CN203923174U - A kind of nucleic acid extraction evenly mixing device - Google Patents
A kind of nucleic acid extraction evenly mixing device Download PDFInfo
- Publication number
- CN203923174U CN203923174U CN201420353934.9U CN201420353934U CN203923174U CN 203923174 U CN203923174 U CN 203923174U CN 201420353934 U CN201420353934 U CN 201420353934U CN 203923174 U CN203923174 U CN 203923174U
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- CN
- China
- Prior art keywords
- erecting frame
- follower
- bar magnet
- driving toothed
- gear
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 18
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 18
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 18
- 238000002156 mixing Methods 0.000 title claims abstract description 16
- 238000000605 extraction Methods 0.000 title claims abstract description 12
- 230000002093 peripheral effect Effects 0.000 claims abstract description 4
- 238000004891 communication Methods 0.000 claims description 3
- 239000011324 bead Substances 0.000 abstract description 9
- 206010011409 Cross infection Diseases 0.000 abstract description 5
- 206010029803 Nosocomial infection Diseases 0.000 abstract description 5
- 239000000443 aerosol Substances 0.000 abstract description 5
- 238000001514 detection method Methods 0.000 abstract description 5
- 238000000926 separation method Methods 0.000 abstract description 4
- 238000012360 testing method Methods 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 abstract description 3
- 239000000523 sample Substances 0.000 description 18
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 238000010009 beating Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 241000276425 Xiphophorus maculatus Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940088623 biologically active substance Drugs 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
A kind of nucleic acid extraction evenly mixing device, comprise erecting frame, drive-motor, driving toothed gear, multiple follower gears, and with multiple follower gears bar magnet cover one to one, the body partial fixing of drive-motor is on erecting frame, the plurality of follower gear and driving toothed gear are all articulated on erecting frame and along linear arrangement, driving toothed gear and the follower gear being adjacent, and two adjacent follower gears all coordinate in the mode of engagement, driving toothed gear is synchronously connected in the rotating shaft of drive-motor, bar magnet cover is arranged at the below of erecting frame, its outer peripheral edges are provided with at least one agitating vane, top ends and the follower gear corresponding with it of bar magnet cover synchronously connect.The utility model can avoid liquid to splash from the top of test tube, reduces aerosol phenomenon, thereby effectively reduces cross infection, the accuracy that improves sample detection, meanwhile, its speed mixing is higher, can coordinate magnetic bead separating device, realize the sharp separation of nucleic acid.
Description
Technical field
The utility model relates to a kind of nucleic acid extraction evenly mixing device.
Background technology
In disease control, the field such as food safety, forensic identification, genomics, conventionally need to extract biological active substance (as DNA) as detecting, the object of research, the extraction of traditional biologically active substance, generally include cracking broken wall, purify, the operations such as washing, conventionally need to be by the reagent adding and sample blending in purification process, for example, while adopting magnetic bead separation method to purify, by after in joining sample with the reagent of magnetic bead, need to utilize pipettor to be inserted in sample tube, the rifle head that utilizes vacuum pump control pipettor suction repeatedly, be the usually said suction product of drawing a design, so that reagent and sample are mixed fully, the evenly mixing device of this structure in actual use, owing to being difficult to control the extracting force of vacuum pump, therefore, in the time of aspirated specimens, be easy to cause splashing of sample, thereby cause the cross infection of sample room, simultaneously, can produce aerosol in sample interior, affect the accuracy of sample detection.
Utility model content
For the deficiencies in the prior art, the purpose of this utility model is intended to provide a kind of nucleic acid extraction evenly mixing device, and it can avoid splashing of sample, reduces aerosol phenomenon, thereby effectively reduces cross infection, improves the accuracy of sample detection.
For achieving the above object, the utility model adopts following technical scheme:
Nucleic acid extraction evenly mixing device, comprise erecting frame, drive-motor, driving toothed gear, multiple follower gears, and with multiple follower gears bar magnet cover one to one, the body partial fixing of drive-motor is on erecting frame, the plurality of follower gear and driving toothed gear are all articulated on erecting frame and along linear arrangement, driving toothed gear and the follower gear being adjacent, and two adjacent follower gears all coordinate in the mode of engagement, driving toothed gear is synchronously connected in the rotating shaft of drive-motor, bar magnet cover is arranged at the below of erecting frame, its outer peripheral edges are provided with at least one agitating vane, top ends and the follower gear corresponding with it of bar magnet cover synchronously connect.
Bar magnet overlaps the hollow structure for upper end opening, is provided with the through hole of the upper end open communication of overlapping with bar magnet on follower gear.
The upper surface of erecting frame is fixed with mount pad, and the body of drive-motor is fixed on the upper surface of mount pad, and driving toothed gear is arranged on holding in gap of forming between mount pad and erecting frame.
