomy 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 3
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- 239000003292 glue Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
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- 230000004720 fertilization Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
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- 230000009261 transgenic effect Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
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Abstract
Description
技术领域technical field
本实用新型涉及胚胎转移技术领域,尤其涉及一种装胚装置。The utility model relates to the technical field of embryo transfer, in particular to an embryo loading device.
背景技术Background technique
在转基因动物、克隆动物以及人类的试管婴儿治疗过程中,越来越多的使用到体外受精技术和胚胎移植技术。在体外进行精子和卵子人工结合,形成受精卵,通过体外培养将受精卵发育成胚胎。利用胚胎移植技术,将胚胎移植回母体子宫进而获得妊娠。在现有技术中,胚胎及配子的转移是用毛细管加胶头,由技术人员通过手指挤压胶头进行操作。操作胚胎装入毛细管时,需要先使毛细管吸入一段保护液,再吸入一段空气,然后才是吸入带有胚胎的液体,之后吸入一段空气,最后再吸入一段保护液,使含有胚胎的液体位于两段空气及两段保护液形之间。技术人员需要经过长时间培训才能熟练掌握这门技术,同时,对新手而言技术难以掌握容易造成失误。手工操作需要非常精细,技术人员容易疲劳,无法长时间或对大量胚胎进行装胚操作。In vitro fertilization technology and embryo transfer technology are increasingly used in the treatment of transgenic animals, cloned animals and human IVF. The artificial combination of sperm and egg is carried out in vitro to form a fertilized egg, and the fertilized egg is developed into an embryo through in vitro culture. Using embryo transfer technology, embryos are transferred back to the mother's uterus to obtain pregnancy. In the prior art, the transfer of embryos and gametes is performed by adding a capillary tube with a glue tip, and the technician squeezes the glue tip with fingers to operate. When manipulating the embryo into the capillary, it is necessary to make the capillary inhale a section of protective solution, then inhale a section of air, and then inhale the liquid with embryos, then inhale a section of air, and finally inhale a section of protective liquid, so that the liquid containing embryos is located between two parts. between the air and the two protective liquids. Technicians need to go through a long period of training to master this technology. At the same time, it is difficult for novices to master the technology, which can easily lead to mistakes. The manual operation is very delicate, and the technician is easily fatigued and cannot perform the embryo loading operation for a long time or for a large number of embryos.
实用新型内容Utility model content
本实用新型的发明目的是,针对上述问题,提供一种装胚装置,解决装胚操作技术不易掌握的技术问题。The purpose of the invention of the present utility model is to provide an embryo loading device in view of the above problems, which solves the technical problem that the embryo loading operation technology is not easy to master.
为达到上述目的,本实用新型所采用的技术方案是:一种装胚装置,包括壳体、拉杆、密封环和装胚管;所述壳体内部设置有柱形腔体,所述腔体的内侧壁上设置有若干环形阻力槽,所述壳体一端开口,所述壳体上与所述开口相对的另一端设置有连接头,所述连接头内设置有与所述腔体连通的通孔;所述拉杆一端滑动地装设于所述腔体内,所述拉杆位于所述腔体内的一端的外周壁设置有环形槽,所述拉杆的另一端经由所述开口伸出所述壳体外;所述密封环具有弹性并卡箍在所述环形槽内,所述密封环的外周与所述腔体的内侧壁相贴,所述装胚管一端可拆地套设在所述连接头上,并通过连接头与所述壳体内的腔体连通。In order to achieve the above purpose, the technical scheme adopted by the present invention is: an embryo loading device, comprising a shell, a pull rod, a sealing ring and an embryo loading tube; a cylindrical cavity is arranged inside the shell, and the cavity of the cavity is A plurality of annular resistance grooves are arranged on the inner side wall, one end of the casing is open, and the other end of the casing opposite to the opening is provided with a connecting head, and the connecting head is provided with a connecting head that communicates with the cavity. one end of the pull rod is slidably installed in the cavity, the outer peripheral wall of one end of the pull rod located in the cavity is provided with an annular groove, and the other end of the pull rod protrudes out of the casing through the opening The sealing ring has elasticity and is clamped in the annular groove, the outer periphery of the sealing ring is in contact with the inner side wall of the cavity, and one end of the embryo-loading tube is detachably sleeved on the connecting head and communicates with the cavity in the housing through the connecting head.