The diameter of driving toothed gear and multiple follower gears all equates.
The beneficial effects of the utility model are:
Than prior art, the utility model adopts bar magnet cover stirred sample and reagent, reagent and sample are mixed fully, and it adopts churned mechanically mode, can avoid liquid to splash from the top of test tube, reduce aerosol phenomenon, thereby effectively reduce cross infection, improve the accuracy of sample detection, simultaneously, inhale the mode of beating than existing employing pipettor, its speed mixing is higher.In addition, the utility model can coordinate magnetic bead separating device, realizes the sharp separation of nucleic acid.
Brief description of the drawings
Fig. 1 is structural representation of the present utility model;
Fig. 2 is use view of the present utility model;
Wherein: 10, erecting frame; 20, drive-motor; 21, driving toothed gear; 22, mount pad; 30, follower gear; 31, through hole; 40, bar magnet cover.
Embodiment
Below, by reference to the accompanying drawings and embodiment, the utility model is described further:
As shown in Figure 1, for a kind of nucleic acid extraction evenly mixing device of the present utility model, it comprises erecting frame 10, drive-motor 20, driving toothed gear 21, multiple follower gears 30 and multiple respectively with follower gear 30 bar magnet cover 40 one to one, wherein, erecting frame 10 is platy structure, the body partial fixing of drive-motor 20 is on erecting frame 10, and the rotating shaft of drive-motor 20 is along short transverse to downward-extension, 21 of driving toothed gears are synchronously connected in the rotating shaft of drive-motor 20, concrete is, be fixed with a mount pad 22 at the upper surface of erecting frame 10, the body of drive-motor 20 is fixed on mount pad 22, between mount pad 22 and erecting frame 10, form the gap that holds that a width is slightly larger than driving toothed gear 21 thickness, driving toothed gear 21 is arranged in this and holds gap, above-mentioned multiple follower gears 30 and driving toothed gear 21 are be all articulated in the upper surface of erecting frame 10 and arrange along the length direction of erecting frame 10, driving toothed gear 21 and the follower gear 30 being adjacent, and two adjacent follower gears 30 are all that the mode engaging coordinates, thereby, in the time that drive-motor 20 drives driving toothed gear 21 to rotate, above-mentioned multiple follower gears 30 rotate under the drive of driving toothed gear 21 simultaneously.Bar magnet cover 40 is all arranged at the below of erecting frame 10, the outer peripheral edges of this bar magnet cover 40 are at least provided with an agitating vane, the top ends of bar magnet cover 40 and the follower gear 30 corresponding with it synchronously connect, the top end part of bar magnet cover 40 can be to be installed in the draw-in groove of follower gear 30 lower surfaces, under the drive of above-mentioned follower gear 30, bar magnet cover 40 is around self central axis rotation.Above-mentioned bar magnet cover 40 is the hollow structure of upper end opening, on follower gear 30, be provided with the through hole 31 with the upper end open communication of bar magnet cover 40, referring to Fig. 2, the bar magnet cover 40 of hollow forms a bar magnet cover, after utilizing bar magnet cover 40 fully to mix by the sample in test tube with the reagent of magnetic bead, nucleic acid is combined with magnetic bead, utilize bar magnet to be inserted into bar magnet cover 40 from through hole 31 from top to bottom, the magnetic bead of being combined with nucleic acid is attracted to the surface of bar magnet cover 40, erecting frame 10 and bar magnet are synchronized with the movement and depart from from sample tube afterwards, realize separating of nucleic acid and sample, finally bar magnet is extracted out from bar magnet cover 40, realize separating of nucleic acid and magnetic bead.
Above-mentioned driving toothed gear 21 and the diameter of multiple follower gear 30 all equate, thereby make the stir speed (S.S.) of multiple bar magnet covers 40 identical.
Than prior art, the utility model adopts bar magnet to overlap 40 stirred samples and reagent, reagent and sample are mixed fully, and it adopts churned mechanically mode, can avoid liquid to splash from the top of test tube, reduce aerosol phenomenon, thereby effectively reduce cross infection, improve the accuracy of sample detection, simultaneously, inhale the mode of beating than existing employing pipettor, its speed mixing is higher.In addition, the utility model can coordinate magnetic bead separating device, realizes the sharp separation of nucleic acid.
To one skilled in the art, can be according to technical scheme described above and design, make other various corresponding changes and deformation, and within these all changes and deformation all should belong to the protection domain of the utility model claim.