进一步的,所述环形阻力槽的数量为五个,五个环形阻力槽自所述连接头到所述开口的方向间隔设置,所述密封环的数量为一个,所述密封环能够受力朝所述开口方向拉出,并依次与五个所述环形阻力槽卡接。Further, the number of the annular resistance grooves is five, the five annular resistance grooves are arranged at intervals from the connecting head to the opening, the number of the sealing ring is one, and the sealing ring can be forced toward the opening. The opening is pulled out in the direction of opening, and is snapped with the five annular resistance grooves in sequence.
进一步的,五个所述环形阻力槽由所述连接头到所述开口方向依次为第一环形阻力槽、第二环形阻力槽、第三环形阻力槽、第四环形阻力槽和第五环形阻力槽;初始状态下,拉杆位于壳体内的一端与壳体相抵,所述拉杆由初始状态拉出至密封环卡入第一环形阻力槽的距离与所述第四环形阻力槽、第五环形阻力槽之间的间距相同;所述第一环形阻力槽、第二环形阻力槽之间的间距与所述第三环形阻力槽、第四环形阻力槽之间的间距相同。Further, the five annular resistance grooves are, from the connector to the opening, a first annular resistance groove, a second annular resistance groove, a third annular resistance groove, a fourth annular resistance groove and a fifth annular resistance groove. In the initial state, the end of the pull rod located in the casing is in contact with the casing, and the distance between the pull rod being pulled out from the initial state and the sealing ring stuck in the first annular resistance groove is the same as the distance between the fourth annular resistance groove and the fifth annular resistance groove. The spacing between the grooves is the same; the spacing between the first annular resistance groove and the second annular resistance groove is the same as the spacing between the third annular resistance groove and the fourth annular resistance groove.
进一步的,所述环形阻力槽的数量为三个,所述密封环和的述环形槽的数量均为二个,每一所述环形槽上均卡箍有一所述密封环。Further, the number of the annular resistance grooves is three, the number of the sealing ring and the annular groove is two, and the sealing ring is clamped on each of the annular grooves.
进一步的,三个所述环形阻力槽由所述连接头到所述开口依次为第一环形阻力槽、第二环形阻力槽和第三环形阻力槽,两个所述密封环由所述连接头到所述开口方向依次为第一密封环和第二密封环;初始状态时,所述拉杆位于壳体内的一端与壳体相抵,两件所述密封环均较第一环形阻力槽靠近连接头。Further, the three annular resistance grooves are sequentially formed from the connecting head to the opening as a first annular resistance groove, a second annular resistance groove and a third annular resistance groove, and the two sealing rings are connected by the connecting head. The opening direction is the first sealing ring and the second sealing ring in sequence; in the initial state, the end of the tie rod located in the casing is in contact with the casing, and the two sealing rings are both closer to the connecting head than the first annular resistance groove. .
进一步的,所述壳体为透明或半透明材料制成。Further, the casing is made of transparent or translucent material.
进一步的,所述密封环为硅胶材料制成。Further, the sealing ring is made of silicone material.
由于采用上述技术方案,本实用新型的有益效果为:Owing to adopting the above-mentioned technical scheme, the beneficial effects of the present utility model are:
1.本实用新型初始状态下,拉杆位于壳体内的一端与壳体相抵;使用时,先将装胚管的自由端置于保护液体内,通过将拉杆向外拉出一段距离并使密封环第一次卡入环形阻力槽内;由于密封环的封闭作用,拉杆向外拉出时腔体内产生负压,装胚管吸入一段保护液;再将装胚管的自由端置于空气中,通过将拉杆向外再拉出一段距离并使密封环第二次卡入环形阻力槽内,此时装胚管吸入一段空气;再将装胚管的自由端置于有胚液体内,通过将拉杆向外再拉出一段距离并使密封环第三次卡入环形阻力槽内,使装胚管吸入有胚液体。同理,最后再吸入一段空气和一段保护液体,将装胚管取下,完成装胚工作。基于上述操作,拉杆拉出过程中,由于密封环与环形阻力槽的相互作用,可使密封环卡于环形阻力槽时产生明显的阻力,提醒操作在感受到明显阻力后转换装胚管的放置位置后再用力拉出,即可以轻易掌握装胚管中吸入各段液体或空气的量,该装胚装置操作简单方便,能够提高工作效率,且准确不易操作失误。1. In the initial state of the present utility model, the end of the pull rod located in the casing is in contact with the casing; when in use, the free end of the embryo-loading tube is first placed in the protective liquid, and the pull rod is pulled out for a distance to make the sealing ring. It is stuck into the annular resistance groove for the first time; due to the sealing effect of the sealing ring, negative pressure is generated in the cavity when the pull rod is pulled out, and the embryo-loading tube sucks a section of protective liquid; then the free end of the embryo-loading tube is placed in the air, By pulling the tie rod outward for a further distance and making the sealing ring snap into the annular resistance groove for the second time, the embryo loading tube sucks a section of air at this time; Pull out another distance and make the sealing ring snap into the annular resistance groove for the third time, so that the embryo loading tube sucks the embryo liquid. In the same way, finally inhale a section of air and a section of protective liquid, remove the embryo-loading tube, and complete the embryo-loading work. Based on the above operations, due to the interaction between the sealing ring and the annular resistance groove during the pull-out process of the tie rod, obvious resistance can be generated when the sealing ring is stuck in the annular resistance groove. After pulling it out after the position, you can easily grasp the amount of liquid or air inhaled in each section of the embryo loading tube.
2.本实用新型可通过设置有两个密封环,通过两个密封环,一密封环卡于环形阻力槽内时,另一密封环持续保持与受体内壁接触,可保证腔体内完全不漏气,吸入空气或液体量的准确性。2. The utility model can be provided with two sealing rings. Through the two sealing rings, when one sealing ring is stuck in the annular resistance groove, the other sealing ring is kept in contact with the inner wall of the receptor, which can ensure that the cavity is completely leak-proof. The accuracy of the amount of air, inhaled air or liquid.
附图说明Description of drawings
图1为本实用新型实施例1剖视结构图;1 is a cross-sectional structural view of
图2为本实用新型实施例2剖视结构图。FIG. 2 is a cross-sectional structural diagram of
附图中,1-壳体、2-拉杆、3-密封环、4-装胚管、11-腔体、12-第一环形阻力槽、13-第二环形阻力槽、14-第三环形阻力槽、15-第四环形阻力槽、16-第五环形阻力槽、17-连接头、21-环形槽、31-第一密封环、32-第二密封环。In the drawings, 1-shell, 2-tie rod, 3-seal ring, 4-embryo tube, 11-cavity, 12-first annular resistance groove, 13-second annular resistance groove, 14-third annular Resistance groove, 15-fourth annular resistance groove, 16-fifth annular resistance groove, 17-connecting head, 21-annular groove, 31-first sealing ring, 32-second sealing ring.
具体实施方式Detailed ways
以下结合附图对实用新型的具体实施进一步说明。The specific implementation of the utility model is further described below with reference to the accompanying drawings.
在本实用新型的描述中,需要理解的是,术语“中心”、“长度”、“宽度”、“上”、“下”、“竖直”、“水平”、“顶”、“底”、“内”等指示的方位或位置关系为基于附图所示的方位或位置关系,仅是为了便于描述本实用新型和简化描述,而不是指示或暗示所指的装置或元件必须具有特定的方位、以特定的方位构造和操作,因此不能理解为对本实用新型的限制。In the description of the present invention, it should be understood that the terms "center", "length", "width", "upper", "lower", "vertical", "horizontal", "top", "bottom" The orientation or positional relationship indicated by , "in", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific Orientation, construction and operation in a particular orientation, and therefore should not be construed as a limitation of the present invention.