Claims (4)
1. a nucleic acid extraction evenly mixing device, it is characterized in that, comprise erecting frame, drive-motor, driving toothed gear, multiple follower gears, and with multiple follower gears bar magnet cover one to one, the body partial fixing of drive-motor is on erecting frame, the plurality of follower gear and driving toothed gear are all articulated on erecting frame and along linear arrangement, driving toothed gear and the follower gear being adjacent, and two adjacent follower gears all coordinate in the mode of engagement, driving toothed gear is synchronously connected in the rotating shaft of drive-motor, bar magnet cover is arranged at the below of erecting frame, its outer peripheral edges are provided with at least one agitating vane, top ends and the follower gear corresponding with it of bar magnet cover synchronously connect.
2. nucleic acid extraction evenly mixing device as claimed in claim 1, is characterized in that, bar magnet overlaps the hollow structure for upper end opening, is provided with the through hole of the upper end open communication of overlapping with bar magnet on follower gear.
3. nucleic acid extraction evenly mixing device as claimed in claim 1, it is characterized in that, the upper surface of erecting frame is fixed with mount pad, and the body of drive-motor is fixed on the upper surface of mount pad, and driving toothed gear is arranged on holding in gap of forming between mount pad and erecting frame.
4. nucleic acid extraction evenly mixing device as claimed in claim 1, is characterized in that, the diameter of driving toothed gear and multiple follower gears all equates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420353934.9U CN203923174U (en) | 2014-06-26 | 2014-06-26 | A kind of nucleic acid extraction evenly mixing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420353934.9U CN203923174U (en) | 2014-06-26 | 2014-06-26 | A kind of nucleic acid extraction evenly mixing device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203923174U true CN203923174U (en) | 2014-11-05 |
Family
ID=51819029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420353934.9U Expired - Lifetime CN203923174U (en) | 2014-06-26 | 2014-06-26 | A kind of nucleic acid extraction evenly mixing device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203923174U (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104059848A (en) * | 2014-06-26 | 2014-09-24 | 广州冠科生物科技有限公司 | Uniform mixing device for nucleic acid extraction |
| CN105062888A (en) * | 2015-09-02 | 2015-11-18 | 苏州东胜兴业科学仪器有限公司 | Magnetic rod pipe sleeves, multi-link assembly and nucleic acid extraction instrument |
| WO2015180561A1 (en) * | 2014-05-27 | 2015-12-03 | 北京自由度科学机器有限公司 | Apparatus and method for magnetic bead method |
| CN105733942A (en) * | 2016-04-11 | 2016-07-06 | 广州市达安医疗器械有限公司 | Device for nucleic acid extraction |
| CN105733927A (en) * | 2016-04-11 | 2016-07-06 | 广州市达安医疗器械有限公司 | Consumable for nucleic acid extraction and multiple combined consumables |
| CN105733941A (en) * | 2016-04-11 | 2016-07-06 | 广州市达安医疗器械有限公司 | Magnetic bead separation device for nucleic acid extraction |
| CN106434336A (en) * | 2016-04-11 | 2017-02-22 | 广州市达安医疗器械有限公司 | Magnetic bead separation apparatus used for nucleic acid extraction |
| TWI706802B (en) * | 2019-11-18 | 2020-10-11 | 瑞基海洋生物科技股份有限公司 | Portable nucleic acid extraction device |
-
2014
- 2014-06-26 CN CN201420353934.9U patent/CN203923174U/en not_active Expired - Lifetime
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015180561A1 (en) * | 2014-05-27 | 2015-12-03 | 北京自由度科学机器有限公司 | Apparatus and method for magnetic bead method |
| CN104059848A (en) * | 2014-06-26 | 2014-09-24 | 广州冠科生物科技有限公司 | Uniform mixing device for nucleic acid extraction |
| CN105062888A (en) * | 2015-09-02 | 2015-11-18 | 苏州东胜兴业科学仪器有限公司 | Magnetic rod pipe sleeves, multi-link assembly and nucleic acid extraction instrument |
| CN105733942A (en) * | 2016-04-11 | 2016-07-06 | 广州市达安医疗器械有限公司 | Device for nucleic acid extraction |
| CN105733927A (en) * | 2016-04-11 | 2016-07-06 | 广州市达安医疗器械有限公司 | Consumable for nucleic acid extraction and multiple combined consumables |
| CN105733941A (en) * | 2016-04-11 | 2016-07-06 | 广州市达安医疗器械有限公司 | Magnetic bead separation device for nucleic acid extraction |
| CN106434336A (en) * | 2016-04-11 | 2017-02-22 | 广州市达安医疗器械有限公司 | Magnetic bead separation apparatus used for nucleic acid extraction |
| CN106434336B (en) * | 2016-04-11 | 2019-05-21 | 广州市达安医疗器械有限公司 | A kind of magnetic bead separating device for nucleic acid extraction |
| TWI706802B (en) * | 2019-11-18 | 2020-10-11 | 瑞基海洋生物科技股份有限公司 | Portable nucleic acid extraction device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20141105 |