在本实用新型中,除非另有明确的规定和限定,术语“安装”、“相连”、“连接”、“固定”等术语应做广义理解,例如,可以是固定连接,也可以是可拆卸连接,或成一体;可以是直接相连,也可以通过中间媒介间接相连,可以是两个元件内部的连通或两个元件的相互作用关系。对于本领域的普通技术人员而言,可以根据具体情况理解上述术语在本实用新型中的具体含义。In the present utility model, unless otherwise expressly specified and limited, the terms "installation", "connection", "connection", "fixed" and other terms should be understood in a broad sense, for example, it may be a fixed connection or a detachable connection Connection, or integration; it can be directly connected, or indirectly connected through an intermediate medium, and it can be the internal communication between two elements or the interaction relationship between the two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.
在本实用新型中,除非另有明确的规定和限定,第一特征在第二特征之“上”或之“下”可以包括第一和第二特征直接接触,也可以包括第一和第二特征不是直接接触而是通过它们之间的另外的特征接触。而且,第一特征在第二特征“之上”、“上方”和“上面”包括第一特征在第二特征正上方和斜上方,或仅仅表示第一特征水平高度高于第二特征。第一特征在第二特征“之下”、“下方”和“下面”包括第一特征在第二特征正下方和斜下方,或仅仅表示第一特征水平高度小于第二特征。In the present invention, unless otherwise expressly specified and limited, a first feature "on" or "under" a second feature may include the first and second features in direct contact, or may include the first and second features The features are not in direct contact but through additional features between them. Also, the first feature being "above", "over" and "above" the second feature includes the first feature being directly above and obliquely above the second feature, or simply means that the first feature is level higher than the second feature. The first feature is "below", "below" and "below" the second feature includes the first feature being directly below and diagonally below the second feature, or simply means that the first feature has a lower level than the second feature.
请参见图1,一种装胚装置,包括壳体1、拉杆2、密封环3和装胚管4;壳体1内部设置有柱形腔体11,腔体11的内侧壁上设置有五个环形阻力槽,壳体1一端开口,壳体1上与开口相对的另一端设置有连接头17,连接头17内设置有与腔体11连通的通孔;拉杆2一端滑动地装设于腔体11内,拉杆2位于腔体11内的一端的外周壁设置有环形槽21,拉杆2 的另一端经由壳体1开口伸出;密封环3具有弹性并卡箍在环形槽21内,密封环3的外周与腔体11的内侧壁相贴,装胚管4一端可拆地套设在连接头17上,并通过连接头17与壳体1 内的腔体11连通。其中,密封环3可以采用硅胶材料制成,壳体1可采用有机玻璃或半透明塑料等透明或半透明材料制成。Please refer to FIG. 1 , an embryo loading device includes a
本实施例中,环形阻力槽的数量为五个,密封环3的数量为一个。五个环形阻力槽由连接头17到开口方向依次为第一环形阻力槽12、第二环形阻力槽13、第三环形阻力槽14、第四环形阻力槽15和第五环形阻力槽16;初始状态下,拉杆2位于壳体1内的一端与壳体1相抵,密封环3位于第一环形阻力槽12和连接头之间;拉杆2由初始状态拉出至密封环3 卡入第一环形阻力槽12的距离与第四环形阻力槽15、第五环形阻力槽16之间的间距相同;第一环形阻力槽12、第二环形阻力槽13之间的间距与第三环形阻力槽14、第四环形阻力槽 15之间的间距相同。使用时,先将装胚管4的自由端置于保护液体内,通过将拉杆2向外拉出一段距离并使密封环3第一次卡入第一环形阻力槽12内;由于密封环3的封闭作用,拉杆 2向外拉出时腔体11内产生负压,装胚管4吸入一段保护液;再将装胚管4的自由端置于空气中,通过将拉杆2向外再拉出一段距离并使密封环3卡入第二环形阻力槽13内,此时装胚管4吸入一段空气;再将装胚管4的自由端置于有胚液体内,通过将拉杆2向外再拉出一段距离并使密封环3卡入第三环形阻力槽14内,使装胚管4吸入有胚液体。最后同理,使密封环3依次卡入第四环形阻力槽15、第五环形阻力槽16,使装胚管4再吸入一段空气和一段保护液体,将装胚管4取下,完成装胚工作。In this embodiment, the number of annular resistance grooves is five, and the number of
实施例2Example 2
请参见图2,一种装胚装置,包括壳体1、拉杆2、密封环3和装胚管4;壳体1内部设置有柱形腔体11,腔体11的内侧壁上设置有若干环形阻力槽,壳体1一端开口,壳体1上与开口相对的另一端设置有连接头17,连接头17内设置有与腔体11连通的通孔;拉杆2一端滑动地装设于腔体11内,拉杆2位于腔体11内一端的外周壁设置有环形槽21,拉杆2的另一端经由壳体1开口伸出;密封环3具有弹性并卡箍在环形槽21内,密封环3的外周与腔体11的内侧壁相贴,装胚管4一端可拆地套设在连接头17外,并通过连接头17与壳体1内的腔体11连通。其中,密封环3可以采用硅胶材料制成,壳体1可采用有机玻璃或半透明塑料等透明或半透明材料制成。Please refer to FIG. 2 , an embryo loading device includes a
本实施例中,环形阻力槽的数量为三个,密封环3和的述环形槽21的数量均为二个,每一环形槽21上均卡箍有一密封环3。三个环形阻力槽由连接头17到开口依次为第一环形阻力槽12、第二环形阻力槽13和第三环形阻力槽14,两个密封环3由连接头17到开口方向依次为第一密封环31和第二密封环32。初始状态时,拉杆2位于壳体1内的一端与壳体1相抵,第一密封环31和第二密封环32均较第一环形阻力槽12靠近连接头17。使用时,先将装胚管4的自由端置于保护液体内,通过将拉杆2向外拉出一段距离并使第二密封环32卡入第一环形阻力槽12内;由于密封环3的封闭作用,拉杆2向外拉出时腔体11内产生负压,装胚管4吸入一段保护液;再将装胚管4的自由端置于空气中,通过将拉杆2向外再拉出一段距离并使第一密封环31卡入第一环形阻力槽12内,此时装胚管4吸入一段空气;再将装胚管4的自由端置于有胚液体内,通过将拉杆2向外再拉出一段距离并使第二密封环32卡入第二环形阻力槽13内,使装胚管4吸入有胚液体。同理,将拉杆2向外拉出一段距离并使第一密封环31卡入第二环形阻力槽13内吸入一段空气;最后将拉杆2向外拉出一段距离并使第二密封环32卡入第三环形阻力槽14内吸入一段保护液体,将装胚管4取下,完成装胚工作。In this embodiment, the number of annular resistance grooves is three, the number of the
上述说明是针对本实用新型较佳可行实施例的详细说明,但实施例并非用以限定本实用新型的专利申请范围,凡本实用新型所提示的技术精神下所完成的同等变化或修饰变更,均应属于本实用新型所涵盖专利范围。The above description is a detailed description of the preferred feasible embodiments of the present utility model, but the embodiments are not intended to limit the scope of the patent application of the present utility model. All should belong to the scope of the patent covered by this utility model.
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| RU208259U1 (en) * | 2021-04-13 | 2021-12-10 | Федеральное государственное бюджетное образовательное учреждение высшего образования Санкт-Петербургский государственный университет ветеринарной медицины ФГБОУ ВО СПбГУВМ | Return needle for follicle puncture in cows |
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Assignee: Nanning Zhanjia Machinery Technology Co.,Ltd. Assignor: GUANGXI ZHUANG AUTONOMOUS REGION BUFFALO INSTITUTE Contract record no.: X2024980027980 Denomination of utility model: A embryo loading device Granted publication date: 20200828 License type: Common License Record date: 20241204 |